Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways

Click to copy article linkArticle link copied!

This article is cited by 715 publications.

1. Jong Won Baek, Euichul Shin, Jinho Lee, Dong-Ha Kim, Seon-Jin Choi, Il-Doo Kim. Present and Future of Emerging Catalysts in Gas Sensors for Breath Analysis. ACS Sensors 2025, 10 (1) , 33-53. https://doi.org/10.1021/acssensors.4c02464
2. Jijuan Zhou, Dianlong Ge, Yue Liu, Yajing Chu, Xiangxue Zheng, Yan Lu, Yannan Chu. Developing Multiple Media Approach to Investigate Reproducible Characteristic VOCs of Lung Cancer Cells. Analytical Chemistry 2024, 96 (52) , 20398-20405. https://doi.org/10.1021/acs.analchem.4c03894
3. Zhengnan Cen, Yuerun Huang, Shangzhewen Li, Shanshan Dong, Wenshan Wang, Xiang Li. Advancing Breathomics through Accurate Discrimination of Endogenous from Exogenous Volatiles in Breath. Environmental Science & Technology 2024, 58 (42) , 18541-18553. https://doi.org/10.1021/acs.est.4c04575
4. Ambika Kumari, Avik Sett, Srijeet Tripathy, Lisa Sarkar, Tarun Kanti Bhattacharyya. Amine and Thiol Cofunctionalized Reduced Graphene Oxide Field-Effect Transistor for the Selective Detection of Formaldehyde. ACS Applied Electronic Materials 2024, 6 (5) , 3464-3473. https://doi.org/10.1021/acsaelm.4c00259
5. Xiaoqi Chen, Qianqian Wan. Ru-Doped MoS2 Monolayer for Exhaled Breath Detection on Early Lung Cancer Diagnosis: A First-Principles Investigation. ACS Omega 2024, 9 (12) , 13951-13959. https://doi.org/10.1021/acsomega.3c09191
6. Chenyu Zhu, Maosheng Yao. Real-Time Monitoring of Air Pollution Health Impacts Using Breath-Borne Gaseous Biomarkers from Rats. Environmental Science & Technology 2024, 58 (10) , 4522-4534. https://doi.org/10.1021/acs.est.3c08629
7. Hongyi Liu, Xuan Luo. Au- and Pd-Doped SnS2 Monolayers for Lung Cancer Biomarkers (C3H6O, C6H6, and C5H8) Detection: A Density Functional Theory Investigation. ACS Omega 2024, 9 (7) , 7658-7667. https://doi.org/10.1021/acsomega.3c06346
8. Viet Bac T. Phung, Thi Nhan Tran, Quang Huy Tran, Thi Theu Luong, Van An Dinh. Graphene as a Sensor for Lung Cancer: Insights into Adsorption of VOCs Using vdW DFT. ACS Omega 2024, 9 (2) , 2302-2313. https://doi.org/10.1021/acsomega.3c06159
9. Xiangyu Meng, Yuening Wang, Xiaoyu Song, Mingjian Zhang, Jian Yu, Lin Qiu, Jie Lin, Xiaotian Wang. Ag-Coated Ternary Layered Double Hydroxide as a High-Performance SERS Sensor for Aldehydes. ACS Applied Materials & Interfaces 2023, 15 (41) , 48818-48825. https://doi.org/10.1021/acsami.3c10565
10. Jing Xu, Ying Xu, Junhan Li, Junjian Zhao, Xiaoxia Jian, Jingwen Xu, Zhida Gao, Yan-Yan Song. Construction of High-Active SERS Cavities in a TiO2 Nanochannels-Based Membrane: A Selective Device for Identifying Volatile Aldehyde Biomarkers. ACS Sensors 2023, 8 (9) , 3487-3497. https://doi.org/10.1021/acssensors.3c01061
11. Peng Jin, Chenglong Guo, Jiahao Li, Dejun Zhou, Guodong Xu, Yongwu Peng. Aggregation-Induced Emission of a Two-Dimensional Covalent Organic Framework for Molecular Recognition in Quantitative Metrics. ACS Applied Polymer Materials 2023, 5 (5) , 3762-3767. https://doi.org/10.1021/acsapm.3c00388
12. Zheng Tan, Jin Wang, Li Xu, Qijun Zheng, Lingfei Han, Chen Wang, Xuewei Liao. Simultaneous Sensing of Multiplex Volatile Organic Compounds by Adsorption and Plasmon Dual-Induced Raman Enhancement Technique. ACS Sensors 2023, 8 (2) , 867-874. https://doi.org/10.1021/acssensors.2c02572
13. Zixia Tang, Hong Tao, Xiao Wang, Lu Chen, Chi Song, Guanhong Lu, Xiaofeng Xie, Jing Sun. Quasi-In Situ Synthesis of Ag NPs@m-MIL-100(Fe) for the Enhanced Photocatalytic Elimination of Flowing Xylenes. ACS Applied Materials & Interfaces 2022, 14 (47) , 52894-52906. https://doi.org/10.1021/acsami.2c15811
