ACS Publications. Most Trusted. Most Cited. Most Read
Technetium and Gallium Derived Radiopharmaceuticals: Comparing and Contrasting the Chemistry of Two Important Radiometals for the Molecular Imaging Era

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Chem. Rev. 2010, 110, 5, 2903-2920
    Review

    Technetium and Gallium Derived Radiopharmaceuticals: Comparing and Contrasting the Chemistry of Two Important Radiometals for the Molecular Imaging Era
    Click to copy article linkArticle link copied!

    View Author Information
    Department of Chemistry, Syracuse University, Syracuse, New York 13244, and Department of Chemistry, McMaster University, Hamilton, Canada ON L8S 4M1
    * Corresponding authors: (J.F.V.) E-mail: [email protected]. Fax: 905-522-7776. Tel.: 905-525-9140 ext. 22840. (J.Z.) E-mail: [email protected]. Fax: 315-443-4070. Tel.: 315-443-2547.
    †Syracuse University.
    ‡McMaster University.
    §Current address: Children’s Hospital Boston, Division of Nuclear Medicine, Department of Radiology, 300 Longwood Avenue, Boston, MA 02115.
    Other Access Options

    Chemical Reviews

    Cite this: Chem. Rev. 2010, 110, 5, 2903–2920
    Click to copy citationCitation copied!
    https://doi.org/10.1021/cr1000755
    Published April 23, 2010
    Copyright © 2010 American Chemical Society
    Request reuse permissions
    Copyright © 2010 American Chemical Society

    Subjects

    what are subjects

    Note: In lieu of an abstract, this is the article's first page.

    Free first page

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 270 publications.

