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Increased Antioxidant Reactivity of Vitamin C at Low pH in Model Membranes

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    Increased Antioxidant Reactivity of Vitamin C at Low pH in Model Membranes
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    Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2002, 124, 38, 11252–11253
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    https://doi.org/10.1021/ja026927b
    Published August 31, 2002
    Copyright © 2002 American Chemical Society
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    Abstract

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    The reactivity of the water-soluble antioxidant vitamin C (l-ascorbic acid) depends on pH. It is generally recognized that the ascorbate monoanion, which predominates at neutral physiological pH, acts as a stronger antioxidant than the protonated form, ascorbic acid. Fluorazophore-L, a long-lived fluorescent probe, was employed as a mimic for lipid peroxyl radicals. The experiments with micellar and bilayer membrane models demonstrate that vitamin C becomes, in fact, a more powerful antioxidant at low pH. This phenomenon may be general for the interception of reactive oxidizing species at the lipid/water interface.

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     To whom correspondence should be addressed. E-mail:  [email protected].

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    Cite this: J. Am. Chem. Soc. 2002, 124, 38, 11252–11253
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja026927b
    Published August 31, 2002
    Copyright © 2002 American Chemical Society
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