ACS Publications. Most Trusted. Most Cited. Most Read
Remotely Triggered Liposome Release by Near-Infrared Light Absorption via Hollow Gold Nanoshells

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2008, 130, 26, 8175-8177
    Communication

    Remotely Triggered Liposome Release by Near-Infrared Light Absorption via Hollow Gold Nanoshells
    Click to copy article linkArticle link copied!

    View Author Information
    Department of Chemical Engineering and Department of Chemistry, University of California, Santa Barbara, California 93106, and Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030
    [email protected]
    †Department of Chemical Engineering, University of California, Santa Barbara.
    ‡Department of Chemistry, University of California, Santa Barbara.
    §Baylor College of Medicine.
    Other Access OptionsSupporting Information (1)

    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2008, 130, 26, 8175–8177
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja802656d
    Published June 11, 2008
    Copyright © 2008 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    An elusive goal for systemic drug delivery is to provide both spatial and temporal control of drug release. Liposomes have been evaluated as drug delivery vehicles for decades, but their clinical significance has been limited by slow release or poor availability of the encapsulated drug. Here we show that near-complete liposome release can be initiated within seconds by irradiating hollow gold nanoshells (HGNs) with a near-infrared (NIR) pulsed laser. Our findings reveal that different coupling methods such as having the HGNs tethered to, encapsulated within, or suspended freely outside the liposomes, all triggered liposome release but with different levels of efficiency. For the underlying content release mechanism, our experiments suggest that the microbubble formation and collapse due to the rapid temperature increase of the HGN is responsible for liposome disruption, as evidenced by the formation of solid gold particles after the NIR irradiation and the coincidence of a laser power threshold for both triggered release and pressure fluctuations in the solution associated with cavitation. These effects are similar to those induced by ultrasound and our approach is conceptually analogous to the use of optically triggered nano-“sonicators” deep inside the body for drug delivery. We expect HGNs can be coupled with any nanocarriers to promote spatially and temporally controlled drug release. In addition, the capability of external HGNs to permeabilize lipid membranes can facilitate the cellular uptake of macromolecules including proteins and DNA and allow for promising applications in gene therapy.

    Copyright © 2008 American Chemical Society

    Subjects

    what are subjects

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    TEM image of HGNs, data showing pulsed NIR laser has no effect on the control solutions, absorption spectra of liposome/HGNs/CF complex exposed to pulsed laser, cryo-EM micrographs of tomographic imaging to demonstrate encapsulation and tethering, comparison of different methods of coupling HGNs to liposomes, as well as Materials and Methods. This material is available free of charge via the Internet at http://pubs.acs.org.

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!
    Citation Statements
    Explore this article's citation statements on scite.ai
    powered by  Scite

    This article is cited by 438 publications.

