ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Figure 1Loading Img

Effects of Aryl Hydrocarbon Receptor-Mediated Early Life Stage Toxicity on Lake Trout Populations in Lake Ontario during the 20th Century

View Author Information
Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, Great Lakes Environmental Research Laboratory, National Oceanographic and Atmospheric Administration, 2205 Commonwealth Boulevard, Ann Arbor, Michigan 48105-1593, Department of Chemical Engineering, University of MinnesotaDuluth, 1303 Ordean Court, Duluth, Minnesota 55812-3025, NIEHS Marine and Freshwater Biomedical Sciences Center, University of WisconsinMilwaukee, 600 East Greenfield Avenue, Milwaukee, Wisconsin 53204, Molecular and Environmental Toxicology Center, University of WisconsinMadison, 1710 University Avenue, Madison, Wisconsin 53726-4098, and School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, Wisconsin 53705-2222
Cite this: Environ. Sci. Technol. 2003, 37, 17, 3864–3877
Publication Date (Web):July 26, 2003
https://doi.org/10.1021/es034045m
Copyright © 2003 American Chemical Society

    Article Views

    814

    Altmetric

    -

    Citations

    LEARN ABOUT THESE METRICS
    Other access options
    Supporting Info (1)»

    Abstract

    Lake trout embryos and sac fry are very sensitive to toxicity associated with maternal exposures to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and structurally related chemicals that act through a common aryl hydrocarbon receptor (AHR)-mediated mechanism of action. The loading of large amounts of these chemicals into Lake Ontario during the middle of the 20th century coincided with a population decline that culminated in extirpation of this species around 1960. Prediction of past TCDD toxicity equivalence concentrations in lake trout eggs (TECeggs) relative to recent conditions required fine resolution of radionuclide-dated contaminant profiles in two sediment cores; reference core specific biota−sediment accumulation factors (BSAFs) for TCDD-like chemicals in lake trout eggs; adjustment of the BSAFs for the effect of temporal changes in the chemical distributions between water and sediments; and toxicity equivalence factors based on trout early life stage mortality. When compared to the dose−response relationship for overt early life stage toxicity of TCDD to lake trout, the resulting TECeggs predict an extended period during which lake trout sac fry survival was negligible. By 1940, following more than a decade of population decline attributable to reduced fry stocking and loss of adult lake trout to commercial fishing, the predicted sac fry mortality due to AHR-mediated toxicity alone explains the subsequent loss of the species. Reduced fry survival, associated with lethal and sublethal adverse effects and possibly complicated by other environmental factors, occurred after 1980 and contributed to a lack of reproductive success of stocked trout despite gradually declining TECeggs. Present exposures are close to the most probable no observable adverse effect level (NOAEL TECegg = 5 pg TCDD toxicity equivalence/g egg). The toxicity predictions are very consistent with the available historical data for lake trout population levels in Lake Ontario, stocking programs, and evidence for recent improvement in natural reproduction concomitant with declining levels of persistent bioaccumulative chemicals in sediments and biota.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    *

     Corresponding author phone:  (218)529-5202; fax (218)529-5003; e-mail:  [email protected].

     U.S. Environmental Protection Agency.

     National Oceanographic and Atmospheric Administration.

    §

     Present address:  Great Lakes Environmental Center.

     University of MinnesotaDuluth.

     University of WisconsinMilwaukee.

    #

     Present address:  S. C. Johnson & Son, Inc.

     University of WisconsinMadison.

     Present address:  College of Pharmacy, University of New Mexico.

    ×

     Present address:  Minnesota Department of Health.

    +

     School of Pharmacy, University of Wisconsin.

    Supporting Information Available

    ARTICLE SECTIONS
    Jump To

    Details of methods used for chemical analyses of fish, egg, and sediment samples and radionuclide dating of sediments. This material is available free of charge via the Internet at http://pubs.acs.org.

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    This article is cited by 112 publications.