14. Di Wang, Libin Qian, Fenni Zhang, Kyle Mallires, Vishal Varun Tipparaju, Jingjing Yu, Erica Forzani, Changku Jia, Qing Yang, Nongjian Tao, Xiaojun Xian. Multiplexed Chemical Sensing CMOS Imager. ACS Sensors 2022, 7 (11) , 3335-3342. https://doi.org/10.1021/acssensors.2c01277
15. Giandrin Barandun, Laura Gonzalez-Macia, Hong Seok Lee, Can Dincer, Firat Güder. Challenges and Opportunities for Printed Electrical Gas Sensors. ACS Sensors 2022, 7 (10) , 2804-2822. https://doi.org/10.1021/acssensors.2c01086
16. M. Sai Bhargava Reddy, Saraswathi Kailasa, Bharat C. G. Marupalli, Kishor Kumar Sadasivuni, Shampa Aich. A Family of 2D-MXenes: Synthesis, Properties, and Gas Sensing Applications. ACS Sensors 2022, 7 (8) , 2132-2163. https://doi.org/10.1021/acssensors.2c01046
17. Swati Nag, Sayan Dey, Debmallya Das, Prasanta Kumar Guha. Adsorption-Mediated n-Type ZnO Surface Reconstruction for Optically Enhanced Volatile Organic Compound Sensing. ACS Applied Electronic Materials 2022, 4 (8) , 3825-3833. https://doi.org/10.1021/acsaelm.2c00452
18. Martyna Jurkiewicz, Marlena Musik, Robert Pełech. Competitive Adsorption of a Binary VOC Mixture from the Gas Phase onto Activated Carbon Modified with Malic Acid. Industrial & Engineering Chemistry Research 2022, 61 (32) , 11947-11952. https://doi.org/10.1021/acs.iecr.2c01621
19. Yasmin Shibli Abu Raya, Yael Hershkovitz-Pollak, Radu Ionescu, Hossam Haick. Non-Invasive Staging of In Vitro Mice Embryos by Means of Volatolomics. ACS Sensors 2022, 7 (7) , 2006-2011. https://doi.org/10.1021/acssensors.2c00792
20. Gaofei Xiao, Ziyang Guo, Beilong Lin, Mingli Fu, Daiqi Ye, Yun Hu. Cu-VWT Catalysts for Synergistic Elimination of NOx and Volatile Organic Compounds from Coal-Fired Flue Gas. Environmental Science & Technology 2022, 56 (14) , 10095-10104. https://doi.org/10.1021/acs.est.2c02083
21. Haoxuan Chen, Yunhao Zheng, Mingyu Wang, Yan Wu, Maosheng Yao. Gene-Regulated Release of Distinctive Volatile Organic Compounds from Stressed Living Cells. Environmental Science & Technology 2022, 56 (13) , 9546-9555. https://doi.org/10.1021/acs.est.2c01774
22. Yingying Jian, Nan Zhang, Taoping Liu, Yujin Zhu, Di Wang, Hao Dong, Lihao Guo, Danyao Qu, Xue Jiang, Tao Du, Youbin Zheng, Miaomiao Yuan, Xuemei Fu, Jinmei Liu, Wei Dou, Fang Niu, Ruizhi Ning, Guangjian Zhang, Jinhai Fan, Hossam Haick, Weiwei Wu. Artificially Intelligent Olfaction for Fast and Noninvasive Diagnosis of Bladder Cancer from Urine. ACS Sensors 2022, 7 (6) , 1720-1731. https://doi.org/10.1021/acssensors.2c00467
23. Muhammad Khatib, Hossam Haick. Sensors for Volatile Organic Compounds. ACS Nano 2022, 16 (5) , 7080-7115. https://doi.org/10.1021/acsnano.1c10827
24. Liping Song, Jing Chen, Ben Bin Xu, Youju Huang. Flexible Plasmonic Biosensors for Healthcare Monitoring: Progress and Prospects. ACS Nano 2021, 15 (12) , 18822-18847. https://doi.org/10.1021/acsnano.1c07176
25. Yu Jia, Jian-Peng Hu, Li-Rong Dang, Hong Yao, Bingbing Shi, You-Ming Zhang, Tai-Bao Wei, Qi Lin. Rational Tuning of Binding Properties of Pillar[5]arene-Based Crystalline Material by Synergistic Effect and Its Application for Fluorescent Detection and Adsorption of 1,2-Ethylenediamine. ACS Sustainable Chemistry & Engineering 2021, 9 (48) , 16203-16209. https://doi.org/10.1021/acssuschemeng.1c05451
26. Jie Ling, Yaxin Dong, Pan Cao, Yixiang Wang, YingYing Li. Preparation of Mn-Fe Oxide by a Hydrolysis-Driven Redox Method and Its Application in Formaldehyde Oxidation. ACS Omega 2021, 6 (36) , 23274-23280. https://doi.org/10.1021/acsomega.1c02994
27. Kuo Yang, Kai Zhu, Yuanzhe Wang, Ziting Qian, Yizhi Zhang, Zhaoyan Yang, Zhuyuan Wang, Lei Wu, Shenfei Zong, Yiping Cui. Ti3C2Tx MXene-Loaded 3D Substrate toward On-Chip Multi-Gas Sensing with Surface-Enhanced Raman Spectroscopy (SERS) Barcode Readout. ACS Nano 2021, 15 (8) , 12996-13006. https://doi.org/10.1021/acsnano.1c01890
