Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium ComplexesClick to copy article linkArticle link copied!
Abstract

MRI contrast agents providing very high relaxivity values can be obtained through the attachment of multiple gadolinium(III) complexes to the interior surfaces of genome-free viral capsids. In previous studies, the contrast enhancement was predicted to depend on the rigidity of the linker attaching the MRI agents to the protein surface. To test this hypothesis, a new set of Gd-hydroxypyridonate based MRI agents was prepared and attached to genetically introduced cysteine residues through flexible and rigid linkers. Greater contrast enhancements were seen for MRI agents that were attached via rigid linkers, validating the design concept and outlining a path for future improvements of nanoscale MRI contrast agents.
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- Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai. PEGylated Amphiphilic Gd-DOTA Backboned-Bound Branched Polymers as Magnetic Resonance Imaging Contrast Agents. Biomacromolecules 2023, 24
(12)
, 5998-6008. https://doi.org/10.1021/acs.biomac.3c00987
- Megan A. Kaster, Mikail D. Levasseur, Thomas G. W. Edwardson, Michael A. Caldwell, Daniela Hofmann, Giulia Licciardi, Giacomo Parigi, Claudio Luchinat, Donald Hilvert, Thomas J. Meade. Engineered Nonviral Protein Cages Modified for MR Imaging. ACS Applied Bio Materials 2023, 6
(2)
, 591-602. https://doi.org/10.1021/acsabm.2c00892
- Thomas G. W. Edwardson, Mikail D. Levasseur, Stephan Tetter, Angela Steinauer, Mao Hori, Donald Hilvert. Protein Cages: From Fundamentals to Advanced Applications. Chemical Reviews 2022, 122
(9)
, 9145-9197. https://doi.org/10.1021/acs.chemrev.1c00877
- Xiao-Zhen Li, Chong-Bin Tian, Qing-Fu Sun. Coordination-Directed Self-Assembly of Functional Polynuclear Lanthanide Supramolecular Architectures. Chemical Reviews 2022, 122
(6)
, 6374-6458. https://doi.org/10.1021/acs.chemrev.1c00602
- Pavankumar Janardhan Bhandari, Mullapudi Mohan Reddy, Kasuladevu Jegannadha Rao, Britto S. Sandanaraj. Rapid Chemical Synthesis of Self-Assembling Semi-Synthetic Proteins. The Journal of Organic Chemistry 2021, 86
(13)
, 8576-8589. https://doi.org/10.1021/acs.joc.1c00195
- Zhuo Wang, Lizhen He, Bingqing Liu, Li-Peng Zhou, Li-Xuan Cai, Shao-Jun Hu, Xiao-Zhen Li, Zhikai Li, Tianfeng Chen, Xiaopeng Li, Qing-Fu Sun. Coordination-Assembled Water-Soluble Anionic Lanthanide Organic Polyhedra for Luminescent Labeling and Magnetic Resonance Imaging. Journal of the American Chemical Society 2020, 142
(38)
, 16409-16419. https://doi.org/10.1021/jacs.0c07514
- Kevin M. Bond, Ioana L. Aanei, Matthew B. Francis, Martin F. Jarrold. Determination of Antibody Population Distributions for Virus-Antibody Conjugates by Charge Detection Mass Spectrometry. Analytical Chemistry 2020, 92
(1)
, 1285-1291. https://doi.org/10.1021/acs.analchem.9b04457
- He Hu, Hema Masarapu, Yuning Gu, Yifan Zhang, Xin Yu, Nicole F. Steinmetz. Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging. ACS Applied Materials & Interfaces 2019, 11
(20)
, 18213-18223. https://doi.org/10.1021/acsami.9b03956
- Estelle Godart, Augustin Long, Roselyne Rosas, Gilles Lemercier, Marion Jean, Sébastien Leclerc, Sabine Bouguet-Bonnet, Célia Godfrin, Laure-Lise Chapellet, Jean-Pierre Dutasta, Alexandre Martinez. High-Relaxivity Gd(III)–Hemicryptophane Complex. Organic Letters 2019, 21
