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Precursor Processing by Kex2/Furin Proteases

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Department of Biological Chemistry, University of Michigan Medical Center, Room 5413 Med Sci I, 1301 East Catherine, Ann Arbor Michigan 48109, and Department of Biochemistry, Stanford University, Stanford, California 94305
Cite this: Chem. Rev. 2002, 102, 12, 4525–4548
Publication Date (Web):November 12, 2002
https://doi.org/10.1021/cr010168i
Copyright © 2002 American Chemical Society

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     Stanford University. Present address:  c/o Thorner lab, 401 Barker Hall, MCB Department, University of California, Berkeley, California 94720.

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     To whom correspondence should be addressed.

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    2. Theo Klein, Ulrich Eckhard, Antoine Dufour, Nestor Solis, and Christopher M. Overall . Proteolytic Cleavage—Mechanisms, Function, and “Omic” Approaches for a Near-Ubiquitous Posttranslational Modification. Chemical Reviews 2018, 118 (3) , 1137-1168. https://doi.org/10.1021/acs.chemrev.7b00120
    3. Sven O. Dahms, Kornelia Hardes, Torsten Steinmetzer, and Manuel E. Than . X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket. Biochemistry 2018, 57 (6) , 925-934. https://doi.org/10.1021/acs.biochem.7b01124
    4. Reem Smoum, Abraham Rubinstein, Valery M. Dembitsky, and Morris Srebnik . Boron Containing Compounds as Protease Inhibitors. Chemical Reviews 2012, 112 (7) , 4156-4220. https://doi.org/10.1021/cr608202m
    5. Gero L. Becker, Frank Sielaff, Manuel E. Than, Iris Lindberg, Sophie Routhier, Robert Day, Yinghui Lu, Wolfgang Garten and Torsten Steinmetzer . Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics. Journal of Medicinal Chemistry 2010, 53 (3) , 1067-1075. https://doi.org/10.1021/jm9012455
    6. Anca Dragulescu-Andrasi, Gaolin Liang and Jianghong Rao. In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates. Bioconjugate Chemistry 2009, 20 (8) , 1660-1666. https://doi.org/10.1021/bc9002508
    7. Yufeng Shen, Kim K. Hixson, Nikola Tolić, David G. Camp, Samuel O. Purvine, Ronald J. Moore and Richard D. Smith . Mass Spectrometry Analysis of Proteome-Wide Proteolytic Post-Translational Degradation of Proteins. Analytical Chemistry 2008, 80 (15) , 5819-5828. https://doi.org/10.1021/ac800077w
    8. Biao Ruan, Viktoriya London, Kathryn E. Fisher, D. Travis Gallagher and Philip N. Bryan. Engineering Substrate Preference in Subtilisin: Structural and Kinetic Analysis of a Specificity Mutant. Biochemistry 2008, 47 (25) , 6628-6636. https://doi.org/10.1021/bi800089f
    9. Champak Chatterjee,, Moushumi Paul,, Lili Xie, and, Wilfred A. van der Donk. Biosynthesis and Mode of Action of Lantibiotics. Chemical Reviews 2005, 105 (2) , 633-684. https://doi.org/10.1021/cr030105v
    10. Limin Wu, Wenyin Bian, Yakubu Saddeeq Abubakar, Jiayi Lin, Huijuan Yan, Huan zhang, Zonghua Wang, Changbiao Wu, WonBo Shim, Guo-dong Lu. FvKex2 is required for development, virulence, and mycotoxin production in Fusarium verticillioides. Applied Microbiology and Biotechnology 2024, 108 (1) https://doi.org/10.1007/s00253-024-13022-8
    11. Bin Gao, Shunyi Zhu. The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization. Cellular and Molecular Life Sciences 2024, 81 (1) https://doi.org/10.1007/s00018-024-05273-5
