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Copper-Catalyzed Alkene Arylation with Diaryliodonium Salts
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    Copper-Catalyzed Alkene Arylation with Diaryliodonium Salts
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    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2012, 134, 26, 10773–10776
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    https://doi.org/10.1021/ja3039807
    Published June 19, 2012
    Copyright © 2012 American Chemical Society

    Abstract

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    Alkenes and arenes represent two classes of feedstock compounds whose union has fundamental importance to synthetic organic chemistry. We report a new approach to alkene arylation using diaryliodonium salts and Cu catalysis. Using a range of simple alkenes, we have shown that the product outcomes differ significantly from those commonly obtained by the Heck reaction. We have used these insights to develop a number of new tandem and cascade reactions that transform readily available alkenes into complex arylated products that may have broad applications in chemical synthesis.

    Copyright © 2012 American Chemical Society

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    Cite this: J. Am. Chem. Soc. 2012, 134, 26, 10773–10776
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    https://doi.org/10.1021/ja3039807
    Published June 19, 2012
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