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    Cell-Permeable and Biocompatible Polymeric Nanoparticles for Apoptosis Imaging
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    Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Haweolgog-Dong, Sungbook-Gu, Seoul 136-791, Korea, Advanced Medical Technology Cluster for Diagnosis & Prediction, Kyungpook National University, Korea, and Department of Biotechnology, College of Engineering, Yonsei University, Korea
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    Cite this: J. Am. Chem. Soc. 2006, 128, 11, 3490–3491
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    https://doi.org/10.1021/ja057712f
    Published March 1, 2006
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    Abstract

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    Here, we report for the first time cell-permeable and biocompatible polymeric nanoparticles consisting of a polymer conjugated to a near-infrared (NIR) fluorescence (Cy5.5)-linked effector caspase-specific peptide. The close spatial proximity of the NIR fluorochromes in polymeric nanoparticles results in an autoquenched state, but polymer nanoparticles give rise to strong NIR fluorescence signal under apoptotic cells. Thus, the smart polymeric nanoparticle developed here is an attractive probe for real-time imaging of apoptosis in single cells.

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    †

     Korea Institute of Science and Technology.

    §

     Yonsei University.

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     Kyungpook National University.

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    In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

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    Detailed experimental procedures and background on the polymeric nanoparticles. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cite this: J. Am. Chem. Soc. 2006, 128, 11, 3490–3491
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