    12. Hiroyuki Tanaka, Mayuko Tamura, Mirai Muto, Yuka Kinoshita, Nobuaki Ito, Akira Oka, Sachiko Kitanaka. A Novel Pathogenic Variant in Fibroblast Growth Factor 23 outside the Furin-Recognizing RXXR Motif in an Autosomal Dominant Hypophosphatemic Rickets Patient. Hormone Research in Paediatrics 2024, , 1-8. https://doi.org/10.1159/000538388
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    14. Nathan C Rockwell, J Clark Lagarias, . GUN4 appeared early in cyanobacterial evolution. PNAS Nexus 2023, 2 (5) https://doi.org/10.1093/pnasnexus/pgad131
    15. Yanjie Jin, Na Yang, Da Teng, Ya Hao, Ruoyu Mao, Jianhua Wang. Molecular Modification of Kex2 P1’ Site Enhances Expression and Druggability of Fungal Defensin. Antibiotics 2023, 12 (4) , 786. https://doi.org/10.3390/antibiotics12040786
    16. Mi-Jin Kim, Bong Hyun Sung, Hyun-Jin Kim, Jung-Hoon Sohn, Jung-Hoon Bae. Production of autolysis-proof Kex2 protease from Candida albicans in Saccharomyces cerevisiae for in vitro processing of fusion proteins. Applied Microbiology and Biotechnology 2022, 106 (21) , 7063-7072. https://doi.org/10.1007/s00253-022-12212-6
    17. Thuy Van Lam van, Teodora Ivanova, Iris Lindberg, Eva Böttcher-Friebertshäuser, Torsten Steinmetzer, Kornelia Hardes. Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7. Analytical Biochemistry 2022, 655 , 114836. https://doi.org/10.1016/j.ab.2022.114836
    18. Daniel Favre, Jackson F. Harmon, Ali Zhang, Matthew S. Miller, Igor A. Kaltashov. Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycle. Journal of Inorganic Biochemistry 2022, 234 , 111899. https://doi.org/10.1016/j.jinorgbio.2022.111899
    19. Ji Sung Cho, Hye Ji Oh, Young Eun Jang, Hyun Jin Kim, Areum Kim, Jong‐Am Song, Eun Jung Lee, Jeewon Lee. Synthetic pro‐peptide design to enhance the secretion of heterologous proteins by Saccharomyces cerevisiae. MicrobiologyOpen 2022, 11 (3) https://doi.org/10.1002/mbo3.1300
    20. Simon C. Kessler, Yit-Heng Chooi. Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi. Natural Product Reports 2022, 39 (2) , 222-230. https://doi.org/10.1039/D1NP00048A
    21. Awad A. Shehata, Youssef A. Attia, Md. Tanvir Rahman, Shereen Basiouni, Hesham R. El-Seedi, Esam I. Azhar, Asmaa F. Khafaga, Hafez M. Hafez. Diversity of Coronaviruses with Particular Attention to the Interspecies Transmission of SARS-CoV-2. Animals 2022, 12 (3) , 378. https://doi.org/10.3390/ani12030378
    22. E. Burchacka, P. Pięta, A. Łupicka-Słowik. Recent advances in fungal serine protease inhibitors. Biomedicine & Pharmacotherapy 2022, 146 , 112523. https://doi.org/10.1016/j.biopha.2021.112523
    23. Yingwei Chen, Eric A. Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman, Yihong Chen, Yanan He, Ruixue Wang, Raquel Godoy-Ruiz, Harlan King, Gregory Custer, D. Travis Gallagher, David A. Rozak, Melani Solomon, Silvia Muro, David J. Weber, John Orban, Thomas R. Fuerst, Philip N. Bryan. Engineering subtilisin proteases that specifically degrade active RAS. Communications Biology 2021, 4 (1) https://doi.org/10.1038/s42003-021-01818-7
    24. Abel Caballero-Pérez, José María Viader-Salvadó, Ana Lucía Herrera-Estala, José Antonio Fuentes-Garibay, Martha Guerrero-Olazarán. Buried Kex2 Sites in Glargine Precursor Aggregates Prevent Its Intracellular Processing in Pichia pastoris Muts Strains and the Effect of Methanol-Feeding Strategy and Induction Temperature on Glargine Precursor Production Parameters. Applied Biochemistry and Biotechnology 2021, 193 (9) , 2806-2829. https://doi.org/10.1007/s12010-021-03567-z