    1. Cinthia Hernández-Juárez, Gilberto Morales-Villafaña, Fernando López-Casillas, Arturo Jiménez-Sánchez. Fluorescent Probe for in Vivo Partitioning into Dynamic Lipid Droplets Enables Monitoring of Water Permeability-Induced Edema. ACS Sensors 2023, 8 (8) , 3076-3085. https://doi.org/10.1021/acssensors.3c00725
    2. Senrong Fan, Beili Wang, Hang Liu, Shixiong Gao, Tong Li, Shuran Wang, Yong Liu, Xueqin Liu, and Yi Wan . Trophodynamics of Organic Pollutants in Pelagic and Benthic Food Webs of Lake Dianchi: Importance of Ingested Sediment As Uptake Route. Environmental Science & Technology 2017, 51 (24) , 14135-14143. https://doi.org/10.1021/acs.est.7b03681
    3. Jijing Tian, Yu Feng, Hualing Fu, Heidi Qunhui Xie, Joy Xiaosong Jiang, and Bin Zhao . The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals. Environmental Science & Technology 2015, 49 (16) , 9518-9531. https://doi.org/10.1021/acs.est.5b00385
    4. Brendan E. Hickie,, Peter S. Ross,, Robie W. Macdonald, and, John K. B. Ford. Killer Whales (Orcinus orca) Face Protracted Health Risks Associated with Lifetime Exposure to PCBs. Environmental Science & Technology 2007, 41 (18) , 6613-6619. https://doi.org/10.1021/es0702519
    5. John P. Sumpter, , Andrew C. Johnson and, Richard J. Williams, , Andreas Kortenkamp and, Martin Scholze. Modeling Effects of Mixtures of Endocrine Disrupting Chemicals at the River Catchment Scale. Environmental Science & Technology 2006, 40 (17) , 5478-5489. https://doi.org/10.1021/es052554d
    6. Daniel L. Villeneuve,, Lawrence R. Curtis,, Jeffrey J. Jenkins,, Kara E. Warner,, Fred Tilton,, Michael L. Kent,, Virginia G. Watral,, Michael E. Cunningham,, Douglas F. Markle,, Doolalai Sethajintanin,, Oraphin Krissanakriangkrai,, Eugene R. Johnson,, Robert Grove, and, Kim A. Anderson. Environmental Stresses and Skeletal Deformities in Fish from the Willamette River, Oregon. Environmental Science & Technology 2005, 39 (10) , 3495-3506. https://doi.org/10.1021/es048570c
    7. Adrian M. H. deBruyn,, Michael G. Ikonomou, and, Frank A. P. C. Gobas. Magnification and Toxicity of PCBs, PCDDs, and PCDFs in Upriver-Migrating Pacific Salmon. Environmental Science & Technology 2004, 38 (23) , 6217-6224. https://doi.org/10.1021/es049607w
    8. Bartłomiej Fliszkiewicz, Marcin Sajdak. Fragments quantum descriptors in classification of bio-accumulative compounds. Journal of Molecular Graphics and Modelling 2023, 125 , 108584. https://doi.org/10.1016/j.jmgm.2023.108584
    9. Jon A. Doering, Donald E. Tillitt, Steve Wiseman. Reevaluation of 2,3,7,8‐Tetrachlorodibenzo‐ p ‐Dioxin Equivalency Factors for Dioxin‐Like Polychlorinated Dibenzo‐ p ‐Dioxins, Polychlorinated Dibenzofurans, and Polychlorinated Biphenyls for Fishes. Environmental Toxicology and Chemistry 2023, 42 (10) , 2215-2228. https://doi.org/10.1002/etc.5690
    10. Salim Arrokhman, Yueh-Hsia Luo, Pinpin Lin. Additive cardiotoxicity of a bisphenol mixture in zebrafish embryos: The involvement of calcium channel and pump. Ecotoxicology and Environmental Safety 2023, 263 , 115225. https://doi.org/10.1016/j.ecoenv.2023.115225
    11. Philip J. Landrigan, Hervé Raps, Maureen Cropper, Caroline Bald, Manuel Brunner, Elvia Maya Canonizado, Dominic Charles, Thomas C. Chiles, Mary J. Donohue, Judith Enck, Patrick Fenichel, Lora E. Fleming, Christine Ferrier-Pages, Richard Fordham, Aleksandra Gozt, Carly Griffin, Mark E. Hahn, Budi Haryanto, Richard Hixson, Hannah Ianelli, Bryan D. James, Pushpam Kumar, Amalia Laborde, Kara Lavender Law, Keith Martin, Jenna Mu, Yannick Mulders, Adetoun Mustapha, Jia Niu, Sabine Pahl, Yongjoon Park, Maria-Luiza Pedrotti, Jordan Avery Pitt, Mathuros Ruchirawat, Bhedita Jaya Seewoo, Margaret Spring, John J. Stegeman, William Suk, Christos Symeonides, Hideshige Takada, Richard C. Thompson, Andrea Vicini, Zhanyun Wang, Ella Whitman, David Wirth, Megan Wolff, Aroub K. Yousuf, Sarah Dunlop. The Minderoo-Monaco Commission on Plastics and Human Health. Annals of Global Health 2023, 89 (1) https://doi.org/10.5334/aogh.4056
    12. Cyril Rigaud, Julia Härme, Eeva-Riikka Vehniäinen. Salmo trutta is more sensitive than Oncorhynchus mykiss to early-life stage exposure to retene. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2022, 252 , 109219. https://doi.org/10.1016/j.cbpc.2021.109219