(7)
, 1999-2003. https://doi.org/10.1021/acs.orglett.9b00081
- Madushani Dharmarwardana, André F. Martins, Zhuo Chen, Philip M. Palacios, Chance M. Nowak, Raymond P. Welch, Shaobo Li, Michael A. Luzuriaga, Leonidas Bleris, Brad S. Pierce, A. Dean Sherry, Jeremiah J. Gassensmith. Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor. Molecular Pharmaceutics 2018, 15
(8)
, 2973-2983. https://doi.org/10.1021/acs.molpharmaceut.8b00262
- Zhuo Chen, Stefanie D. Boyd, Jenifer S. Calvo, Kyle W. Murray, Galo L. Mejia, Candace E. Benjamin, Raymond P. Welch, Duane D. Winkler, Gabriele Meloni, Sheena D’Arcy, and Jeremiah J. Gassensmith . Fluorescent Functionalization across Quaternary Structure in a Virus-like Particle. Bioconjugate Chemistry 2017, 28
(9)
, 2277-2283. https://doi.org/10.1021/acs.bioconjchem.7b00305
- Ioana L. Aanei, Adel M. ElSohly, Michelle E. Farkas, Chawita Netirojjanakul, Melanie Regan, Stephanie Taylor Murphy, James P. O’Neil, Youngho Seo, and Matthew B. Francis . Biodistribution of Antibody-MS2 Viral Capsid Conjugates in Breast Cancer Models. Molecular Pharmaceutics 2016, 13
(11)
, 3764-3772. https://doi.org/10.1021/acs.molpharmaceut.6b00566
- Atanu Jana, Bethany J. Crowston, Jonathan R. Shewring, Luke K. McKenzie, Helen E. Bryant, Stanley W. Botchway, Andrew D. Ward, Angelo J. Amoroso, Elizabeth Baggaley, and Michael D. Ward . Heteronuclear Ir(III)–Ln(III) Luminescent Complexes: Small-Molecule Probes for Dual Modal Imaging and Oxygen Sensing. Inorganic Chemistry 2016, 55
(11)
, 5623-5633. https://doi.org/10.1021/acs.inorgchem.6b00702
- Adel M. ElSohly, Chawita Netirojjanakul, Ioana L. Aanei, Astraea Jager, Sean C. Bendall, Michelle E. Farkas, Garry P. Nolan, and Matthew B. Francis . Synthetically Modified Viral Capsids as Versatile Carriers for Use in Antibody-Based Cell Targeting. Bioconjugate Chemistry 2015, 26
(8)
, 1590-1596. https://doi.org/10.1021/acs.bioconjchem.5b00226
- Matthew W. Rotz, Kayla S. B. Culver, Giacomo Parigi, Keith W. MacRenaris, Claudio Luchinat, Teri W. Odom, and Thomas J. Meade . High Relaxivity Gd(III)–DNA Gold Nanostars: Investigation of Shape Effects on Proton Relaxation. ACS Nano 2015, 9
(3)
, 3385-3396. https://doi.org/10.1021/nn5070953
- Andy H. Hung, Robert J. Holbrook, Matthew W. Rotz, Cameron J. Glasscock, Nikhita D. Mansukhani, Keith W. MacRenaris, Lisa M. Manus, Matthew C. Duch, Kevin T. Dam, Mark C. Hersam, and Thomas J. Meade . Graphene Oxide Enhances Cellular Delivery of Hydrophilic Small Molecules by Co-incubation. ACS Nano 2014, 8
(10)
, 10168-10177. https://doi.org/10.1021/nn502986e
- Deju Ye, Prachi Pandit, Paul Kempen, Jianguo Lin, Liqin Xiong, Robert Sinclair, Brian Rutt, and Jianghong Rao . Redox-Triggered Self-Assembly of Gadolinium-Based MRI Probes for Sensing Reducing Environment. Bioconjugate Chemistry 2014, 25
(8)
, 1526-1536. https://doi.org/10.1021/bc500254g
- Marie C. Heffern, Lauren M. Matosziuk, and Thomas J. Meade . Lanthanide Probes for Bioresponsive Imaging. Chemical Reviews 2014, 114
(8)
, 4496-4539. https://doi.org/10.1021/cr400477t
- Junseon Min, Hoesu Jung, Hyun-Hee Shin, Gyunggoo Cho, HyungJoon Cho, and Sebyung Kang . Implementation of P22 Viral Capsids As Intravascular Magnetic Resonance T1 Contrast Conjugates via Site-Selective Attachment of Gd(III)-Chelating Agents. Biomacromolecules 2013, 14
(7)
, 2332-2339. https://doi.org/10.1021/bm400461j