    25. Manita Shakya, Iris Lindberg. Mouse Models of Human Proprotein Convertase Insufficiency. Endocrine Reviews 2021, 42 (3) , 259-294. https://doi.org/10.1210/endrev/bnaa033
    26. Giacomo Rossi, Livio Galosi, Alessandra Gavazza, Matteo Cerquetella, Sara Mangiaterra. Therapeutic approaches to coronavirus infection according to “One Health” concept. Research in Veterinary Science 2021, 136 , 81-88. https://doi.org/10.1016/j.rvsc.2021.02.009
    27. Elizabeth Estevez-Fregoso, Eunice D. Farfán-García, Itzel H. García-Coronel, Erick Martínez-Herrera, Alberto Alatorre, Romulus I. Scorei, Marvin A. Soriano-Ursúa. Effects of boron-containing compounds in the fungal kingdom. Journal of Trace Elements in Medicine and Biology 2021, 65 , 126714. https://doi.org/10.1016/j.jtemb.2021.126714
    28. Pablo Aza, Gonzalo Molpeceres, Felipe de Salas, Susana Camarero. Design of an improved universal signal peptide based on the α-factor mating secretion signal for enzyme production in yeast. Cellular and Molecular Life Sciences 2021, 78 (7) , 3691-3707. https://doi.org/10.1007/s00018-021-03793-y
    29. Antonín Sedlář, Martina Trávníčková, Roman Matějka, Šimon Pražák, Zuzana Mészáros, Pavla Bojarová, Lucie Bačáková, Vladimír Křen, Kristýna Slámová. Growth Factors VEGF-A165 and FGF-2 as Multifunctional Biomolecules Governing Cell Adhesion and Proliferation. International Journal of Molecular Sciences 2021, 22 (4) , 1843. https://doi.org/10.3390/ijms22041843
    30. Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Science Alliance 2020, 3 (9) , e202000786. https://doi.org/10.26508/lsa.202000786
    31. John Nemunaitis, Laura Stanbery, Neil Senzer. Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) Infection: Let the Virus Be Its Own Demise. Future Virology 2020, 15 (6) , 381-395. https://doi.org/10.2217/fvl-2020-0068
    32. Jie Sun, Jie Jiang, Xinyang Zhai, Shaoming Zhu, Zhenzhen Qu, Wei Yuan, Zhao Wang, Chun Wei. Coexpression of Kex2 Endoproteinase and Hac1 Transcription Factor to Improve the Secretory Expression of Bovine Lactoferrin in Pichia pastoris. Biotechnology and Bioprocess Engineering 2019, 24 (6) , 934-941. https://doi.org/10.1007/s12257-019-0176-5
    33. Hong Zhu, Elizabeth Mathew, Sara M. Connelly, Jeffrey Zuber, Mark Sullivan, Michael S. Piepenbrink, James J. Kobie, Mark E. Dumont, . Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies. PLOS ONE 2019, 14 (9) , e0221550. https://doi.org/10.1371/journal.pone.0221550
    34. Marc W.T. Werten, Gerrit Eggink, Martien A. Cohen Stuart, Frits A. de Wolf. Production of protein-based polymers in Pichia pastoris. Biotechnology Advances 2019, 37 (5) , 642-666. https://doi.org/10.1016/j.biotechadv.2019.03.012
    35. Jason C. Casler, Effrosyni Papanikou, Juan J. Barrero, Benjamin S. Glick. Maturation-driven transport and AP-1–dependent recycling of a secretory cargo in the Golgi. Journal of Cell Biology 2019, 218 (5) , 1582-1601. https://doi.org/10.1083/jcb.201807195
    36. Sujuan Sun, Yanan Liu, Julan Xia, Miao Wang, Rui Tang, Chunyang Lei, Yan Huang, Zhou Nie, Shouzhuo Yao. A semisynthetic fluorescent protein assembly-based FRET probe for real-time profiling of cell membrane protease functions in situ. Chemical Communications 2019, 55 (15) , 2218-2221. https://doi.org/10.1039/C8CC09634A
    37. Yide Huang, Yanyu Long, Suhuan Li, Ting Lin, Jingwen Wu, Yafei Zhang, Yao Lin. Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris. Microbial Cell Factories 2018, 17 (1) https://doi.org/10.1186/s12934-018-1020-x