    13. Frederick W. Goetz, J. Ellen Marsden, Catherine A. Richter, Donald E. Tillitt, Shawn P. Sitar, Stephen C. Riley, Charles C. Krueger. Reproduction. 2021, 315-354. https://doi.org/10.1007/978-3-030-62259-6_10
    14. Derek C. G. Muir, Marlene S. Evans, Elizabeth W. Murphy, Daryl J. McGoldrick. Contaminants and Ecotoxicology. 2021, 355-427. https://doi.org/10.1007/978-3-030-62259-6_11
    15. Simon Schaub, Thomas Braunbeck. Transition towards sustainable pharmacy? The influence of public debates on policy responses to pharmaceutical contaminants in water. Environmental Sciences Europe 2020, 32 (1) https://doi.org/10.1186/s12302-020-00423-5
    16. Ron van der Oost, David J. McKenzie, Frank Verweij, Carl Satumalay, Natascha van der Molen, Matthew J. Winter, J. Kevin Chipman. Identifying adverse outcome pathways (AOP) for Amsterdam city fish by integrated field monitoring. Environmental Toxicology and Pharmacology 2020, 74 , 103301. https://doi.org/10.1016/j.etap.2019.103301
    17. Kathryn Hassell, Luke Barrett, Tim Dempster. Impacts of Human-Induced Pollution on Wild Fish Welfare. 2020, 487-507. https://doi.org/10.1007/978-3-030-41675-1_20
    18. Mark E. Hahn, Kirsten C. Sadler. Casting a wide net: use of diverse model organisms to advance toxicology. Disease Models & Mechanisms 2020, 126 https://doi.org/10.1242/dmm.043844
    19. Claude Belpaire, Peter Hodson, Fabien Pierron, Marko Freese. Impact of chemical pollution on Atlantic eels: Facts, research needs, and implications for management. Current Opinion in Environmental Science & Health 2019, 11 , 26-36. https://doi.org/10.1016/j.coesh.2019.06.008
    20. Brian P. Morrison. Chronology of Lake Ontario ecosystem and fisheries. Aquatic Ecosystem Health & Management 2019, 22 (3) , 294-304. https://doi.org/10.1080/14634988.2019.1669377
    21. Andrew J. Garner, James J. Pagano. Trends of polychlorinated dioxins, polychlorinated furans, and dioxin-like polychlorinated biphenyls in Chinook and Coho salmonid eggs from a Great Lakes tributary. Environmental Pollution 2019, 247 , 1039-1045. https://doi.org/10.1016/j.envpol.2019.01.117
    22. Chao Shen, Yixi Zhou, Jinpeng Ruan, Yung-Jen Chuang, Chonggang Wang, Zhenghong Zuo. Generation of a Tg(cyp1a-12DRE:EGFP) transgenic zebrafish line as a rapid in vivo model for detecting dioxin-like compounds. Aquatic Toxicology 2018, 205 , 174-181. https://doi.org/10.1016/j.aquatox.2018.10.022
    23. Hilaire Drouineau, Caroline Durif, Martin Castonguay, Maria Mateo, Eric Rochard, Guy Verreault, Kazuki Yokouchi, Patrick Lambert. Freshwater eels: A symbol of the effects of global change. Fish and Fisheries 2018, 19 (5) , 903-930. https://doi.org/10.1111/faf.12300
    24. Neil L. Rose, Simon D. Turner, Handong Yang, Congqiao Yang, Charlotte Hall, Stuart Harrad. Palaeotoxicity: reconstructing the risk of multiple sedimentary pollutants to freshwater organisms. Environmental Geochemistry and Health 2018, 40 (4) , 1667-1682. https://doi.org/10.1007/s10653-018-0080-5
    25. Sharilyn J. Hoobin, Jonathan D. Byer, Mehran Alaee, R. Stephen Brown, Peter V. Hodson. Dioxin‐like contaminants are no longer a risk to the American eel ( Anguilla rostrata ) in Lake Ontario. Environmental Toxicology and Chemistry 2018, 37 (4) , 1061-1070. https://doi.org/10.1002/etc.4033
    26. Zhanna Tairova, Jakob Strand, Rossana Bossi, Martin M. Larsen, Lars Förlin, Anders Bignert, Jenny Hedman, Jens Gercken, Thomas Lang, Nicolai F. Fricke, Gert Asmund, Manhai Long, Eva C. Bonefeld-Jørgensen. Persistent organic pollutants and related biological responses measured in coastal fish using chemical and biological screening methods. Journal of Toxicology and Environmental Health, Part A 2017, 80 (16-18) , 862-880. https://doi.org/10.1080/15287394.2017.1372870
    27. Andrew Whitehead, Bryan W. Clark, Noah M. Reid, Mark E. Hahn, Diane Nacci. When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish ( Fundulus heteroclitus ) populations. Evolutionary Applications 2017, 10 (8) , 762-783. https://doi.org/10.1111/eva.12470