    1. Armin Hajipour Keyvani, Parizad Mohammadnejad, Hamidreza Pazoki-Toroudi, Irati Perez Gilabert, Tianjiao Chu, Bella B. Manshian, Stefaan J. Soenen, Beheshteh Sohrabi. Advancements in Cancer Treatment: Harnessing the Synergistic Potential of Graphene-Based Nanomaterials in Combination Therapy. ACS Applied Materials & Interfaces 2025, 17 (2) , 2756-2790. https://doi.org/10.1021/acsami.4c15536
    2. Tatsuya Shoji, Miyako Iida, Mitsuhiro Matsumoto, Ken-ichi Yuyama, Yasuyuki Tsuboi. Measurements of Spontaneous and External Stimuli Molecular Release Processes from a Single Optically Trapped Poly(lactic-co-glycolic) Acid Microparticle and a Liposome Containing Gold Nanospheres. Analytical Chemistry 2024, 96 (32) , 12957-12965. https://doi.org/10.1021/acs.analchem.3c05950
    3. Aleksandra Szwed-Georgiou, Przemysław Płociński, Barbara Kupikowska-Stobba, Mateusz M. Urbaniak, Paulina Rusek-Wala, Konrad Szustakiewicz, Paweł Piszko, Agnieszka Krupa, Monika Biernat, Małgorzata Gazińska, Mirosław Kasprzak, Katarzyna Nawrotek, Nuno Pereira Mira, Karolina Rudnicka. Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems. ACS Biomaterials Science & Engineering 2023, 9 (9) , 5222-5254. https://doi.org/10.1021/acsbiomaterials.3c00609
    4. Nagavendra Kommineni, Ruchita Chaudhari, João Conde, Sedef Tamburaci, Berivan Cecen, Pranjal Chandra, Rajendra Prasad. Engineered Liposomes in Interventional Theranostics of Solid Tumors. ACS Biomaterials Science & Engineering 2023, 9 (8) , 4527-4557. https://doi.org/10.1021/acsbiomaterials.3c00510
    5. Beatrix Peter, Nicolett Kanyo, Kinga Dora Kovacs, Viktor Kovács, Inna Szekacs, Béla Pécz, Kinga Molnár, Hideyuki Nakanishi, Istvan Lagzi, Robert Horvath. Glycocalyx Components Detune the Cellular Uptake of Gold Nanoparticles in a Size- and Charge-Dependent Manner. ACS Applied Bio Materials 2023, 6 (1) , 64-73. https://doi.org/10.1021/acsabm.2c00595
    6. Colin M. Basham, Stephanie Spittle, Joshua Sangoro, Joyce El-Beyrouthy, Eric Freeman, Stephen A. Sarles. Entrapment and Voltage-Driven Reorganization of Hydrophobic Nanoparticles in Planar Phospholipid Bilayers. ACS Applied Materials & Interfaces 2022, 14 (49) , 54558-54571. https://doi.org/10.1021/acsami.2c16677
    7. Igor V. Zhigaltsev, Yuen Yi C. Tam, Jayesh A. Kulkarni, Pieter R. Cullis. Synthesis and Characterization of Hybrid Lipid Nanoparticles Containing Gold Nanoparticles and a Weak Base Drug. Langmuir 2022, 38 (25) , 7858-7866. https://doi.org/10.1021/acs.langmuir.2c01221
    8. Andrew J. Burris, Quan Cheng. Plasmon-Enhanced Fluorescence in Electrospun Nanofibers of Polydiacetylenes Infused with Silver Nanoparticles. Langmuir 2021, 37 (51) , 14920-14929. https://doi.org/10.1021/acs.langmuir.1c02805
    9. Jin-Hu Dong, Yao Ma, Rong Li, Wen-Tao Zhang, Meng-Qian Zhang, Fan-Ning Meng, Kai Ding, Hai-Tao Jiang, Yong-Kuan Gong. Smart MSN-Drug-Delivery System for Tumor Cell Targeting and Tumor Microenvironment Release. ACS Applied Materials & Interfaces 2021, 13 (36) , 42522-42532. https://doi.org/10.1021/acsami.1c14189
    10. Hao Lv, Dongdong Xu, Lizhi Sun, Ben Liu. Surfactant Design Strategy for One-Pot Seedless Synthesis of Hollow Mesoporous AuAg Alloy Nanospheres. The Journal of Physical Chemistry Letters 2020, 11 (14) , 5777-5784. https://doi.org/10.1021/acs.jpclett.0c01577
    11. Ashish Trital, Weili Xue, Shengfu Chen. Development of a Negative-Biased Zwitterionic Polypeptide-Based Nanodrug Vehicle for pH-Triggered Cellular Uptake and Accelerated Drug Release. Langmuir 2020, 36 (26) , 7181-7189. https://doi.org/10.1021/acs.langmuir.0c00166