    1. Axia Marlin, Angus Koller, Enikö Madarasi, Marie Cordier, David Esteban-Gómez, Carlos Platas-Iglesias, Gyula Tircsó, Eszter Boros, Véronique Patinec, Raphaël Tripier. H3nota Derivatives Possessing Picolyl and Picolinate Pendants for Ga3+ Coordination and 67Ga3+ Radiolabeling. Inorganic Chemistry 2023, 62 (50) , 20634-20645. https://doi.org/10.1021/acs.inorgchem.3c01417
    2. Thomas W. Price, Laurène Wagner, Veronika Rosecker, Jana Havlíčková, Timothy J. Prior, Vojtěch Kubíček, Petr Hermann, Graeme J. Stasiuk. Inorganic Chemistry of the Tripodal Picolinate Ligand Tpaa with Gallium(III) and Radiolabeling with Gallium-68. Inorganic Chemistry 2023, 62 (50) , 20769-20776. https://doi.org/10.1021/acs.inorgchem.3c02459
    3. Hongxia Sun, Ruiying He, Jianwen Shi, Xiaoge Niu, Huimin Ren, Yan Liu, Lulu Kang, Gang Li, Jinpeng Li. Water-Mediated Proton Conduction in Metal–Organic Frameworks with High Water Stability Constructed by a Terpyridine Tricarboxylate Ligand. Crystal Growth & Design 2022, 22 (11) , 6667-6677. https://doi.org/10.1021/acs.cgd.2c00875
    4. Thomas W. Price, Isaline Renard, Timothy J. Prior, Vojtěch Kubíček, David M. Benoit, Stephen J. Archibald, Anne-Marie Seymour, Petr Hermann, Graeme J. Stasiuk. Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−. Inorganic Chemistry 2022, 61 (43) , 17059-17067. https://doi.org/10.1021/acs.inorgchem.2c01992
    5. Maximilian Roca Jungfer, Ulrich Abram. Unlocking Air- and Water-Stable Technetium Acetylides and Other Organometallic Complexes. Inorganic Chemistry 2022, 61 (20) , 7765-7779. https://doi.org/10.1021/acs.inorgchem.2c00070
    6. Saul M. Cooper, Andrew J. P. White, Thomas R. Eykyn, Michelle T. Ma, Philip W. Miller, Nicholas J. Long. N-Centered Tripodal Phosphine Re(V) and Tc(V) Oxo Complexes: Revisiting a [3 + 2] Mixed-Ligand Approach. Inorganic Chemistry 2022, 61 (20) , 8000-8014. https://doi.org/10.1021/acs.inorgchem.2c00693
    7. Sophia Sarpaki, Fernando Cortezon-Tamarit, Rüdiger Maria Exner, Kexin Song, Sara Raquel Mota Merelo de Aguiar, Haobo Ge, Charareh Pourzand, Stephen James Paisey, Gabriele Kociok-Köhn, Jonathan Robin Dilworth, Laurence Carroll, Sofia Ioana Pascu. Functional, Aromatic, and Fluorinated Monothiosemicarbazones: Investigations into Their Structures and Activity toward the Gallium-68 Incorporation by Microwave Irradiation. ACS Omega 2022, 7 (16) , 13750-13777. https://doi.org/10.1021/acsomega.1c07396
    8. Maximilian Roca Jungfer, Laura Elsholz, Ulrich Abram. Technetium(I) Carbonyl Chemistry with Small Inorganic Ligands. Inorganic Chemistry 2022, 61 (6) , 2980-2997. https://doi.org/10.1021/acs.inorgchem.1c03919
    9. Andrzej Mular, Abraham Shanzer, Henryk Kozłowski, Isabella Hubmann, Matthias Misslinger, Julia Krzywik, Clemens Decristoforo, Elzbieta Gumienna-Kontecka. Cyclic Analogs of Desferrioxamine E Siderophore for 68Ga Nuclear Imaging: Coordination Chemistry and Biological Activity in Staphylococcus aureus. Inorganic Chemistry 2021, 60 (23) , 17846-17857. https://doi.org/10.1021/acs.inorgchem.1c02453
    10. Maximilian Roca Jungfer, Ulrich Abram. [Tc(OH2)(CO)3(PPh3)2]+: A Synthon for Tc(I) Complexes and Its Reactions with Neutral Ligands. Inorganic Chemistry 2021, 60 (21) , 16734-16753. https://doi.org/10.1021/acs.inorgchem.1c02599
    11. Benjamin Spyrou, Ingebjørg N. Hungnes, Filipa Mota, Jayanta Bordoloi, Philip J. Blower, Jonathan M. White, Michelle T. Ma, Paul S. Donnelly. Oxorhenium(V) and Oxotechnetium(V) Complexes of N3S Tetradentate Ligands with a Styrylpyridyl Functional Group: Toward Imaging Agents to Assist in the Diagnosis of Alzheimer’s Disease. Inorganic Chemistry 2021, 60 (17) , 13669-13680. https://doi.org/10.1021/acs.inorgchem.1c01992
    12. Xiaoge Niu, Yihong Yu, Chenyu Mu, Xiaoxin Xie, Yan Liu, Zhongyi Liu, Linke Li, Gang Li, Jinpeng Li. High Proton Conduction in Two Highly Water-Stable Lanthanide Coordination Polymers from a Triazole Multicarboxylate Ligand. Inorganic Chemistry 2021, 60 (17) , 13242-13251. https://doi.org/10.1021/acs.inorgchem.1c01616
    13. Lindsay E. Calderon, Carrie A. Black, Joseph D. Rollins, Brittany Overbay, Semekidus Shiferawe, Andrew Elliott, Sara Reitz, Shu Liu, Junling Li, Chin K. Ng, Margaret W. Ndinguri. Synthesis of Radiolabeled Technetium- and Rhenium-Luteinizing Hormone-Releasing Hormone (99mTc/Re-Acdien-LHRH) Conjugates for Targeted Detection of Breast Cancer Cells Overexpressing the LHRH Receptor. ACS Omega 2021, 6 (3) , 1846-1856. https://doi.org/10.1021/acsomega.0c03991
