Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

Re(CO)3 Complexes Synthesized via an Improved Preparation of Aqueous fac-[Re(CO)3(H2O)3]+ as an Aid in Assessing 99mTc Imaging Agents. Structural Characterization and Solution Behavior of Complexes with Thioether-Bearing Amino Acids as Tridentate Ligands

View Author Information
Department of Radiology, Emory University, Atlanta, Georgia 30322, and Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803
Cite this: Inorg. Chem. 2005, 44, 15, 5437–5446
Publication Date (Web):June 18, 2005
Copyright © 2005 American Chemical Society

    Article Views





    Other access options
    Supporting Info (2)»


    Abstract Image

    Parallel studies of the preparation of Re and 99mTc agents aid in interpreting the nature of tracer 99mTc radiopharmaceuticals. Aqueous solutions of the fac-[99mTc(CO)3(H2O)3]+ cation are gaining wide use and are readily prepared, but such solutions of the fac-[Re(CO)3(H2O)3]+ cation (1) are not so easily accessible. Herein we describe a new, reliable, and straightforward preparation of aqueous solutions of 1, characterized by HPLC and ESI-MS. Treatment of solutions of 1 with thioether-bearing amino acids, AAH = S-methyl-l-cysteine (MECYSH), S-propyl-l-cysteine (PRCYSH), and methionine (METH), gave high yields of fac-Re(CO)3AA complexes. X-ray crystallographic and NMR analyses indicated that MECYS-, PRCYS-, and MET- were bound in fac-Re(CO)3AA complexes as tridentate monoanionic ligands through amino, thioether, and α-carboxyl groups. In CD3OD, 1H NMR spectra have broad signals but have two sets of signals at −10 °C, consistent with two isomers with different configurations at the pyramidal sulfur; these interconvert slowly on the NMR time scale at low temperatures. Indeed, the crystal structure of the fac-Re(CO)3(PRCYS) reveals a mixture of the two possible diastereoisomers. S-(Carboxymethyl)-l-cysteine (CCMH2) and 1 gave two products, 5A (kinetically favored) and 5B (thermodynamically favored). X-ray crystallographic analyses of a crystal of 5B and of a 1:1 cocrystal of 5A and 5B showed that 5A and 5B are diastereoisomers with the CCMH- α-carboxyl group dangling. In addition to the amino and thioether groups, the S-(carboxymethyl) carboxyl group is coordinated, a feature that slows interconversion of diastereoisomers relative to the other fac-Re(CO)3AA complexes because interconversion can now occur only after the rupture of Re−ligand bonds. These N, O, and S tridentate adducts are quite stable, and the grouping has promise in 99mTc(CO)3 tracer development.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.


    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

     Emory University.

     Louisiana State University.


     Author to whom correspondence should be addressed. E-mail:  [email protected]. Tel.:  225-578-0933. Fax:  225-578-3463.

    Supporting Information Available

    Jump To

    X-ray crystallographic data for structure determinations of compounds 3, 4, and 5B and the cocrystal of 5A and 5B in CIF format, a one-dimensional hydrogen-bonded strand formed by Re(CO)3(d-MET) within crystals of 4 viewed along the b axis and along the c axis, and a table of selected bond angles of 3, 4, and 5A and 5B. This material is available free of charge via the Internet at

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system:

    Cited By

    This article is cited by 85 publications.