28. Shuangxi Tang, Linyuan Guo, Shicai Zhu, Liran Ma, Yu Tian. Paper-Like Visual Indicator Films for Harmful Hydrophilic Liquids and Vapors. ACS Applied Polymer Materials 2021, 3 (8) , 4027-4034. https://doi.org/10.1021/acsapm.1c00551
29. Oleg Lupan, David Santos-Carballal, Nicolai Ababii, Nicolae Magariu, Sandra Hansen, Alexander Vahl, Lukas Zimoch, Mathias Hoppe, Thierry Pauporté, Vardan Galstyan, Victor Sontea, Lee Chow, Franz Faupel, Rainer Adelung, Nora H de Leeuw, Elisabetta Comini. TiO2/Cu2O/CuO Multi-Nanolayers as Sensors for H2 and Volatile Organic Compounds: An Experimental and Theoretical Investigation. ACS Applied Materials & Interfaces 2021, 13 (27) , 32363-32380. https://doi.org/10.1021/acsami.1c04379
30. Zhengzhou Li, Yuze Li, Lingpeng Zhan, Lingwei Meng, Xi Huang, Tie Wang, Yafeng Li, Zongxiu Nie. Point-of-Care Test Paper for Exhaled Breath Aldehyde Analysis via Mass Spectrometry. Analytical Chemistry 2021, 93 (26) , 9158-9165. https://doi.org/10.1021/acs.analchem.1c01011
31. Sergii Kalytchuk, Lukáš Zdražil, Zdeněk Bad’ura, Miroslav Medved’, Michal Langer, Markéta Paloncýová, Giorgio Zoppellaro, Stephen V. Kershaw, Andrey L. Rogach, Michal Otyepka, Radek Zbořil. Carbon Dots Detect Water-to-Ice Phase Transition and Act as Alcohol Sensors via Fluorescence Turn-Off/On Mechanism. ACS Nano 2021, 15 (4) , 6582-6593. https://doi.org/10.1021/acsnano.0c09781
32. Zhaoping Xia, Dan Li, Wei Deng. Identification and Detection of Volatile Aldehydes as Lung Cancer Biomarkers by Vapor Generation Combined with Paper-Based Thin-Film Microextraction. Analytical Chemistry 2021, 93 (11) , 4924-4931. https://doi.org/10.1021/acs.analchem.0c05348
33. Sana Jamshaid, Shreedhar Devkota, Yong Rok Lee. Catalyst- and Substituent-Controlled Regio- and Stereoselective Synthesis of Indolyl Acrylates by Lewis-Acid-Catalyzed Direct Functionalization of 3-Formylindoles with Diazo Esters. Organic Letters 2021, 23 (6) , 2140-2146. https://doi.org/10.1021/acs.orglett.1c00277
34. Tun Liu, Ziwen Cui, Xin Li, Hao Cui, Yun Liu. Al-Doped MoSe2 Monolayer as a Promising Biosensor for Exhaled Breath Analysis: A DFT Study. ACS Omega 2021, 6 (1) , 988-995. https://doi.org/10.1021/acsomega.0c05654
35. Koichi Suematsu, Wataru Harano, Shigeto Yamasaki, Ken Watanabe, Kengo Shimanoe. One-Trillionth Level Toluene Detection Using a Dual-Designed Semiconductor Gas Sensor: Material and Sensor-Driven Designs. ACS Applied Electronic Materials 2020, 2 (12) , 4122-4126. https://doi.org/10.1021/acsaelm.0c00902
36. Zeenat Khatoon, Hassan Fouad, Othman Y. Alothman, Mohamed Hashem, Zubaida A. Ansari, Shafeeque Ahmed Ansari. Doped SnO2 Nanomaterials for E-Nose Based Electrochemical Sensing of Biomarkers of Lung Cancer. ACS Omega 2020, 5 (42) , 27645-27654. https://doi.org/10.1021/acsomega.0c04231
37. Jianxin Ma, Na Xu, Yu Liu, Yue Wang, Hui Li, Guocheng Liu, Xiuli Wang, Jianrong Li. A Stable 3D Zn-Coordination Polymer Sensor Based on Dual Luminescent Ligands for Efficient Detection of Multiple Analytes under Acid or Alkaline Environment. Inorganic Chemistry 2020, 59 (20) , 15495-15503. https://doi.org/10.1021/acs.inorgchem.0c02523
38. Shun Ohta, Yurika Iwabuchi, Ryota Mukai, Manabu Ishizaki, Tomoyuki Toda, Masato Kurihara, Masaaki Okazaki. Adsorption of Polar Volatile Organic Compounds by a Crystalline Network Structure Based on a Bis(benzimidazole)NiCl2 Complex. Crystal Growth & Design 2020, 20 (6) , 4046-4053. https://doi.org/10.1021/acs.cgd.0c00328
39. Zhiyuan Liu, Jingpeng Niu, Weimin Long, Bing Cui, Kun Song, Fan Dong, Dong Xu. Highly Efficient MnO2/AlOOH Composite Catalyst for Indoor Low-Concentration Formaldehyde Removal at Room Temperature. Inorganic Chemistry 2020, 59 (10) , 7335-7343. https://doi.org/10.1021/acs.inorgchem.0c00852