    28. Marko Freese, Roxana Sühring, Lasse Marohn, Jan-Dag Pohlmann, Hendrik Wolschke, Jonathan D. Byer, Mehran Alaee, Ralf Ebinghaus, Reinhold Hanel. Maternal transfer of dioxin-like compounds in artificially matured European eels. Environmental Pollution 2017, 227 , 348-356. https://doi.org/10.1016/j.envpol.2017.04.096
    29. John P. Incardona, Nathaniel L. Scholz. Environmental Pollution and the Fish Heart. 2017, 373-433. https://doi.org/10.1016/bs.fp.2017.09.006
    30. Philip M. Cook, Joseph Swintek, Timothy D. Dawson, David Chapman, Mathew A. Etterson, Dale Hoff. Quantitative structure–mesothelioma potency model optimization for complex mixtures of elongated particles in rat pleura: A retrospective study. Journal of Toxicology and Environmental Health, Part B 2016, 19 (5-6) , 266-288. https://doi.org/10.1080/10937404.2016.1195326
    31. Francesca Grisoni, Viviana Consonni, Marco Vighi, Sara Villa, Roberto Todeschini. Investigating the mechanisms of bioconcentration through QSAR classification trees. Environment International 2016, 88 , 198-205. https://doi.org/10.1016/j.envint.2015.12.024
    32. Jenni M. Prokkola, Ioanna Katsiadaki, Marion Sebire, Jessica Elphinstone-Davis, Sanna Pausio, Mikko Nikinmaa, Erica H. Leder. Microarray analysis of di-n-butyl phthalate and 17α ethinyl-oestradiol responses in three-spined stickleback testes reveals novel candidate genes for endocrine disruption. Ecotoxicology and Environmental Safety 2016, 124 , 96-104. https://doi.org/10.1016/j.ecoenv.2015.09.039
    33. Bryanna K. Eisner, Jon A. Doering, Shawn C. Beitel, Steve Wiseman, Jason C. Raine, Markus Hecker. Cross‐species comparison of relative potencies and relative sensitivities of fishes to dibenzo‐ p ‐dioxins, dibenzofurans, and polychlorinated biphenyls in vitro. Environmental Toxicology and Chemistry 2016, 35 (1) , 173-181. https://doi.org/10.1002/etc.3173
    34. Cyril Rigaud, Catherine M. Couillard, Jocelyne Pellerin, Benoît Légaré, Jonathan D. Byer, Mehran Alaee, Michel Lebeuf, John M. Casselman, Peter V. Hodson. Temporal variations in embryotoxicity of Lake Ontario American eel (Anguilla rostrata) extracts to developing Fundulus heteroclitus. Science of The Total Environment 2016, 541 , 765-775. https://doi.org/10.1016/j.scitotenv.2015.09.049
    35. David H. Miller, Xiangsheng Xia, Wei-Chuang Huang, Ronald Rossmann. Distribution of Sediment Measurements in Lake Michigan as a Case Study: Implications for Estimating Sediment and Water Interactions in Eutrophication and Bioaccumulation Models. Applied Mathematics 2016, 07 (15) , 1846-1867. https://doi.org/10.4236/am.2016.715153
    36. Nathaniel L. Scholz, Jenifer K. McIntyre. Chemical pollution. 2015, 149-177. https://doi.org/10.1017/CBO9781139627085.006
    37. Nic Bury. Toxicology. 2015, 695-716. https://doi.org/10.1002/9781118394380.ch51
    38. Jonathan D. Byer, Michel Lebeuf, Steve Trottier, Meriem Raach, Mehran Alaee, R. Stephen Brown, Sean Backus, John M. Casselman, Peter V. Hodson. Trends of persistent organic pollutants in American eel (Anguilla rostrata) from eastern Lake Ontario, Canada, and their potential effects on recruitment. Science of The Total Environment 2015, 529 , 231-242. https://doi.org/10.1016/j.scitotenv.2015.05.054
    39. T. B. Henry. Ecotoxicology of polychlorinated biphenyls in fish—a critical review. Critical Reviews in Toxicology 2015, 45 (8) , 643-661. https://doi.org/10.3109/10408444.2015.1038498
    40. Jin Wuk Lee, Eun-Ji Won, Sheikh Raisuddin, Jae-Seong Lee. Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms. Journal of Environmental Sciences 2015, 35 , 115-127. https://doi.org/10.1016/j.jes.2015.05.002
    41. David H. Miller, Joseph E. Tietge, Mark E. McMaster, Kelly R. Munkittrick, Xiangsheng Xia, David A. Griesmer, Gerald T. Ankley. Linking mechanistic toxicology to population models in forecasting recovery from chemical stress: A case study from Jackfish Bay, Ontario, Canada. Environmental Toxicology and Chemistry 2015, 34 (7) , 1623-1633. https://doi.org/10.1002/etc.2972
    42. Linda M. Campbell, Paul E. Drevnick. Use of Catalogued Long-term Biological Collections and Samples for Determining Changes in Contaminant Exposure to Organisms. 2015, 431-459. https://doi.org/10.1007/978-94-017-9541-8_15
