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Genetically Encoded Calcium Indicators
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    Genetically Encoded Calcium Indicators
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    Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18, 82152 Martinsried, Germany
    * To whom correspondence should be addressed. E-mail: [email protected]
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    Chemical Reviews

    Cite this: Chem. Rev. 2008, 108, 5, 1550–1564
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    https://doi.org/10.1021/cr078213v
    Published May 1, 2008
    Copyright © 2008 American Chemical Society
    Copyright © 2008 American Chemical Society

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    2. Valeriia D. Andreeva, Irene Regeni, Tingxiang Yang, Anna Elmanova, Martin Presselt, Benjamin Dietzek-Ivanšić, Sylvestre Bonnet. Red-to-Blue Triplet–Triplet Annihilation Upconversion for Calcium Sensing. The Journal of Physical Chemistry Letters 2024, 15 (29) , 7430-7435. https://doi.org/10.1021/acs.jpclett.4c01528
    3. Masafumi Minoshima, Shahi Imam Reja, Ryu Hashimoto, Kohei Iijima, Kazuya Kikuchi. Hybrid Small-Molecule/Protein Fluorescent Probes. Chemical Reviews 2024, 124 (10) , 6198-6270. https://doi.org/10.1021/acs.chemrev.3c00549
    4. Shumao Xu, Xiao Xiao, Farid Manshaii, Jun Chen. Injectable Fluorescent Neural Interfaces for Cell-Specific Stimulating and Imaging. Nano Letters 2024, 24 (16) , 4703-4716. https://doi.org/10.1021/acs.nanolett.4c00815
    5. Sarah M. Roelle, Nisha D. Kamath, Kenneth A. Matreyek. Mammalian Genomic Manipulation with Orthogonal Bxb1 DNA Recombinase Sites for the Functional Characterization of Protein Variants. ACS Synthetic Biology 2023, 12 (11) , 3352-3365. https://doi.org/10.1021/acssynbio.3c00355
    6. Haowen Zhao, Melissa L. Zastrow. Transition Metals Induce Quenching of Monomeric Near-Infrared Fluorescent Proteins. Biochemistry 2022, 61 (7) , 494-504. https://doi.org/10.1021/acs.biochem.1c00705
    7. Irina A. Okkelman, Ryan McGarrigle, Shane O’Carroll, Daniel Carvajal Berrio, Katja Schenke-Layland, James Hynes, Ruslan I. Dmitriev. Extracellular Ca2+-Sensing Fluorescent Protein Biosensor Based on a Collagen-Binding Domain. ACS Applied Bio Materials 2020, 3 (8) , 5310-5321. https://doi.org/10.1021/acsabm.0c00649
    8. Landon Zarowny, Abhi Aggarwal, Virginia M. S. Rutten, Ilya Kolb, The GENIE ProjectRonak Patel, Hsin-Yi Huang, Yu-Fen Chang, Tiffany Phan, Richard Kanyo, Misha B. Ahrens, W. Ted Allison, Kaspar Podgorski, Robert E. Campbell. Bright and High-Performance Genetically Encoded Ca2+ Indicator Based on mNeonGreen Fluorescent Protein. ACS Sensors 2020, 5 (7) , 1959-1968. https://doi.org/10.1021/acssensors.0c00279
    9. Rajesh Kumar, Amit Sharma, Hardev Singh, Paolo Suating, Hyeong Seok Kim, Kyoung Sunwoo, Inseob Shim, Bruce C. Gibb, Jong Seung Kim. Revisiting Fluorescent Calixarenes: From Molecular Sensors to Smart Materials. Chemical Reviews 2019, 119 (16) , 9657-9721. https://doi.org/10.1021/acs.chemrev.8b00605
    10. Lin Xue, Efthymia Prifti, and Kai Johnsson . A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range. Journal of the American Chemical Society 2016, 138 (16) , 5258-5261. https://doi.org/10.1021/jacs.6b03034