    1. Benjamin B. Kasten, Xiaowei Ma, Kai Cheng, Lihong Bu, Winston S. Slocumb, Thomas R. Hayes, Steven Trabue, Zhen Cheng, and Paul D. Benny . Isothiocyanate-Functionalized Bifunctional Chelates and fac-[MI(CO)3]+ (M = Re, 99mTc) Complexes for Targeting uPAR in Prostate Cancer. Bioconjugate Chemistry 2016, 27 (1) , 130-142.
    2. Andrea J. North, David J. Hayne, Christine Schieber, Katherine Price, Anthony R. White, Peter J. Crouch, Angela Rigopoulos, Graeme J. O’Keefe, Henri Tochon-Danguy, Andrew M. Scott, Jonathan M. White, Uwe Ackermann, and Paul S. Donnelly . Toward Hypoxia-Selective Rhenium and Technetium Tricarbonyl Complexes. Inorganic Chemistry 2015, 54 (19) , 9594-9610.
    3. Jeffrey Klenc, Malgorzata Lipowska, Pramuditha L. Abhayawardhana, Andrew T. Taylor, and Luigi G. Marzilli . Structure and Properties of fac-[ReI(CO)3(NTA)]2– (NTA3– = Trianion of Nitrilotriacetic Acid) and fac-[ReI(CO)3(L)]n– Analogues Useful for Assessing the Excellent Renal Clearance of the fac-[99mTcI(CO)3(NTA)]2– Diagnostic Renal Agent. Inorganic Chemistry 2015, 54 (13) , 6281-6290.
    4. Thomas R. Hayes, Patrice A. Lyon, Charles L. Barnes, Steven Trabue, and Paul D. Benny . Influence of Functionalized Pyridine Ligands on the Radio/Chemical Behavior of [MI(CO)3]+ (M = Re and 99mTc) 2 + 1 Complexes. Inorganic Chemistry 2015, 54 (4) , 1528-1534.
    5. Nerissa A. Lewis, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli . Models for B12-Conjugated Radiopharmaceuticals. Cobaloxime Binding to New fac-[Re(CO)3(Me2Bipyridine)(amidine)]BF4 Complexes Having an Exposed Pyridyl Nitrogen. Inorganic Chemistry 2014, 53 (20) , 11096-11107.
    6. Benjamin B. Kasten, Xiaowei Ma, Hongguang Liu, Thomas R. Hayes, Charles L. Barnes, Shibo Qi, Kai Cheng, Shalina C. Bottorff, Winston S. Slocumb, Jing Wang, Zhen Cheng, and Paul D. Benny . Clickable, Hydrophilic Ligand for fac-[MI(CO)3]+ (M = Re/99mTc) Applied in an S-Functionalized α-MSH Peptide. Bioconjugate Chemistry 2014, 25 (3) , 579-592.
    7. Pramuditha L. Abhayawardhana, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli . Complexes Possessing Rare “Tertiary” Sulfonamide Nitrogen-to-Metal Bonds of Normal Length: fac-[Re(CO)3(N(SO2R)dien)]PF6 Complexes with Hydrophilic Sulfonamide Ligands. Inorganic Chemistry 2014, 53 (2) , 1144-1155.
    8. Shalina C. Bottorff, Adam L. Moore, Ariana R. Wemple, Dejan-Krešimir Bučar, Leonard R. MacGillivray, and Paul D. Benny . pH-Controlled Coordination Mode Rearrangements of “Clickable” Huisgen-Based Multidentate Ligands with [MI(CO)3]+ (M = Re, 99mTc). Inorganic Chemistry 2013, 52 (6) , 2939-2950.
    9. Thomas R. Hayes, Patrice A. Lyon, Elsa Silva-Lopez, Brendan Twamley, and Paul D. Benny . Photo-initiated Thiol-ene Click Reactions as a Potential Strategy for Incorporation of [MI(CO)3]+ (M = Re, 99mTc) Complexes. Inorganic Chemistry 2013, 52 (6) , 3259-3267.
    10. Theshini Perera, Pramuditha Abhayawardhana, Patricia A. Marzilli, Frank R. Fronczek, and Luigi G. Marzilli . Formation of a Metal-to-Nitrogen Bond of Normal Length by a Neutral Sufonamide Group within a Tridentate Ligand. A New Approach to Radiopharmaceutical Bioconjugation. Inorganic Chemistry 2013, 52 (5) , 2412-2421.
    11. Daniela Maggioni, Fabio Fenili, Laura D’Alfonso, Daniela Donghi, Monica Panigati, Ivan Zanoni, Roberta Marzi, Amedea Manfredi, Paolo Ferruti, Giuseppe D’Alfonso, and Elisabetta Ranucci . Luminescent Rhenium and Ruthenium Complexes of an Amphoteric Poly(amidoamine) Functionalized with 1,10-Phenanthroline. Inorganic Chemistry 2012, 51 (23) , 12776-12788.