40. Qianqian Wan, Xiaoqi Chen, Yingang Gui. First-Principles Insight into a Ru-Doped SnS2 Monolayer as a Promising Biosensor for Exhale Gas Analysis. ACS Omega 2020, 5 (15) , 8919-8926. https://doi.org/10.1021/acsomega.0c00651
41. Qiaofen Chen, Zhao Chen, Dong Liu, Zhengfu He, Jianmin Wu. Constructing an E-Nose Using Metal-Ion-Induced Assembly of Graphene Oxide for Diagnosis of Lung Cancer via Exhaled Breath. ACS Applied Materials & Interfaces 2020, 12 (15) , 17713-17724. https://doi.org/10.1021/acsami.0c00720
42. Shihao Wang, Qi Liu, Ziqi Zhao, Chi Fan, Xiaoping Chen, Gang Xu, Minghong Wu, Jianjun Chen, Junhua Li. Enhanced Low-Temperature Activity of Toluene Oxidation over the Rod-like MnO2/LaMnO3 Perovskites with Alkaline Hydrothermal and Acid-Etching Treatment. Industrial & Engineering Chemistry Research 2020, 59 (14) , 6556-6564. https://doi.org/10.1021/acs.iecr.0c00373
43. Haoxuan Chen, Xinyue Li, Maosheng Yao. Rats Sniff Off Toxic Air. Environmental Science & Technology 2020, 54 (6) , 3437-3446. https://doi.org/10.1021/acs.est.9b07592
44. Ana Margarida Araújo, Maria Enea, Eduarda Fernandes, Félix Carvalho, Maria de Lourdes Bastos, Márcia Carvalho, Paula Guedes de Pinho. 3,4-Methylenedioxymethamphetamine Hepatotoxicity under the Heat Stress Condition: Novel Insights from in Vitro Metabolomic Studies. Journal of Proteome Research 2020, 19 (3) , 1222-1234. https://doi.org/10.1021/acs.jproteome.9b00741
45. Arni Sturluson, Rachel Sousa, Yujing Zhang, Melanie T. Huynh, Caleb Laird, Arthur H. P. York, Carson Silsby, Chih-Hung Chang, Cory M. Simon. Curating Metal–Organic Frameworks To Compose Robust Gas Sensor Arrays in Dilute Conditions. ACS Applied Materials & Interfaces 2020, 12 (5) , 6546-6564. https://doi.org/10.1021/acsami.9b16561
46. Yoav Y. Broza, Xi Zhou, Miaomiao Yuan, Danyao Qu, Youbing Zheng, Rotem Vishinkin, Muhammad Khatib, Weiwei Wu, Hossam Haick. Disease Detection with Molecular Biomarkers: From Chemistry of Body Fluids to Nature-Inspired Chemical Sensors. Chemical Reviews 2019, 119 (22) , 11761-11817. https://doi.org/10.1021/acs.chemrev.9b00437
47. Peihua Zhu, Shanshan Li, Xinyue Jiang, Qian Wang, Fuqing Fan, Mei Yan, Yan Zhang, Peini Zhao, Jinghua Yu. Noninvasive and Wearable Respiration Sensor Based on Organic Semiconductor Film with Strong Electron Affinity. Analytical Chemistry 2019, 91 (15) , 10320-10327. https://doi.org/10.1021/acs.analchem.9b02811
48. Hangzhen Lan, Jani Holopainen, Kari Hartonen, Matti Jussila, Mikko Ritala, Marja-Liisa Riekkola. Fully Automated Online Dynamic In-Tube Extraction for Continuous Sampling of Volatile Organic Compounds in Air. Analytical Chemistry 2019, 91 (13) , 8507-8515. https://doi.org/10.1021/acs.analchem.9b01668
49. Guang Zeng, Chen Wu, Ye Chang, Cheng Zhou, Bingbin Chen, Menglun Zhang, Jiuyan Li, Xuexin Duan, Qingrui Yang, Wei Pang. Detection and Discrimination of Volatile Organic Compounds using a Single Film Bulk Acoustic Wave Resonator with Temperature Modulation as a Multiparameter Virtual Sensor Array. ACS Sensors 2019, 4 (6) , 1524-1533. https://doi.org/10.1021/acssensors.8b01678
50. Huang Wen, Hao Wang, Jun Hai, Suisui He, Fengjuan Chen, Baodui Wang. Photochemical Synthesis of Porous CuFeSe2/Au Heterostructured Nanospheres as SERS Sensor for Ultrasensitive Detection of Lung Cancer Cells and Their Biomarkers. ACS Sustainable Chemistry & Engineering 2019, 7 (5) , 5200-5208. https://doi.org/10.1021/acssuschemeng.8b06116
51. Andreas T. Güntner, Sebastian Abegg, Karsten Königstein, Philipp A. Gerber, Arno Schmidt-Trucksäss, Sotiris E. Pratsinis. Breath Sensors for Health Monitoring. ACS Sensors 2019, 4 (2) , 268-280. https://doi.org/10.1021/acssensors.8b00937