    11. Xiaojiang Xie, Jingying Zhai, and Eric Bakker . Potentiometric Response from Ion-Selective Nanospheres with Voltage-Sensitive Dyes. Journal of the American Chemical Society 2014, 136 (47) , 16465-16468. https://doi.org/10.1021/ja5107578
    12. Amnon Bar-Shir, Assaf A. Gilad, Kannie W. Y. Chan, Guanshu Liu, Peter C. M. van Zijl, Jeff W. M. Bulte, and Michael T. McMahon . Metal Ion Sensing Using Ion Chemical Exchange Saturation Transfer 19F Magnetic Resonance Imaging. Journal of the American Chemical Society 2013, 135 (33) , 12164-12167. https://doi.org/10.1021/ja403542g
    13. Peter Dedecker, Frans C. De Schryver, and Johan Hofkens . Fluorescent Proteins: Shine on, You Crazy Diamond. Journal of the American Chemical Society 2013, 135 (7) , 2387-2402. https://doi.org/10.1021/ja309768d
    14. Vedangi Sample, Qiang Ni, Sohum Mehta, Takanari Inoue, and Jin Zhang . Controlling Enzymatic Action in Living Cells with a Kinase-Inducible Bimolecular Switch. ACS Chemical Biology 2013, 8 (1) , 116-121. https://doi.org/10.1021/cb300393w
    15. Hannah W. Mbatia and Shawn C. Burdette . Photochemical Tools for Studying Metal Ion Signaling and Homeostasis. Biochemistry 2012, 51 (37) , 7212-7224. https://doi.org/10.1021/bi3001769
    16. Hideo Takakura, Mitsuru Hattori, Masaki Takeuchi, and Takeaki Ozawa . Visualization and Quantitative Analysis of G Protein-Coupled Receptor−β-Arrestin Interaction in Single Cells and Specific Organs of Living Mice Using Split Luciferase Complementation. ACS Chemical Biology 2012, 7 (5) , 901-910. https://doi.org/10.1021/cb200360z
    17. Robert H. Newman, Matthew D. Fosbrink, and Jin Zhang . Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells. Chemical Reviews 2011, 111 (5) , 3614-3666. https://doi.org/10.1021/cr100002u
    18. Graham C. R. Ellis-Davies . Two-Photon Microscopy for Chemical Neuroscience. ACS Chemical Neuroscience 2011, 2 (4) , 185-197. https://doi.org/10.1021/cn100111a
    19. Michael Bannwarth, Ivan R. Corrêa, Jr., Monika Sztretye, Sandrine Pouvreau, Cindy Fellay, Annina Aebischer, Leandro Royer, Eduardo Ríos and Kai Johnsson . Indo-1 Derivatives for Local Calcium Sensing. ACS Chemical Biology 2009, 4 (3) , 179-190. https://doi.org/10.1021/cb800258g
    20. Dechuan Sun, Mona Amiri, Qi Meng, Ranjith R. Unnithan, Chris French. Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy. Cells 2025, 14 (1) , 4. https://doi.org/10.3390/cells14010004
    21. Hengze You, Huakun Li, Tong Ling. Electromechanical deformation of biological neurons: an intrinsic marker for label-free functional neuroimaging. Journal of Physics D: Applied Physics 2024, https://doi.org/10.1088/1361-6463/ad8deb
    22. Shan Jiang, Xiaoting Jia. Novel Functional Fibers for Neural Interfacing. 2024, 179-196. https://doi.org/10.1002/9783527839322.ch8
    23. Jihwan Myung. Enhancing Bioluminescence Imaging of Cultured Tissue Explants Using Optical Telecompression. Sensors 2024, 24 (18) , 6041. https://doi.org/10.3390/s24186041
    24. Remi Janicot, Mikel Garcia-Marcos. Get Ready to Sharpen Your Tools: A Short Guide to Heterotrimeric G Protein Activity Biosensors. Molecular Pharmacology 2024, 106 (3) , 129-144. https://doi.org/10.1124/molpharm.124.000949