    43. Florane Le Bihanic, Bénédicte Morin, Xavier Cousin, Karyn Le Menach, Hélène Budzinski, Jérôme Cachot. Developmental toxicity of PAH mixtures in fish early life stages. Part I: adverse effects in rainbow trout. Environmental Science and Pollution Research 2014, 21 (24) , 13720-13731. https://doi.org/10.1007/s11356-014-2804-0
    44. Adam M Reitzel, Sibel I Karchner, Diana G Franks, Brad R Evans, Diane Nacci, Denise Champlin, Verónica M Vieira, Mark E Hahn. Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evolutionary Biology 2014, 14 (1) https://doi.org/10.1186/1471-2148-14-6
    45. Megan V. Kepler, Tyler Wagner, John A. Sweka. Comparative Bioenergetics Modeling of Two Lake Trout Morphotypes. Transactions of the American Fisheries Society 2014, 143 (6) , 1592-1604. https://doi.org/10.1080/00028487.2014.954051
    46. Pål A. Olsvik, Timothy D. Williams, Hui-shan Tung, Leda Mirbahai, Monica Sanden, Kaja H. Skjaerven, Ståle Ellingsen. Impacts of TCDD and MeHg on DNA methylation in zebrafish (Danio rerio) across two generations. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2014, 165 , 17-27. https://doi.org/10.1016/j.cbpc.2014.05.004
    47. Kevin A. Lanham, Jessica Plavicki, Richard E. Peterson, Warren Heideman. Cardiac Myocyte-Specific AHR Activation Phenocopies TCDD-Induced Toxicity in Zebrafish. Toxicological Sciences 2014, 141 (1) , 141-154. https://doi.org/10.1093/toxsci/kfu111
    48. Danielle Chollett, Kathryn E. Perez, Tisha C. King‐Heiden. Embryonic exposure to 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin impairs prey capture by zebrafish larvae. Environmental Toxicology and Chemistry 2014, 33 (4) , 784-790. https://doi.org/10.1002/etc.2477
    49. Cyril Rigaud, Catherine M. Couillard, Jocelyne Pellerin, Benoît Légaré, Peter V. Hodson. Applicability of the TCDD-TEQ approach to predict sublethal embryotoxicity in Fundulus heteroclitus. Aquatic Toxicology 2014, 149 , 133-144. https://doi.org/10.1016/j.aquatox.2014.02.002
    50. D.L. Swackhamer. Water Quality in the Great Lakes: Persistent Organic Pollutants (POPs). 2014, 120-135. https://doi.org/10.1016/B978-0-12-382182-9.00067-0
    51. Qing Liu, Matthew L. Rise, Jan M. Spitsbergen, Tiago S. Hori, Mark Mieritz, Steven Geis, Joseph E. McGraw, Giles Goetz, Jeremy Larson, Reinhold J. Hutz, Michael J. Carvan. Gene expression and pathologic alterations in juvenile rainbow trout due to chronic dietary TCDD exposure. Aquatic Toxicology 2013, 140-141 , 356-368. https://doi.org/10.1016/j.aquatox.2013.06.018
    52. Peter Hofsteen, Jessica Plavicki, Shaina D. Johnson, Richard E. Peterson, Warren Heideman. Sox9b Is Required for Epicardium Formation and Plays a Role in TCDD-Induced Heart Malformation in Zebrafish. Molecular Pharmacology 2013, 84 (3) , 353-360. https://doi.org/10.1124/mol.113.086413
    53. P.S. Ross, C.J. Kennedy, L.K. Shelley, K.B. Tierney, D.A. Patterson, W.L. Fairchild, R.W. Macdonald, . The trouble with salmon: relating pollutant exposure to toxic effect in species with transformational life histories and lengthy migrations. Canadian Journal of Fisheries and Aquatic Sciences 2013, 70 (8) , 1252-1264. https://doi.org/10.1139/cjfas-2012-0540
    54. Christopher Faßbender, Thomas Braunbeck. Assessment of Genotoxicity in Gonads, Liver and Gills of Zebrafish (Danio rerio) by Use of the Comet Assay and Micronucleus Test after In Vivo Exposure to Methyl Methanesulfonate. Bulletin of Environmental Contamination and Toxicology 2013, 91 (1) , 89-95. https://doi.org/10.1007/s00128-013-1007-6
    55. Jonathan D. Byer, Mehran Alaee, R. Stephen Brown, Michel Lebeuf, Sean Backus, Michael Keir, Grazina Pacepavicius, John Casselman, Claude Belpaire, Kenneth Oliveira, Guy Verreault, Peter V. Hodson. Spatial trends of dioxin-like compounds in Atlantic anguillid eels. Chemosphere 2013, 91 (10) , 1439-1446. https://doi.org/10.1016/j.chemosphere.2013.01.062
    56. Cyril Rigaud, Catherine M. Couillard, Jocelyne Pellerin, Benoît Légaré, Patrice Gonzalez, Peter V. Hodson. Relative potency of PCB126 to TCDD for sublethal embryotoxicity in the mummichog (Fundulus heteroclitus). Aquatic Toxicology 2013, 128-129 , 203-214. https://doi.org/10.1016/j.aquatox.2012.12.013
