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Sulfido-Bridged Dinuclear Molybdenum−Copper Complexes Related to the Active Site of CO Dehydrogenase:  [(dithiolate)Mo(O)S2Cu(SAr)]2- (dithiolate = 1,2-S2C6H4, 1,2-S2C6H2-3,6-Cl2, 1,2-S2C2H4)

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    Sulfido-Bridged Dinuclear Molybdenum−Copper Complexes Related to the Active Site of CO Dehydrogenase:  [(dithiolate)Mo(O)S2Cu(SAr)]2- (dithiolate = 1,2-S2C6H4, 1,2-S2C6H2-3,6-Cl2, 1,2-S2C2H4)
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    Department of Chemistry, Graduate School of Science and Research Center for Materials Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan
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    Inorganic Chemistry

    Cite this: Inorg. Chem. 2005, 44, 17, 6034–6043
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    https://doi.org/10.1021/ic050294v
    Published July 29, 2005
    Copyright © 2005 American Chemical Society
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    The [MoCu] carbon monoxide dehydrogenase (CODH) is a Cu-containing molybdo-flavoprotein, the active site of which contains a pterin-dithiolene cofactor bound to a sulfido-bridged dinuclear Mo−Cu complex. In this paper, the synthesis and characterization of dinuclear Mo−Cu complexes relevant to the active site of [MoCu]-CODH are described. Reaction of [MoO2S2]2- with CuCN affords the dinuclear complex [O2MoS2Cu(CN)]2- (1), in which the CN- ligand can be replaced with various aryl thiolates to give rise to a series of dinuclear complexes [O2MoS2Cu(SAr)]2- (Ar = Ph (2), o-Tol (3), and p-Tol (4)). An alternative synthesis of complex 2 is the reaction of [MoO2S2]2- with [Cu(SPh)3]2-. Similarly, [O2MoS2Cu(PPh3)]- (5), [O2MoS2Cu(dppe)]- (dppe = 1,2-bis(diphenylphosphino)ethane) (6), and [O2MoS2Cu(triphos)]- (triphos = 1,1,1-tris[(diphenylphosphino)methyl]ethane) (7) were prepared from the reactions of [MoO2S2]2- with the Cu(I) phosphine complexes. Treatment of 1, 2, 4, or 5 with dithiols (1,2-(SH)2C6H4, 1,2-(SH)2C6H2-3,6-Cl2, and 1,2-(SH)2C2H4), in acetonitrile, leads to the replacement of a molybdenum-bound oxo ligand to yield [(dithiolate)Mo(O)S2CuL]2- (L = CN, SAr; dithiolate = 1,2-S2C6H4, 1,2-S2C6H2-3,6-Cl2, or 1,2-S2C2H4) (8−13) or [(1,2-S2C6H4)Mo(O)S2Cu(PPh3)]- (14) complexes.

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     To whom corresponce should be addressed. E-mail:  i45100a@ nucc.cc.nagoya-u.ac.jp. Fax:  Int.code +81-52-789-2943.

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    Crystallographic data for 2 and 7−9 (CIF) or 3−6, 10, 12, and 13 (CIF and PDF), and cyclic voltammogram of 8−11. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Inorganic Chemistry

    Cite this: Inorg. Chem. 2005, 44, 17, 6034–6043
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ic050294v
    Published July 29, 2005
    Copyright © 2005 American Chemical Society
    Request reuse permissions

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