    12. Damien V. B. Batchelor, Radwa H. Abou-Saleh, P. Louise Coletta, James. R. McLaughlan, Sally A. Peyman, Stephen D. Evans. Nested Nanobubbles for Ultrasound-Triggered Drug Release. ACS Applied Materials & Interfaces 2020, 12 (26) , 29085-29093. https://doi.org/10.1021/acsami.0c07022
    13. Saikat Das, Robert A. Lazenby, Zheng Yuan, Ryan J. White, Yoonjee C. Park. Effect of Laser Irradiation on Reversibility and Drug Release of Light-Activatable Drug-Encapsulated Liposomes. Langmuir 2020, 36 (13) , 3573-3582. https://doi.org/10.1021/acs.langmuir.0c00215
    14. Giuseppe Nocito, Salvatore Petralia, Milo Malanga, Szabolcs Béni, Giovanna Calabrese, Rosalba Parenti, Sabrina Conoci, Salvatore Sortino. Biofriendly Route to Near-Infrared-Active Gold Nanotriangles and Nanoflowers through Nitric Oxide Photorelease for Photothermal Applications. ACS Applied Nano Materials 2019, 2 (12) , 7916-7923. https://doi.org/10.1021/acsanm.9b01925
    15. Zahraa S. Al-Ahmady, Roberto Donno, Arianna Gennari, Eric Prestat, Roberto Marotta, Aleksandr Mironov, Leon Newman, M. Jayne Lawrence, Nicola Tirelli, Marianne Ashford, Kostas Kostarelos. Enhanced Intraliposomal Metallic Nanoparticle Payload Capacity Using Microfluidic-Assisted Self-Assembly. Langmuir 2019, 35 (41) , 13318-13331. https://doi.org/10.1021/acs.langmuir.9b00579
    16. Zhe Zhang, Madison Taylor, Necati Kaval, Yoonjee C. Park. Phase-Transition Temperature of Gold-Nanorod-Coated Nanodroplets to Microbubbles by Pulsed Laser. The Journal of Physical Chemistry A 2019, 123 (23) , 4844-4852. https://doi.org/10.1021/acs.jpca.9b02566
    17. Beatrix Peter, Istvan Lagzi, Satoshi Teraji, Hideyuki Nakanishi, Laszlo Cervenak, Dániel Zámbó, András Deák, Kinga Molnár, Monika Truszka, Inna Szekacs, Robert Horvath. Interaction of Positively Charged Gold Nanoparticles with Cancer Cells Monitored by an in Situ Label-Free Optical Biosensor and Transmission Electron Microscopy. ACS Applied Materials & Interfaces 2018, 10 (32) , 26841-26850. https://doi.org/10.1021/acsami.8b01546
    18. Jessica T. Wen, Jenna M. Roper, Hideaki Tsutsui. Polydiacetylene Supramolecules: Synthesis, Characterization, and Emerging Applications. Industrial & Engineering Chemistry Research 2018, 57 (28) , 9037-9053. https://doi.org/10.1021/acs.iecr.8b00848
    19. Dyego Miranda, Nasi Li, Changning Li, Filip Stefanovic, G. Ekin Atilla-Gokcumen, Jonathan F. Lovell. Detection of Sunlight Exposure with Solar-Sensitive Liposomes that Capture and Release Food Dyes. ACS Applied Nano Materials 2018, 1 (6) , 2739-2747. https://doi.org/10.1021/acsanm.8b00435
    20. Sathiya Balasubramanian and Dhamodharan Raghavachari . Green Synthesis of Triangular Au Nanoplates: Role of Small Molecules Present in Bael Gum. ACS Sustainable Chemistry & Engineering 2017, 5 (11) , 10317-10326. https://doi.org/10.1021/acssuschemeng.7b02346
    21. Akram Abbasi, Keunhan Park, Arijit Bose, and Geoffrey D. Bothun . Near-Infrared Responsive Gold–Layersome Nanoshells. Langmuir 2017, 33 (21) , 5321-5327. https://doi.org/10.1021/acs.langmuir.7b01273
    22. Yingjie Wu, Kai Wang, Shuo Huang, Cangjie Yang, and Mingfeng Wang . Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect. ACS Applied Materials & Interfaces 2017, 9 (15) , 13602-13610. https://doi.org/10.1021/acsami.7b01016
