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Protein Ectodomain Shedding

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Laboratori de Recerca Oncològica, Servei d'Oncologia Mèdica, Hospital Universitari Vall d'Hebron, Psg. Vall d'Hebron 119-129, Barcelona 08035, Spain
Cite this: Chem. Rev. 2002, 102, 12, 4627–4638
Publication Date (Web):October 19, 2002
Copyright © 2002 American Chemical Society

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    11. Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock. Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity. Journal of Extracellular Vesicles 2022, 11 (3)
    12. Saigopalakrishna S. Yerneni, Talia Solomon, Jason Smith, Phil G. Campbell. Radioiodination of extravesicular surface constituents to study the biocorona, cell trafficking and storage stability of extracellular vesicles. Biochimica et Biophysica Acta (BBA) - General Subjects 2022, 1866 (2) , 130069.
    13. Pyong Woo Park. Extracellular Matrix: Surface Proteoglycans. 2022, 157-163.
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    17. Katarina Hočevar, Matej Vizovišek, Alicia Wong, Joanna Kozieł, Marko Fonović, Barbara Potempa, Richard J. Lamont, Jan Potempa, Boris Turk. Proteolysis of Gingival Keratinocyte Cell Surface Proteins by Gingipains Secreted From Porphyromonas gingivalis – Proteomic Insights Into Mechanisms Behind Tissue Damage in the Diseased Gingiva. Frontiers in Microbiology 2020, 11
    18. Alessandra Zingoni, Elisabetta Vulpis, Luisa Loconte, Angela Santoni. NKG2D Ligand Shedding in Response to Stress: Role of ADAM10. Frontiers in Immunology 2020, 11
    19. Pin‑Hao Ko, Govinda Lenka, Yu‑An Chen, Eric Chuang, Mong‑Hsun Tsai, Yuh‑Pyng Sher, Liang‑Chuan Lai. Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells. International Journal of Oncology 2019,
    20. Jessica Schira-Heinen, Leonie Grube, Daniel M. Waldera-Lupa, Falk Baberg, Maike Langini, Omid Etemad-Parishanzadeh, Gereon Poschmann, Kai Stühler. Pitfalls and opportunities in the characterization of unconventionally secreted proteins by secretome analysis. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2019, 1867 (12) , 140237.
    21. Ehteramolsadat Hosseini, Maryam Mohtashami, Mehran Ghasemzadeh. Down-regulation of platelet adhesion receptors is a controlling mechanism of thrombosis, while also affecting post-transfusion efficacy of stored platelets. Thrombosis Journal 2019, 17 (1)
    22. Linlin Zhao, Gereon Poschmann, Daniel Waldera-Lupa, Nima Rafiee, Markus Kollmann, Kai Stühler. OutCyte: a novel tool for predicting unconventional protein secretion. Scientific Reports 2019, 9 (1)
    23. Jan P. Bogen, Steffen C. Hinz, Julius Grzeschik, Aileen Ebenig, Simon Krah, Stefan Zielonka, Harald Kolmar. Dual Function pH Responsive Bispecific Antibodies for Tumor Targeting and Antigen Depletion in Plasma. Frontiers in Immunology 2019, 10
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    25. Jessica Bertrand, Miriam Bollmann. Soluble syndecans: biomarkers for diseases and therapeutic options. British Journal of Pharmacology 2019, 176 (1) , 67-81.
    26. Yoav Evron, Clark K. Colton, Barbara Ludwig, Gordon C. Weir, Baruch Zimermann, Shiri Maimon, Tova Neufeld, Nurit Shalev, Tali Goldman, Assaf Leon, Karina Yavriyants, Noa Shabtay, Tania Rozenshtein, Dimitri Azarov, Amanda R. DiIenno, Anja Steffen, Paul de Vos, Stefan R. Bornstein, Uriel Barkai, Avi Rotem. Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply. Scientific Reports 2018, 8 (1)
    27. Andrew T. Holdbrooks, Colleen M. Britain, Susan L. Bellis. ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor. Journal of Biological Chemistry 2018, 293 (5) , 1610-1622.
    28. Laura M. Jenkins, Ben Horst, Carly L. Lancaster, Karthikeyan Mythreye. Dually modified transmembrane proteoglycans in development and disease. Cytokine & Growth Factor Reviews 2018, 39 , 124-136.
    29. Ji Won Um, Jaewon Ko. Neural Glycosylphosphatidylinositol-Anchored Proteins in Synaptic Specification. Trends in Cell Biology 2017, 27 (12) , 931-945.
