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Is Indirect Exposure a Significant Contributor to the Burden of Perfluorinated Acids Observed in Humans?

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2011, 45, 19, 7974-7984
    Critical Review

    Is Indirect Exposure a Significant Contributor to the Burden of Perfluorinated Acids Observed in Humans?
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    Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6 Canada
    Phone: 416 978-1780; fax: 416 978-1631; e-mail: [email protected]
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    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2011, 45, 19, 7974–7984
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    https://doi.org/10.1021/es200171y
    Published June 1, 2011
    Copyright © 2011 American Chemical Society
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    Abstract

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    In comparison to other persistent organic pollutants, human fluorochemical contamination is relatively complicated. This complication arises at least in part from a disparity between the chemicals used commercially and those measured in the environment and humans. Commercial fluorochemical products are dominated by fluorinated polymers used in textile or carpet applications, or fluorosurfactants used in applications ranging from personal care products, leveling and wetting agents, to greaseproofing food-contact materials. Investigations into environmental and human fluorochemical contamination have focused on perfluorinated acids (PFAs), either the perfluorinated carboxylates (PFCAs) or sulfonates (PFSAs). In this review we will present an overview of data related to human fluorochemical exposure including a discussion of fluorochemical production, concentrations in exposure media, biotransformation processes producing PFAs, and trends in human sera. These data will be presented in the context of how they can inform sources of human PFA contamination, specifically whether the contamination results from direct PFA exposure or indirect exposure via the biotransformation of commercial fluorochemicals or their residuals. Concentrations of both perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) began to decrease in human sera around the year 2000, a change that mirrored the 2000–2002 phase-out of perfluorooctane sulfonyl fluoride (POSF) production. These temporal trends suggest exposure to current-use POSF-based materials was a significant source of PFOA and PFOS exposure prior to 2000. Relatively slow PFOA elimination and increasing concentrations of the C9 and C10 PFCAs in human sera suggest continued PFCA exposure, without similar exposure to PFOS, which is consistent with indirect exposure via the biotransformation of fluorotelomer-based materials. Conversely, human exposure models have suggested direct exposure to PFAs present in food items is the major source of human contamination. The data set presented here cannot unequivocally delineate between direct and indirect human exposure, however temporal trends in human sera and exposure media are consistent with indirect exposure representing a significant portion of observed human PFA contamination.

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    7. Carrie A. McDonough, Wenting Li, Heather N. Bischel, Amila O. De Silva, Jamie C. DeWitt. Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs). Environmental Science & Technology 2022, 56 (10) , 6004-6013. https://doi.org/10.1021/acs.est.2c00254
    8. Daniele de A. Miranda, Juliana Leonel, Jonathan P. Benskin, Jana Johansson, Vanessa Hatje. Perfluoroalkyl Substances in the Western Tropical Atlantic Ocean. Environmental Science & Technology 2021, 55 (20) , 13749-13758. https://doi.org/10.1021/acs.est.1c01794
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    44. Sarah B. Gewurtz, Amila O. De Silva, Sean M. Backus, Daryl J. McGoldrick, Michael J. Keir, Jeff Small, Lisa Melymuk, and Derek C. G. Muir . Perfluoroalkyl Contaminants in Lake Ontario Lake Trout: Detailed Examination of Current Status and Long-Term Trends. Environmental Science & Technology 2012, 46 (11) , 5842-5850. https://doi.org/10.1021/es3006095
