Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer: A Synthetic Route to Anticancer Vaccine CandidatesClick to copy article linkArticle link copied!
- Govind Ragupathi
- Fusataka Koide
- Philip O. Livingston
- Young Shin Cho
- Atsushi Endo
- Qian Wan
- Maria K. Spassova
- Stacy J. Keding
- Jennifer Allen
- Ouathek Ouerfelli
- Rebecca M. Wilson
- Samuel J. Danishefsky
Abstract
Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein.
†
Laboratory of Tumor Vaccinology, Clinical Immunology Service, Department of Medicine, Sloan-Kettering Institute for Cancer Research.
‡
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research.
§
Organic Synthesis Core Laboratory, Sloan-Kettering Institute for Cancer Research.
*
In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
⊥
Columbia University.
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