    30. Yongcheol Cho, Dongeun Park, Chungho Kim. Disruption of TACE-filamin interaction can inhibit TACE-mediated ectodomain shedding. Biochemical and Biophysical Research Communications 2017, 490 (3) , 997-1003.
    31. Huiliang Yang, Wayne Bond Lau, Bonnie Lau, Yu Xuan, Shengtao Zhou, Linjie Zhao, Zhongyue Luo, Qiao Lin, Ning Ren, Xia Zhao, Yuquan Wei. A mass spectrometric insight into the origins of benign gynecological disorders. Mass Spectrometry Reviews 2017, 36 (3) , 450-470.
    32. Wei-Sheng Tien, Jun-Hong Chen, Kun-Pin Wu. SheddomeDB: the ectodomain shedding database for membrane-bound shed markers. BMC Bioinformatics 2017, 18 (S3)
    33. Pavel Montes de Oca Balderas. Metalloproteases in Adaptative Cell Responses. 2017, 121-142.
    34. David W. Greening, Eugene A. Kapp, Richard J. Simpson. The Peptidome Comes of Age: Mass Spectrometry-Based Characterization of the Circulating Cancer Peptidome. 2017, 27-64.
    35. Sook-Kyoung Heo, Eui-Kyu Noh, Gi-Dong Gwon, Jeong Yi Kim, Jae-Cheol Jo, Yunsuk Choi, SuJin Koh, Jin Ho Baek, Young Joo Min, Hawk Kim, . LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells. PLOS ONE 2016, 11 (11) , e0166589.
    36. Mayra Álvarez‐Santos, Verónica Carbajal, Olivia Tellez‐Jiménez, Erasmo Martínez‐Cordero, Victor Ruiz, Rogelio Hernández‐Pando, Ricardo Lascurain, Alfredo Santibañez‐Salgado, Blanca Bazan‐Perkins. Airway Hyperresponsiveness in Asthma Model Occurs Independently of Secretion of β1 Integrins in Airway Wall and Focal Adhesions Proteins Down Regulation. Journal of Cellular Biochemistry 2016, 117 (10) , 2385-2396.
    37. Katherine L. Gill, Krishna K. Machavaram, Rachel H. Rose, Manoranjenni Chetty. Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics. Clinical Pharmacokinetics 2016, 55 (7) , 789-805.
    38. Woo Yong Bae, Seong Kook Park, Do Hun Kim, Tae Kyung Koh, Dae Young Hur, Hee Won Chueh. Expression of ADAM17 and ADAM10 in nasal polyps. International Forum of Allergy & Rhinology 2016, 6 (7) , 731-736.
    39. Tiziana Triulzi, Giulia Valeria Bianchi, Elda Tagliabue. Predictive biomarkers in the treatment of HER2-positive breast cancer: an ongoing challenge. Future Oncology 2016, 12 (11) , 1413-1428.
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    42. Jyoti Chhibber-Goel, Caroline Coleman-Vaughan, Vishal Agrawal, Neha Sawhney, Emer Hickey, James C. Powell, Justin V. McCarthy. γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling. Journal of Biological Chemistry 2016, 291 (11) , 5971-5985.
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    44. Hee Won Chueh, Seong Kook Park, Dae Young Hur, Woo Yong Bae. Expression profile of ADAM10 and ADAM17 in allergic rhinitis. International Forum of Allergy & Rhinology 2015, 5 (11) , 1036-1041.
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    49. Wei Deng, Sungyun Cho, Pin-Chuan Su, Bryan W. Berger, Renhao Li. Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10. Proceedings of the National Academy of Sciences 2014, 111 (45) , 15987-15992.
    50. Youngshang Pak, Ira Pastan, Robert J. Kreitman, Byungkook Lee, . Effect of Antigen Shedding on Targeted Delivery of Immunotoxins in Solid Tumors from a Mathematical Model. PLoS ONE 2014, 9 (10) , e110716.
    51. Jennifer L. Elderbroom, Jennifer J. Huang, Catherine E. Gatza, Jian Chen, Tam How, Mark Starr, Andrew B. Nixon, Gerard C. Blobe, . Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion. Molecular Biology of the Cell 2014, 25 (16) , 2320-2332.
    52. Arrash Vahidi, Gary Glenn, Peter van der Geer. Identification and mutagenesis of the TACE and γ-secretase cleavage sites in the colony-stimulating factor 1 receptor. Biochemical and Biophysical Research Communications 2014, 450 (1) , 782-787.
