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Neoglucosylated Collagen Matrices Drive Neuronal Cells to Differentiate
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    Neoglucosylated Collagen Matrices Drive Neuronal Cells to Differentiate
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    Department of Biotechnology and Biosciences, University of Milano-Bicocca , P.zza della Scienza 2, I-20126 Milano, Italy
    Department of Human Morphology, Human Morphology Laboratory, University of Insubria Via Monte Generoso 71, I- 21100 Varese, Italy
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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2014, 5, 4, 261–265
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    https://doi.org/10.1021/cn400222s
    Published March 13, 2014
    Copyright © 2014 American Chemical Society

    Abstract

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    Despite the relevance of carbohydrates as cues in eliciting specific biological responses, glycans have been rarely exploited in the study of neuronal physiology. We report thereby the study of the effect of neoglucosylated collagen matrices on neuroblastoma F11 cell line behavior. Morphological and functional analysis clearly showed that neoglucosylated collagen matrices were able to drive cells to differentiate. These data show for the first time that F11 cells can be driven from proliferation to differentiation without the use of chemical differentiating agents. Our work may offer to cell biologists new opportunities to study neuronal cell differentiation mechanisms in a cell environment closer to physiological conditions.

    Copyright © 2014 American Chemical Society

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    Figure S1. Transmission images of F11 cells. This material is available free of charge via the Internet at http://pubs.acs.org.

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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2014, 5, 4, 261–265
    Click to copy citationCitation copied!
    https://doi.org/10.1021/cn400222s
    Published March 13, 2014
    Copyright © 2014 American Chemical Society

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