- Mo Sun, Heng-Yi Zhang, Bo-Wen Liu, and Yu Liu . Construction of a Supramolecular Polymer by Bridged Bis(permethyl-β-cyclodextrin)s with Porphyrins and Its Highly Efficient Magnetic Resonance Imaging. Macromolecules 2013, 46
(11)
, 4268-4275. https://doi.org/10.1021/ma400806s
- Dustin P. Patterson, Agnieszka Rynda-Apple, Ann L. Harmsen, Allen G. Harmsen, and Trevor Douglas . Biomimetic Antigenic Nanoparticles Elicit Controlled Protective Immune Response to Influenza. ACS Nano 2013, 7
(4)
, 3036-3044. https://doi.org/10.1021/nn4006544
- Stacy L. Capehart, Michael P. Coyle, Jeff E. Glasgow, and Matthew B. Francis . Controlled Integration of Gold Nanoparticles and Organic Fluorophores Using Synthetically Modified MS2 Viral Capsids. Journal of the American Chemical Society 2013, 135
(8)
, 3011-3016. https://doi.org/10.1021/ja3078472
- Shefah Qazi, Lars O. Liepold, Md Joynal Abedin, Ben Johnson, Peter Prevelige, Joseph A. Frank, and Trevor Douglas . P22 Viral Capsids as Nanocomposite High-Relaxivity MRI Contrast Agents. Molecular Pharmaceutics 2013, 10
(1)
, 11-17. https://doi.org/10.1021/mp300208g
- Eszter Boros, Miloslav Polasek, Zhaoda Zhang, and Peter Caravan . Gd(DOTAla): A Single Amino Acid Gd-complex as a Modular Tool for High Relaxivity MR Contrast Agent Development. Journal of the American Chemical Society 2012, 134
(48)
, 19858-19868. https://doi.org/10.1021/ja309187m
- Jeff E. Glasgow, Stacy L. Capehart, Matthew B. Francis, and Danielle Tullman-Ercek . Osmolyte-Mediated Encapsulation of Proteins inside MS2 Viral Capsids. ACS Nano 2012, 6
(10)
, 8658-8664. https://doi.org/10.1021/nn302183h
- Lisa M. Manus, Renee C. Strauch, Andy H. Hung, Amanda L. Eckermann, and Thomas J. Meade . Analytical Methods for Characterizing Magnetic Resonance Probes. Analytical Chemistry 2012, 84
(15)
, 6278-6287. https://doi.org/10.1021/ac300527z
- Alexandra K. Duncan, Piper J. Klemm, Kenneth N. Raymond, and Christopher C. Landry . Silica Microparticles as a Solid Support for Gadolinium Phosphonate Magnetic Resonance Imaging Contrast Agents. Journal of the American Chemical Society 2012, 134
(19)
, 8046-8049. https://doi.org/10.1021/ja302183w
- Sunita Birara, Vinay Kumar Yadav, Abinash Kumar Jena, Sudipta Bhattacharyya, Ramesh K. Metre. Antimicrobial Potential of a Formazanate‐Based Mercury(II) Complex:
In Vitro
‐ and
In Silico
‐Based Insights. ChemPlusChem 2025, 90
(3)
https://doi.org/10.1002/cplu.202400696
- Pawel Kraj, Nathasha D. Hewagama, Trevor Douglas. Diffusion and molecular partitioning in hierarchically complex virus-like particles. Virology 2023, 580 , 50-60. https://doi.org/10.1016/j.virol.2023.01.012
- Niharika Keot, Manabendra Sarma. Computational insight into a mechanistic overview of water exchange kinetics and thermodynamic stabilities of bis and tris-aquated complexes of lanthanides. RSC Advances 2023, 13
(3)
, 1516-1529. https://doi.org/10.1039/D2RA05810C
- Yalini H. Wijesundara, Fabian C. Herbert, Sneha Kumari, Thomas Howlett, Shailendra Koirala, Orikeda Trashi, Ikeda Trashi, Noora M. Al-Kharji, Jeremiah J. Gassensmith. Rip it, stitch it, click it: A Chemist's guide to VLP manipulation. Virology 2022, 577 , 105-123. https://doi.org/10.1016/j.virol.2022.10.008
- Zheng-Bin Tang, Yu-Ming Guan, Zhe Zhang, Qixia Bai, Peiyang Su, Gang Chen, Liao-Yuan Yao, Liang-Huan Xu, Tun Wu, Guo-Hong Ning, Pingshan Wang, Ting-Zheng Xie. A giant cuboctahedron based on imidazolium-terpyridine spacer. Cell Reports Physical Science 2022, 3