    25. Megha Rasaily, Serena Ngiimei D, Rahul Kumar Thaosen, Surabhi Gupta, Sangeeta Deka, Ranjan Tamuli. Methods for the detection of intracellular calcium in filamentous fungi. MethodsX 2024, 12 , 102570. https://doi.org/10.1016/j.mex.2024.102570
    26. Bo Pang, Xiaoyan Wu, Hailun Chen, Yiwen Yan, Zibo Du, Zihan Yu, Xiai Yang, Wanshan Wang, Kangrong Lu. Exploring the memory: existing activity-dependent tools to tag and manipulate engram cells. Frontiers in Cellular Neuroscience 2024, 17 https://doi.org/10.3389/fncel.2023.1279032
    27. Anne C. Lyons, Sohum Mehta, Jin Zhang. Fluorescent biosensors illuminate the spatial regulation of cell signaling across scales. Biochemical Journal 2023, 480 (20) , 1693-1717. https://doi.org/10.1042/BCJ20220223
    28. Ariel A. Valiente‐Gabioud, Arne Fabritius, Oliver Griesbeck. Probing the interstitial calcium compartment. The Journal of Physiology 2023, 601 (19) , 4217-4226. https://doi.org/10.1113/JP279510
    29. Sruthi Sridhar, Abdulrahman Khamaj, Manish Kumar Asthana. Cognitive neuroscience perspective on memory: overview and summary. Frontiers in Human Neuroscience 2023, 17 https://doi.org/10.3389/fnhum.2023.1217093
    30. A. I. Erofeev, E. K. Vinokurov, O. L. Vlasova, I. B. Bezprozvanny. GCaMP, a Family of Single-Fluorophore Genetically Encoded Calcium Indicators. Journal of Evolutionary Biochemistry and Physiology 2023, 59 (4) , 1195-1214. https://doi.org/10.1134/S0022093023040142
    31. Tamara Boto, Seth M. Tomchik. Functional Imaging of Learning-Induced Plasticity in the Central Nervous System with Genetically Encoded Reporters in Drosophila. Cold Spring Harbor Protocols 2023, https://doi.org/10.1101/pdb.top107799
    32. Hamid Hasani, Jipeng Sun, Shuyu I. Zhu, Qiangzhou Rong, Florian Willomitzer, Rumelo Amor, Gail McConnell, Oliver Cossairt, Geoffrey J. Goodhill. Whole-brain imaging of freely-moving zebrafish. Frontiers in Neuroscience 2023, 17 https://doi.org/10.3389/fnins.2023.1127574
    33. Taylor D. Krueger, Longteng Tang, Chong Fang. Delineating Ultrafast Structural Dynamics of a Green-Red Fluorescent Protein for Calcium Sensing. Biosensors 2023, 13 (2) , 218. https://doi.org/10.3390/bios13020218
    34. Julian Day‐Cooney, Rochelin Dalangin, Haining Zhong, Tianyi Mao. Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo. Journal of Neurochemistry 2023, 164 (3) , 284-308. https://doi.org/10.1111/jnc.15608
    35. Hendrik Backhaus, Nicolas Ruffini, Anna Wierczeiko, Albrecht Stroh. An All-Optical Physiology Pipeline Toward Highly Specific and Artifact-Free Circuit Mapping. 2023, 137-163. https://doi.org/10.1007/978-1-0716-2764-8_5
    36. Laura B. Teal, Shalonda M. Ingram, Michael Bubser, Elliott McClure, Carrie K. Jones. The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders. 2023, 37-99. https://doi.org/10.1007/978-3-031-21054-9_3
    37. William F. Jackson, Nathan R. Tykocki. Exploring urinary bladder neural circuitry through calcium imaging. 2023, 169-192. https://doi.org/10.1016/B978-0-12-822455-7.00005-2
    38. Christine Grienberger, Andrea Giovannucci, William Zeiger, Carlos Portera-Cailliau. Two-photon calcium imaging of neuronal activity. Nature Reviews Methods Primers 2022, 2 (1) https://doi.org/10.1038/s43586-022-00147-1
    39. Gabriela Romero, Jimin Park, Florian Koehler, Arnd Pralle, Polina Anikeeva. Modulating cell signalling in vivo with magnetic nanotransducers. Nature Reviews Methods Primers 2022, 2 (1) https://doi.org/10.1038/s43586-022-00170-2