    12. Han Jiang, Benjamin B. Kasten, Hongguang Liu, Shibo Qi, Yang Liu, Mei Tian, Charles L. Barnes, Hong Zhang, Zhen Cheng, and Paul D. Benny . Novel, Cysteine-Modified Chelation Strategy for the Incorporation of [MI(CO)3]+ (M = Re, 99mTc) in an α-MSH Peptide. Bioconjugate Chemistry 2012, 23 (11) , 2300-2312.
    13. J. Lecina, A. Carrer, A. Álvarez-Larena, U. Mazzi, L. Melendez-Alafort, and J. Suades . New Bioconjugated Rhenium Carbonyls by Transmetalation Reaction with Zinc Derivatives. Organometallics 2012, 31 (16) , 5884-5893.
    14. Goreti Ribeiro Morais, António Paulo, and Isabel Santos . Organometallic Complexes for SPECT Imaging and/or Radionuclide Therapy. Organometallics 2012, 31 (16) , 5693-5714.
    15. Pramuditha Abhayawardhana, Patricia A. Marzilli, Theshini Perera, Frank R. Fronczek, and Luigi G. Marzilli . New Monodentate Amidine Superbasic Ligands with a Single Configuration in fac-[Re(CO)3(5,5′- or 6,6′-Me2bipyridine)(amidine)]BF4 Complexes. Inorganic Chemistry 2012, 51 (13) , 7271-7283.
    16. I. Pirmettis, Y. Arano, T. Tsotakos, K. Okada, A. Yamaguchi, T. Uehara, M. Morais, J. D. G. Correia, I. Santos, M. Martins, S. Pereira, C. Triantis, P. Kyprianidou, M. Pelecanou, and M. Papadopoulos . New 99mTc(CO)3 Mannosylated Dextran Bearing S-Derivatized Cysteine Chelator for Sentinel Lymph Node Detection. Molecular Pharmaceutics 2012, 9 (6) , 1681-1692.
    17. Theshini Perera, Frank R. Fronczek, Patricia A. Marzilli and Luigi G. Marzilli. Superbasic Amidine Monodentate Ligands in fac-[Re(CO)3(5,5′-Me2bipy)(Amidine)]BF4 Complexes: Dependence of Amidine Configuration on the Remote Nitrogen Substituents. Inorganic Chemistry 2010, 49 (15) , 7035-7045.
    18. Theshini Perera, Patricia A. Marzilli, Frank R. Fronczek and Luigi G. Marzilli. NH NMR Shifts of New Structurally Characterized fac-[Re(CO)3(polyamine)]n+ Complexes Probed via Outer-Sphere Hydrogen-Bonding Interactions to Anions, Including the Paramagnetic [ReIVBr6]2− Anion. Inorganic Chemistry 2010, 49 (12) , 5560-5572.
    19. Malgorzata Lipowska, Haiyang He, Xiaolong Xu, Andrew T. Taylor, Patricia A. Marzilli and Luigi G. Marzilli . Coordination Modes of Multidentate Ligands in fac-[Re(CO)3(polyaminocarboxylate)] Analogues of 99mTc Radiopharmaceuticals. Dependence on Aqueous Solution Reaction Conditions. Inorganic Chemistry 2010, 49 (7) , 3141-3151.
    20. Theshini Perera, Patricia A. Marzilli, Frank R. Fronczek and Luigi G. Marzilli. Several Novel N-Donor Tridentate Ligands Formed in Chemical Studies of New fac-Re(CO)3 Complexes Relevant to fac-99mTc(CO)3 Radiopharmaceuticals: Attack of a Terminal Amine on Coordinated Acetonitrile. Inorganic Chemistry 2010, 49 (5) , 2123-2131.
    21. Daniela Donghi, Daniela Maggioni, Giuseppe D’Alfonso, Federica Amigoni, Elisabetta Ranucci, Paolo Ferruti, Amedea Manfredi, Fabio Fenili, Agnese Bisazza and Roberta Cavalli . Tricarbonyl−Rhenium Complexes of a Thiol-Functionalized Amphoteric Poly(amidoamine). Biomacromolecules 2009, 10 (12) , 3273-3282.
    22. Haiyang He, Jennifer E. Morley, Brendan Twamley, Ryan H. Groeneman, Dejan-Krešimir Buč̌ar, Leonard R. MacGillivray and Paul D. Benny . Investigation of the Coordination Interactions of S-(Pyridin-2-ylmethyl)-l-Cysteine Ligands with M(CO)3+ (M = Re, 99mTc). Inorganic Chemistry 2009, 48 (22) , 10625-10634.