(8)
, 100982. https://doi.org/10.1016/j.xcrp.2022.100982
- Imtiyaz Yousuf, Masrat Bashir, Farukh Arjmand, Sartaj Tabassum. Advancement of metal compounds as therapeutic and diagnostic metallodrugs: Current frontiers and future perspectives. Coordination Chemistry Reviews 2021, 445 , 214104. https://doi.org/10.1016/j.ccr.2021.214104
- Caner Cebeci, Burcu Ucar, Tayfun Acar, Ibrahim Erden. Colorimetric detection of hydrogen peroxide with gadolinium complex of phenylboronic acid functionalized 4,5-diazafluorene. Inorganica Chimica Acta 2021, 522 , 120386. https://doi.org/10.1016/j.ica.2021.120386
- Yasushi Yoshida, Mayu Kukita, Kazuki Omori, Takashi Mino, Masami Sakamoto. Iminophosphorane-mediated regioselective umpolung alkylation reaction of α-iminoesters. Organic & Biomolecular Chemistry 2021, 19
(20)
, 4551-4564. https://doi.org/10.1039/D1OB00596K
- Shengxiang Fu, Zhongyuan Cai, Hua Ai. Stimulus‐Responsive Nanoparticle Magnetic Resonance Imaging Contrast Agents: Design Considerations and Applications. Advanced Healthcare Materials 2021, 10
(5)
https://doi.org/10.1002/adhm.202001091
- Yuqi Wang, Jianhui Weng, Xidan Wen, Yuxuan Hu, Deju Ye. Recent advances in stimuli-responsive
in situ
self-assembly of small molecule probes for
in vivo
imaging of enzymatic activity. Biomaterials Science 2021, 9
(2)
, 406-421. https://doi.org/10.1039/D0BM00895H
- Richard A. Layfield. Lanthanides. 2021, 418-470. https://doi.org/10.1016/B978-0-08-102688-5.00057-X
- Qi-Yuan Yang, Qian-Qian Cao, Yun-Liang Zhang, Xiao-Fang Xu, Cai-Xing Deng, Rajesh Kumar, Xiao-Min Zhu, Xiu-Jian Wang, Hong Liang, Zhen-Feng Chen. Synthesis, structural characterization and antitumor activity of six rare earth metal complexes with 8-hydroxyquinoline derivatives. Journal of Inorganic Biochemistry 2020, 211 , 111175. https://doi.org/10.1016/j.jinorgbio.2020.111175
- Jabadurai Jayapaul, Leif Schröder. Molecular Sensing with Host Systems for Hyperpolarized 129Xe. Molecules 2020, 25
(20)
, 4627. https://doi.org/10.3390/molecules25204627
- Kehan Xu, Na Xu, Beibei Zhang, Weijun Tang, Yun Ding, Aiguo Hu. Gadolinium complexes of macrocyclic diethylenetriamine-
N
-oxide pentaacetic acid-bisamide as highly stable MRI contrast agents with high relaxivity. Dalton Transactions 2020, 49
(26)
, 8927-8932. https://doi.org/10.1039/D0DT00248H
- Imtiyaz Yousuf, Masrat Bashir. Metallodrugs in Medicine. 2020, 1-39. https://doi.org/10.1002/9781119640868.ch1
- Minfeng Huo, Liying Wang, Yu Chen, Jianlin Shi. Nanomaterials/microorganism-integrated microbiotic nanomedicine. Nano Today 2020, 32 , 100854. https://doi.org/10.1016/j.nantod.2020.100854
- Thomas J. Clough, Nicoleta Baxan, Emma J. Coakley, Charlotte Rivas, Lan Zhao, Isabelle Leclerc, Aida Martinez-Sanchez, Guy A. Rutter, Nicholas J. Long. Synthesis and
in vivo
behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas. Dalton Transactions 2020, 49
(15)
, 4732-4740. https://doi.org/10.1039/D0DT00332H
- Hamilton Lee, Arezoo Shahrivarkevishahi, Jenica L. Lumata, Michael A. Luzuriaga, Laurel M. Hagge, Candace E. Benjamin, Olivia R. Brohlin, Christopher R. Parish, Hamid R. Firouzi, Steven O. Nielsen, Lloyd L. Lumata, Jeremiah J. Gassensmith. Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents. Chemical Science 2020, 11
(8)
, 2045-2050. https://doi.org/10.1039/C9SC05510J