    45. Jeffrey M. Peters and Frank J. Gonzalez . Why Toxic Equivalency Factors Are Not Suitable for Perfluoroalkyl Chemicals. Chemical Research in Toxicology 2011, 24 (10) , 1601-1609. https://doi.org/10.1021/tx200316x
    46. Emily Awad, Xianming Zhang, Satyendra P. Bhavsar, Steve Petro, Patrick W. Crozier, Eric J. Reiner, Rachael Fletcher, Sheryl A. Tittlemier, and Eric Braekevelt . Long-Term Environmental Fate of Perfluorinated Compounds after Accidental Release at Toronto Airport. Environmental Science & Technology 2011, 45 (19) , 8081-8089. https://doi.org/10.1021/es2001985
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    54. Sori Mok, Sunggyu Lee, Younghun Choi, Junho Jeon, Young Hee Kim, Hyo-Bang Moon. Target and non-target analyses of neutral per- and polyfluoroalkyl substances from fluorochemical industries using GC-MS/MS and GC-TOF: Insights on their environmental fate. Environment International 2023, 182 , 108311. https://doi.org/10.1016/j.envint.2023.108311
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    57. Nan Zhao, Hangbiao Jin, Weili Mao, Meirong Zhao, Yuanchen Chen. Concentrations and isomer profiles of perfluoroalkyl carboxylates in house rats (Rattus norvegicus) and human blood: Implication for human exposure sources. Science of The Total Environment 2023, 881 , 163431. https://doi.org/10.1016/j.scitotenv.2023.163431
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    66. Catharina Vendl, Patrice Pottier, Matthew D. Taylor, Jennifer Bräunig, Matthew J. Gibson, Daniel Hesselson, G. Gregory Neely, Malgorzata Lagisz, Shinichi Nakagawa. Thermal processing reduces PFAS concentrations in blue food – A systematic review and meta-analysis. Environmental Pollution 2022, 304 , 119081. https://doi.org/10.1016/j.envpol.2022.119081
    67. Mei-Sheng Ku, Wen-Chi Pan, Yen-Tsung Huang, Wu-Shiun Hsieh, Yi-Hsiang Hsu, Pau-Chung Chen, Chen-Yu Liu. Associations between prenatal exposure to perfluoroalkyl substances, hypomethylation of MEST imprinted gene and birth outcomes. Environmental Pollution 2022, 304 , 119183. https://doi.org/10.1016/j.envpol.2022.119183
    68. Phum Tachachartvanich, Ettayapuram Ramaprasad Azhagiya Singam, Kathleen A. Durkin, J. David Furlow, Martyn T. Smith, Michele A. La Merrill. In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor. Journal of Hazardous Materials 2022, 429 , 128243. https://doi.org/10.1016/j.jhazmat.2022.128243
    69. Feng Xiao. An Overview of the Formation of PFOA and PFOS in Drinking-Water and Wastewater Treatment Processes. Journal of Environmental Engineering 2022, 148 (4) https://doi.org/10.1061/(ASCE)EE.1943-7870.0001986
    70. Zhuo Gao, Jian Zhou, Mingming Xue, Siqian Liu, Jia Guo, Ying Zhang, Chunshuai Cao, Tiecheng Wang, Lingyan Zhu. Theoretical and experimental insights into the mechanisms of C6/C6 PFPiA degradation by dielectric barrier discharge plasma. Journal of Hazardous Materials 2022, 424 , 127522. https://doi.org/10.1016/j.jhazmat.2021.127522
    71. Shira Joudan, Scott A. Mabury. Aerobic biotransformation of a novel highly functionalized polyfluoroether-based surfactant using activated sludge from a wastewater treatment plant. Environmental Science: Processes & Impacts 2022, 24 (1) , 62-71. https://doi.org/10.1039/D1EM00358E
    72. Ryan Holman, Orane Lorton, Pauline C. Guillemin, Stéphane Desgranges, Christiane Contino-Pépin, Rares Salomir. Perfluorocarbon Emulsion Contrast Agents: A Mini Review. Frontiers in Chemistry 2022, 9 https://doi.org/10.3389/fchem.2021.810029
    73. Fatma Beduk, Senar Aydin, Arzu Ulvi, Mehmet Emin Aydin. Fingerprint of Persistent Organic Pollutants (POPs) in the Environment: Ecological Assessment and Human Health Effects. 2022, 153-161. https://doi.org/10.1007/978-3-030-95288-4_13
    74. Kavitha Dasu, Xiaoyan Xia, Dinusha Siriwardena, Theodore P. Klupinski, Brannon Seay. Concentration profiles of per- and polyfluoroalkyl substances in major sources to the environment. Journal of Environmental Management 2022, 301 , 113879. https://doi.org/10.1016/j.jenvman.2021.113879