    40. Maria V. Kulakova, Azamat V. Karginov, Alexander I. Alexandrov, Michael O. Agaphonov. The GEM-GECO Calcium Indicator Is Useable in Ogataea parapolymorpha Yeast, but Aggravates Effects of Increased Cytosolic Calcium Levels. International Journal of Molecular Sciences 2022, 23 (17) , 10004. https://doi.org/10.3390/ijms231710004
    41. Farah Mustapha, Kheya Sengupta, Pierre-Henri Puech. May the force be with your (immune) cells: an introduction to traction force microscopy in Immunology. Frontiers in Immunology 2022, 13 https://doi.org/10.3389/fimmu.2022.898558
    42. Annika Kempmann, Thomas Gensch, Andreas Offenhäusser, Irina Tihaa, Vanessa Maybeck, Sabine Balfanz, Arnd Baumann. The Functional Characterization of GCaMP3.0 Variants Specifically Targeted to Subcellular Domains. International Journal of Molecular Sciences 2022, 23 (12) , 6593. https://doi.org/10.3390/ijms23126593
    43. Preston D. Donaldson, Sarah L. Swisher. Transparent, Low‐Impedance Inkjet‐Printed PEDOT:PSS Microelectrodes for Multimodal Neuroscience. physica status solidi (a) 2022, 219 (10) https://doi.org/10.1002/pssa.202100683
    44. Clara Ortega-de San Luis, Tomás J. Ryan. Understanding the physical basis of memory: Molecular mechanisms of the engram. Journal of Biological Chemistry 2022, 298 (5) , 101866. https://doi.org/10.1016/j.jbc.2022.101866
    45. Sheng-Yi Wu, Yi Shen, Irene Shkolnikov, Robert E. Campbell. Fluorescent Indicators For Biological Imaging of Monatomic Ions. Frontiers in Cell and Developmental Biology 2022, 10 https://doi.org/10.3389/fcell.2022.885440
    46. Jingzhe Guo, Jiangman He, Katayoon Dehesh, Xinping Cui, Zhenbiao Yang. CamelliA-based simultaneous imaging of Ca2+ dynamics in subcellular compartments. Plant Physiology 2022, 188 (4) , 2253-2271. https://doi.org/10.1093/plphys/kiac020
    47. Weikun Huang, Tongzhi Wu, Cong Xie, Christopher K. Rayner, Craig Priest, Heike Ebendorff‐Heidepriem, Jiangbo (Tim) Zhao. Sensing Intra‐ and Extra‐Cellular Ca 2+ in the Islet of Langerhans. Advanced Functional Materials 2022, 32 (3) https://doi.org/10.1002/adfm.202106020
    48. Adam S. Charles, Nathan Cermak, Rifqi O. Affan, Benjamin B. Scott, Jackie Schiller, Gal Mishne. GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging. IEEE Transactions on Image Processing 2022, 31 , 3509-3524. https://doi.org/10.1109/TIP.2022.3171414
    49. Alfons Penzkofer, Arita Silapetere, Peter Hegemann. Photocycle dynamics of the Archaerhodopsin 3 based fluorescent voltage sensor Archon2. Journal of Photochemistry and Photobiology B: Biology 2021, 225 , 112331. https://doi.org/10.1016/j.jphotobiol.2021.112331
    50. Richard Kanyo, Md Ruhul Amin, Laszlo F. Locskai, Danika D. Bouvier, Alexandria M. Olthuis, W. Ted Allison, Declan W. Ali. Medium-throughput zebrafish optogenetic platform identifies deficits in subsequent neural activity following brief early exposure to cannabidiol and Δ9-tetrahydrocannabinol. Scientific Reports 2021, 11 (1) https://doi.org/10.1038/s41598-021-90902-3
    51. Yugo Miyata, Hiroto Fuse, Shoko Tokumoto, Yusuke Hiki, Ruslan Deviatiiarov, Yuki Yoshida, Takahiro G. Yamada, Richard Cornette, Oleg Gusev, Elena Shagimardanova, Akira Funahashi, Takahiro Kikawada. Cas9-mediated genome editing reveals a significant contribution of calcium signaling pathways to anhydrobiosis in Pv11 cells. Scientific Reports 2021, 11 (1) https://doi.org/10.1038/s41598-021-98905-w