- Candace Benjamin, Olivia Brohlin, Arezoo Shahrivarkevishahi, Jeremiah J. Gassensmith. Virus like particles: fundamental concepts, biological interactions, and clinical applications. 2020, 153-174. https://doi.org/10.1016/B978-0-12-816662-8.00011-4
- Amy C. Maguire, Vikas Kumar, Stephen J. Connon. Highly chemoselective, sterically sensitive NHC-catalysed amine acylation with pyridil. Chemical Communications 2019, 55
(90)
, 13526-13529. https://doi.org/10.1039/C9CC06937B
- Febrina Sandra, Nisar Ul Khaliq, Anwar Sunna, Andrew Care. Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging. Nanomaterials 2019, 9
(9)
, 1329. https://doi.org/10.3390/nano9091329
- He Hu, Qi Yang, Simona Baroni, Hong Yang, Silvio Aime, Nicole F. Steinmetz. Polydopamine-decorated tobacco mosaic virus for photoacoustic/magnetic resonance bimodal imaging and photothermal cancer therapy. Nanoscale 2019, 11
(19)
, 9760-9768. https://doi.org/10.1039/C9NR02065A
- Volodymyr Malytskyi, Juliette Moreau, Maité Callewaert, Guillaume Rigaux, Cyril Cadiou, Sophie Laurent, Françoise Chuburu. Organic nanoparticles and gadolinium chelates: seeking hypersensitive probes for T1 magnetic resonance imaging. 2019, 425-476. https://doi.org/10.1016/B978-0-12-818433-2.00013-3
- Yu-I Hsu, Atsushi Mahara, Tetsuji Yamaoka. Influence of Molecular Mobility on Contrast Efficiency of Branched Polyethylene Glycol Contrast Agent. Contrast Media & Molecular Imaging 2018, 2018 , 1-8. https://doi.org/10.1155/2018/1259325
- Weiqiao Qian, Qin Zhu, Bing Duan, Weijun Tang, Yuan Yuan, Aiguo Hu. Electrostatic self-assembled nanoparticles based on spherical polyelectrolyte brushes for magnetic resonance imaging. Dalton Transactions 2018, 47
(23)
, 7663-7668. https://doi.org/10.1039/C8DT01069B
- Atsushi Mahara, Jun‐ichiro Enmi, Yu‐I Hsu, Naoki Kobayashi, Yoshiaki Hirano, Hidehiro Iida, Tetsuji Yamaoka. Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self‐Assembled Branched Polyethylene Glycol–Gd Contrast Agent. Macromolecular Bioscience 2018, 18
(5)
https://doi.org/10.1002/mabi.201700391
- Yuqi Wang, Ruibing An, Zhiliang Luo, Deju Ye. Firefly Luciferin‐Inspired Biocompatible Chemistry for Protein Labeling and In Vivo Imaging. Chemistry – A European Journal 2018, 24
(22)
, 5707-5722. https://doi.org/10.1002/chem.201704349
- Ioana L. Aanei, Jeff E. Glasgow, Stacy L. Capehart, Matthew B. Francis. Encapsulation of Negatively Charged Cargo in MS2 Viral Capsids. 2018, 303-317. https://doi.org/10.1007/978-1-4939-7808-3_21
- Ioana L. Aanei, Matthew B. Francis. Dual Surface Modification of Genome-Free MS2 Capsids for Delivery Applications. 2018, 629-642. https://doi.org/10.1007/978-1-4939-7808-3_40
- Adel M. ElSohly, Chawita Netirojjanakul, Matthew B. Francis. Antibody Modification of p-Aminophenylalanine-Containing Proteins. 2018, 195-201. https://doi.org/10.1007/978-1-4939-7893-9_15
- Bongseo Choi, Hansol Kim, Hyukjun Choi, Sebyung Kang. Protein Cage Nanoparticles as Delivery Nanoplatforms. 2018, 27-43. https://doi.org/10.1007/978-981-13-0445-3_2
- Takahito Kawano, Masaharu Murata, Jeong-Hun Kang, Jing Shu Piao, Sayoko Narahara, Fuminori Hyodo, Nobuhito Hamano, Jie Guo, Susumu Oguri, Kenoki Ohuchida, Makoto Hashizume. Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent. Biomaterials 2018, 152 , 37-46. https://doi.org/10.1016/j.biomaterials.2017.10.029
- Arianna Rossetti, Stefano Landoni, Fiorella Meneghetti, Carlo Castellano, Matteo Mori, Greta Colombo Dugoni, Alessandro Sacchetti. Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(