    38. Hana Raschmanová, Leona Paulová, Barbora Branská, Zdeněk Knejzlík, Karel Melzoch, Karin Kovar. Production and cleavage of a fusion protein of porcine trypsinogen and enhanced green fluorescent protein (EGFP) in Pichia pastoris. Folia Microbiologica 2018, 63 (6) , 773-787. https://doi.org/10.1007/s12223-018-0619-y
    39. Torsten Steinmetzer, Kornelia Hardes. The Antiviral Potential of Host Protease Inhibitors. 2018, 279-325. https://doi.org/10.1007/978-3-319-75474-1_11
    40. Wolfgang Garten. Characterization of Proprotein Convertases and Their Involvement in Virus Propagation. 2018, 205-248. https://doi.org/10.1007/978-3-319-75474-1_9
    41. Shenghan Chen, Hao Wang, Heng Li, Yue Zhang, Qingyu Wu. Functional analysis of corin protein domains required for PCSK6-mediated activation. The International Journal of Biochemistry & Cell Biology 2018, 94 , 31-39. https://doi.org/10.1016/j.biocel.2017.11.010
    42. Takahisa Imamura, Yoji Murakami, Hidetoshi Nitta. Aeromonas sobria serine protease (ASP): a subtilisin family endopeptidase with multiple virulence activities. Biological Chemistry 2017, 398 (10) , 1055-1068. https://doi.org/10.1515/hsz-2016-0344
    43. Jing-Si Zha, Bing-Lin Zhu, Lu Liu, Yu-Jie Lai, Yan Long, Xiao-Tong Hu, Xiao-Juan Deng, Xue-Feng Wang, Zhen Yan, Guo-Jun Chen. Phorbol esters dPPA/dPA promote furin expression involving transcription factor CEBPβ in neuronal cells. Oncotarget 2017, 8 (36) , 60159-60172. https://doi.org/10.18632/oncotarget.18569
    44. Kornelia Hardes, Teodora Ivanova, Bastian Thaa, Gerald M. McInerney, Tove Irene Klokk, Kirsten Sandvig, Sebastian Künzel, Iris Lindberg, Torsten Steinmetzer. Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin. ChemMedChem 2017, 12 (8) , 613-620. https://doi.org/10.1002/cmdc.201700108
    45. Antonija Grbavac, Iva Čanak, Igor Stuparević, Renata Teparić, Vladimir Mrša. Proteolytic processing of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2017, 1864 (3) , 507-515. https://doi.org/10.1016/j.bbamcr.2016.12.009
    46. Marcella Araújo Manfredi, Alyne Alexandrino Antunes, Larissa de Oliveira Passos Jesus, Maria Aparecida Juliano, Luiz Juliano, Wagner Alves de Souza Judice. Specificity characterization of the α-mating factor hormone by Kex2 protease. Biochimie 2016, 131 , 149-158. https://doi.org/10.1016/j.biochi.2016.10.003
    47. Qin Li, Xianzong Shi, Shengjian Ye, Sheng Wang, Ron Chan, Troy Harkness, Hong Wang. A short motif in Arabidopsis CDK inhibitor ICK 1 decreases the protein level, probably through a ubiquitin‐independent mechanism. The Plant Journal 2016, 87 (6) , 617-628. https://doi.org/10.1111/tpj.13223
    48. Kasturi Haldar. Protein trafficking in apicomplexan parasites: crossing the vacuolar Rubicon. Current Opinion in Microbiology 2016, 32 , 38-45. https://doi.org/10.1016/j.mib.2016.04.013
    49. Ying Ye, Atsushi Minami, Yuya Igarashi, Miho Izumikawa, Myco Umemura, Nozomi Nagano, Masayuki Machida, Teppei Kawahara, Kazuo Shin‐ya, Katsuya Gomi, Hideaki Oikawa. Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post‐translationally Modified Peptide Ustiloxin B in Filamentous Fungi. Angewandte Chemie 2016, 128 (28) , 8204-8207. https://doi.org/10.1002/ange.201602611
    50. Ying Ye, Atsushi Minami, Yuya Igarashi, Miho Izumikawa, Myco Umemura, Nozomi Nagano, Masayuki Machida, Teppei Kawahara, Kazuo Shin‐ya, Katsuya Gomi, Hideaki Oikawa. Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post‐translationally Modified Peptide Ustiloxin B in Filamentous Fungi. Angewandte Chemie International Edition 2016, 55 (28) , 8072-8075. https://doi.org/10.1002/anie.201602611
