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Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure

† Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan.
‡ Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan
§ CREST, Japan Science and Technology Corporation (JST), Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
J. Am. Chem. Soc., 2012, 134 (6), pp 2852–2855
DOI: 10.1021/ja2074856
Publication Date (Web): January 26, 2012
Copyright © 2012 American Chemical Society
Cite this:J. Am. Chem. Soc.  134, 6, 2852-2855

Abstract

Abstract Image

A transcription regulation system initiated by DNA nanostructure changes was designed and constructed. Using the toehold system, specific DNA strands induced the opening of the tubular structure. A transcription product from the purified tube-attached dsDNA template was observed by addition of DNA strands that were specific for opening the tubular structure.

Experimental procedures, sequences of oligonucleotides, and additional AFM images. This material is available free of charge via the Internet at http://pubs.acs.org.

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Article Views: 1,707 Times
Received 9 August 2011
Published online 26 January 2012
Published in print 15 February 2012
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