    52. Chenbiao Li, Peifang Chen, Zhouping Wang, Xiaoyuan Ma. A DNAzyme-gold nanostar probe for SERS-fluorescence dual-mode detection and imaging of calcium ions in living cells. Sensors and Actuators B: Chemical 2021, 347 , 130596. https://doi.org/10.1016/j.snb.2021.130596
    53. Cecilia Villarruel, Pablo S. Aguilar, Silvina Ponce Dawson. High rates of calcium-free diffusion in the cytosol of living cells. Biophysical Journal 2021, 120 (18) , 3960-3972. https://doi.org/10.1016/j.bpj.2021.08.019
    54. Christopher Miranda, Madeleine R. Howell, Joel F. Lusk, Ethan Marschall, Jarrett Eshima, Trent Anderson, Barbara S. Smith. Automated microscope-independent fluorescence-guided micropipette. Biomedical Optics Express 2021, 12 (8) , 4689. https://doi.org/10.1364/BOE.431372
    55. Christian Lohr, Antonia Beiersdorfer, Timo Fischer, Daniela Hirnet, Natalie Rotermund, Jessica Sauer, Kristina Schulz, Christine E. Gee. Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide. Frontiers in Cellular Neuroscience 2021, 15 https://doi.org/10.3389/fncel.2021.690147
    56. Ekaterina S. Potekhina, Dina Y. Bass, Ilya V. Kelmanson, Elena S. Fetisova, Alexander V. Ivanenko, Vsevolod V. Belousov, Dmitry S. Bilan. Drug Screening with Genetically Encoded Fluorescent Sensors: Today and Tomorrow. International Journal of Molecular Sciences 2021, 22 (1) , 148. https://doi.org/10.3390/ijms22010148
    57. Longteng Tang, Shuce Zhang, Yufeng Zhao, Nikita D. Rozanov, Liangdong Zhu, Jiahui Wu, Robert E. Campbell, Chong Fang. Switching between Ultrafast Pathways Enables a Green-Red Emission Ratiometric Fluorescent-Protein-Based Ca2+ Biosensor. International Journal of Molecular Sciences 2021, 22 (1) , 445. https://doi.org/10.3390/ijms22010445
    58. Lan Phuong Nguyen, Huong Thi Nguyen, Hyo Jeong Yong, Arfaxad Reyes-Alcaraz, Yoo-Na Lee, Hee-Kyung Park, Yun Hee Na, Cheol Soon Lee, Byung-Joo Ham, Jae Young Seong, Jong-Ik Hwang. Establishment of a NanoBiT-Based Cytosolic Ca2+ Sensor by Optimizing Calmodulin-Binding Motif and Protein Expression Levels. Molecules and Cells 2020, 43 (11) , 909-920. https://doi.org/10.14348/molcells.2020.0144
    59. Georgia Kouroupi, Nasia Antoniou, Kanella Prodromidou, Era Taoufik, Rebecca Matsas. Patient-Derived Induced Pluripotent Stem Cell-Based Models in Parkinson’s Disease for Drug Identification. International Journal of Molecular Sciences 2020, 21 (19) , 7113. https://doi.org/10.3390/ijms21197113
    60. Vasilisa V. Krasitskaya, Eugenia E. Bashmakova, Ludmila A. Frank. Coelenterazine-Dependent Luciferases as a Powerful Analytical Tool for Research and Biomedical Applications. International Journal of Molecular Sciences 2020, 21 (20) , 7465. https://doi.org/10.3390/ijms21207465
    61. Paul D. E. Williams, Saurabh Verma, Alan P. Robertson, Richard J. Martin. Adapting techniques for calcium imaging in muscles of adult Brugia malayi. Invertebrate Neuroscience 2020, 20 (3) https://doi.org/10.1007/s10158-020-00247-1
    62. Alfons Penzkofer, Arita Silapetere, Peter Hegemann. Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor Archon2. International Journal of Molecular Sciences 2020, 21 (18) , 6576. https://doi.org/10.3390/ijms21186576