ii
)-catalyzed asymmetric Henry reaction. New Journal of Chemistry 2018, 42
(14)
, 12072-12081. https://doi.org/10.1039/C8NJ01930D
- Sergei V. Kochetkov, Alexander S. Kucherenko, Sergei G. Zlotin. Asymmetric synthesis of warfarin and its analogs catalyzed by
C
2
-symmetric squaramide-based primary diamines. Organic & Biomolecular Chemistry 2018, 16
(35)
, 6423-6429. https://doi.org/10.1039/C8OB01576G
- Rugmani Meenambal, Pavan Poojar, Sairam Geethanath, S. Kannan. Substitutional limit of gadolinium in
β
‐tricalcium phosphate and its magnetic resonance imaging characteristics. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2017, 105
(8)
, 2545-2552. https://doi.org/10.1002/jbm.b.33775
- Giovanni B. Giovenzana, Luciano Lattuada, Roberto Negri. Recent Advances in Bifunctional Paramagnetic Chelates for MRI. Israel Journal of Chemistry 2017, 57
(9)
, 825-832. https://doi.org/10.1002/ijch.201700028
- Jan Reutzel, Timm M. Diogo, Armin Geyer. Reversible Folding of a β‐Hairpin Peptide by a Metal‐Chelating Amino Acid. Chemistry – A European Journal 2017, 23
(35)
, 8450-8456. https://doi.org/10.1002/chem.201700698
- Qin Zhu, Zhenyu Yuan, Weiqiao Qian, Yuanyuan Li, Zhiqiang Qiu, Weijun Tang, Jie Wang, Yun Ding, Aiguo Hu. Spherical Polyelectrolyte Brushes as a Novel Platform for Paramagnetic Relaxation Enhancement and Passive Tumor Targeting. Advanced Healthcare Materials 2017, 6
(12)
https://doi.org/10.1002/adhm.201700071
- Michael D. Glidden, John F. Edelbrock, Amy M. Wen, Sourabh Shukla, Yingfang Ma, Roger H. French, Jonathan K. Pokorski, Nicole F. Steinmetz. Application of Engineered Viral Nanoparticles in Materials and Medicine. 2017, 631-710. https://doi.org/10.1002/9783527683451.ch18
- Duygu Ayd.n TekdasC, Devrim Atilla, Vefa Ahsen, AysCe Gul Gurek. 11 Tetrapyrrole-based theranostic combinations of photodynamic action and magnetic resonance imaging. 2017, 211-248. https://doi.org/10.1201/9781315278179-12
- J.A. Peters, K. Djanashvili, C.F.G.C. Geraldes. Imaging With Lanthanides. 2017, 261-293. https://doi.org/10.1016/B978-0-12-409547-2.12621-6
- Simin Zhang, Yanmei Zheng, Ding-Yi Fu, Wen Li, Yuqing Wu, Bao Li, Lixin Wu. Biocompatible supramolecular dendrimers bearing a gadolinium-substituted polyanionic core for MRI contrast agents. Journal of Materials Chemistry B 2017, 5
(22)
, 4035-4043. https://doi.org/10.1039/C6TB03263J
- Q. Guo, G. C. Thomas, K. J. Woycechowsky. Reversible loading of thiol-modified curcumin in an engineered protein capsid. RSC Advances 2017, 7
(55)
, 34676-34686. https://doi.org/10.1039/C7RA05890J
- Sylvie L. Pailloux, Sean Nguyen, Stephanie Zhou, Marisa E. Hom, Michelle N. Keyser, Danil Smiles, Kenneth N. Raymond. Synthesis and Chemical Reactivity of a 6‐Me‐3,2‐Hydroxypyridinone Dithiazolide with Primary Amines: A route to New Hexadentate Chelators for Hard Metal(III) Ions. Journal of Heterocyclic Chemistry 2016, 53
(4)
, 1065-1073. https://doi.org/10.1002/jhet.2372
- Zhuo Chen, Na Li, Shaobo Li, Madushani Dharmarwardana, Anna Schlimme, Jeremiah J Gassensmith. Viral chemistry: the chemical functionalization of viral architectures to create new technology. WIREs Nanomedicine and Nanobiotechnology 2016, 8
(4)
, 512-534. https://doi.org/10.1002/wnan.1379
- J.A. Peters, K. Djanashvili. An Introduction to MRI Contrast Agents. 2016https://doi.org/10.1016/B978-0-12-803581-8.01826-9