    57. Floranne Le Bihanic, Catherine M. Couillard, Cyril Rigaud, Benoît Légaré. A simple and reliable in vivo EROD activity measurement in single Fundulus heteroclitus embryo and larva. Marine Environmental Research 2013, 84 , 17-23. https://doi.org/10.1016/j.marenvres.2012.11.003
    58. Lyndal L. Johnson, Bernadita F. Anulacion, Mary R. Arkoosh, Douglas G. Burrows, Denis A.M. da Silva, Joseph P. Dietrich, Mark S. Myers, Julann Spromberg, Gina M. Ylitalo. Effects of Legacy Persistent Organic Pollutants (POPs) in Fish—Current and Future Challenges. 2013, 53-140. https://doi.org/10.1016/B978-0-12-398254-4.00002-9
    59. Tisha C. King-Heiden, Vatsal Mehta, Kong M. Xiong, Kevin A. Lanham, Dagmara S. Antkiewicz, Alissa Ganser, Warren Heideman, Richard E. Peterson. Reproductive and developmental toxicity of dioxin in fish. Molecular and Cellular Endocrinology 2012, 354 (1-2) , 121-138. https://doi.org/10.1016/j.mce.2011.09.027
    60. . References. 2011, 309-320. https://doi.org/10.1002/9781118162729.refs
    61. Gretchen Welfinger‐Smith, David O. Carpenter. Addressing Sources of PCBs and Other Chemical Pollutants in Water. 2011, 359-384. https://doi.org/10.1002/9781118148594.ch29
    62. David C. Volz, Scott Belanger, Michelle Embry, Stephanie Padilla, Hans Sanderson, Kristin Schirmer, Stefan Scholz, Daniel Villeneuve. Adverse Outcome Pathways during Early Fish Development: A Conceptual Framework for Identification of Chemical Screening and Prioritization Strategies. Toxicological Sciences 2011, 123 (2) , 349-358. https://doi.org/10.1093/toxsci/kfr185
    63. Jacqueline Iannuzzi, Matthew Butcher, Timothy Iannuzzi. Evaluation of potential relationships between chemical contaminants in sediments and aquatic organisms from the lower Passaic River, New Jersey, USA. Environmental Toxicology and Chemistry 2011, 30 (7) , 1721-1728. https://doi.org/10.1002/etc.550
    64. Catherine M. Couillard, Benoît Légaré, Andréane Bernier, Zara Dionne. Embryonic exposure to environmentally relevant concentrations of PCB126 affect prey capture ability of Fundulus heteroclitus larvae. Marine Environmental Research 2011, 71 (4) , 257-265. https://doi.org/10.1016/j.marenvres.2011.01.010
    65. Corinne E. Hicken, Tiffany L. Linbo, David H. Baldwin, Maryjean L. Willis, Mark S. Myers, Larry Holland, Marie Larsen, Michael S. Stekoll, Stanley D. Rice, Tracy K. Collier, Nathaniel L. Scholz, John P. Incardona. Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish. Proceedings of the National Academy of Sciences 2011, 108 (17) , 7086-7090. https://doi.org/10.1073/pnas.1019031108
    66. Vincent J. Kramer, Matthew A. Etterson, Markus Hecker, Cheryl A. Murphy, Guritno Roesijadi, Daniel J. Spade, Julann A. Spromberg, Magnus Wang, Gerald T. Ankley. Adverse outcome pathways and ecological risk assessment: Bridging to population‐level effects. Environmental Toxicology and Chemistry 2011, 30 (1) , 64-76. https://doi.org/10.1002/etc.375
    67. Anne E. McElroy, Mace G. Barron, Nancy Beckvar, Susan B. Kane Driscoll, James P. Meador, Tom F. Parkerton, Thomas G. Preuss, Jeffery A. Steevens. A review of the tissue residue approach for organic and organometallic compounds in aquatic organisms. Integrated Environmental Assessment and Management 2011, 7 (1) , 50-74. https://doi.org/10.1002/ieam.132
    68. Helmut Segner. Reproductive and developmental toxicity in fishes. 2011, 1145-1166. https://doi.org/10.1016/B978-0-12-382032-7.10086-4
    69. David O. Carpenter. Health effects of persistent organic pollutants: the challenge for the Pacific Basin and for the world. Reviews on Environmental Health 2011, 26 (1) https://doi.org/10.1515/reveh.2011.009
    70. Henryka Dabrowska, Albertinka J. Murk, Hans J. van den Berg. Bioassay-derived dioxin equivalent concentrations in gonads and livers of the Atlantic cod females from the Baltic Sea. Ecotoxicology and Environmental Safety 2010, 73 (8) , 1829-1834. https://doi.org/10.1016/j.ecoenv.2010.08.030
    71. Sarah R. Greytak, Ann M. Tarrant, Diane Nacci, Mark E. Hahn, Gloria V. Callard. Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific. Aquatic Toxicology 2010, 99 (2) , 291-299. https://doi.org/10.1016/j.aquatox.2010.05.009