52. Emilia Bramanti, Massimo Onor, Laura Colombaioni. Neurotoxicity Induced by Low Thallium Doses in Living Hippocampal Neurons: Evidence of Early Onset Mitochondrial Dysfunction and Correlation with Ethanol Production. ACS Chemical Neuroscience 2019, 10 (1) , 451-459. https://doi.org/10.1021/acschemneuro.8b00343
53. Vera Schroeder, Suchol Savagatrup, Maggie He, Sibo Lin, Timothy M. Swager. Carbon Nanotube Chemical Sensors. Chemical Reviews 2019, 119 (1) , 599-663. https://doi.org/10.1021/acs.chemrev.8b00340
54. Tesfalem Geremariam Welearegay, Mohamed Fethi Diouani, Lars Österlund, Florina Ionescu, Kamel Belgacem, Hanen Smadhi, Samira Khaled, Abdelhamid Kidar, Umut Cindemir, Dhafer Laouini, Radu Ionescu. Ligand-Capped Ultrapure Metal Nanoparticle Sensors for the Detection of Cutaneous Leishmaniasis Disease in Exhaled Breath. ACS Sensors 2018, 3 (12) , 2532-2540. https://doi.org/10.1021/acssensors.8b00759
55. Zhaolong Wang, Ke Liu, Xingmao Chang, Yanyu Qi, Congdi Shang, Taihong Liu, Jing Liu, Liping Ding, Yu Fang. Highly Sensitive and Discriminative Detection of BTEX in the Vapor Phase: A Film-Based Fluorescent Approach. ACS Applied Materials & Interfaces 2018, 10 (41) , 35647-35655. https://doi.org/10.1021/acsami.8b13747
56. Dong-Kyu Lee, Euiyeon Na, Seongoh Park, Jeong Hill Park, Johan Lim, Sung Won Kwon. In Vitro Tracking of Intracellular Metabolism-Derived Cancer Volatiles via Isotope Labeling. ACS Central Science 2018, 4 (8) , 1037-1044. https://doi.org/10.1021/acscentsci.8b00296
57. Jun-Hwe Cha, Dong-Ha Kim, Seon-Jin Choi, Won-Tae Koo, Il-Doo Kim. Sub-Parts-per-Million Hydrogen Sulfide Colorimetric Sensor: Lead Acetate Anchored Nanofibers toward Halitosis Diagnosis. Analytical Chemistry 2018, 90 (15) , 8769-8775. https://doi.org/10.1021/acs.analchem.8b01273
58. Ahmed H. Jalal, Fahmida Alam, Sohini Roychoudhury, Yogeswaran Umasankar, Nezih Pala, Shekhar Bhansali. Prospects and Challenges of Volatile Organic Compound Sensors in Human Healthcare. ACS Sensors 2018, 3 (7) , 1246-1263. https://doi.org/10.1021/acssensors.8b00400
59. Zhunan Jia, Hui Zhang, Choon Nam Ong, Abhijeet Patra, Yonghai Lu, Chwee Teck Lim, Thirumalai Venkatesan. Detection of Lung Cancer: Concomitant Volatile Organic Compounds and Metabolomic Profiling of Six Cancer Cell Lines of Different Histological Origins. ACS Omega 2018, 3 (5) , 5131-5140. https://doi.org/10.1021/acsomega.7b02035
60. Niharendu Mahapatra, Avi Ben-Cohen, Yonathan Vaknin, Alex Henning, Joseph Hayon, Klimentiy Shimanovich, Hayit Greenspan, Yossi Rosenwaks. Electrostatic Selectivity of Volatile Organic Compounds Using Electrostatically Formed Nanowire Sensor. ACS Sensors 2018, 3 (3) , 709-715. https://doi.org/10.1021/acssensors.8b00044
61. Dong-Hoon Park, Jung-Moo Heo, Woomin Jeong, Young Hyuk Yoo, Bum Jun Park, and Jong-Man Kim . Smartphone-Based VOC Sensor Using Colorimetric Polydiacetylenes. ACS Applied Materials & Interfaces 2018, 10 (5) , 5014-5021. https://doi.org/10.1021/acsami.7b18121
62. Yoav Y. Broza, Lior Har-Shai, Raneen Jeries, John C. Cancilla, Lea Glass-Marmor, Izabella Lejbkowicz, José S. Torrecilla, Xuelin Yao, Xinliang Feng, Akimitsu Narita, Klaus Müllen, Ariel Miller, and Hossam Haick . Exhaled Breath Markers for Nonimaging and Noninvasive Measures for Detection of Multiple Sclerosis. ACS Chemical Neuroscience 2017, 8 (11) , 2402-2413. https://doi.org/10.1021/acschemneuro.7b00181
63. Sang-Joon Kim, Seon-Jin Choi, Ji-Soo Jang, Hee-Jin Cho, and Il-Doo Kim . Innovative Nanosensor for Disease Diagnosis. Accounts of Chemical Research 2017, 50 (7) , 1587-1596. https://doi.org/10.1021/acs.accounts.7b00047
64. Runkun Zhang, Wanting Huang, Gongke Li, and Yufei Hu . Noninvasive Strategy Based on Real-Time in Vivo Cataluminescence Monitoring for Clinical Breath Analysis. Analytical Chemistry 2017, 89 (6) , 3353-3361. https://doi.org/10.1021/acs.analchem.6b03898