    14. Anna C. Grunwald, Clemens Scholtysik, Adelheid Hagenbach, Ulrich Abram. One Ligand, One Metal, Seven Oxidation States: Stable Technetium Complexes with the “Kläui Ligand”. Inorganic Chemistry 2020, 59 (13) , 9396-9405. https://doi.org/10.1021/acs.inorgchem.0c01264
    15. Guilhem Claude, Federico Salsi, Adelheid Hagenbach, Milan Gembicky, Michael Neville, Chinglin Chan, Joshua S. Figueroa, Ulrich Abram. Structural and Redox Variations in Technetium Complexes Supported by m-Terphenyl Isocyanides. Organometallics 2020, 39 (12) , 2287-2294. https://doi.org/10.1021/acs.organomet.0c00238
    16. Albertus Wijnand Hensbergen, Danny M. van Willigen, Florian van Beurden, Pim J. van Leeuwen, Tessa Buckle, Margret Schottelius, Tobias Maurer, Hans-Jürgen Wester, Fijs W. B. van Leeuwen. Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?. Bioconjugate Chemistry 2020, 31 (2) , 375-395. https://doi.org/10.1021/acs.bioconjchem.9b00758
    17. Abdullah F. Alshamrani, Timothy J. Prior, Benjamin P. Burke, David P. Roberts, Stephen J. Archibald, Lee J. Higham, Graeme Stasiuk, Carl Redshaw. Water-Soluble Rhenium Phosphine Complexes Incorporating the Ph2C(X) Motif (X = O–, NH–): Structural and Cytotoxicity Studies. Inorganic Chemistry 2020, 59 (4) , 2367-2378. https://doi.org/10.1021/acs.inorgchem.9b03239
    18. Federico Salsi, Gisele Bulhões Portapilla, Saskia Simon, Maximilian Roca Jungfer, Adelheid Hagenbach, Sérgio de Albuquerque, Ulrich Abram. Effect of Fluorination on the Structure and Anti-Trypanosoma cruzy Activity of Oxorhenium(V) Complexes with S,N,S-Tridentate Thiosemicarbazones and Benzoylthioureas. Synthesis and Structures of Technetium(V) Analogues. Inorganic Chemistry 2019, 58 (15) , 10129-10138. https://doi.org/10.1021/acs.inorgchem.9b01260
    19. Lachlan E. McInnes, Asif Noor, Kai Kysenius, Carleen Cullinane, Peter Roselt, Catriona A. McLean, Francis C. K. Chiu, Andrew K. Powell, Peter J. Crouch, Jonathan M. White, Paul S. Donnelly. Potential Diagnostic Imaging of Alzheimer’s Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques. Inorganic Chemistry 2019, 58 (5) , 3382-3395. https://doi.org/10.1021/acs.inorgchem.8b03466
    20. Xiaohui Wang, Xiaoyong Wang, Suxing Jin, Nafees Muhammad, Zijian Guo. Stimuli-Responsive Therapeutic Metallodrugs. Chemical Reviews 2019, 119 (2) , 1138-1192. https://doi.org/10.1021/acs.chemrev.8b00209
    21. Eszter Boros, Alan B. Packard. Radioactive Transition Metals for Imaging and Therapy. Chemical Reviews 2019, 119 (2) , 870-901. https://doi.org/10.1021/acs.chemrev.8b00281
    22. Nicola Salvarese, Davide Carta, Cristina Marzano, Gabriele Gerardi, Laura Melendez-Alafort, Cristina Bolzati. [99mTc][Tc(N)(DASD)(PNPn)]+ (DASD = 1,4-Dioxa-8-azaspiro[4,5]decandithiocarbamate, PNPn = Bisphosphinoamine) for Myocardial Imaging: Synthesis, Pharmacological and Pharmacokinetic Studies. Journal of Medicinal Chemistry 2018, 61 (24) , 11114-11126. https://doi.org/10.1021/acs.jmedchem.8b01191
    23. Benjamin P. Burke, William Grantham, Michael J. Burke, Gary. S. Nichol, David Roberts, Isaline Renard, Rebecca Hargreaves, Christopher Cawthorne, Stephen J. Archibald, Paul J. Lusby. Visualizing Kinetically Robust CoIII4L6 Assemblies in Vivo: SPECT Imaging of the Encapsulated [99mTc]TcO4– Anion. Journal of the American Chemical Society 2018, 140 (49) , 16877-16881. https://doi.org/10.1021/jacs.8b09582
    24. Xiaoyang Zhang, Yaqin Hou, Cheng Peng, Chu Wang, Xiang Wang, Zhigang Liang, Jing Lu, Baian Chen, Jiapei Dai, Boli Liu, and Mengchao Cui . Oligoethyleneoxy-Modified 99mTc-Labeled β-Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography. Journal of Medicinal Chemistry 2018, 61 (3) , 1330-1339. https://doi.org/10.1021/acs.jmedchem.7b01834
    25. Christos Kiritsis, Barbara Mavroidi, Antonio Shegani, Lazaros Palamaris, George Loudos, Marina Sagnou, Ioannis Pirmettis, Minas Papadopoulos, and Maria Pelecanou . 2-(4′-Aminophenyl)benzothiazole Labeled with 99mTc-Cyclopentadienyl for Imaging β-Amyloid Plaques. ACS Medicinal Chemistry Letters 2017, 8 (10) , 1089-1092. https://doi.org/10.1021/acsmedchemlett.7b00294