    23. Haiyang He, Jennifer E. Morely, Elsa Silva-Lopez, Brienne Bottenus, Maribel Montajano, Glenn A. Fugate, Brendan Twamley and Paul D. Benny . Synthesis and Characterization of Nonsteroidal-Linked M(CO)3+(M = 99mTc, Re) Compounds Based on the Androgen Receptor Targeting Molecule Flutamide. Bioconjugate Chemistry 2009, 20 (1) , 78-86.
    24. Brenton R. Franklin , Richard S. Herrick , Christopher J. Ziegler , Anıl Çetin , Natalie Barone , and Laura R. Condon . Reactions of the Re(CO)3(H2O)3 + Synthon with Monodentate Ligands under Aqueous Conditions. Inorganic Chemistry 2008, 47 (13) , 5902-5909.
    25. Georgy V. Sidorenko, Alexander E. Miroslavov, Margarita Yu. Tyupina. Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect. Coordination Chemistry Reviews 2023, 476 , 214911.
    26. Konstantina Makrypidi, Christos Kiritsis, Ioanna Roupa, Sotiria Triantopoulou, Antonio Shegani, Maria Paravatou-Petsotas, Aristeidis Chiotellis, Maria Pelecanou, Minas Papadopoulos, Ioannis Pirmettis. Evaluation of Rhenium and Technetium-99m Complexes Bearing Quinazoline Derivatives as Potential EGFR Agents. Molecules 2023, 28 (4) , 1786.
    27. Kokila Ranasinghe, Patricia A. Marzilli, Svetlana Pakhomova, Luigi G. Marzilli. New fac-[ReI(CO)3(Ltri)]Y complexes of linear N,N′,N′′-tridentate ligands (Ltri) with terminal imidazolyl or pyridyl ring (N and N′′) and central tertiary sulfonamide (N′) N-donors. Effects of size and substituents of the terminal N-donor rings and the rarely found direct sulfonamide N to metal bond. Inorganica Chimica Acta 2022, 533 , 120781.
    28. Margaret W. Ndinguri, Carrie A. Black, Anna L. Gosser, Sara Reitz, Cody Sutphin, Frank R. Fronczek, Lindsay E. Cormier. Exploring the synthesis and characterization of fac-Re(CO)3L complexes using diethylenetriamine derivative functionalized at the central nitrogen. Inorganica Chimica Acta 2021, 520 , 120291.
    29. Taniya Darshani, Frank R. Fronczek, Varuni V. Priyadarshani, Sameera R. Samarakoon, Inoka C. Perera, Theshini Perera. Synthesis and characterization of novel naphthalene-derivatized tridentate ligands and their net neutral rhenium tricarbonyl complexes and cytotoxic effects on non-small cell lung cancer cells of interest. Polyhedron 2020, 187 , 114652.
    30. Taniya Darshani, Nadini Thushara, Piyumali Weerasuriya, Frank R. Fronczek, Inoka C. Perera, Theshini Perera. Fluorescent di-(2-picolyl)amine based drug-like ligands and their Re(CO)3 complexes towards biological applications. Polyhedron 2020, 185 , 114592.
    31. Nadeem Ahmed Lodhi, Ji Yong Park, Mi Kyung Hong, Young Joo Kim, Yun-Sang Lee, Gi Jeong Cheon, Jae Min Jeong. Development of 99mTc-labeled trivalent isonitrile radiotracer for folate receptor imaging. Bioorganic & Medicinal Chemistry 2019, 27 (10) , 1925-1931.
    32. Malgorzata Lipowska, Jeffrey Klenc, Andrew T. Taylor, Luigi G. Marzilli. fac-99mTc/Re-tricarbonyl complexes with tridentate aminocarboxyphosphonate ligands: Suitability of the phosphonate group in chelate ligand design of new imaging agents. Inorganica Chimica Acta 2019, 486 , 529-537.
    33. William L. Turnbull, Lihai Yu, Emily Murrell, Mark Milne, Carlie L. Charron, Leonard G. Luyt. A dual modality 99m Tc/Re( i )-labelled T140 analogue for imaging of CXCR4 expression. Organic & Biomolecular Chemistry 2019, 17 (3) , 598-608.
    34. Shahbaz Nazir, Jamil Anwar, Munawar Ali Munawar, Javed Iqbal Qazi, Stephen Peter Best, Michael Cheah, Muhammad Yaseen. Metal complexation induces antibiotic activity in S-ethyl-l-cysteine sulfoxide. Inorganica Chimica Acta 2018, 478 , 166-175.