    63. Colin P O’Banion, Ryohei Yasuda. Fluorescent sensors for neuronal signaling. Current Opinion in Neurobiology 2020, 63 , 31-41. https://doi.org/10.1016/j.conb.2020.02.007
    64. Erika K. Harding, Samuel Wanchi Fung, Robert P. Bonin. Insights Into Spinal Dorsal Horn Circuit Function and Dysfunction Using Optical Approaches. Frontiers in Neural Circuits 2020, 14 https://doi.org/10.3389/fncir.2020.00031
    65. Wenping Zou, Khoa Le, Melissa L. Zastrow. Live‐Cell Copper‐Induced Fluorescence Quenching of the Flavin‐Binding Fluorescent Protein CreiLOV. ChemBioChem 2020, 21 (9) , 1356-1363. https://doi.org/10.1002/cbic.201900669
    66. Elena von Molitor, Katja Riedel, Mathias Hafner, Rüdiger Rudolf, Tiziana Cesetti. Sensing Senses: Optical Biosensors to Study Gustation. Sensors 2020, 20 (7) , 1811. https://doi.org/10.3390/s20071811
    67. Jung-Eun Choi, Jiwon Kim, Jinhyun Kim. Capturing activated neurons and synapses. Neuroscience Research 2020, 152 , 25-34. https://doi.org/10.1016/j.neures.2019.12.020
    68. Mohammad M. Aria. . 2020, 105. https://doi.org/10.1016/B978-0-12-817070-0.00005-1
    69. Sunaina Surana, David Villarroel‐Campos, Oscar M. Lazo, Edoardo Moretto, Andrew P. Tosolini, Elena R. Rhymes, Sandy Richter, James N. Sleigh, Giampietro Schiavo. The evolution of the axonal transport toolkit. Traffic 2020, 21 (1) , 13-33. https://doi.org/10.1111/tra.12710
    70. Alfons Penzkofer, Arita Silapetere, Peter Hegemann. Photocycle Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1. International Journal of Molecular Sciences 2020, 21 (1) , 160. https://doi.org/10.3390/ijms21010160
    71. Nyantsz Wu, Walter K. Nishioka, Noël C. Derecki, Michael P. Maher. High-throughput-compatible assays using a genetically-encoded calcium indicator. Scientific Reports 2019, 9 (1) https://doi.org/10.1038/s41598-019-49070-8
    72. Margriet Roelse, Ron Wehrens, Maurice Gl Henquet, Renger F Witkamp, Robert D Hall, Maarten A Jongsma. The Effect of Calcium Buffering and Calcium Sensor Type on the Sensitivity of an Array-Based Bitter Receptor Screening Assay. Chemical Senses 2019, 44 (7) , 497-505. https://doi.org/10.1093/chemse/bjz044
    73. Alfons Penzkofer, Arita Silapetere, Peter Hegemann. Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1. International Journal of Molecular Sciences 2019, 20 (17) , 4086. https://doi.org/10.3390/ijms20174086
    74. Shouliang Guan, Jinfen Wang, Ying Fang. Transparent graphene bioelectronics as a new tool for multimodal neural interfaces. Nano Today 2019, 26 , 13-15. https://doi.org/10.1016/j.nantod.2019.01.003
    75. Rosana S. Molina, Yong Qian, Jiahui Wu, Yi Shen, Robert E. Campbell, Mikhail Drobizhev, Thomas E. Hughes. Understanding the Fluorescence Change in Red Genetically Encoded Calcium Ion Indicators. Biophysical Journal 2019, 116 (10) , 1873-1886. https://doi.org/10.1016/j.bpj.2019.04.007
    76. Gal Mishne, Adam S. Charles. Learning Spatially-correlated Temporal Dictionaries for Calcium Imaging. 2019, 1065-1069. https://doi.org/10.1109/ICASSP.2019.8683375
    77. Guilin Chen, Zaicai Zhou, Hui Feng, Chenyan Zhang, Yifan Wang, Zhaosheng Qian, Jianwei Pan. An aggregation-induced phosphorescence probe for calcium ion-specific detection and live-cell imaging in Arabidopsis thaliana. Chemical Communications 2019, 55 (33) , 4841-4844. https://doi.org/10.1039/C9CC01580A