    51. Xing Cheng, Weijia Wang, Qi Xu, James Harper, Danielle Carroll, Mark S. Galinski, JoAnn Suzich, Hong Jin, . Genetic Modification of Oncolytic Newcastle Disease Virus for Cancer Therapy. Journal of Virology 2016, 90 (11) , 5343-5352. https://doi.org/10.1128/JVI.00136-16
    52. Jie Qu, Shin Gene Kang, Cyrus Hah, Jyan-Chyun Jang. Molecular and cellular characterization of GA-Stimulated Transcripts GASA4 and GASA6 in Arabidopsis thaliana. Plant Science 2016, 246 , 1-10. https://doi.org/10.1016/j.plantsci.2016.01.009
    53. Wenming Zhang, Liqin Kang, Mingmei Yang, Yajun Zhou, Jun Wang, Zhonghua Liu, Sheng Yuan, . Purification, characterization and function analysis of an extracellular β-glucosidase from elongating stipe cell walls in Coprinopsis cinerea. FEMS Microbiology Letters 2016, 363 (9) , fnw078. https://doi.org/10.1093/femsle/fnw078
    54. Laurent-Olivier Roy, Marie-Belle Poirier, David Fortin. Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta. Investigational New Drugs 2015, 33 (5) , 1020-1031. https://doi.org/10.1007/s10637-015-0275-x
    55. Shenghan Chen, Pengxiu Cao, Ningzheng Dong, Jianhao Peng, Chunyi Zhang, Hao Wang, Tiantian Zhou, Junhua Yang, Yue Zhang, Elizabeth E Martelli, Sathyamangla V Naga Prasad, Rachel E Miller, Anne-Marie Malfait, Yiqing Zhou, Qingyu Wu. PCSK6-mediated corin activation is essential for normal blood pressure. Nature Medicine 2015, 21 (9) , 1048-1053. https://doi.org/10.1038/nm.3920
    56. Verena Puxbaum, Clemens Gruber, Silvia Heiss, Friedrich Altmann, Brigitte Gasser, Diethard Mattanovich. Multistep processing of the secretion leader of the extracellular protein Epx1 in Pichia pastoris and implications for protein localization. Microbiology 2015, 161 (7) , 1356-1368. https://doi.org/10.1099/mic.0.000105
    57. Abdullah M. Khamis, Magbubah Essack, Xin Gao, Vladimir B. Bajic. Distinct profiling of antimicrobial peptide families. Bioinformatics 2015, 31 (6) , 849-856. https://doi.org/10.1093/bioinformatics/btu738
    58. Jingyang Wang, Hui Zhou, Hua Lu, Ting Du, Yuanming Luo, Iain B.H. Wilson, Cheng Jin. Kexin-like endoprotease KexB is required for N-glycan processing, morphogenesis and virulence in Aspergillus fumigatus. Fungal Genetics and Biology 2015, 76 , 57-69. https://doi.org/10.1016/j.fgb.2015.02.006
    59. Jing Mu, Fang Liu, Muhammad Shafiq Rajab, Meng Shi, Shuang Li, Chiching Goh, Lei Lu, Qing‐Hua Xu, Bin Liu, Lai Guan Ng, Bengang Xing. A Small‐Molecule FRET Reporter for the Real‐Time Visualization of Cell‐Surface Proteolytic Enzyme Functions. Angewandte Chemie International Edition 2014, 53 (52) , 14357-14362. https://doi.org/10.1002/anie.201407182
    60. Jing Mu, Fang Liu, Muhammad Shafiq Rajab, Meng Shi, Shuang Li, Chiching Goh, Lei Lu, Qing‐Hua Xu, Bin Liu, Lai Guan Ng, Bengang Xing. A Small‐Molecule FRET Reporter for the Real‐Time Visualization of Cell‐Surface Proteolytic Enzyme Functions. Angewandte Chemie 2014, 126 (52) , 14585-14590. https://doi.org/10.1002/ange.201407182
    61. Fatma Sfaxi, Nathalie Scamuffa, Claude Lalou, Jia Ma, Peter Metrakos, Géraldine Siegfried, Hermann Ragg, Andreas Bikfalvi, Fabien Calvo, Abdel-Majid Khatib. Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases. Oncotarget 2014, 5 (12) , 4195-4210. https://doi.org/10.18632/oncotarget.1966
    62. Song Yang, Ye Kuang, Hongbo Li, Yuehong Liu, Xiaoyan Hui, Peng Li, Zhiwu Jiang, Yulai Zhou, Yu Wang, Aimin Xu, Shiwu Li, Pentao Liu, Donghai Wu, . Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1’ site. PLoS ONE 2013, 8 (9) , e75347. https://doi.org/10.1371/journal.pone.0075347
