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Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors

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Millennium Pharmaceuticals, Inc., 75 Sidney Street, Cambridge, Massachusetts 02139
Cite this: J. Am. Chem. Soc. 2002, 124, 40, 11852–11853
Publication Date (Web):September 12, 2002
Copyright © 2002 American Chemical Society

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    Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and selective ACE2 inhibitors. To this end, picomolar inhibitors of ACE2 were designed and synthesized.

     Medicinal Chemistry.

     Lead Discovery.




     To whom correspondence should be addressed. E-mail:  [email protected].

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    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Your Mendeley pairing has expired. Please reconnect