    75. Jiajun Luo, Cecilia Høst Ramlau-Hansen, Ulrik Schiøler Kesmodel, Jingyuan Xiao, Vasilis Vasiliou, Nicole C. Deziel, Yawei Zhang, Jørn Olsen, Zeyan Liew. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130 (1) https://doi.org/10.1289/EHP9478
    76. Zhenzhen Xie, Jing Tan, Guanghong Fang, Honglei Ji, Maohua Miao, Yuan Tian, Hui Hu, Wencheng Cao, Hong Liang, Wei Yuan. Associations between Prenatal Exposure to Perfluoroalkyl Substances and Neurobehavioral Development in Early Childhood: A Prospective Cohort Study. SSRN Electronic Journal 2022, 21 https://doi.org/10.2139/ssrn.4001160
    77. Xingchun Jiao, Qingyang Shi, Jay Gan. Uptake, accumulation and metabolism of PFASs in plants and health perspectives: A critical review. Critical Reviews in Environmental Science and Technology 2021, 51 (23) , 2745-2776. https://doi.org/10.1080/10643389.2020.1809219
    78. Takanobu Horikoshi, Tomoko Nishimura, Yoko Nomura, Toshiki Iwabuchi, Hiroaki Itoh, Takumi Takizawa, Kenji J. Tsuchiya. Umbilical cord serum concentrations of perfluorooctane sulfonate, perfluorooctanoic acid, and the body mass index changes from birth to 5 1/2 years of age. Scientific Reports 2021, 11 (1) https://doi.org/10.1038/s41598-021-99174-3
    79. Maria H. Harris, Emily Oken, Sheryl L. Rifas-Shiman, Antonia M. Calafat, David C. Bellinger, Thomas F. Webster, Roberta F. White, Sharon K. Sagiv. Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFAS) and child executive function and behavioral problems. Environmental Research 2021, 202 , 111621. https://doi.org/10.1016/j.envres.2021.111621
    80. Rachel D. Rogers, Christopher M. Reh, Patrick Breysse. Advancing per- and polyfluoroalkyl substances (PFAS) research: an overview of ATSDR and NCEH activities and recommendations. Journal of Exposure Science & Environmental Epidemiology 2021, 31 (6) , 961-971. https://doi.org/10.1038/s41370-021-00316-6
    81. Hongmei Hu, Yingying Zhang, Nan Zhao, Jiahui Xie, Yanqiu Zhou, Meirong Zhao, Hangbiao Jin. Legacy and emerging poly- and perfluorochemicals in seawater and sediment from East China Sea. Science of The Total Environment 2021, 797 , 149052. https://doi.org/10.1016/j.scitotenv.2021.149052
    82. Hun Kim, Min-Wook Hong, Yun-ho Bae, Sung-Jin Lee. Epigenetic toxicity and cytotoxicity of perfluorooctanoic acid and its effects on gene expression in embryonic mouse hypothalamus cells. Archives of Industrial Hygiene and Toxicology 2021, 72 (3) , 182-190. https://doi.org/10.2478/aiht-2021-72-3555
    83. Anna S. Young, Emily H. Sparer-Fine, Heidi M. Pickard, Elsie M. Sunderland, Graham F. Peaslee, Joseph G. Allen. Per- and polyfluoroalkyl substances (PFAS) and total fluorine in fire station dust. Journal of Exposure Science & Environmental Epidemiology 2021, 31 (5) , 930-942. https://doi.org/10.1038/s41370-021-00288-7
    84. Tamara Tal, Carolina Vogs. Invited Perspective: PFAS Bioconcentration and Biotransformation in Early Life Stage Zebrafish and Its Implications for Human Health Protection. Environmental Health Perspectives 2021, 129 (7) https://doi.org/10.1289/EHP9625
    85. Joshua Garcia-Barrios, Mallory Drysdale, Mylène Ratelle, Éric Gaudreau, Alain LeBlanc, Mary Gamberg, Brian D. Laird. Biomarkers of poly- and perfluoroalkyl substances (PFAS) in Sub-Arctic and Arctic communities in Canada. International Journal of Hygiene and Environmental Health 2021, 235 , 113754. https://doi.org/10.1016/j.ijheh.2021.113754
    86. Raj Kamal Singh, Elizabeth Brown, Selma Mededovic Thagard, Thomas M. Holsen. Treatment of PFAS-containing landfill leachate using an enhanced contact plasma reactor. Journal of Hazardous Materials 2021, 408 , 124452. https://doi.org/10.1016/j.jhazmat.2020.124452
    87. Wenping Zhang, Shimei Pang, Ziqiu Lin, Sandhya Mishra, Pankaj Bhatt, Shaohua Chen. Biotransformation of perfluoroalkyl acid precursors from various environmental systems: advances and perspectives. Environmental Pollution 2021, 272 , 115908. https://doi.org/10.1016/j.envpol.2020.115908
    88. Dongmei Chen, Ying Zhao, Wei Xu, Yuanhu Pan, Qu Wei, Shuyu Xie. Biotransformation and tissue bioaccumulation of 8:2 fluorotelomer alcohol in broiler by oral exposure. Environmental Pollution 2020, 267 , 115611. https://doi.org/10.1016/j.envpol.2020.115611