    23. Changyou Zhan, Weiping Wang, Claudia Santamaria, Bruce Wang, Alina Rwei, Brian P. Timko, and Daniel S. Kohane . Ultrasensitive Phototriggered Local Anesthesia. Nano Letters 2017, 17 (2) , 660-665. https://doi.org/10.1021/acs.nanolett.6b03588
    24. Qian Liu, Changyou Zhan, and Daniel S. Kohane . Phototriggered Drug Delivery Using Inorganic Nanomaterials. Bioconjugate Chemistry 2017, 28 (1) , 98-104. https://doi.org/10.1021/acs.bioconjchem.6b00448
    25. Tatu Lajunen, Leena-Stiina Kontturi, Lauri Viitala, Moutusi Manna, Oana Cramariuc, Tomasz Róg, Alex Bunker, Timo Laaksonen, Tapani Viitala, Lasse Murtomäki, and Arto Urtti . Indocyanine Green-Loaded Liposomes for Light-Triggered Drug Release. Molecular Pharmaceutics 2016, 13 (6) , 2095-2107. https://doi.org/10.1021/acs.molpharmaceut.6b00207
    26. Lin Tang, Saina Yang, Fuxin Liang, Qian Wang, Xiaozhong Qu, and Zhenzhong Yang . Janus Nanocage toward Platelet Delivery. ACS Applied Materials & Interfaces 2016, 8 (19) , 12056-12062. https://doi.org/10.1021/acsami.6b03208
    27. Juewen Liu . Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications. Langmuir 2016, 32 (18) , 4393-4404. https://doi.org/10.1021/acs.langmuir.6b00493
    28. Zahraa Al-Ahmady and Kostas Kostarelos . Chemical Components for the Design of Temperature-Responsive Vesicles as Cancer Therapeutics. Chemical Reviews 2016, 116 (6) , 3883-3918. https://doi.org/10.1021/acs.chemrev.5b00578
    29. Changyou Zhan, Weiping Wang, James B. McAlvin, Shutao Guo, Brian P. Timko, Claudia Santamaria, and Daniel S. Kohane . Phototriggered Local Anesthesia. Nano Letters 2016, 16 (1) , 177-181. https://doi.org/10.1021/acs.nanolett.5b03440
    30. Fang Guo, Meng Yu, Jinping Wang, Fengping Tan, and Nan Li . Smart IR780 Theranostic Nanocarrier for Tumor-Specific Therapy: Hyperthermia-Mediated Bubble-Generating and Folate-Targeted Liposomes. ACS Applied Materials & Interfaces 2015, 7 (37) , 20556-20567. https://doi.org/10.1021/acsami.5b06552
    31. Cancan Xu, Yihui Huang, Jinglei Wu, Liping Tang, and Yi Hong . Triggerable Degradation of Polyurethanes for Tissue Engineering Applications. ACS Applied Materials & Interfaces 2015, 7 (36) , 20377-20388. https://doi.org/10.1021/acsami.5b06242
    32. Ricardo M. Gorgoll, Takuya Tsubota, Koji Harano, and Eiichi Nakamura . Cooperative Self-Assembly of Gold Nanoparticles on the Hydrophobic Surface of Vesicles in Water. Journal of the American Chemical Society 2015, 137 (24) , 7568-7571. https://doi.org/10.1021/jacs.5b03632
    33. Demosthenes P. Morales, Gary B. Braun, Alessia Pallaoro, Renwei Chen, Xiao Huang, Joseph A. Zasadzinski, and Norbert O. Reich . Targeted Intracellular Delivery of Proteins with Spatial and Temporal Control. Molecular Pharmaceutics 2015, 12 (2) , 600-609. https://doi.org/10.1021/mp500675p
    34. Eun-Kyung Lim, Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh, and Kwangyeol Lee . Nanomaterials for Theranostics: Recent Advances and Future Challenges. Chemical Reviews 2015, 115 (1) , 327-394. https://doi.org/10.1021/cr300213b
    35. Liang Cheng, Chao Wang, Liangzhu Feng, Kai Yang, and Zhuang Liu . Functional Nanomaterials for Phototherapies of Cancer. Chemical Reviews 2014, 114 (21) , 10869-10939. https://doi.org/10.1021/cr400532z
    36. Raghavendra Palankar, Bat-El Pinchasik, Boris N. Khlebtsov, Tatiana A. Kolesnikova, Helmuth Möhwald, Mathias Winterhalter, and Andre G. Skirtach . Nanoplasmonically-Induced Defects in Lipid Membrane Monitored by Ion Current: Transient Nanopores versus Membrane Rupture. Nano Letters 2014, 14 (8) , 4273-4279. https://doi.org/10.1021/nl500907k
