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Rapid Heteronuclear Single Quantum Correlation NMR Spectra at Natural Abundance

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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2014, 136, 4, 1242-1245
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    Rapid Heteronuclear Single Quantum Correlation NMR Spectra at Natural Abundance
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    Institut für Organische Chemie and Institut für Biologische Grenzflächen, Karlsruher Institut für Technologie (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2014, 136, 4, 1242–1245
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    https://doi.org/10.1021/ja411588d
    Published January 13, 2014
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    Abstract

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    A novel NMR experiment, the so-called ASAP-HSQC, is introduced that allows the detection of heteronuclear one-bond correlations in less than 30 s on small molecules at natural abundance without compromises in sweep width, resolution or spectral quality. Equally, the experiment allows a significant increase in digital resolution or a moderate senstitivity enhancement in the same overall experiment time compared to a conventional HSQC. The gain is a consequence of keeping all unused proton magnetization along z during acquisition, so that the previously reported ASAP and ALSOFAST approaches can be transferred from HMQC to HSQC-type experiments. Next to basic and broadband pulse sequences, a characterization of the sequence with respect to minimum measurement time, sensitivity gain, and advantages in resolution compared to state-of-the-art experiments is given.

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    Cite this: J. Am. Chem. Soc. 2014, 136, 4, 1242–1245
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    https://doi.org/10.1021/ja411588d
    Published January 13, 2014
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