    78. Elena Montagni, Francesco Resta, Emilia Conti, Alessandro Scaglione, Maria Pasquini, Silvestro Micera, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone. Wide-field imaging of cortical neuronal activity with red-shifted functional indicators during motor task execution. Journal of Physics D: Applied Physics 2019, 52 (7) , 074001. https://doi.org/10.1088/1361-6463/aaf26c
    79. Maarten E. Witte, Adrian-Minh Schumacher, Christoph F. Mahler, Jan P. Bewersdorf, Jonas Lehmitz, Alexander Scheiter, Paula Sánchez, Philip R. Williams, Oliver Griesbeck, Ronald Naumann, Thomas Misgeld, Martin Kerschensteiner. Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron 2019, 101 (4) , 615-624.e5. https://doi.org/10.1016/j.neuron.2018.12.023
    80. Wenjing Wang, Christina K. Kim, Alice Y. Ting. Molecular tools for imaging and recording neuronal activity. Nature Chemical Biology 2019, 15 (2) , 101-110. https://doi.org/10.1038/s41589-018-0207-0
    81. Uday Kumar Sukumar, Arutselvan Natarajan, Tarik F. Massoud, Ramasamy Paulmurugan. . 2019, 149. https://doi.org/10.1007/7355_2019_90
    82. Lucas Borges-Pereira, Célia R. S. Garcia. Employing Transgenic Parasite Strains to Study the Ca2+ Dynamics in the Human Malaria Parasite Plasmodium falciparum. 2019, 157-162. https://doi.org/10.1007/978-1-4939-9018-4_14
    83. Yajie Liang, Olga Garaschuk. Labeling Microglia with Genetically Encoded Calcium Indicators. 2019, 243-265. https://doi.org/10.1007/978-1-4939-9658-2_18
    84. Jihae Oh, Chiwoo Lee, Bong-Kiun Kaang. Imaging and analysis of genetically encoded calcium indicators linking neural circuits and behaviors. The Korean Journal of Physiology & Pharmacology 2019, 23 (4) , 237. https://doi.org/10.4196/kjpp.2019.23.4.237
    85. Rotem Rehani, Yara Atamna, Lior Tiroshi, Wei-Hua Chiu, José de Jesús Aceves Buendía, Gabriela J. Martins, Gilad A. Jacobson, Joshua A. Goldberg. Activity Patterns in the Neuropil of Striatal Cholinergic Interneurons in Freely Moving Mice Represent Their Collective Spiking Dynamics. eneuro 2019, 6 (1) , ENEURO.0351-18.2018. https://doi.org/10.1523/ENEURO.0351-18.2018
    86. Yaxiong Yang, Nan Liu, Yuanyuan He, Yuxia Liu, Lin Ge, Linzhi Zou, Sen Song, Wei Xiong, Xiaodong Liu. Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP. Nature Communications 2018, 9 (1) https://doi.org/10.1038/s41467-018-03719-6
    87. Alastair I. Grainger, Marianne C. King, David A. Nagel, H. Rheinallt Parri, Michael D. Coleman, Eric J. Hill. In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells. Frontiers in Neuroscience 2018, 12 https://doi.org/10.3389/fnins.2018.00590
    88. John J. Bassett, Alice H.L. Bong, Ellen K. Janke, Mélanie Robitaille, Sarah J. Roberts-Thomson, Amelia A. Peters, Gregory R. Monteith. Assessment of cytosolic free calcium changes during ceramide-induced cell death in MDA-MB-231 breast cancer cells expressing the calcium sensor GCaMP6m. Cell Calcium 2018, 72 , 39-50. https://doi.org/10.1016/j.ceca.2018.02.003
    89. Christopher A. R. Chapman, Noah Goshi, Erkin Seker. Multifunctional Neural Interfaces for Closed‐Loop Control of Neural Activity. Advanced Functional Materials 2018, 28 (12) , 1703523. https://doi.org/10.1002/adfm.201703523
