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Flow Induced Dispersion Analysis Quantifies Noncovalent Interactions in Nanoliter Samples

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    Flow Induced Dispersion Analysis Quantifies Noncovalent Interactions in Nanoliter Samples
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    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2010, 132, 12, 4070–4071
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    https://doi.org/10.1021/ja100484d
    Published March 4, 2010
    Copyright © 2010 American Chemical Society
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    Abstract

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    Flow Induced Dispersion Analysis (FIDA) is presented as a new approach to characterize noncovalent interactions. The new method only requires nanoliter samples, is easy to implement, and also provides diffusivities of the free analyte and the formed complex. The technique is based on signal analysis of temporal variances obtained for pressure driven flows in micrometer sized fused silica capillaries.

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    Cite this: J. Am. Chem. Soc. 2010, 132, 12, 4070–4071
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja100484d
    Published March 4, 2010
    Copyright © 2010 American Chemical Society
    Request reuse permissions

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