65. Roberto Paolesse, Sara Nardis, Donato Monti, Manuela Stefanelli, and Corrado Di Natale . Porphyrinoids for Chemical Sensor Applications. Chemical Reviews 2017, 117 (4) , 2517-2583. https://doi.org/10.1021/acs.chemrev.6b00361
66. Zhen Zhang, Wei Yu, Jing Wang, Dan Luo, Xuezhi Qiao, Xiaoyun Qin, and Tie Wang . Ultrasensitive Surface-Enhanced Raman Scattering Sensor of Gaseous Aldehydes as Biomarkers of Lung Cancer on Dendritic Ag Nanocrystals. Analytical Chemistry 2017, 89 (3) , 1416-1420. https://doi.org/10.1021/acs.analchem.6b05117
67. Morad K. Nakhleh, Haitham Amal, Raneen Jeries, Yoav Y. Broza, Manal Aboud, Alaa Gharra, Hodaya Ivgi, Salam Khatib, Shifaa Badarneh, Lior Har-Shai, Lea Glass-Marmor, Izabella Lejbkowicz, Ariel Miller, Samih Badarny, Raz Winer, John Finberg, Sylvia Cohen-Kaminsky, Frédéric Perros, David Montani, Barbara Girerd, Gilles Garcia, Gérald Simonneau, Farid Nakhoul, Shira Baram, Raed Salim, Marwan Hakim, Maayan Gruber, Ohad Ronen, Tal Marshak, Ilana Doweck, Ofer Nativ, Zaher Bahouth, Da-you Shi, Wei Zhang, Qing-ling Hua, Yue-yin Pan, Li Tao, Hu Liu, Amir Karban, Eduard Koifman, Tova Rainis, Roberts Skapars, Armands Sivins, Guntis Ancans, Inta Liepniece-Karele, Ilze Kikuste, Ieva Lasina, Ivars Tolmanis, Douglas Johnson, Stuart Z. Millstone, Jennifer Fulton, John W. Wells, Larry H. Wilf, Marc Humbert, Marcis Leja, Nir Peled, and Hossam Haick . Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules. ACS Nano 2017, 11 (1) , 112-125. https://doi.org/10.1021/acsnano.6b04930
68. Jian Wang, Min Jiang, Ling Yan, Ren Peng, Mengjie Huangfu, Xinxin Guo, Yang Li, and Pengyan Wu . Multifunctional Luminescent Eu(III)-Based Metal–Organic Framework for Sensing Methanol and Detection and Adsorption of Fe(III) Ions in Aqueous Solution. Inorganic Chemistry 2016, 55 (24) , 12660-12668. https://doi.org/10.1021/acs.inorgchem.6b01815
69. Yunsheng Chen, Yixia Zhang, Fei Pan, Jie Liu, Kan Wang, Chunlei Zhang, Shangli Cheng, Lungen Lu, Wei Zhang, Zheng Zhang, Xiao Zhi, Qian Zhang, Gabriel Alfranca, Jesús M. de la Fuente, Di Chen, and Daxiang Cui . Breath Analysis Based on Surface-Enhanced Raman Scattering Sensors Distinguishes Early and Advanced Gastric Cancer Patients from Healthy Persons. ACS Nano 2016, 10 (9) , 8169-8179. https://doi.org/10.1021/acsnano.6b01441
70. Yan Chen, Hao Zhang, Zhihong Feng, Hongxiang Zhang, Rui Zhang, Yuanyuan Yu, Jin Tao, Hongyuan Zhao, Wenlan Guo, Wei Pang, Xuexin Duan, Jing Liu, and Daihua Zhang . Chemiresistive and Gravimetric Dual-Mode Gas Sensor toward Target Recognition and Differentiation. ACS Applied Materials & Interfaces 2016, 8 (33) , 21742-21749. https://doi.org/10.1021/acsami.6b02682
71. Arianna Aprile, Federica Ciuchi, Roberta Pinalli, Enrico Dalcanale, and Pasquale Pagliusi . Probing Molecular Recognition at the Solid–Gas Interface by Sum-Frequency Vibrational Spectroscopy. The Journal of Physical Chemistry Letters 2016, 7 (15) , 3022-3026. https://doi.org/10.1021/acs.jpclett.6b01300
72. Nisreen Shehada, John C. Cancilla, Jose S. Torrecilla, Enrique S. Pariente, Gerald Brönstrup, Silke Christiansen, Douglas W. Johnson, Marcis Leja, Michael P. A. Davies, Ori Liran, Nir Peled, and Hossam Haick . Silicon Nanowire Sensors Enable Diagnosis of Patients via Exhaled Breath. ACS Nano 2016, 10 (7) , 7047-7057. https://doi.org/10.1021/acsnano.6b03127
73. Andreas T. Güntner, Vitaly Koren, Kiran Chikkadi, Marco Righettoni, and Sotiris E. Pratsinis . E-Nose Sensing of Low-ppb Formaldehyde in Gas Mixtures at High Relative Humidity for Breath Screening of Lung Cancer?. ACS Sensors 2016, 1 (5) , 528-535. https://doi.org/10.1021/acssensors.6b00008
