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Lactosylated Poly(ethylene glycol)-siRNA Conjugate through Acid-Labile β-Thiopropionate Linkage to Construct pH-Sensitive Polyion Complex Micelles Achieving Enhanced Gene Silencing in Hepatoma Cells

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Department of Materials Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan, Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan, and Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Cite this: J. Am. Chem. Soc. 2005, 127, 6, 1624–1625
Publication Date (Web):January 22, 2005
https://doi.org/10.1021/ja044941d
Copyright © 2005 American Chemical Society
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Abstract

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The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling lactosylated-PEG−siRNA conjugates bearing acid-labile β-thiopropionate linkages into polyion complex (PIC) micelles through the mixing with poly(l-lysine). The PIC micelles with clustered lactose moieties on the periphery were successfully transported into hepatoma cells in a receptor-mediated manner, releasing hundreds of active siRNA molecules into the cellular interior responding to the pH decrease in the endosomal compartment. Eventually, almost 100 times enhancement in gene silencing activity compared to that of the free conjugate was achieved for the micelle system, facilitating the practical utility of siRNA therapeutics.

†

 Tokyo University of Science.

⊥

 Current address:  Tsukuba Research Center for Interdisciplinary Materials Science (TIMS), University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaragi 305-8573, Japan.

*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

‡

 Faculty of Medicine, The University of Tokyo.

§

 Graduate School of Engineering, The University of Tokyo.

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Experimental details, materials, and the dual luciferase reporter assay. This material is available free of charge via the Internet at http://pubs.acs.org.

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