    35. Malgorzata Lipowska, Nashwa Jarkas, Ronald J. Voll, Jonathon A. Nye, Jeffrey Klenc, Mark M. Goodman, Andrew T. Taylor. Re(CO) 3 ([ 18 F]FEDA), a novel 18 F PET renal tracer: Radiosynthesis and preclinical evaluation. Nuclear Medicine and Biology 2018, 58 , 42-50.
    36. Jelena M. Mašković, Antonios Hatzidimitriou, Ana Damjanović, Tatjana P. Stanojković, Srećko R. Trifunović, Athina A. Geronikaki, Dionysia Papagiannopoulou. Synthesis, characterization and biological evaluation of Pd( ii ), Cu( ii ), Re( i ) and 99m Tc( i ) thiazole-based complexes. MedChemComm 2018, 9 (5) , 831-842.
    37. Dionysia Papagiannopoulou. Technetium‐99m radiochemistry for pharmaceutical applications. Journal of Labelled Compounds and Radiopharmaceuticals 2017, 60 (11) , 502-520.
    38. Malgorzata Lipowska, Jeffrey Klenc, Nashwa Jarkas, Luigi G. Marzilli, Andrew T. Taylor. Monoanionic 99m Tc-tricarbonyl-aminopolycarboxylate complexes with uncharged pendant groups: Radiosynthesis and evaluation as potential renal tubular tracers. Nuclear Medicine and Biology 2017, 47 , 48-55.
    39. Thomas R. Hayes, Shalina C. Bottorff, Winston S. Slocumb, Charles L. Barnes, Aurora E. Clark, Paul D. Benny. Influence of bidentate ligand donor types on the formation and stability in 2 + 1 fac-[M I (CO) 3 ] + (M = Re, 99m Tc) complexes. Dalton Transactions 2017, 46 (4) , 1134-1144.
    40. Kokila Ranasinghe, Shiroma Handunnetti, Inoka C. Perera, Theshini Perera. Synthesis and characterization of novel rhenium(I) complexes towards potential biological imaging applications. Chemistry Central Journal 2016, 10 (1)
    41. Theocharis E. Kydonaki, Evangelos Tsoukas, Filipa Mendes, Antonios G. Hatzidimitriou, António Paulo, Lefkothea C. Papadopoulou, Dionysia Papagiannopoulou, George Psomas. Synthesis, characterization and biological evaluation of 99mTc/Re–tricarbonyl quinolone complexes. Journal of Inorganic Biochemistry 2016, 160 , 94-105.
    42. Kseniia O. Piletska, Kostiantyn V. Domasevitch, Alexander V. Shtemenko. Crystal structure of fac -aquatricarbonyl[( S )-valinato-κ 2 N , O ]rhenium(I). Acta Crystallographica Section E Crystallographic Communications 2016, 72 (4) , 590-592.
    43. George Makris, Lauren Radford, Fabio Gallazzi, Silvia Jurisson, Heather Hennkens, Dionysia Papagiannopoulou. Synthesis and evaluation of fac-[99mTc/Re(CO)3]+ complexes with a new (N,S,N) bifunctional chelating agent: The first example of a fac-[Re(CO)3(N,S,N-sst2-ANT)] complex bearing a somatostatin receptor antagonist peptide. Journal of Organometallic Chemistry 2016, 805 , 100-107.
    44. Amali Subasinghe, Inoka C. Perera, Svetlana Pakhomova, Theshini Perera. Synthesis, Characterization, and Biological Studies of a Piperidinyl Appended Dipicolylamine Ligand and Its Rhenium Tricarbonyl Complex as Potential Therapeutic Agents for Human Breast Cancer. Bioinorganic Chemistry and Applications 2016, 2016 , 1-10.
    45. Thomas R. Hayes, Ashton S. Powell, Charles L. Barnes, Paul D. Benny. Synthesis and stability of 2+1 complexes of N,N-diethylbenzoylthiourea with [M I (CO) 3 ] + (M = Re, 99m Tc). Journal of Coordination Chemistry 2015, 68 (19) , 3432-3448.
    46. Jeffrey Klenc, Malgorzata Lipowska, Andrew T. Taylor. Identification of lead compounds for 99mTc and 18F GPR91 radiotracers. Bioorganic & Medicinal Chemistry Letters 2015, 25 (11) , 2335-2339.
    47. Joan Lecina, Òscar Palacios, Sílvia Atrian, Mercè Capdevila, Joan Suades. Rhenium and technetium tricarbonyl, {M(CO)3}+ (M = Tc, Re), binding to mammalian metallothioneins: new insights into chemical and radiopharmaceutical implications. JBIC Journal of Biological Inorganic Chemistry 2015, 20 (3) , 465-474.