74. Yang Yu, Jian-Ping Ma, Chao-Wei Zhao, Jing Yang, Xiao-Meng Zhang, Qi-Kui Liu, and Yu-Bin Dong . Copper(I) Metal–Organic Framework: Visual Sensor for Detecting Small Polar Aliphatic Volatile Organic Compounds. Inorganic Chemistry 2015, 54 (24) , 11590-11592. https://doi.org/10.1021/acs.inorgchem.5b02150
75. Yao Lu, Ye Chang, Ning Tang, Hemi Qu, Jing Liu, Wei Pang, Hao Zhang, Daihua Zhang, and Xuexin Duan . Detection of Volatile Organic Compounds Using Microfabricated Resonator Array Functionalized with Supramolecular Monolayers. ACS Applied Materials & Interfaces 2015, 7 (32) , 17893-17903. https://doi.org/10.1021/acsami.5b04385
76. Ajeet Kaushik, Rajesh Kumar, Sunil K. Arya, Madhavan Nair, B. D. Malhotra, and Shekhar Bhansali . Organic–Inorganic Hybrid Nanocomposite-Based Gas Sensors for Environmental Monitoring. Chemical Reviews 2015, 115 (11) , 4571-4606. https://doi.org/10.1021/cr400659h
77. Diego García-Gómez, Pablo Martínez-Lozano Sinues, César Barrios-Collado, Guillermo Vidal-de-Miguel, Martin Gaugg, and Renato Zenobi . Identification of 2-Alkenals, 4-Hydroxy-2-alkenals, and 4-Hydroxy-2,6-alkadienals in Exhaled Breath Condensate by UHPLC-HRMS and in Breath by Real-Time HRMS. Analytical Chemistry 2015, 87 (5) , 3087-3093. https://doi.org/10.1021/ac504796p
78. Nisreen Shehada, Gerald Brönstrup, Konrads Funka, Silke Christiansen, Marcis Leja, and Hossam Haick . Ultrasensitive Silicon Nanowire for Real-World Gas Sensing: Noninvasive Diagnosis of Cancer from Breath Volatolome. Nano Letters 2015, 15 (2) , 1288-1295. https://doi.org/10.1021/nl504482t
79. Qing Miao, Xiangli Chen, Lingling Liu, Junxia Peng, and Yu Fang . Synergetic Effect Based Gel-Emulsions and Their Utilization for the Template Preparation of Porous Polymeric Monoliths. Langmuir 2014, 30 (45) , 13680-13688. https://doi.org/10.1021/la502988x
80. Jong-Seon Kim, Hae-Wook Yoo, Hyung Ouk Choi, and Hee-Tae Jung . Tunable Volatile Organic Compounds Sensor by Using Thiolated Ligand Conjugation on MoS2. Nano Letters 2014, 14 (10) , 5941-5947. https://doi.org/10.1021/nl502906a
81. Miguel del Nogal Sánchez, Pedro Ángel Callejo Gómez, José Luis Pérez Pavón, Bernardo Moreno Cordero, Ángel Pedro Crisolino Pozas, and Ángel Sánchez Rodríguez . Sensitivity Enhancement in the Determination of Volatile Biomarkers in Saliva Using a Mass Spectrometry-Based Electronic Nose with a Programmed Temperature Vaporizer. Analytical Chemistry 2014, 86 (15) , 7890-7898. https://doi.org/10.1021/ac501917a
82. Stefan Hanf, Robert Keiner, Di Yan, Jürgen Popp, and Torsten Frosch . Fiber-Enhanced Raman Multigas Spectroscopy: A Versatile Tool for Environmental Gas Sensing and Breath Analysis. Analytical Chemistry 2014, 86 (11) , 5278-5285. https://doi.org/10.1021/ac404162w
83. L. Sandhiya, P. Kolandaivel, and K. Senthilkumar . Oxidation and Nitration of Tyrosine by Ozone and Nitrogen Dioxide: Reaction Mechanisms and Biological and Atmospheric Implications. The Journal of Physical Chemistry B 2014, 118 (13) , 3479-3490. https://doi.org/10.1021/jp4106037
84. Bin Wang, John C. Cancilla, Jose S. Torrecilla, and Hossam Haick . Artificial Sensing Intelligence with Silicon Nanowires for Ultraselective Detection in the Gas Phase. Nano Letters 2014, 14 (2) , 933-938. https://doi.org/10.1021/nl404335p
85. Muhammad Y. Bashouti, Adi-Solomon de la Zerda, Dolev Geva, and Hossam Haick . Designing Thin Film-Capped Metallic Nanoparticles Configurations for Sensing Applications. The Journal of Physical Chemistry C 2014, 118 (4) , 1903-1909. https://doi.org/10.1021/jp4083823
86. Gady Konvalina and Hossam Haick . Sensors for Breath Testing: From Nanomaterials to Comprehensive Disease Detection. Accounts of Chemical Research 2014, 47 (1) , 66-76. https://doi.org/10.1021/ar400070m