    26. Andrea J. North, John A. Karas, Michelle T. Ma, Philip J. Blower, Uwe Ackermann, Jonathan M. White, and Paul S. Donnelly . Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK. Inorganic Chemistry 2017, 56 (16) , 9725-9741. https://doi.org/10.1021/acs.inorgchem.7b01247
    27. F. Y. Adeowo, B. Honarparvar, and A. A. Skelton . Density Functional Theory Study on the Complexation of NOTA as a Bifunctional Chelator with Radiometal Ions. The Journal of Physical Chemistry A 2017, 121 (32) , 6054-6062. https://doi.org/10.1021/acs.jpca.7b01017
    28. Xiaoyang Zhang, Pingrong Yu, Yanping Yang, Yaqin Hou, Cheng Peng, Zhigang Liang, Jing Lu, Baian Chen, Jiapei Dai, Boli Liu, and Mengchao Cui . 99mTc-Labeled 2-Arylbenzothiazoles: Aβ Imaging Probes with Favorable Brain Pharmacokinetics for Single-Photon Emission Computed Tomography. Bioconjugate Chemistry 2016, 27 (10) , 2493-2504. https://doi.org/10.1021/acs.bioconjchem.6b00444
    29. Yuki Mizuno, Tomoya Uehara, Hirofumi Hanaoka, Yota Endo, Chun-Wei Jen, and Yasushi Arano . Purification-Free Method for Preparing Technetium-99m-Labeled Multivalent Probes for Enhanced in Vivo Imaging of Saturable Systems. Journal of Medicinal Chemistry 2016, 59 (7) , 3331-3339. https://doi.org/10.1021/acs.jmedchem.6b00024
    30. Sophie Poty, Eleni Gourni, Pauline Désogère, Frédéric Boschetti, Christine Goze, Helmut R. Maecke, and Franck Denat . AMD3100: A Versatile Platform for CXCR4 Targeting 68Ga-Based Radiopharmaceuticals. Bioconjugate Chemistry 2016, 27 (3) , 752-761. https://doi.org/10.1021/acs.bioconjchem.5b00689
    31. Stuart A. McNelles, Spencer D. Knight, Nancy Janzen, John F. Valliant, and Alex Adronov . Synthesis, Radiolabeling, and In Vivo Imaging of PEGylated High-Generation Polyester Dendrimers. Biomacromolecules 2015, 16 (9) , 3033-3041. https://doi.org/10.1021/acs.biomac.5b00911
    32. Caterina F. Ramogida, Jinhe Pan, Cara L. Ferreira, Brian O. Patrick, Karla Rebullar, Donald T. T. Yapp, Kuo-Shyan Lin, Michael J. Adam, and Chris Orvig . Nitroimidazole-Containing H2dedpa and H2CHXdedpa Derivatives as Potential PET Imaging Agents of Hypoxia with 68Ga. Inorganic Chemistry 2015, 54 (10) , 4953-4965. https://doi.org/10.1021/acs.inorgchem.5b00554
    33. Pierre-Marie Gassin, Luc Girard, Gaelle Martin-Gassin, Damien Brusselle, Alban Jonchère, Olivier Diat, Clara Viñas, Francesc Teixidor, and Pierre Bauduin . Surface Activity and Molecular Organization of Metallacarboranes at the Air–Water Interface Revealed by Nonlinear Optics. Langmuir 2015, 31 (8) , 2297-2303. https://doi.org/10.1021/acs.langmuir.5b00125
    34. Caterina F. Ramogida, Jacqueline F. Cawthray, Eszter Boros, Cara L. Ferreira, Brian O. Patrick, Michael J. Adam, and Chris Orvig . H2CHXdedpa and H4CHXoctapa—Chiral Acyclic Chelating Ligands for 67/68Ga and 111In Radiopharmaceuticals. Inorganic Chemistry 2015, 54 (4) , 2017-2031. https://doi.org/10.1021/ic502942a
    35. Asif Noor, Gregory S. Huff, Sreedhar V. Kumar, James E. M. Lewis, Brett M. Paterson, Christine Schieber, Paul S. Donnelly, Heather J. L. Brooks, Keith C. Gordon, Stephen C. Moratti, and James D. Crowley . [Re(CO)3]+ Complexes of exo-Functionalized Tridentate “Click” Macrocycles: Synthesis, Stability, Photophysical Properties, Bioconjugation, and Antibacterial Activity. Organometallics 2014, 33 (24) , 7031-7043. https://doi.org/10.1021/om500664v
    36. Eric W. Price, Brian M. Zeglis, Jacqueline F. Cawthray, Jason S. Lewis, Michael J. Adam, and Chris Orvig . What a Difference a Carbon Makes: H4octapa vs H4C3octapa, Ligands for In-111 and Lu-177 Radiochemistry. Inorganic Chemistry 2014, 53 (19) , 10412-10431. https://doi.org/10.1021/ic501466z
    37. Ashutosh Dash and Rubel Chakravarty . Electrochemical Separation: Promises, Opportunities, and Challenges To Develop Next-Generation Radionuclide Generators To Meet Clinical Demands. Industrial & Engineering Chemistry Research 2014, 53 (10) , 3766-3777. https://doi.org/10.1021/ie404369y
    38. Brian M. Zeglis, Jacob L. Houghton, Michael J. Evans, Nerissa Viola-Villegas, and Jason S. Lewis . Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals. Inorganic Chemistry 2014, 53 (4) , 1880-1899. https://doi.org/10.1021/ic401607z
    39. Anupriya Adhikari, Anupama Datta, Manish Adhikari, Kanchan Chauhan, Krishna Chuttani, Sanjiv Saw, Abha Shukla, and Anil K. Mishra . Preclinical Evaluation of DO3A-Act-AQ: A Polyazamacrocyclic Monomeric Anthraquinone Derivative as a Theranostic Agent. Molecular Pharmaceutics 2014, 11 (2) , 445-456. https://doi.org/10.1021/mp4004089
