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Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions

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    Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions
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    † Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    ‡ University of Bordeaux, IINS, CNRS, UMR 5297, F-33000 Bordeaux, France
    § CNRS, IINS, UMR 5297, F-33000 Bordeaux, France
    [email protected]
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2013, 135, 12, 4580–4583
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    https://doi.org/10.1021/ja309870q
    Published March 8, 2013
    Copyright © 2013 American Chemical Society
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    Abstract

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    We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.

    Copyright © 2013 American Chemical Society

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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2013, 135, 12, 4580–4583
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja309870q
    Published March 8, 2013
    Copyright © 2013 American Chemical Society
    Request reuse permissions

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