    48. Jennifer L. Hickey, Emily J. Simpson, Jinqiang Hou, Leonard G. Luyt. An Integrated Imaging Probe Design: The Synthesis of 99m Tc/Re‐Containing Macrocyclic Peptide Scaffolds. Chemistry – A European Journal 2015, 21 (2) , 568-578.
    49. Francisco Yoe, Marcos Flores-Alamo, Francisco Morales, Roberto Escudero, Héctor Cortes-Hernández, Miguel Castro, Norah Barba-Behrens. Structural, magnetic and theoretical study of mononuclear nickel(II) and cobalt(II) compounds of a benzimidazole thiobutanoic acid derivative. Inorganica Chimica Acta 2014, 423 , 36-45.
    50. Jonathan R. Dilworth, Sofia I. Pascu. The Radiopharmaceutical Chemistry of Technetium and Rhenium. 2014, 137-164.
    51. Joan Lecina, Pilar Cortés, Montserrat Llagostera, Carlos Piera, Joan Suades. New rhenium complexes with ciprofloxacin as useful models for understanding the properties of [99mTc]-ciprofloxacin radiopharmaceutical. Bioorganic & Medicinal Chemistry 2014, 22 (13) , 3262-3269.
    52. J. Giglio, S. Dematteis, S. Fernández, H. Cerecetto, A. Rey. Synthesis and evaluation of a new 99m Tc(I)‐tricarbonyl complex bearing the 5‐nitroimidazol‐1‐yl moiety as potential hypoxia imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals 2014, 57 (6) , 403-409.
    53. S. Hapuarachchige, B. K. Bryant, J. B. Arterburn. Synthesis of (Pyridin-2-YL)Hydrazone Rhenium(I) Tricarbonyl Complexes that Exhibit pH-Sensitive Fluorescence. Chemistry of Heterocyclic Compounds 2014, 50 (2) , 254-263.
    54. Daniela Maggioni, Paolo Arosio, Francesco Orsini, Anna M. Ferretti, Tomas Orlando, Amedea Manfredi, Elisabetta Ranucci, Paolo Ferruti, Giuseppe D'Alfonso, Alessandro Lascialfari. Superparamagnetic iron oxide nanoparticles stabilized by a poly(amidoamine)-rhenium complex as potential theranostic probe. Dalton Trans. 2014, 43 (3) , 1172-1183.
    55. Xuegang Chen, Kai Guo, Fanchao Li, Li Zhou, Hongbin Qiao. Synthesis and properties of Zn 2+ /Cd 2+ -directed self-assembled metallo-supramolecular polymers based on 1,4-diketo-pyrrolo[3,4-c]pyrrole (DPP) derivatives. RSC Adv. 2014, 4 (101) , 58027-58035.
    56. Dipak Kumar Nayak, Kamal Krishna Halder, Rinku Baishya, Tuhinadri Sen, Partha Mitra, Mita Chatterjee Debnath. Tricarbonyltechnetium(i) and tricarbonylrhenium(i) complexes of amino acids: crystal and molecular structure of a novel cyclic dimeric Re(CO)3-amino acid complex comprised of the OON donor atom set of the tridentate ligand. Dalton Transactions 2013, 42 (37) , 13565.
    57. Jeffrey Klenc, Malgorzata Lipowska, Andrew T. Taylor, Luigi G. Marzilli. Synthesis and Characterization of fac ‐Re(CO) 3 ‐aspartic‐ N ‐monoacetic Acid: Structural Analogue of a Potential Renal Tracer, fac ‐ 99m Tc(CO) 3 (ASMA). European Journal of Inorganic Chemistry 2012, 2012 (27) , 4334-4341.
    58. George Makris, Ourania Karagiorgou, Dionysia Papagiannopoulou, Angeliki Panagiotopoulou, Catherine P. Raptopoulou, Aris Terzis, Vassilis Psycharis, Maria Pelecanou, Ioannis Pirmettis, Minas S. Papadopoulos. Rhenium(I) and Technetium(I) Tricarbonyl Complexes with [NSO]‐Type Chelators: Synthesis, Structural Characterization, and Radiochemistry. European Journal of Inorganic Chemistry 2012, 2012 (19) , 3132-3139.
    59. Jinxia Xu, Ruiying Wang, Yameng Li, Zhiyang Gao, Rui Yao, Song Wang, Benlai Wu. Chiral Supramolecular Frameworks Based on Chiral Metallocycles: Crystal Structures and Photophysical Properties. European Journal of Inorganic Chemistry 2012, 2012 (20) , 3349-3360.