    40. Eric W. Price, Brian M. Zeglis, Jacqueline F. Cawthray, Caterina F. Ramogida, Nicholas Ramos, Jason S. Lewis, Michael J. Adam, and Chris Orvig . H4octapa-Trastuzumab: Versatile Acyclic Chelate System for 111In and 177Lu Imaging and Therapy. Journal of the American Chemical Society 2013, 135 (34) , 12707-12721. https://doi.org/10.1021/ja4049493
    41. Wenchan Jiang, John D. Gorden, and Christian R. Goldsmith . Catalysis of Alkene Epoxidation by a Series of Gallium(III) Complexes with Neutral N-Donor Ligands. Inorganic Chemistry 2013, 52 (10) , 5814-5823. https://doi.org/10.1021/ic400570h
    42. Murthi S. Kandanapitiye, Benjamin Valley, Liu D. Yang, Allyson M. Fry, Patrick M. Woodward, and Songping D. Huang . Gallium Analogue of Soluble Prussian Blue KGa[Fe(CN)6]·nH2O: Synthesis, Characterization, and Potential Biomedical Applications. Inorganic Chemistry 2013, 52 (6) , 2790-2792. https://doi.org/10.1021/ic302262g
    43. Yunjun Shen, Margret Schottelius, Karel Zelenka, Mariarosaria De Simone, Karolin Pohle, Horst Kessler, Hans-Jürgen Wester, Paul Schmutz, and Roger Alberto . Orthogonally Protected Artificial Amino Acid as Tripod Ligand for Automated Peptide Synthesis and Labeling with [99mTc(OH2)3(CO)3]+. Bioconjugate Chemistry 2013, 24 (1) , 26-35. https://doi.org/10.1021/bc3003327
    44. Gwendolyn A. Bailey, Eric W. Price, Brian M. Zeglis, Cara L. Ferreira, Eszter Boros, Michael J. Lacasse, Brian O. Patrick, Jason S. Lewis, Michael J. Adam, and Chris Orvig . H2azapa: a Versatile Acyclic Multifunctional Chelator for 67Ga, 64Cu, 111In, and 177Lu. Inorganic Chemistry 2012, 51 (22) , 12575-12589. https://doi.org/10.1021/ic302225z
    45. Samer Sulieman, Daniel Can, John Mertens, Harmel W. Peindy N’Dongo, Yu Liu, Paul Schmutz, Matthias Bauwens, Bernhard Spingler, and Roger Alberto . Cyclopentadienyl-Based Amino Acids (Cp-aa) As Phenylalanine Analogues for Tumor Targeting: Syntheses and Biological Properties of [(Cp-aa)M(CO)3](M = Mn, Re, 99mTc). Organometallics 2012, 31 (19) , 6880-6886. https://doi.org/10.1021/om300695k
    46. Ji-Ae Park, Jung Young Kim, Hee-Kyung Kim, Wonho Lee, Sang Moo Lim, Yongmin Chang, Tae-Jeong Kim, and Kyeong Min Kim . Heteronuclear Gd-99mTc Complex of DTPA-Bis(histidylamide) Conjugate as a Bimodal MR/SPECT Imaging Probe. ACS Medicinal Chemistry Letters 2012, 3 (4) , 299-302. https://doi.org/10.1021/ml200285p
    47. Yan Cheng, Masahiro Ono, Hiroyuki Kimura, Masashi Ueda, and Hideo Saji . Technetium-99m Labeled Pyridyl Benzofuran Derivatives as Single Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Alzheimer’s Brains. Journal of Medicinal Chemistry 2012, 55 (5) , 2279-2286. https://doi.org/10.1021/jm201513c
    48. Gopal Pathuri, Andria F. Hedrick, Bryan C. Disch, John T. Doan, Michael A. Ihnat, Vibhudutta Awasthi, and Hariprasad Gali . Synthesis and Evaluation of Novel Tc-99m Labeled Probestin Conjugates for Imaging APN/CD13 Expression In Vivo. Bioconjugate Chemistry 2012, 23 (1) , 115-124. https://doi.org/10.1021/bc200546b
    49. Michelle T. Ma, Oliver C. Neels, Delphine Denoyer, Peter Roselt, John A. Karas, Denis B. Scanlon, Jonathan M. White, Rodney J. Hicks, and Paul S. Donnelly . Gallium-68 Complex of a Macrobicyclic Cage Amine Chelator Tethered to Two Integrin-Targeting Peptides for Diagnostic Tumor Imaging. Bioconjugate Chemistry 2011, 22 (10) , 2093-2103. https://doi.org/10.1021/bc200319q
    50. Jean-François Morfin and Éva Tóth . Kinetics of Ga(NOTA) Formation from Weak Ga-Citrate Complexes. Inorganic Chemistry 2011, 50 (20) , 10371-10378. https://doi.org/10.1021/ic201445e
    51. Karel Zelenka, Lubor Borsig, and Roger Alberto . Metal Complex Mediated Conjugation of Peptides to Nucleus Targeting Acridine Orange: A Modular Concept for Dual-Modality Imaging Agents. Bioconjugate Chemistry 2011, 22 (5) , 958-967. https://doi.org/10.1021/bc2000269
    52. Eszter Boros, Cara L. Ferreira, Jacqueline F. Cawthray, Eric W. Price, Brian O. Patrick, Dennis W. Wester, Michael J. Adam, and Chris Orvig. Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration. Journal of the American Chemical Society 2010, 132 (44) , 15726-15733. https://doi.org/10.1021/ja106399h
    53. Domenik Nowak, Adelheid Hagenbach, Till Erik Sawallisch, Ulrich Abram. Thionitrosyl Complexes of Rhenium and Technetium with PPh3 and Chelating Ligands—Synthesis and Reactivity. Inorganics 2024, 12 (8) , 210. https://doi.org/10.3390/inorganics12080210