87. Alona Bayn, Pauline Nol, Ulrike Tisch, Jack Rhyan, Christine K. Ellis, and Hossam Haick . Detection of Volatile Organic Compounds in Brucella abortus-Seropositive Bison. Analytical Chemistry 2013, 85 (22) , 11146-11152. https://doi.org/10.1021/ac403134f
88. Rotem Ermanok, Ossama Assad, Keren Zigelboim, Bin Wang, and Hossam Haick . Discriminative Power of Chemically Sensitive Silicon Nanowire Field Effect Transistors to Volatile Organic Compounds. ACS Applied Materials & Interfaces 2013, 5 (21) , 11172-11183. https://doi.org/10.1021/am403421g
89. Bin Wang and Hossam Haick . Effect of Chain Length on the Sensing of Volatile Organic Compounds by means of Silicon Nanowires. ACS Applied Materials & Interfaces 2013, 5 (12) , 5748-5756. https://doi.org/10.1021/am401265z
90. Alona Bayn, Xinliang Feng, Klaus Müllen, and Hossam Haick . Field Effect Transistors Based on Polycyclic Aromatic Hydrocarbons for the Detection and Classification of Volatile Organic Compounds. ACS Applied Materials & Interfaces 2013, 5 (8) , 3431-3440. https://doi.org/10.1021/am4005144
91. Bin Wang and Hossam Haick . Effect of Functional Groups on the Sensing Properties of Silicon Nanowires toward Volatile Compounds. ACS Applied Materials & Interfaces 2013, 5 (6) , 2289-2299. https://doi.org/10.1021/am4004649
92. Boyang Zong, Shufang Wu, Yuehong Yang, Qiuju Li, Tian Tao, Shun Mao. Smart Gas Sensors: Recent Developments and Future Prospective. Nano-Micro Letters 2025, 17 (1) https://doi.org/10.1007/s40820-024-01543-w
93. Xiaofeng Liu, Yuqin Lu, Yufeng Chi, Chunxi Lin, Xudong Chen, Qi Qin. Synthesis of Pd/SiO2 catalyst with outstanding ambient-temperature formaldehyde decomposition via NH3 treatment of silica supports. Journal of Environmental Sciences 2025, 154 , 774-783. https://doi.org/10.1016/j.jes.2024.09.013
94. Xiaofeng Liu, Xudong Chen, Chunying Wang, Shaohua Xie, Jingyi Wang, Yaobin Li, Fudong Liu, Hong He. Diverse impacts of water on Pd/SiO2 catalysts for formaldehyde oxidation: Unraveling the crucial role of support defects. Applied Catalysis B: Environment and Energy 2025, 364 , 124843. https://doi.org/10.1016/j.apcatb.2024.124843
95. S. Vanstraelen, F. Van Herpe, J. Dekervel, P. Nafteux. Breath- and blood-based molecular assessment for gastroesophageal cancer. ESMO Gastrointestinal Oncology 2025, 7 , 100132. https://doi.org/10.1016/j.esmogo.2025.100132
96. Rajat Srivastava, Dhanashri Sabale, Shravani Kale, Sangeeta Kale. Resonator based sensing towards disease diagnostics using volatile organic compounds as biomarkers. Sensors and Actuators A: Physical 2025, 382 , 116119. https://doi.org/10.1016/j.sna.2024.116119
97. Amgith G S, Ing Kong, Sayan Kanungo. Comparative study of different volatile organic compound sensing in pristine and defective PtS2 monolayer- An Ab-initio calculation-based theoretical perspective. Surfaces and Interfaces 2025, 58 , 105828. https://doi.org/10.1016/j.surfin.2025.105828
98. Chih-Dao Chen, Yong-Xiang Zheng, Heng-Fu Lin, Hsiao-Yu Yang. Development of Electronic Nose as a Complementary Screening Tool for Breath Testing in Colorectal Cancer. Biosensors 2025, 15 (2) , 82. https://doi.org/10.3390/bios15020082
99. Yuli Xu, Xueyuan Zhang, Jingren Lin, Yuejun Wu, Nguyen Duc Hoa, Nguyen Van Hieu, Alexander A. Ganeev, Abolghasem Jouyban, Mingjiong Zhou, Daxiang Cui, Li Dong, Han Jin. YSZ-Based In₂O₃/SnO₂ Electrochemical Sensing Device for Highly Selective Tracking Hexanal. IEEE Sensors Journal 2025, 25 (2) , 3404-3411. https://doi.org/10.1109/JSEN.2024.3510102
100. Sachindra Kumar, B. Harish Kumar, Raksha Nayak, Samyak Pandey, Nitesh Kumar, K. Sreedhara Ranganath Pai. Computational screening and molecular dynamics of natural compounds targeting the SH2 domain of STAT3: a multitarget approach using network pharmacology. Molecular Diversity 2025, 6 https://doi.org/10.1007/s11030-024-11075-5