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Phenomenon of Optical Self-Purification of Chiral Non-Racemic Compounds

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Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, and Department of Chemistry, Texas A&M University, College Station, Texas 77842
Cite this: J. Am. Chem. Soc. 2007, 129, 40, 12112–12113
Publication Date (Web):September 13, 2007
https://doi.org/10.1021/ja065603a
Copyright © 2007 American Chemical Society

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Abstract

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Owing to a faster rate of sublimation of the racemic form as compared to the optically pure form, optical purification occurred without any external action or special environmental condition. We believe that the phenomenon of optical self-purification reported here deserves further systematic study as possibly one of the mechanisms leading to the emergence and maintenance of prebiotic homochirality.

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In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

 University of Oklahoma.

 Texas A&M University.

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Experimental procedure for the determination of enantiomeric purity of acid 1; crystallographic data for (S)-1 and racemic 1; preliminary kinetic studies. This material is available free of charge via the Internet at http://pubs.acs.org.

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