    63. Kasey J. Day, L. Andrew Staehelin, Benjamin S. Glick. A three-stage model of Golgi structure and function. Histochemistry and Cell Biology 2013, 140 (3) , 239-249. https://doi.org/10.1007/s00418-013-1128-3
    64. Beth N. Licitra, Jean K. Millet, Andrew D. Regan, Brian S. Hamilton, Vera D. Rinaldi, Gerald E. Duhamel, Gary R. Whittaker. Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline Coronavirus. Emerging Infectious Diseases 2013, 19 (7) , 1066-1073. https://doi.org/10.3201/eid1907.121094
    65. Robert T. Yang, Glendale L. Lim, Zhihong Dong, Arthur M. Lee, Colin T. Yee, Robert S. Fuller, Helena H. Ritchie. The Efficiency of Dentin Sialoprotein-Phosphophoryn Processing Is Affected by Mutations Both Flanking and Distant from the Cleavage Site*. Journal of Biological Chemistry 2013, 288 (8) , 6024-6033. https://doi.org/10.1074/jbc.M112.382952
    66. Eizo Takahashi, Keinosuke Okamoto. ASP Peptidase. 2013, 3209-3213. https://doi.org/10.1016/B978-0-12-382219-2.00706-7
    67. Robert S. Fuller. Kexin. 2013, 3270-3277. https://doi.org/10.1016/B978-0-12-382219-2.00722-5
    68. . References. 2012, 231-284. https://doi.org/10.1002/9781118414514.refs
    69. Susan Michaelis, Jemima Barrowman. Biogenesis of the Saccharomyces cerevisiae Pheromone a -Factor, from Yeast Mating to Human Disease. Microbiology and Molecular Biology Reviews 2012, 76 (3) , 626-651. https://doi.org/10.1128/MMBR.00010-12
    70. Jin Hou, Keith E.J. Tyo, Zihe Liu, Dina Petranovic, Jens Nielsen. Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae. FEMS Yeast Research 2012, 12 (5) , 491-510. https://doi.org/10.1111/j.1567-1364.2012.00810.x
    71. Gero L. Becker, Yinghui Lu, Kornelia Hardes, Boris Strehlow, Christine Levesque, Iris Lindberg, Kirsten Sandvig, Udo Bakowsky, Robert Day, Wolfgang Garten, Torsten Steinmetzer. Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases. Journal of Biological Chemistry 2012, 287 (26) , 21992-22003. https://doi.org/10.1074/jbc.M111.332643
    72. Debora Jacob-Wilk, Marino Moretti, Massimo Turina, Pam Kazmierczak, Neal K. Van Alfen. Differential expression of the putative Kex2 processed and secreted aspartic proteinase gene family of Cryphonectria parasitica. Fungal Biology 2012, 116 (3) , 363-378. https://doi.org/10.1016/j.funbio.2011.12.006
    73. Hiroyuki Takahara, Aurelie Huser, Richard O'Connell. Two arginine biosynthesis genes are essential for pathogenicity of Colletotrichum higginsianum on Arabidopsis. Mycology 2012, 3 (1) , 54-64. https://doi.org/10.1080/21501203.2011.654353
    74. Jay Shockey, Dorselyn Chapital, Satinder Gidda, Catherine Mason, Gaynelle Davis, K. Thomas Klasson, Heping Cao, Robert Mullen, John Dyer. Expression of a lipid-inducible, self-regulating form of Yarrowia lipolytica lipase LIP2 in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 2011, 92 (6) , 1207-1217. https://doi.org/10.1007/s00253-011-3505-y
    75. Ikram Jemel, Hiromi Ii, Rob C. Oslund, Christine Payré, Anne-Sophie Dabert-Gay, Dominique Douguet, Khaoula Chargui, Sabine Scarzello, Michael H. Gelb, Gérard Lambeau. Group X Secreted Phospholipase A2 Proenzyme Is Matured by a Furin-like Proprotein Convertase and Releases Arachidonic Acid inside of Human HEK293 Cells. Journal of Biological Chemistry 2011, 286 (42) , 36509-36521. https://doi.org/10.1074/jbc.M111.268540
    76. D. Dafydd Jones, . Recombining Low Homology, Functionally Rich Regions of Bacterial Subtilisins by Combinatorial Fragment Exchange. PLoS ONE 2011, 6 (9) , e24319. https://doi.org/10.1371/journal.pone.0024319