    54. Antonella Guerriero, Andrea Ienco, Thomas Hicks, Agostino Cilibrizzi. Beyond transition block metals: exploring the reactivity of phosphine PTA and its oxide [PTA(O)] towards gallium( iii ). RSC Advances 2024, 14 (29) , 21139-21150. https://doi.org/10.1039/D4RA02877E
    55. Shahnaz Saednia, Saeed Emami, Masoud Moslehi, Seyed Jalal Hosseinimehr. Insights into the development of 99mTc-radioligands for serotonergic receptors imaging: Synthesis, labeling, In vitro, and In vivo studies. European Journal of Medicinal Chemistry 2024, 270 , 116349. https://doi.org/10.1016/j.ejmech.2024.116349
    56. Akshita Arora, Anshul Sharma, Richa Kumari, Nitin Sharma. Radiopharmaceutical-based approaches for the determination of colon-targeting efficiency. 2024, 367-383. https://doi.org/10.1016/B978-0-443-14044-0.00006-5
    57. Ulrich Abram. Innovative PET and SPECT Tracers. 2024, 301-321. https://doi.org/10.1007/978-3-031-61846-8_13
    58. Timofei Rusu, Matthieu Delion, Charlotte Pirot, Amaury Blin, Anita Rodenas, Jean-Noël Talbot, Nicolas Veran, Christophe Portal, Françoise Montravers, Jacques Cadranel, Aurélie Prignon. Fully automated radiolabeling of [68Ga]Ga-EMP100 targeting c-MET for PET-CT clinical imaging. EJNMMI Radiopharmacy and Chemistry 2023, 8 (1) https://doi.org/10.1186/s41181-023-00213-3
    59. Marcus Mkhatshwa, Frederick P. Malan, Katlego Makgopa, Amanda-Lee E. Manicum. The crystal structure of fac -tricarbonyl(6-bromo-2,2-bipyridine-κ 2 N,N )-(nitrato-κ O )rhenium(I), C 13 H 7 BrN 3 O 6 Re. Zeitschrift für Kristallographie - New Crystal Structures 2023, 238 (4) , 667-669. https://doi.org/10.1515/ncrs-2023-0141
    60. Mingliang Ren, Bolin Yao, Bing Han, Cong Li. Nuclear Imaging of CAR T Immunotherapy to Solid Tumors: In Terms of Biodistribution, Viability, and Cytotoxic Effect. Advanced Biology 2023, 7 (6) https://doi.org/10.1002/adbi.202200293
    61. Guilhem Claude, Erika Kulitzki, Adelheid Hagenbach, Maximilian Roca Jungfer, Joshua S. Figueroa, Ulrich Abram. Phenylimido complexes of rhenium: fluorine substituents provide protection, reactivity, and solubility. Dalton Transactions 2023, 52 (15) , 4768-4778. https://doi.org/10.1039/D3DT00446E
    62. Katayoun Saatchi, François Bénard, Navjit Hundal, Joshua Grimes, Sergey Shcherbinin, Maral Pourghiasian, Donald E. Brooks, Anna Celler, Urs O. Häfeli. Preclinical PET Imaging and Toxicity Study of a 68Ga-Functionalized Polymeric Cardiac Blood Pool Agent. Pharmaceutics 2023, 15 (3) , 767. https://doi.org/10.3390/pharmaceutics15030767
    63. Leila Valipour Yekany, Tayebeh Akbarzadeh Chiniforoush, Yousef Fazaeli, Mohammadreza Aboudzadeh, Mahdi Sadeghi. Preparation and quality control of a new porphyrin complex labeled with 45Ti for PET imaging. Applied Radiation and Isotopes 2023, 193 , 110650. https://doi.org/10.1016/j.apradiso.2023.110650
    64. Smita Majumder, Jagannath Bhuyan. A new strategy for the synthesis of oxo-rhenium(V) porphyrins: Synthesis, characterization, theoretical calculations and electrochemical aspects. Inorganica Chimica Acta 2023, 547 , 121344. https://doi.org/10.1016/j.ica.2022.121344
    65. Kusum Vats, Avik Chakraborty, Sutapa Rakshit, Archana Damle, Haladhar Dev Sarma, Drishty Satpati. [99mTc]Tc-HYNIC-RM2: A potential SPECT probe targeting GRPR expression in prostate cancers. Nuclear Medicine and Biology 2023, 118-119 , 108331. https://doi.org/10.1016/j.nucmedbio.2023.108331
    66. Georgy V. Sidorenko, Alexander E. Miroslavov, Margarita Yu. Tyupina. Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect. Coordination Chemistry Reviews 2023, 476 , 214911. https://doi.org/10.1016/j.ccr.2022.214911
    67. Maria-Argyro Karageorgou, Penelope Bouziotis, Efstathios Stiliaris, Dimosthenis Stamopoulos. Radiolabeled Iron Oxide Nanoparticles as Dual Modality Contrast Agents in SPECT/MRI and PET/MRI. Nanomaterials 2023, 13 (3) , 503. https://doi.org/10.3390/nano13030503
    68. Asma Akter, Oliver Lyons, Varun Mehra, Heather Isenman, Vincenzo Abbate. Radiometal chelators for infection diagnostics. Frontiers in Nuclear Medicine 2023, 2 https://doi.org/10.3389/fnume.2022.1058388
