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Classics in Chemical Neuroscience: Diazepam (Valium)

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Department of Pharmacology, Johns Hopkins University, Baltimore, Maryland 21205, United States
Lieber Institute for Brain Development, Baltimore, Maryland 21205, United States
Cite this: ACS Chem. Neurosci. 2014, 5, 4, 253–260
Publication Date (Web):February 19, 2014
https://doi.org/10.1021/cn5000056
Copyright © 2014 American Chemical Society

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    Abstract

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    Diazepam (Valium) is among the most successful drugs from the onset of the psychopharmacological revolution that began during the 1950s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues.

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