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Tanshinone IIA Exhibits Anticonvulsant Activity in Zebrafish and Mouse Seizure Models

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Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Chem. Neurosci. 2013, 4, 11, 1479-1487
    Research Article

    Tanshinone IIA Exhibits Anticonvulsant Activity in Zebrafish and Mouse Seizure Models
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    † Laboratory for Molecular Biodiscovery, Department of Pharmaceutical & Pharmacological Sciences, KU Leuven - University of Leuven, 3000 Leuven, Belgium
    ‡ Facultad de Ciencias Quimicas, Escuela de Bioquimica y Farmacia, Universidad de Cuenca, Cuenca 101168, Ecuador
    § College of Pharmacy, Gannan Medical University, Ganzhou 341000, China
    College of Pharmacy, Nankai University, Tianjin 300071, China
    ○ Analysis Center, Tsinghua University, Beijing 100084, China
    ⊥ Molecular Design and Synthesis, Department of Chemistry, KU Leuven - University of Leuven, 3001 Leuven, Belgium
    ∥ Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg
    ▽ Department of Biology, KU Leuven - University of Leuven, 3000 Leuven, Belgium
    *E-mail: [email protected]
    *E-mail: [email protected]
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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2013, 4, 11, 1479–1487
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    https://doi.org/10.1021/cn400140e
    Published August 12, 2013
    Copyright © 2013 American Chemical Society
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    Abstract

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    Danshen or Chinese red sage (Salvia miltiorrhiza, Bunge) is used by traditional Chinese medicine (TCM) practitioners to treat neurological, cardiovascular, and cerebrovascular disorders and is included in some TCM formulations to control epileptic seizures. In this study, acetonic crude extracts of danshen inhibited pentylenetetrazol (PTZ)-induced seizure activity in zebrafish larvae. Subsequent zebrafish bioassay-guided fractionation of the extract resulted in the isolation of four major tanshinones, which suppressed PTZ-induced activity to varying degrees. One of the active tanshinones, tanshinone IIA, also reduced c-fos expression in the brains of PTZ-exposed zebrafish larvae. In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i.v. PTZ seizure assay. Interestingly, tanshinone IIA is used as a prescription drug in China to address cerebral ischemia in patients. Here, we provide the first in vivo evidence demonstrating that tanshinone IIA has anticonvulsant properties as well.

    Copyright © 2013 American Chemical Society

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    This article is cited by 72 publications.

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    Cite this: ACS Chem. Neurosci. 2013, 4, 11, 1479–1487
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