    60. A. Chiotellis, C. Tsoukalas, M. Pelecanou, I. Pirmettis, M. Papadopoulos. Synthesis, characterization and biological evaluation of novel neutral fac-M(CO)3(SNO) complexes (M=Re, 99mTc) bearing the o-methoxyphenylpiperazine moiety. Applied Radiation and Isotopes 2012, 70 (6) , 957-964.
    61. Theshini Perera, Pramuditha Abhayawardhana, Frank R. Fronczek, Patricia A. Marzilli, Luigi G. Marzilli. Iminoether Complexes of the Type, fac ‐[Re(CO) 3 L{HNC(CH 3 )OCH 3 }]BF 4 (L = Bipyridine or a Substituted Bipyridine): Synthesis and Properties. European Journal of Inorganic Chemistry 2012, 2012 (4) , 618-627.
    62. Dipak Kumar Nayak, Rinku Baishya, Kamal Krishna Halder, Tuhinadri Sen, Bharat R. Sarkar, Shantanu Ganguly, M. K. Das, Mita Chatterjee Debnath. Evaluation of 99mTc(i)-tricarbonyl complexes of fluoroquinolones for targeting bacterial infection. Metallomics 2012, 4 (11) , 1197.
    63. Cheng Wang, Wei Zhou, Junfeng Yu, Lan Zhang, Ni Wang. A study of the radiosynthesis of fac-[188Re(CO)3(H2O)3]+ and its application in labeling 1,2,3-triazole analogs obtained by click chemistry. Nuclear Medicine Communications 2012, 33 (1) , 84-89.
    64. Carolina Moura, Lurdes Gano, Isabel C. Santos, Isabel Santos, António Paulo. 99m Tc I /Re I Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation. European Journal of Inorganic Chemistry 2011, 2011 (35) , 5405-5413.
    65. Dionysia Papagiannopoulou, Charalambos Tsoukalas, George Makris, Catherine P. Raptopoulou, Vassilis Psycharis, Leondios Leondiadis, Ewa Gniazdowska, Przemyslaw Koźmiński, Leon Fuks, Maria Pelecanou, Ioannis Pirmettis, Minas S. Papadopoulos. Histidine derivatives as tridentate chelators for the fac-[MI(CO)3] (Re, 99mTc, 188Re) core: Synthesis, structural characterization, radiochemistry and stability. Inorganica Chimica Acta 2011, 378 (1) , 333-337.
    66. T.I.A. Gerber, R. Betz, I.N. Booysen, K.C. Potgieter, P. Mayer. Coordination of bidentate aniline derivatives to the fac-[Re(CO)3]+ core. Polyhedron 2011, 30 (10) , 1739-1745.
    67. Marta Sánchez-Lozano, Ezequiel M. Vázquez-López, José M. Hermida-Ramón, Carlos M. Estévez. Synthesis, spectral studies, crystal structures and TDDFT studies of the rhenium(I) complexes of 2,4-dihydroxy-N′-(4-hydroxybenzilidene) benzohydrazide. Polyhedron 2011, 30 (6) , 953-962.
    68. Wei Xu, Wen Liu, Fang-Yang Yao, Yue-Qing Zheng. Synthesis, crystal structure and properties of the novel chiral 3D coordination polymer with S-carboxymethyl-l-cysteine. Inorganica Chimica Acta 2011, 365 (1) , 297-301.
    69. Paul D. Benny, Glenn A. Fugate, Tanushree Ganguly, Brendan Twamley, Dejan-Krešimir Bučar, Leonard R. MacGillivray. Unusual reactivity of acetylacetone with imidazole/histamine complexes and (M=Re, 99mTc). Inorganica Chimica Acta 2011, 365 (1) , 356-362.
    70. Sarah L. Binkley, Thomas C. Leeper, Roger S. Rowlett, Richard S. Herrick, Christopher J. Ziegler. Re(CO)3(H2O)3+ binding to lysozyme: structure and reactivity. Metallomics 2011, 3 (9) , 909.
    71. Paula Barbazán, Adelheid Hagenbach, Elisabeth Oehlke, Ulrich Abram, Rosa Carballo, Sabina Rodríguez‐Hermida, Ezequiel M. Vázquez‐López. Tricarbonyl Rhenium(I) and Technetium(I) Complexes with Hydrazones Derived from 4,5‐Diazafluoren‐9‐one and 1,10‐Phenanthroline‐5,6‐dione. European Journal of Inorganic Chemistry 2010, 2010 (29) , 4622-4630.