- Amy M. Wen, Nicole F. Steinmetz. Design of virus-based nanomaterials for medicine, biotechnology, and energy. Chemical Society Reviews 2016, 45
(15)
, 4074-4126. https://doi.org/10.1039/C5CS00287G
- Martin G. Nussbaumer, Christoph Bisig, Nico Bruns. Using the dendritic polymer PAMAM to form gold nanoparticles in the protein cage thermosome. Chemical Communications 2016, 52
(69)
, 10537-10539. https://doi.org/10.1039/C6CC04739D
- Martin Rother, Martin G. Nussbaumer, Kasper Renggli, Nico Bruns. Protein cages and synthetic polymers: a fruitful symbiosis for drug delivery applications, bionanotechnology and materials science. Chemical Society Reviews 2016, 45
(22)
, 6213-6249. https://doi.org/10.1039/C6CS00177G
- YoungKyu Song, Young Ji Kang, Hoesu Jung, Hansol Kim, Sebyung Kang, HyungJoon Cho. Lumazine Synthase Protein Nanoparticle-Gd(III)-DOTA Conjugate as a T1 contrast agent for high-field MRI. Scientific Reports 2015, 5
(1)
https://doi.org/10.1038/srep15656
- Sourabh Shukla, Nicole F. Steinmetz. Virus‐based nanomaterials as positron emission tomography and magnetic resonance contrast agents: from technology development to translational medicine. WIREs Nanomedicine and Nanobiotechnology 2015, 7
(5)
, 708-721. https://doi.org/10.1002/wnan.1335
- Lei Zhang, Yu Sun, Le Chang, Tingting Jia, Guojing Wang, Rui Zhang, Kuo Zhang, Jinming Li. A novel method to produce armored double-stranded DNA by encapsulation of MS2 viral capsids. Applied Microbiology and Biotechnology 2015, 99
(17)
, 7047-7057. https://doi.org/10.1007/s00253-015-6664-4
- Rindia M. Putri, Jeroen J. L. M. Cornelissen, Melissa S. T. Koay. Self‐Assembled Cage‐Like Protein Structures. ChemPhysChem 2015, 16
(5)
, 911-918. https://doi.org/10.1002/cphc.201402722
- L. Prodi, E. Rampazzo, F. Rastrelli, A. Speghini, N. Zaccheroni. Imaging agents based on lanthanide doped nanoparticles. Chemical Society Reviews 2015, 44
(14)
, 4922-4952. https://doi.org/10.1039/C4CS00394B
- Michael A. Bruckman, Lauren N. Randolph, Neetu M. Gulati, Phoebe L. Stewart, Nicole F. Steinmetz. Silica-coated Gd(DOTA)-loaded protein nanoparticles enable magnetic resonance imaging of macrophages. Journal of Materials Chemistry B 2015, 3
(38)
, 7503-7510. https://doi.org/10.1039/C5TB01014D
- Mo Sun, Heng-Yi Zhang, Qian Zhao, Xin-Yue Hu, Li-Hua Wang, Bo-Wen Liu, Yu Liu. A supramolecular brush polymer via the self-assembly of bridged tris(β-cyclodextrin) with a porphyrin derivative and its magnetic resonance imaging. Journal of Materials Chemistry B 2015, 3
(41)
, 8170-8179. https://doi.org/10.1039/C5TB01537E
- Divya Agrawal, Christian P. R. Hackenberger. Chemoselective Protein Modifications: Methods and Applications for the Functionalization of Viral Capsids. 2014, 299-348. https://doi.org/10.1002/9781118870068.ch9
- Amy M. Wen, Choi‐Fong Cho, John D. Lewis, Nicole F. Steinmetz. The Application of Plant Viral Nanoparticles in Tissue‐Specific Imaging. 2014, 401-427. https://doi.org/10.1002/9781118873151.ch14
- François Guérard, Geoffrey L. Ray, Martin W. Brechbiel. MRI with Gadolinium‐Based Nanoparticles. 2014, 223-262. https://doi.org/10.1002/9781118873151.ch8
- Yingying Chen, Qin Zhu, Xinghui Cui, Weijun Tang, Heng Yang, Yuan Yuan, Aiguo Hu. Preparation of Highly Efficient MRI Contrast Agents through Complexation of Cationic Gd
III
‐Containing Metallosurfactant with Biocompatible Polyelectrolytes. Chemistry – A European Journal 2014, 20