    77. Gero L. Becker, Kornelia Hardes, Torsten Steinmetzer. New substrate analogue furin inhibitors derived from 4-amidinobenzylamide. Bioorganic & Medicinal Chemistry Letters 2011, 21 (16) , 4695-4697. https://doi.org/10.1016/j.bmcl.2011.06.091
    78. Akihiko Ozawa, Adam N. Lick, Iris Lindberg. Processing of Proaugurin Is Required to Suppress Proliferation of Tumor Cell Lines. Molecular Endocrinology 2011, 25 (5) , 776-784. https://doi.org/10.1210/me.2010-0389
    79. Rajesh T. Shenoy, Saravanan Thangamani, Adrian Velazquez-Campoy, Bow Ho, Jeak Ling Ding, J. Sivaraman, . Structural Basis for Dual-Inhibition Mechanism of a Non-Classical Kazal-Type Serine Protease Inhibitor from Horseshoe Crab in Complex with Subtilisin. PLoS ONE 2011, 6 (4) , e18838. https://doi.org/10.1371/journal.pone.0018838
    80. Michael Gamble, Georg Künze, Eleanor J. Dodson, Keith S. Wilson, D. Dafydd Jones. Regulation of an intracellular subtilisin protease activity by a short propeptide sequence through an original combined dual mechanism. Proceedings of the National Academy of Sciences 2011, 108 (9) , 3536-3541. https://doi.org/10.1073/pnas.1014229108
    81. Celine Denais, Carolyn L. Dent, Laura Southgate, Jacqueline Hoyle, Dimitra Dafou, Richard C. Trembath, Rajiv D. Machado. Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and golgi organization and is associated with protein secretion pathways critical in bone development. Human Mutation 2011, 32 (2) , 231-239. https://doi.org/10.1002/humu.21413
    82. Cathal Wilson, Rossella Venditti, Laura R. Rega, Antonino Colanzi, Giovanni D'Angelo, M. Antonietta De Matteis. The Golgi apparatus: an organelle with multiple complex functions. Biochemical Journal 2011, 433 (1) , 1-9. https://doi.org/10.1042/BJ20101058
    83. Gregory Pearce, Yube Yamaguchi, Gerhard Munske, Clarence A. Ryan. Structure–activity studies of RALF, Rapid Alkalinization Factor, reveal an essential – YISY – motif. Peptides 2010, 31 (11) , 1973-1977. https://doi.org/10.1016/j.peptides.2010.08.012
    84. Swapna Apte, David Avram Sanders. Effects of retroviral envelope-protein cleavage upon trafficking, incorporation, and membrane fusion. Virology 2010, 405 (1) , 214-224. https://doi.org/10.1016/j.virol.2010.06.004
    85. Mario A. Izidoro, Diego M. Assis, Vitor Oliveira, Jorge A.N. Santos, Maria A. Juliano, Iris Lindberg, Luiz Juliano. Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein. Biological Chemistry 2010, 391 (9) https://doi.org/10.1515/bc.2010.114
    86. Monika Schmoll, Christian Seibel, Doris Tisch, Marcel Dorrer, Christian P. Kubicek. A novel class of peptide pheromone precursors in ascomycetous fungi. Molecular Microbiology 2010, 77 (6) , 1483-1501. https://doi.org/10.1111/j.1365-2958.2010.07295.x
    87. Jitka Vévodová, Michael Gamble, Georg Künze, Antonio Ariza, Eleanor Dodson, D. Dafydd Jones, Keith S. Wilson. Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family. Structure 2010, 18 (6) , 744-755. https://doi.org/10.1016/j.str.2010.03.008
    88. Rosaria De Marco, Maria L. Di Gioia, Antonella Leggio, Angelo Liguori, Francesca Perri, Carlo Siciliano, Maria C. Viscomi. A new non-natural arginine-like amino acid derivative with a sulfamoyl group in the side-chain. Amino Acids 2010, 38 (3) , 691-700. https://doi.org/10.1007/s00726-009-0267-2
    89. Keith F. Chater, Sandor Biró, Kye Joon Lee, Tracy Palmer, Hildgund Schrempf. The complex extracellular biology of Streptomyces. FEMS Microbiology Reviews 2010, 34 (2) , 171-198. https://doi.org/10.1111/j.1574-6976.2009.00206.x