    72. Sarah L. Binkley, Natalie V. Barone, Adam C. Underwood, Amy Milsted, Brenton R. Franklin, Richard S. Herrick, Christopher J. Ziegler. The synthesis and toxicity of tripodal tricarbonyl rhenium complexes as radiopharmaceutical models. Journal of Inorganic Biochemistry 2010, 104 (6) , 632-638.
    73. Dionysia Papagiannopoulou, George Makris, Charalambos Tsoukalas, Catherine P. Raptopoulou, Aris Terzis, Maria Pelecanou, Ioannis Pirmettis, Minas S. Papadopoulos. Rhenium(I) and technetium(I) fac-M(NSO)(CO)3 (M=Re, 99mTc) tricarbonyl complexes, with a tridentate NSO bifunctional agent: Synthesis, structural characterization, and radiochemistry. Polyhedron 2010, 29 (2) , 876-880.
    74. Sarah L. Binkley, Christopher J. Ziegler, Richard S. Herrick, Roger S. Rowlett. Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3+. Chemical Communications 2010, 46 (8) , 1203.
    75. Paul Bichler, Alex D. Sun, Brian O. Patrick, Jennifer A. Love. Design, synthesis and coordination chemistry of sidearm substituted bisoxazoline ligands. Inorganica Chimica Acta 2009, 362 (12) , 4546-4552.
    76. Malgorzata Lipowska, Luigi G. Marzilli, Andrew T. Taylor. 99m Tc(CO) 3 -Nitrilotriacetic Acid: A New Renal Radiopharmaceutical Showing Pharmacokinetic Properties in Rats Comparable to Those of 131 I-OIH. Journal of Nuclear Medicine 2009, 50 (3) , 454-460.
    77. Vladimir A. Alfonsov, Alexander A. Bredikhin, Zemfira A. Bredikhina, Rimma M. Eliseenkova, Olga N. Kataeva, Igor A. Litvinov, Michael A. Pudovik. First examples of the cocrystallization of diastereomers of chiral phosphorus compounds. Structural Chemistry 2008, 19 (6) , 873-878.
    78. Maxim N. Sokolov, Pavel A. Abramov, Eugenia V. Peresypkina, Alexander V. Virovets, Vladimir P. Fedin. In situ generation of H2Se and hydrothermal synthesis of new polynuclear rhenium carbonyl polyselenides. Polyhedron 2008, 27 (15) , 3259-3262.
    79. Anna Maria Christoforou, Patricia A. Marzilli, Frank R. Fronczek, Luigi G. Marzilli. fac-[Re(CO)3L] Complexes Containing Tridentate Monoanionic Ligands (L−) Having a Terminal Amido and Two Amine Ligating Groups. Journal of Chemical Crystallography 2008, 38 (2) , 115-121.
    80. Lukas Kromer, Bernhard Spingler, Roger Alberto. Substitution reactions with [ReBr2(CO)2(NCCH3)2]−: a convenient route to complexes with the cis-[Re(CO)2]+ core. Dalton Transactions 2008, 192 (42) , 5800.
    81. Haiyang He, Malgorzata Lipowska, Anna Maria Christoforou, Luigi G. Marzilli, Andrew T. Taylor. Initial evaluation of new 99mTc(CO)3 renal imaging agents having carboxyl-rich thioether ligands and chemical characterization of Re(CO)3 analogues. Nuclear Medicine and Biology 2007, 34 (6) , 709-716.
    82. Richard S. Herrick, Christopher J. Ziegler, Aníl Çetin, Brenton R. Franklin. Structure of the Triaquatricarbonylrhenium(I) Cation and Its Conjugate Base. European Journal of Inorganic Chemistry 2007, 2007 (12) , 1632-1634.
    83. Catarina Xavier, Jae-Kyoung Pak, Isabel Santos, Roger Alberto. Evaluation of two chelators for labelling a PNA monomer with the fac-[99mTc(CO)3]+ moiety. Journal of Organometallic Chemistry 2007, 692 (6) , 1332-1339.
    84. Cara L. Ferreira, Simon R. Bayly, David E. Green, Tim Storr, Cheri A. Barta, Jennifer Steele, Michael J. Adam, Chris Orvig. Carbohydrate-Appended 3-Hydroxy-4-pyridinone Complexes of the [M(CO) 3 ] + Core (M = Re, 99m Tc, 186 Re). Bioconjugate Chemistry 2006, 17 (5) , 1321-1329.
    85. David S. Urch, Michael J. Welch. Radiochemistry and radiopharmaceuticals. Annual Reports Section "A" (Inorganic Chemistry) 2006, 102 , 542.