    89. Jiajun Luo, Jingyuan Xiao, Yu Gao, Cecilia Høst Ramlau-Hansen, Gunnar Toft, Jiong Li, Carsten Obel, Stine Linding Andersen, Nicole C. Deziel, Wan-Ling Tseng, Kosuke Inoue, Eva Cecilie Bonefeld-Jørgensen, Jørn Olsen, Zeyan Liew. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191 , 110111. https://doi.org/10.1016/j.envres.2020.110111
    90. Elgun E. Hasanov, Ravan A. Rahimov, Yusif Abdullayev, Ziyafaddin H. Asadov, Gulnara A. Ahmadova, Aygun M. Isayeva, Ulviyya Yolcuyeva, Fedor I. Zubkov, Jochen Autschbach. Counterion-coupled gemini surfactants based on propoxylated hexamethylenediamine and fatty acids: Theory and application. Journal of Molecular Liquids 2020, 318 , 114050. https://doi.org/10.1016/j.molliq.2020.114050
    91. Bo Zhang, Yuan He, Yingyan Huang, Danhong Hong, Yiming Yao, Lei Wang, Wenwen Sun, Baoqin Yang, Xiongfei Huang, Shiming Song, Xueyuan Bai, Yuankai Guo, Tao Zhang, Hongwen Sun. Novel and legacy poly- and perfluoroalkyl substances (PFASs) in indoor dust from urban, industrial, and e-waste dismantling areas: The emergence of PFAS alternatives in China. Environmental Pollution 2020, 263 , 114461. https://doi.org/10.1016/j.envpol.2020.114461
    92. Shoji F. Nakayama, Tomohiko Isobe, Miyuki Iwai-Shimada, Yayoi Kobayashi, Yukiko Nishihama, Yu Taniguchi, Makiko Sekiyama, Takehiro Michikawa, Shin Yamazaki, Hiroshi Nitta, Masako Oda, Hiroshi Mitsubuchi, Masafumi Sanefuji, Shouichi Ohga, Nathan Mise, Akihiko Ikegami, Reiko Suga, Masayuki Shimono. Poly- and perfluoroalkyl substances in maternal serum: Method development and application in Pilot Study of the Japan Environment and Children's Study. Journal of Chromatography A 2020, 1618 , 460933. https://doi.org/10.1016/j.chroma.2020.460933
    93. Hangbiao Jin, Shu Lin, Wei Dai, Lingfang Feng, Tao Li, Jianlin Lou, Quan Zhang. Exposure sources of perfluoroalkyl acids and influence of age and gender on concentrations of chlorinated polyfluorinated ether sulfonates in human serum from China. Environment International 2020, 138 , 105651. https://doi.org/10.1016/j.envint.2020.105651
    94. Hangbiao Jin, Lingling Mao, Jiahui Xie, Meirong Zhao, Xiaoxia Bai, Jie Wen, Tao Shen, Pengfei Wu. Poly- and perfluoroalkyl substance concentrations in human breast milk and their associations with postnatal infant growth. Science of The Total Environment 2020, 713 , 136417. https://doi.org/10.1016/j.scitotenv.2019.136417
    95. Zeyan Liew, Jiajun Luo, Ellen A. Nohr, Bodil Hammer Bech, Rossana Bossi, Onyebuchi A. Arah, Jørn Olsen. Maternal Plasma Perfluoroalkyl Substances and Miscarriage: A Nested Case–Control Study in the Danish National Birth Cohort. Environmental Health Perspectives 2020, 128 (4) https://doi.org/10.1289/EHP6202
    96. Clara M. A. Eichler, John C. Little. A framework to model exposure to per- and polyfluoroalkyl substances in indoor environments. Environmental Science: Processes & Impacts 2020, 22 (3) , 500-511. https://doi.org/10.1039/C9EM00556K
    97. Shira Joudan, Runzeng Liu, Jessica C. D'eon, Scott A. Mabury. Unique analytical considerations for laboratory studies identifying metabolic products of per- and polyfluoroalkyl substances (PFASs). TrAC Trends in Analytical Chemistry 2020, 124 , 115431. https://doi.org/10.1016/j.trac.2019.02.032
    98. Hongna Zhang, Bei Wen, Honglin Huang, Sen Wang, Zongwei Cai, Shuzhen Zhang. Biotransformation of 6:2 fluorotelomer alcohol by the whole soybean (Glycine max L. Merrill) seedlings. Environmental Pollution 2020, 257 , 113513. https://doi.org/10.1016/j.envpol.2019.113513
    99. Houman Goudarzi, Keiko Yamazaki. Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring. 2020, 301-357. https://doi.org/10.1007/978-981-15-0520-1_13
    100. Somrutai Poothong, Eleni Papadopoulou, Juan Antonio Padilla-Sánchez, Cathrine Thomsen, Line Småstuen Haug. Multiple pathways of human exposure to poly- and perfluoroalkyl substances (PFASs): From external exposure to human blood. Environment International 2020, 134 , 105244. https://doi.org/10.1016/j.envint.2019.105244
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    Cite this: Environ. Sci. Technol. 2011, 45, 19, 7974–7984
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