    90. Sylvia M. Nelsen, Jan L. Christian. Site-specific Cleavage of BMP4 by Furin, PC6, and PC7. Journal of Biological Chemistry 2009, 284 (40) , 27157-27166. https://doi.org/10.1074/jbc.M109.028506
    91. Hidetomo Kobayashi, Hiroko Utsunomiya, Hiroyasu Yamanaka, Yoshihisa Sei, Nobuhiko Katunuma, Keinosuke Okamoto, Hideaki Tsuge. Structural Basis for the Kexin-like Serine Protease from Aeromonas sobria as Sepsis-causing Factor. Journal of Biological Chemistry 2009, 284 (40) , 27655-27663. https://doi.org/10.1074/jbc.M109.006114
    92. Mohamed Rholam, Christine Fahy. Processing of peptide and hormone precursors at the dibasic cleavage sites. Cellular and Molecular Life Sciences 2009, 66 (13) , 2075-2091. https://doi.org/10.1007/s00018-009-0007-5
    93. Mario A. Izidoro, Iuri E. Gouvea, Jorge A.N. Santos, Diego M. Assis, Vitor Oliveira, Wagner A.S. Judice, Maria A. Juliano, Iris Lindberg, Luiz Juliano. A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions. Archives of Biochemistry and Biophysics 2009, 487 (2) , 105-114. https://doi.org/10.1016/j.abb.2009.05.013
    94. Tomoko Komiyama, Julia M. Coppola, Martha J. Larsen, Marcian E. van Dort, Brian D. Ross, Robert Day, Alnawaz Rehemtulla, Robert S. Fuller. Inhibition of Furin/Proprotein Convertase-catalyzed Surface and Intracellular Processing by Small Molecules. Journal of Biological Chemistry 2009, 284 (23) , 15729-15738. https://doi.org/10.1074/jbc.M901540200
    95. Jaana Künnapuu, Ida Björkgren, Osamu Shimmi. The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites. Proceedings of the National Academy of Sciences 2009, 106 (21) , 8501-8506. https://doi.org/10.1073/pnas.0809885106
    96. Dae Wi Kim, Andy Hesketh, Eun Sook Kim, Ju Yeon Song, Dae Hoon Lee, In Seop Kim, Keith F. Chater, Kye Joon Lee. Complex extracellular interactions of proteases and a protease inhibitor influence multicellular development of Streptomyces coelicolor. Molecular Microbiology 2008, 70 (5) , 1180-1193. https://doi.org/10.1111/j.1365-2958.2008.06471.x
    97. Jiraphan Junjhon, Matthawee Lausumpao, Sunpetchuda Supasa, Sansanee Noisakran, Adisak Songjaeng, Prakaimuk Saraithong, Kridsada Chaichoun, Utaiwan Utaipat, Poonsook Keelapang, Amornrat Kanjanahaluethai, Chunya Puttikhunt, Watchara Kasinrerk, Prida Malasit, Nopporn Sittisombut. Differential Modulation of prM Cleavage, Extracellular Particle Distribution, and Virus Infectivity by Conserved Residues at Nonfurin Consensus Positions of the Dengue Virus pr-M Junction. Journal of Virology 2008, 82 (21) , 10776-10791. https://doi.org/10.1128/JVI.01180-08
    98. Juliana L. Matos, Celso S. Fiori, Marcio C. Silva-Filho, Daniel S. Moura. A conserved dibasic site is essential for correct processing of the peptide hormone AtRALF1 in Arabidopsis thaliana. FEBS Letters 2008, 582 (23-24) , 3343-3347. https://doi.org/10.1016/j.febslet.2008.08.025
    99. Suming Wang, Jinbo Han, Yanfang Wang, Wuyuan Lu, Chengwu Chi. Design of peptide inhibitors for furin based on the C-terminal fragment of histone H1.2. Acta Biochimica et Biophysica Sinica 2008, 40 (10) , 848-854. https://doi.org/10.1111/j.1745-7270.2008.00470.x
    100. Alexei Diakov, Katarzyna Bera, Marianna Mokrushina, Bettina Krueger, Christoph Korbmacher. Cleavage in the γ‐subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near‐silent channels. The Journal of Physiology 2008, 586 (19) , 4587-4608. https://doi.org/10.1113/jphysiol.2008.154435
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