    53. Clark K. Colton. Oxygen supply to encapsulated therapeutic cells. Advanced Drug Delivery Reviews 2014, 67-68 , 93-110.
    54. Birgit Leitinger. Discoidin Domain Receptor Functions in Physiological and Pathological Conditions. 2014, 39-87.
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    56. L Li, I Gardner, R Rose, M Jamei. Incorporating Target Shedding Into a Minimal PBPK–TMDD Model for Monoclonal Antibodies. CPT: Pharmacometrics & Systems Pharmacology 2014, 3 (1) , 1-13.
    57. David W. Greening, Eugene A. Kapp, Hong Ji, Terry P. Speed, Richard J. Simpson. Colon tumour secretopeptidome: Insights into endogenous proteolytic cleavage events in the colon tumour microenvironment. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2013, 1834 (11) , 2396-2407.
    58. Wei Deng, Sungyun Cho, Renhao Li. FERM Domain of Moesin Desorbs the Basic-Rich Cytoplasmic Domain of l-Selectin from the Anionic Membrane Surface. Journal of Molecular Biology 2013, 425 (18) , 3549-3562.
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    61. Wei Deng, John A. Putkey, Renhao Li, . Calmodulin Adopts an Extended Conformation when Interacting with L-Selectin in Membranes. PLoS ONE 2013, 8 (5) , e62861.
    62. Ulrike Schnell, Jeroen Kuipers, Ben N. G. Giepmans. EpCAM proteolysis: new fragments with distinct functions?. Bioscience Reports 2013, 33 (2)
    63. Hsueh-Liang Fu, Anjum Sohail, Rajeshwari R. Valiathan, Benjamin D. Wasinski, Malika Kumarasiri, Kiran V. Mahasenan, M.Margarida Bernardo, Dorota Tokmina-Roszyk, Gregg B. Fields, Shahriar Mobashery, Rafael Fridman. Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases*. Journal of Biological Chemistry 2013, 288 (17) , 12114-12129.
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    65. Yu Cao, Michael G. Rosenblum. Design, Development, and Characterization of Recombinant Immunotoxins Targeting HER2/neu. 2013, 319-348.
    66. Manish K. Gupta, Gagandip Singh, Swati Gupta. Hydroxamic Acid Derivatives as Potential Anticancer Agents. 2013, 173-204.
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    69. Min Fei, Lei Zhou, Jianhui Xie, Yuanyuan Ruan, Jiejie Xu, Songbin He, Hongjie Shen, Yumin Hu, Shifang Ren, Changgeng Ruan. The production of soluble C-type lectin-like receptor 2 is a regulated process. Glycoconjugate Journal 2012, 29 (5-6) , 315-321.
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    71. Hee Doo Lee, Bon‐Hun Koo, Yeon Hyang Kim, Ok‐Hee Jeon, Doo‐Sik Kim. Exosome release of ADAM15 and the functional implications of human macrophage‐derived ADAM15 exosomes. The FASEB Journal 2012, 26 (7) , 3084-3095.
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    78. Yu Cao, James D. Marks, Qian Huang, Stephen I. Rudnick, Chiyi Xiong, Walter N. Hittelman, Xiaoxia Wen, John W. Marks, Lawrence H. Cheung, Kim Boland, Chun Li, Gregory P. Adams, Michael G. Rosenblum. Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity. Molecular Cancer Therapeutics 2012, 11 (1) , 143-153.
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    80. Nataša Todorović-Raković, Jelena Milovanović, Dragica Nikolić-Vukosavljević. TGF-β and its Coreceptors in Cancerogenesis: an Overview. Biomarkers in Medicine 2011, 5 (6) , 855-863.
    81. Yue Wang, John D. Robertson, Bruce Walcheck. Different Signaling Pathways Stimulate a Disintegrin and Metalloprotease-17 (ADAM17) in Neutrophils during Apoptosis and Activation. Journal of Biological Chemistry 2011, 286 (45) , 38980-38988.
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    85. Guoyan Cheng, Aixin Yu, Thomas R. Malek. T‐cell tolerance and the multi‐functional role of IL‐2R signaling in T‐regulatory cells. Immunological Reviews 2011, 241 (1) , 63-76.
    86. J Malapeira, C Esselens, J J Bech-Serra, F Canals, J Arribas. ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin. Oncogene 2011, 30 (16) , 1912-1922.
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    100. Dolores D. Mruk, C. Y. Cheng. Tight junctions in the testis: new perspectives. Philosophical Transactions of the Royal Society B: Biological Sciences 2010, 365 (1546) , 1621-1635.
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