    69. Henryk Kozlowski, Karolina Piasta, Aleksandra Hecel, Magdalena Rowinska-Zyrek, Elzbieta Gumienna-Kontecka. Metallophores: How do human pathogens withdraw metal ions from the colonized host. 2023, 553-574. https://doi.org/10.1016/B978-0-12-823144-9.00086-8
    70. Mohammad-Nabil Savari, Ali Jabali. Diagnosis. 2023, 241-345. https://doi.org/10.1007/978-981-99-6507-6_8
    71. Patrick R. W. J. Davey, Brett M. Paterson. Modern Developments in Bifunctional Chelator Design for Gallium Radiopharmaceuticals. Molecules 2023, 28 (1) , 203. https://doi.org/10.3390/molecules28010203
    72. Qianna Wang, Junbo Zhang. Current status and progress in using radiolabelled PARP-1 inhibitors for imaging PARP-1 expression in tumours. European Journal of Medicinal Chemistry 2022, 242 , 114690. https://doi.org/10.1016/j.ejmech.2022.114690
    73. Alexander Wurzer, Stephan G. Nekolla, Calogero D’Alessandria. Stand der Technik in der Radiopharmazie. Angewandte Nuklearmedizin 2022, 45 (03) , 167-188. https://doi.org/10.1055/a-1715-5069
    74. Saul M. Cooper, Christina Siakalli, Andrew J. P. White, Angelo Frei, Philip W. Miller, Nicholas J. Long. Synthesis and anti-microbial activity of a new series of bis(diphosphine) rhenium( v ) dioxo complexes. Dalton Transactions 2022, 51 (34) , 12791-12795. https://doi.org/10.1039/D2DT02157A
    75. Maria-Argyro Karageorgou, Aristotelis-Nikolaos Rapsomanikis, Marija Mirković, Sanja Vranješ-Ðurić, Efstathios Stiliaris, Penelope Bouziotis, Dimosthenis Stamopoulos. 99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models. Nanomaterials 2022, 12 (15) , 2728. https://doi.org/10.3390/nano12152728
    76. Evangelia-Alexandra Salvanou, Argiris Kolokithas-Ntoukas, Christos Liolios, Stavros Xanthopoulos, Maria Paravatou-Petsotas, Charalampos Tsoukalas, Konstantinos Avgoustakis, Penelope Bouziotis. Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents. Nanomaterials 2022, 12 (14) , 2490. https://doi.org/10.3390/nano12142490
    77. Sara Brunello, Nicola Salvarese, Debora Carpanese, Carolina Gobbi, Laura Melendez-Alafort, Cristina Bolzati. A Review on the Current State and Future Perspectives of [99mTc]Tc-Housed PSMA-i in Prostate Cancer. Molecules 2022, 27 (9) , 2617. https://doi.org/10.3390/molecules27092617
    78. Quim Peña, Alec Wang, Orysia Zaremba, Yang Shi, Hans W. Scheeren, Josbert M. Metselaar, Fabian Kiessling, Roger M. Pallares, Stefan Wuttke, Twan Lammers. Metallodrugs in cancer nanomedicine. Chemical Society Reviews 2022, 51 (7) , 2544-2582. https://doi.org/10.1039/D1CS00468A
    79. Mark Bartholomae, Nerissa Viola-Villegas, Jayme L. Workinger, Robert P. Doyle, Jon Zubieta. The Role of Fundamental Coordination Chemistry in the Development of Radioimaging Agents. 2022, 89-148. https://doi.org/10.1039/9781782624028-00089
    80. Xinghao Han, Bin Liu, Zhihong Wang, Alexander Ross Craze, Hongxia Sun, Misbha Rafiq Khan, Jing Liu, Zhongyi Liu, Jinpeng Li. Structure diversity and magnetic properties of manganese and cobalt coordination polymers with multiple carboxyl bridges. Inorganica Chimica Acta 2022, 533 , 120788. https://doi.org/10.1016/j.ica.2021.120788
    81. Stephan Pflock, Frauke Langer, Michaela Reil, Lisa Strinitz, Rebecca Lorenz, Eike G. Hübner, Nicolai Burzlaff. p -Block metal complexes with bis(pyrazol-1-yl)acetato ligands. Dalton Transactions 2022, 51 (10) , 3902-3912. https://doi.org/10.1039/D1DT04040E
    82. Nicolas Lepareur. Cold Kit Labeling: The Future of 68Ga Radiopharmaceuticals?. Frontiers in Medicine 2022, 9 https://doi.org/10.3389/fmed.2022.812050
    83. Patrick R. W. J. Davey, Craig M. Forsyth, Brett M. Paterson. Crystallographic and Computational Characterisation of the Potential PET Tracer 1,4,7‐Triazacyclononane‐1,4,7‐tri(methylenephosphonato)gallium(III). ChemistrySelect 2022, 7 (5) https://doi.org/10.1002/slct.202103698
    84. Roger Alberto. Organometallic Chemistry of Drugs Based on Technetium and Rhenium. 2022, 226-260. https://doi.org/10.1016/B978-0-12-820206-7.00029-9
    85. Abdullah Abdulkader, Adelheid Hagenbach, Ulrich Abram. [Tc(NO)Cl(Cp)(PPh 3 )] – A Technetium(I) Compound with an Unexpected Synthetic Potential. European Journal of Inorganic Chemistry 2021, 2021 (37) , 3812-3818. https://doi.org/10.1002/ejic.202100521
    86. Natalia Herrero Álvarez, David Bauer, Javier Hernández‐Gil, Jason S. Lewis. Recent Advances in Radiometals for Combined Imaging and Therapy in Cancer. ChemMedChem 2021, 16 (19) , 2909-2941. https://doi.org/10.1002/cmdc.202100135