    72. Dennis R Helsel. Summing nondetects: Incorporating low‐level contaminants in risk assessment. Integrated Environmental Assessment and Management 2010, 6 (3) , 361-366. https://doi.org/10.1002/ieam.31
    73. Melanie Boettcher, Stefanie Grund, Steffen Keiter, Thomas Kosmehl, Georg Reifferscheid, Nadja Seitz, Paula Suares Rocha, Henner Hollert, Thomas Braunbeck. Comparison of in vitro and in situ genotoxicity in the Danube River by means of the comet assay and the micronucleus test. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2010, 700 (1-2) , 11-17. https://doi.org/10.1016/j.mrgentox.2010.04.016
    74. Gerald T. Ankley, Richard S. Bennett, Russell J. Erickson, Dale J. Hoff, Michael W. Hornung, Rodney D. Johnson, David R. Mount, John W. Nichols, Christine L. Russom, Patricia K. Schmieder, Jose A. Serrrano, Joseph E. Tietge, Daniel L. Villeneuve. Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment. Environmental Toxicology and Chemistry 2010, 29 (3) , 730-741. https://doi.org/10.1002/etc.34
    75. Sean M. Bugel, Lori A. White, Keith R. Cooper. Impaired reproductive health of killifish (Fundulus heteroclitus) inhabiting Newark Bay, NJ, a chronically contaminated estuary. Aquatic Toxicology 2010, 96 (3) , 182-193. https://doi.org/10.1016/j.aquatox.2009.10.016
    76. John D. Fitzsimons, Scott B. Brown, Bill Williston, Georgina Williston, Lisa R. Brown, Kristin Moore, Dale C. Honeyfield, Donald E. Tillitt. Influence of Thiamine Deficiency on Lake Trout Larval Growth, Foraging, and Predator Avoidance. Journal of Aquatic Animal Health 2009, 21 (4) , 302-314. https://doi.org/10.1577/H08-019.1
    77. David H. Baldwin, Julann A. Spromberg, Tracy K. Collier, Nathaniel L. Scholz. A fish of many scales: extrapolating sublethal pesticide exposures to the productivity of wild salmon populations. Ecological Applications 2009, 19 (8) , 2004-2015. https://doi.org/10.1890/08-1891.1
    78. MICHAEL GILBERTSON. Index of Congenital Minamata Disease in Canadian Areas of Concern in the Great Lakes: An Eco-Social Epidemiological Approach. Journal of Environmental Science and Health, Part C 2009, 27 (4) , 246-275. https://doi.org/10.1080/10590500903310120
    79. Henryka Dabrowska, Ewelina Bernard, Iwona Barska, Krzysztof Radtke. Inter-tissue distribution and evaluation of potential toxicity of PCBs in Baltic cod (Gadus morhua L.). Ecotoxicology and Environmental Safety 2009, 72 (7) , 1975-1984. https://doi.org/10.1016/j.ecoenv.2009.07.007
    80. Tisha C. King Heiden, Jan Spitsbergen, Warren Heideman, Richard E. Peterson. Persistent Adverse Effects on Health and Reproduction Caused by Exposure of Zebrafish to 2,3,7,8-Tetrachlorodibenzo-p-dioxin During Early Development and Gonad Differentiation. Toxicological Sciences 2009, 109 (1) , 75-87. https://doi.org/10.1093/toxsci/kfp048
    81. S. Keiter, M. Böttcher, S. Grund, N. Seitz, T. Braunbeck, H. Hollert. Der Fischrückgang in der oberen Donau. Environmental Sciences Europe 2009, 21 (2) , 186-196. https://doi.org/10.1007/s12302-009-0040-x
    82. T. Braunbeck, A. Brauns, S. Keiter, H. Hollert, P. Schwartz. Fischpopulationen unter Stress – das Beispiel des Unteren Neckars. Environmental Sciences Europe 2009, 21 (2) , 197-211. https://doi.org/10.1007/s12302-009-0044-6
    83. Catherine M. Couillard. Utilisation des poissons pour évaluer les effets biologiques des contaminants dans l’estuaire du Saint-Laurent et le fjord du Saguenay. Revue des sciences de l'eau 2009, 22 (2) , 291-314. https://doi.org/10.7202/037486ar
    84. Catherine M. Couillard, Simon C. Courtenay, Robie W. Macdonald. Chemical–environment interactions affecting the risk of impacts on aquatic organisms: A review with a Canadian perspective — interactions affecting vulnerability. Environmental Reviews 2008, 16 (NA) , 19-44. https://doi.org/10.1139/A07-008
    85. Michael J. Carvan, John P. Incardona, Matthew L. Rise. Meeting the Challenges of Aquatic Vertebrate Ecotoxicology. BioScience 2008, 58 (11) , 1015-1025. https://doi.org/10.1641/B581105