    90. Nathan A. Smith, Benjamin T. Kress, Yuan Lu, Devin Chandler-Militello, Abdellatif Benraiss, Maiken Nedergaard. Fluorescent Ca 2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions. Science Signaling 2018, 11 (515) https://doi.org/10.1126/scisignal.aal2039
    91. Qiang Ni, Sohum Mehta, Jin Zhang. Live‐cell imaging of cell signaling using genetically encoded fluorescent reporters. The FEBS Journal 2018, 285 (2) , 203-219. https://doi.org/10.1111/febs.14134
    92. Karl J. Lewis, Dorra Frikha-Benayed, Joyce Louie, Samuel Stephen, David C. Spray, Mia M. Thi, Zeynep Seref-Ferlengez, Robert J. Majeska, Sheldon Weinbaum, Mitchell B. Schaffler. Osteocyte calcium signals encode strain magnitude and loading frequency in vivo. Proceedings of the National Academy of Sciences 2017, 114 (44) , 11775-11780. https://doi.org/10.1073/pnas.1707863114
    93. Tae-Jin Kim, Kyung-A Kim, Sang Hoon Jung. Development of an endoplasmic reticulum calcium sensor based on fluorescence resonance energy transfer. Sensors and Actuators B: Chemical 2017, 247 , 520-525. https://doi.org/10.1016/j.snb.2017.03.083
    94. Philipp Bethge, Stefano Carta, Dayra A. Lorenzo, Ladan Egolf, Despoina Goniotaki, Linda Madisen, Fabian F. Voigt, Jerry L. Chen, Bernard Schneider, Masamichi Ohkura, Junichi Nakai, Hongkui Zeng, Adriano Aguzzi, Fritjof Helmchen, . An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator. PLOS ONE 2017, 12 (6) , e0179460. https://doi.org/10.1371/journal.pone.0179460
    95. Guolin Ma, Shufan Wen, Lian He, Yun Huang, Youjun Wang, Yubin Zhou. Optogenetic toolkit for precise control of calcium signaling. Cell Calcium 2017, 64 , 36-46. https://doi.org/10.1016/j.ceca.2017.01.004
    96. , , Margaret C. Carpenter, Amy E. Palmer. Native and engineered sensors for Ca2+ and Zn2+: lessons from calmodulin and MTF1. Essays in Biochemistry 2017, 61 (2) , 237-243. https://doi.org/10.1042/EBC20160069
    97. Qiang Ma, Lingyan Ye, Hongxia Liu, Ying Shi, Naiming Zhou. An overview of Ca 2+ mobilization assays in GPCR drug discovery. Expert Opinion on Drug Discovery 2017, 12 (5) , 511-523. https://doi.org/10.1080/17460441.2017.1303473
    98. Quanchao Zhang, Jiwei Yao, Yu Guang, Shanshan Liang, Jiangheng Guan, Han Qin, Xiang Liao, Wenjun Jin, Jianxiong Zhang, Junxia Pan, Hongbo Jia, Junan Yan, Zhengzhi Feng, Weibing Li, Xiaowei Chen. Locomotion-Related Population Cortical Ca2+ Transients in Freely Behaving Mice. Frontiers in Neural Circuits 2017, 11 https://doi.org/10.3389/fncir.2017.00024
    99. Mikhail A. Lebedev, Miguel A. L. Nicolelis. Brain-Machine Interfaces: From Basic Science to Neuroprostheses and Neurorehabilitation. Physiological Reviews 2017, 97 (2) , 767-837. https://doi.org/10.1152/physrev.00027.2016
    100. Alexander Song, Adam S Charles, Sue Ann Koay, Jeff L Gauthier, Stephan Y Thiberge, Jonathan W Pillow, David W Tank. Volumetric two-photon imaging of neurons using stereoscopy (vTwINS). Nature Methods 2017, 14 (4) , 420-426. https://doi.org/10.1038/nmeth.4226
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    Cite this: Chem. Rev. 2008, 108, 5, 1550–1564
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    https://doi.org/10.1021/cr078213v
    Published May 1, 2008
    Copyright © 2008 American Chemical Society

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