    87. Imtiyaz Yousuf, Masrat Bashir, Farukh Arjmand, Sartaj Tabassum. Advancement of metal compounds as therapeutic and diagnostic metallodrugs: Current frontiers and future perspectives. Coordination Chemistry Reviews 2021, 445 , 214104. https://doi.org/10.1016/j.ccr.2021.214104
    88. Khurram Shahzad, Aman Shah Abdul Majid, Mumtaz Khan, Muhammad Adnan Iqbal, Asjad Ali. Recent advances in the synthesis of ( 99m Technetium) based radio-pharmaceuticals. Reviews in Inorganic Chemistry 2021, 41 (3) , 151-198. https://doi.org/10.1515/revic-2020-0021
    89. Irina V. Lunegova, Valery V. Tyts, Alexander M. Lunegov. Foreign experience in veterinaryapplication of scintigraphy. Pharmacy Formulas 2021, 3 (2) , 36-39. https://doi.org/10.17816/phf71488
    90. Chunfei Wang, Wenjing Wang, Jingyun Tan, Xuanjun Zhang, Daqiang Yuan, Hong-Cai Zhou. Coordination-based molecular nanomaterials for biomedically relevant applications. Coordination Chemistry Reviews 2021, 438 , 213752. https://doi.org/10.1016/j.ccr.2020.213752
    91. Fabio Travagin, Luciano Lattuada, Giovanni B. Giovenzana. AAZTA: The rise of mesocyclic chelating agents for metal coordination in medicine. Coordination Chemistry Reviews 2021, 438 , 213908. https://doi.org/10.1016/j.ccr.2021.213908
    92. Sofia Papadopoulou, Argiris Kolokithas-Ntoukas, Evangelia-Alexandra Salvanou, Anastasios Gaitanis, Stavros Xanthopoulos, Konstantinos Avgoustakis, Maria Gazouli, Maria Paravatou-Petsotas, Charalampos Tsoukalas, Aristides Bakandritsos, Penelope Bouziotis. Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging. Nanomaterials 2021, 11 (7) , 1677. https://doi.org/10.3390/nano11071677
    93. Raphael Lengacher, Roger Alberto. Bioorganometallics: 99mTc cytectrenes, syntheses and applications in nuclear medicine. Coordination Chemistry Reviews 2021, 437 , 213869. https://doi.org/10.1016/j.ccr.2021.213869
    94. Nikolay Ivanovich Gorshkov, Andrei Yur'evich Murko, Yulia Igorevna Zolotova, Olga Vladimirovna Nazarova, Valerii Dmitrievich Krasikov, Sergei Vasilievich Shatik, Evgenii Fedorovich Panarin. Introduction of Re(CO)3+/99mTc(CO)3+ Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers. Polymers 2021, 13 (11) , 1832. https://doi.org/10.3390/polym13111832
    95. Artur V. da Silva, Simoni M. P. Meneghetti, Mario R. Meneghetti. Benzodiazepines: Drugs with Chemical Skeletons Suitable for the Preparation of Metallacycles with Potential Pharmacological Activity. Molecules 2021, 26 (9) , 2796. https://doi.org/10.3390/molecules26092796
    96. Viviana S. Prado, Renan C. F. Leitao, Francisco Silva, Lurdes Gano, Isabel C. Santos, Fabio L. N. Marques, António Paulo, Victor M. Deflon. Gallium and indium complexes with new hexadentate bis(semicarbazone) and bis(thiosemicarbazone) chelators. Dalton Transactions 2021, 50 (5) , 1631-1640. https://doi.org/10.1039/D0DT04028B
    97. Theodosia Maina, Mathew Thakur. SPECT Radiochemistry. 2021, 479-492. https://doi.org/10.1016/B978-0-12-816386-3.00023-5
    98. Bohan Li, Dehua Huang, Tianze Zhang, Xiaoge Niu, Jing Liu, Wenjing Zhang, Yan Liu, Zhongyi Liu, Panke Zhang, Jinpeng Li. Five lead(II) coordinated polymers assembled from asymmetric azoles carboxylate ligands: Synthesis, structures and fluorescence properties. Inorganica Chimica Acta 2021, 514 , 120035. https://doi.org/10.1016/j.ica.2020.120035
    99. Xu Zhou, Lin-Lin Dong, Yuying Li, Meng-Chao Cui, Lang-Tao Shen. Design and synthesis of a new conjugate of a tris(3-hydroxy-4-pyridinone) chelator (KC18) for potential use as gallium-68-labeled prostate-specific membrane antigen (PSMA) radiopharmaceutical. Results in Chemistry 2021, 3 , 100240. https://doi.org/10.1016/j.rechem.2021.100240
    100. Charlotte Rivas, Jessica A. Jackson, Ingebjørg N. Hungnes, Michelle T. Ma. Radioactive Metals in Imaging and Therapy. 2021, 706-740. https://doi.org/10.1016/B978-0-08-102688-5.00010-6
    Load more citations
    Download PDF
    Go to Chemical Reviews
    Get e-Alerts
    Get e-Alerts

    Chemical Reviews

    Cite this: Chem. Rev. 2010, 110, 5, 2903–2920
    Click to copy citationCitation copied!
    https://doi.org/10.1021/cr1000755
    Published April 23, 2010
    Copyright © 2010 American Chemical Society
    Request reuse permissions

    Article Views

    5337

    Altmetric

    -

    Citations

    270
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.