(39)
, 12477-12482. https://doi.org/10.1002/chem.201402530
- Danielle Rand, Masaki Uchida, Trevor Douglas, Christoph Rose-Petruck. X-ray spatial frequency heterodyne imaging of protein-based nanobubble contrast agents. Optics Express 2014, 22
(19)
, 23290. https://doi.org/10.1364/OE.22.023290
- Jeff Glasgow, Danielle Tullman-Ercek. Production and applications of engineered viral capsids. Applied Microbiology and Biotechnology 2014, 98
(13)
, 5847-5858. https://doi.org/10.1007/s00253-014-5787-3
- Jealemy Galindo Millán, Melanie Brasch, Eduardo Anaya-Plaza, Andrés de la Escosura, Aldrik H. Velders, David N. Reinhoudt, Tomás Torres, Melissa S.T. Koay, Jeroen J.L.M. Cornelissen. Self-assembly triggered by self-assembly: Optically active, paramagnetic micelles encapsulated in protein cage nanoparticles. Journal of Inorganic Biochemistry 2014, 136 , 140-146. https://doi.org/10.1016/j.jinorgbio.2014.01.004
- Alexey V. Laptev, Alexey Yu. Lukin, Nikolay E. Belikov, Olga V. Demina, Andrey A. Khodonov, Vitalii I. Shvets. New maleimide spirobenzopyran derivatives as photochromic labels for macromolecules with sulfhydryl groups. Mendeleev Communications 2014, 24
(4)
, 245-246. https://doi.org/10.1016/j.mencom.2014.06.020
- Allie C. Obermeyer, Stacy L. Capehart, John B. Jarman, Matthew B. Francis, . Multivalent Viral Capsids with Internal Cargo for Fibrin Imaging. PLoS ONE 2014, 9
(6)
, e100678. https://doi.org/10.1371/journal.pone.0100678
- Krishnan K. Palaniappan, Matthew B. Francis, Alexander Pines, David E. Wemmer. Molecular Sensing Using Hyperpolarized Xenon NMR Spectroscopy. Israel Journal of Chemistry 2014, 54
(1-2)
, 104-112. https://doi.org/10.1002/ijch.201300128
- Akhila N. W. Kuda-Wedagedara, Matthew J. Allen. Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths. The Analyst 2014, 139
(18)
, 4401-4410. https://doi.org/10.1039/C4AN00990H
- Xiao-xia Song, Xian-zhu Xu, Hong-ping Wan, Qun Tang. Development of biocompatible nanocubes as a T
1
-contrast enhancer for MR imaging of primary and metastatic liver cancer. RSC Adv. 2014, 4
(98)
, 55003-55009. https://doi.org/10.1039/C4RA09554E
- Michael A Bruckman, Xin Yu, Nicole F Steinmetz. Engineering Gd-loaded nanoparticles to enhance MRI sensitivity via
T
1
shortening. Nanotechnology 2013, 24
(46)
, 462001. https://doi.org/10.1088/0957-4484/24/46/462001
- Jürgen Schatz, Daniel Schühle. Supramolecular Metal Complexes for Imaging and Radiotherapy. 2013, 300-330. https://doi.org/10.1039/9781849737821-00300
- Guohai Liang, Lili Cao, Hui Chen, Zhengyong Zhang, Song Zhang, Shaoning Yu, Xianrong Shen, Jilie Kong. Ultrasmall gadolinium hydrated carbonate nanoparticle: an advanced T
1
MRI contrast agent with large longitudinal relaxivity. J. Mater. Chem. B 2013, 1
(5)
, 629-638. https://doi.org/10.1039/C2TB00243D
- Abdolrasoul Soleimani, Francisco Martínez, Vasiliki Economopoulos, Paula J. Foster, Timothy J. Scholl, Elizabeth R. Gillies. Polymer cross-linking: a nanogel approach to enhancing the relaxivity of MRI contrast agents. J. Mater. Chem. B 2013, 1
(7)
, 1027-1034. https://doi.org/10.1039/C2TB00352J
- Eric M. Gale, Nathaniel Kenton, Peter Caravan. [Gd(CyPic3A)(H2O)2]−: a stable, bis(aquated) and high-relaxivity Gd(iii) complex. Chemical Communications 2013, 49
(73)
, 8060. https://doi.org/10.1039/c3cc44116d
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