    86. Pann Pann Chung, Ross V. Hyne, Reinier M. Mann, J. William O. Ballard. Genetic and life-history trait variation of the amphipod Melita plumulosa from polluted and unpolluted waterways in eastern Australia. Science of The Total Environment 2008, 403 (1-3) , 222-229. https://doi.org/10.1016/j.scitotenv.2008.05.038
    87. Y. D. Wu, L. Jiang, Z. Zhou, M. H. Zheng, J. Zhang, Y. Liang. CYP1A/Regucalcin Gene Expression and Edema Formation in Zebrafish Embryos Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Bulletin of Environmental Contamination and Toxicology 2008, 80 (6) , 482-486. https://doi.org/10.1007/s00128-008-9395-8
    88. Steffen Keiter, Stefanie Grund, Bert van Bavel, Jessika Hagberg, Magnus Engwall, Ulrike Kammann, Martin Klempt, Werner Manz, Helena Olsman, Thomas Braunbeck, Henner Hollert. Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river. Analytical and Bioanalytical Chemistry 2008, 390 (8) , 2009-2019. https://doi.org/10.1007/s00216-007-1652-x
    89. Mark Hahn, Eli Hestermann. Receptor-Mediated Mechanisms of Toxicity. 2008, 235-272. https://doi.org/10.1201/9780203647295.ch5
    90. C. M. Couillard, M. Lebeuf, B. Légaré, S. Trottier. Effects of Diazinon on Mummichog (Fundulus heteroclitus) Larvae Produced from Eggs Differentially Treated with PCB126. Archives of Environmental Contamination and Toxicology 2008, 54 (2) , 283-291. https://doi.org/10.1007/s00244-007-9030-4
    91. Barry C. Kelly, Michael G. Ikonomou, Joel D. Blair, Anne E. Morin, Frank A. P. C. Gobas. Food WebSpecific Biomagnification of Persistent Organic Pollutants. Science 2007, 317 (5835) , 236-239. https://doi.org/10.1126/science.1138275
    92. Ron A Heintz. Chronic exposure to polynuclear aromatic hydrocarbons in natal habitats leads to decreased equilibrium size, growth, and stability of pink salmon populations. Integrated Environmental Assessment and Management 2007, 3 (3) , 351-363. https://doi.org/10.1002/ieam.5630030306
    93. David O Carpenter. Commentary: The Importance of the Great Lakes Water Quality Agreement. Journal of Public Health Policy 2007, 28 (2) , 216-220. https://doi.org/10.1057/palgrave.jphp.3200129
    94. Michael Gilbertson, Andrew E Watterson. Diversionary Reframing of the Great Lakes Water Quality Agreement. Journal of Public Health Policy 2007, 28 (2) , 201-215. https://doi.org/10.1057/palgrave.jphp.3200134
    95. Roderick Nigel Finn. The physiology and toxicology of salmonid eggs and larvae in relation to water quality criteria. Aquatic Toxicology 2007, 81 (4) , 337-354. https://doi.org/10.1016/j.aquatox.2006.12.021
    96. P Brzuzan, M Woźny, S Dobosz, H Kuźmiński, M K Łuczyński, M Góra. Blue sac disease in larval whitefish, Coregonus lavaretus (L.): pathological changes in mRNA levels of CYP1A, ER α , and p53. Journal of Fish Diseases 2007, 30 (3) , 169-173. https://doi.org/10.1111/j.1365-2761.2007.00784.x
    97. Karl Theo von der Trenck, Frank Baum, Heiner Hartwig, Rainer Malisch, Friedrich Schilling, Hans-Peter Straub, Ralf-Dieter Zimmermann. Organochlorverbindungen in Eiern von Wanderfalken und anderen wild lebenden Vogelarten in Baden-Württemberg. Umweltwissenschaften und Schadstoff-Forschung 2006, 18 (4) , 228-241. https://doi.org/10.1065/uwsf2006.07.119
    98. Gail F. Jurgella, Ashok Marwah, Jeffrey A. Malison, Richard Peterson, Terence P. Barry. Effects of xenobiotics and steroids on renal and hepatic estrogen metabolism in lake trout. General and Comparative Endocrinology 2006, 148 (2) , 273-281. https://doi.org/10.1016/j.ygcen.2006.03.011
    99. Amy L. Prasch, Robert L. Tanguay, Vatsal Mehta, Warren Heideman, Richard E. Peterson. Identification of Zebrafish ARNT1 Homologs: 2,3,7,8-Tetrachlorodibenzo- p -dioxin Toxicity in the Developing Zebrafish Requires ARNT1. Molecular Pharmacology 2006, 69 (3) , 776-787. https://doi.org/10.1124/mol.105.016873
    100. Nirmal K. Roy, Simon C. Courtenay, R. Christopher Chambers, Isaac I. Wirgin. Characterization of the aryl hydrocarbon receptor repressor and a comparison of its expression in Atlantic tomcod from resistant and sensitive populations. Environmental Toxicology and Chemistry 2006, 25 (2) , 560-571. https://doi.org/10.1897/05-347R.1
    Load all citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect