Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
Potentiation of the Human GABAA Receptor As a Novel Mode of Action of Lower-Chlorinated Non-Dioxin-Like PCBs

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2010, 44, 8, 2864-2869
    Article

    Potentiation of the Human GABAA Receptor As a Novel Mode of Action of Lower-Chlorinated Non-Dioxin-Like PCBs†
    Click to copy article linkArticle link copied!

    View Author Information
    Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, P.O. Box 80.177, NL-3508 TD Utrecht, The Netherlands
    * Corresponding author tel: +31-30-253 5217; fax: +31-30-253 5077; e-mail: [email protected]
    †Part of the special section “Sources, Exposures, and Toxicities of PCBs in Humans and the Environment”.
    ‡These authors contributed equally to this study.
    Other Access Options

    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2010, 44, 8, 2864–2869
    Click to copy citationCitation copied!
    https://doi.org/10.1021/es902321a
    Published December 16, 2009
    Copyright © 2009 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!

    PCBs are still ubiquitous pollutants despite the ban on their industrial and commercial use. To date, risk characterization and assessment of non-dioxin-like PCBs (NDL-PCBs), especially with respect to neurotoxicity, is hampered by a lack of data. Therefore, the effects of six common NDL congeners (PCB28, 52, 101, 138, 153 and 180) on human GABAA receptors, expressed in Xenopus oocytes, were investigated using the two-electrode voltage-clamp technique. When coapplied with GABA (at EC20), PCB28 and PCB52 concentration-dependently potentiate the GABAA receptor-mediated ion current. Though the LOEC for both PCB28 and PCB52 is 0.3 μM, PCB28 is more potent than PCB52 (maximum potentiation at 10 μM amounting to 98.3 ± 12.5% and 25.5 ± 1.4%, respectively). Importantly, coapplication of PCB28 (0.3 μM) and PCB52 (10 μM) resulted in an apparently additive potentiation of the GABAA response, whereas coapplication of PCB28 (0.3 μM) and PCB153 (10 μM) attenuated the PCB28-induced potentiation. The present results suggest that the potentiation of human GABAA receptor function is specific for lower-chlorinated NDL-PCBs and that higher molecular weight PCBs may attenuate this potentiation as a result of competitive binding to human GABAA receptors. Nonetheless, this novel mode of action could (partly) underlie the previously recognized NDL-PCB-induced neurobehavioral alterations.

    Copyright © 2009 American Chemical Society

    Subjects

    what are subjects

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 24 publications.

    1. Sonja K. Ostertag, Alyssa C. Shaw, Niladri Basu, and Hing Man Chan . Molecular and Neurochemical Biomarkers in Arctic Beluga Whales (Delphinapterus leucas) Were Correlated to Brain Mercury and Selenium Concentrations.. Environmental Science & Technology 2014, 48 (19) , 11551-11559. https://doi.org/10.1021/es501369b
    2. Patrick De Boever, Britt Wens, Jordi Boix, Vicente Felipo, and Greet Schoeters . Perinatal Exposure to Purity-Controlled Polychlorinated Biphenyl 52, 138, or 180 Alters Toxicogenomic Profiles in Peripheral Blood of Rats after 4 Months. Chemical Research in Toxicology 2013, 26 (8) , 1159-1167. https://doi.org/10.1021/tx300510v
    3. Barbara Taferner, Wolfgang Schuehly, Antje Huefner, Igor Baburin, Katharina Wiesner, Gerhard F. Ecker, and Steffen Hering . Modulation of GABAA-Receptors by Honokiol and Derivatives: Subtype Selectivity and Structure–Activity Relationship. Journal of Medicinal Chemistry 2011, 54 (15) , 5349-5361. https://doi.org/10.1021/jm200186n
    4. Tom Muir, Joel E Michalek, Raymond F Palmer. Determination of safe levels of persistent organic pollutants in toxicology and epidemiology. Reviews on Environmental Health 2023, 38 (3) , 401-408. https://doi.org/10.1515/reveh-2021-0105
    5. Chenwei Pan, Huijuan Zhao, Qiaoling Du, Yong Xu, Dajun Tian, Shuo Xiao, Haiyin Wang, Xiao Wei, Chunfeng Wu, Yuanyuan Ruan, Chunhua Zhao, Gonghua Tao, Weiwei Zheng. Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females. International Journal of Environmental Research and Public Health 2022, 19 (12) , 6958. https://doi.org/10.3390/ijerph19126958
    6. Harmanpreet Kaur Panesar, Rebecca J. Wilson, Pamela J. Lein. Cellular and Molecular Mechanisms of PCB Developmental Neurotoxicity. 2022, 1-30. https://doi.org/10.1007/978-3-030-71519-9_204-1
    7. Harmanpreet Kaur Panesar, Rebecca J. Wilson, Pamela J. Lein. Cellular and Molecular Mechanisms of PCB Developmental Neurotoxicity. 2022, 1197-1226. https://doi.org/10.1007/978-3-031-15080-7_204
    8. Nadja R. Brun, Jennifer M. Panlilio, Kun Zhang, Yanbin Zhao, Evgeny Ivashkin, John J. Stegeman, Jared V. Goldstone. Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish. Communications Biology 2021, 4 (1) https://doi.org/10.1038/s42003-021-02626-9
    9. Sarah E. Latchney, Ania K. Majewska. Persistent organic pollutants at the synapse: Shared phenotypes and converging mechanisms of developmental neurotoxicity. Developmental Neurobiology 2021, 81 (5) , 623-652. https://doi.org/10.1002/dneu.22825
    10. Anke M. Tukker, Lianne M. S. Bouwman, Regina G. D. M. van Kleef, Hester S. Hendriks, Juliette Legler, Remco H. S. Westerink. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro. Scientific Reports 2020, 10 (1) https://doi.org/10.1038/s41598-020-62152-2
    11. Carolyn Klocke, Sunjay Sethi, Pamela J. Lein. The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences. Environmental Science and Pollution Research 2020, 27 (9) , 8885-8896. https://doi.org/10.1007/s11356-019-06723-5
    12. Carolyn Klocke, Pamela J. Lein. Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity. International Journal of Molecular Sciences 2020, 21 (3) , 1013. https://doi.org/10.3390/ijms21031013
    13. Afaf El-Ansary, Abeer Al-Dbass, Hanan Qasem. Neurotoxins and Autism. 2018https://doi.org/10.5772/intechopen.69431
    14. Remco H. S. Westerink. Modulation of cell viability, oxidative stress, calcium homeostasis, and voltage- and ligand-gated ion channels as common mechanisms of action of (mixtures of) non-dioxin-like polychlorinated biphenyls and polybrominated diphenyl ethers. Environmental Science and Pollution Research 2014, 21 (10) , 6373-6383. https://doi.org/10.1007/s11356-013-1759-x
    15. Damon Delistraty. Ecotoxicity and risk to human fish consumers of polychlorinated biphenyls in fish near the Hanford Site (USA). Science of The Total Environment 2013, 445-446 , 14-21. https://doi.org/10.1016/j.scitotenv.2012.12.028
    16. Hester S. Hendriks, Regina G.D.M. van Kleef, Remco H.S. Westerink. Modulation of human α4β2 nicotinic acetylcholine receptors by brominated and halogen-free flame retardants as a measure for in vitro neurotoxicity. Toxicology Letters 2012, 213 (2) , 266-274. https://doi.org/10.1016/j.toxlet.2012.06.013
    17. Marijke de Cock, Yolanda G.H. Maas, Margot van de Bor. Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review. Acta Paediatrica 2012, 101 (8) , 811-818. https://doi.org/10.1111/j.1651-2227.2012.02693.x
    18. Hester S. Hendriks, Regina G. D. M. van Kleef, Martin van den Berg, Remco H. S. Westerink. Multiple Novel Modes of Action Involved in the In Vitro Neurotoxic Effects of Tetrabromobisphenol-A. Toxicological Sciences 2012, 128 (1) , 235-246. https://doi.org/10.1093/toxsci/kfs136
    19. Laura Brunelli, Marta LLansola, Vicente Felipo, Roberta Campagna, Luisa Airoldi, Massimiliano De Paola, Roberto Fanelli, Alessandro Mariani, Marco Mazzoletti, Roberta Pastorelli. Insight into the neuroproteomics effects of the food-contaminant non-dioxin like polychlorinated biphenyls. Journal of Proteomics 2012, 75 (8) , 2417-2430. https://doi.org/10.1016/j.jprot.2012.02.023
    20. Partha Sarathi Mitra, Somiranjan Ghosh, Shizhu Zang, Dean Sonneborn, Irva Hertz-Picciotto, Tomas Trnovec, Lubica Palkovicova, Eva Sovcikova, Svetlana Ghimbovschi, Eric P. Hoffman, Sisir K. Dutta. Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: Correlations between gene expression and disease risk. Environment International 2012, 39 (1) , 188-199. https://doi.org/10.1016/j.envint.2011.09.003
    21. Mia Stenberg, Timo Hamers, Miroslav Machala, Frode Fonnum, Ulla Stenius, Al-Anati Lauy, Majorie B.M. van Duursen, Remco H.S. Westerink, Elsa C. Antunes Fernandes, Patrik L. Andersson. Multivariate toxicity profiles and QSAR modeling of non-dioxin-like PCBs – An investigation of in vitro screening data from ultra-pure congeners. Chemosphere 2011, 85 (9) , 1423-1429. https://doi.org/10.1016/j.chemosphere.2011.08.019
    22. Jordi Boix, Omar Cauli, Heather Leslie, Vicente Felipo. Differential long-term effects of developmental exposure to polychlorinated biphenyls 52, 138 or 180 on motor activity and neurotransmission. Gender dependence and mechanisms involved. Neurochemistry International 2011, 58 (1) , 69-77. https://doi.org/10.1016/j.neuint.2010.10.014
    23. Hester S. Hendriks, Elsa C. Antunes Fernandes, Åke Bergman, Martin van den Berg, Remco H. S. Westerink. PCB-47, PBDE-47, and 6-OH-PBDE-47 Differentially Modulate Human GABAA and α4β2 Nicotinic Acetylcholine Receptors. Toxicological Sciences 2010, 118 (2) , 635-642. https://doi.org/10.1093/toxsci/kfq284
    24. Elsa C. Antunes Fernandes, Hester S. Hendriks, Regina G. D. M. van Kleef, Ad Reniers, Patrik L. Andersson, Martin van den Berg, Remco H. S. Westerink. Activation and Potentiation of Human GABAA Receptors by Non-Dioxin–Like PCBs Depends on Chlorination Pattern. Toxicological Sciences 2010, 118 (1) , 183-190. https://doi.org/10.1093/toxsci/kfq257
    Download PDF
    Go to Environmental Science & Technology
    Get e-Alerts
    Get e-Alerts

    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2010, 44, 8, 2864–2869
    Click to copy citationCitation copied!
    https://doi.org/10.1021/es902321a
    Published December 16, 2009
    Copyright © 2009 American Chemical Society
    Request reuse permissions

    Article Views

    715

    Altmetric

    -

    Citations

    24
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.