    37. Hongjin Qiu, Bin Cui, Guangming Li, Jianhui Yang, Hongxia Peng, Yingsai Wang, Nini Li, Ruicheng Gao, Zhuguo Chang, and Yaoyu Wang . Novel Fe3O4@ZnO@mSiO2 Nanocarrier for Targeted Drug Delivery and Controllable Release with Microwave Irradiation. The Journal of Physical Chemistry C 2014, 118 (27) , 14929-14937. https://doi.org/10.1021/jp502820r
    38. Alaaldin M. Alkilany, Stefano P. Boulos, Samuel E. Lohse, Lucas B. Thompson, and Catherine J. Murphy . Homing Peptide-Conjugated Gold Nanorods: The Effect of Amino Acid Sequence Display on Nanorod Uptake and Cellular Proliferation. Bioconjugate Chemistry 2014, 25 (6) , 1162-1171. https://doi.org/10.1021/bc500174b
    39. Mathieu L. Viger, Wangzhong Sheng, Kim Doré, Ali H. Alhasan, Carl-Johan Carling, Jacques Lux, Caroline de Gracia Lux, Madeleine Grossman, Roberto Malinow, and Adah Almutairi . Near-Infrared-Induced Heating of Confined Water in Polymeric Particles for Efficient Payload Release. ACS Nano 2014, 8 (5) , 4815-4826. https://doi.org/10.1021/nn500702g
    40. Chunqiu Zhang, Shubin Jin, Shengliang Li, Xiangdong Xue, Juan Liu, Yuran Huang, Yonggang Jiang, Wei-Qiang Chen, Guozhang Zou, and Xing-Jie Liang . Imaging Intracellular Anticancer Drug Delivery by Self-Assembly Micelles with Aggregation-Induced Emission (AIE Micelles). ACS Applied Materials & Interfaces 2014, 6 (7) , 5212-5220. https://doi.org/10.1021/am5005267
    41. Simon J. Webb . Supramolecular Approaches to Combining Membrane Transport with Adhesion. Accounts of Chemical Research 2013, 46 (12) , 2878-2887. https://doi.org/10.1021/ar400032c
    42. Hyunwoo Kim, Duhwan Lee, Jinhwan Kim, Tae-il Kim, and Won Jong Kim . Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide. ACS Nano 2013, 7 (8) , 6735-6746. https://doi.org/10.1021/nn403096s
    43. Jianping Yang, Dengke Shen, Lei Zhou, Wei Li, Xiaomin Li, Chi Yao, Rui Wang, Ahmed Mohamed El-Toni, Fan Zhang, and Dongyuan Zhao . Spatially Confined Fabrication of Core–Shell Gold Nanocages@Mesoporous Silica for Near-Infrared Controlled Photothermal Drug Release. Chemistry of Materials 2013, 25 (15) , 3030-3037. https://doi.org/10.1021/cm401115b
    44. Ziyong Cheng, Ruitao Chai, Pingan Ma, Yunlu Dai, Xiaojiao Kang, Hongzhou Lian, Zhiyao Hou, Chunxia Li, and Jun Lin . Multiwalled Carbon Nanotubes and NaYF4:Yb3+/Er3+ Nanoparticle-Doped Bilayer Hydrogel for Concurrent NIR-Triggered Drug Release and Up-Conversion Luminescence Tagging. Langmuir 2013, 29 (30) , 9573-9580. https://doi.org/10.1021/la402036p
    45. Justin E. Silpe, Janine K. Nunes, Albert T. Poortinga, and Howard A. Stone . Generation of Antibubbles from Core–Shell Double Emulsion Templates Produced by Microfluidics. Langmuir 2013, 29 (28) , 8782-8787. https://doi.org/10.1021/la4009015
    46. Hee-Young Lee, Sun Hae Ra Shin, Ludmila L. Abezgauz, Sean A. Lewis, Aaron M. Chirsan, Dganit D. Danino, and Kyle J. M. Bishop . Integration of Gold Nanoparticles into Bilayer Structures via Adaptive Surface Chemistry. Journal of the American Chemical Society 2013, 135 (16) , 5950-5953. https://doi.org/10.1021/ja400225n
    47. Jaroslav Hanuš, Martin Ullrich, Jiří Dohnal, Mandeep Singh, and František Štěpánek . Remotely Controlled Diffusion from Magnetic Liposome Microgels. Langmuir 2013, 29 (13) , 4381-4387. https://doi.org/10.1021/la4000318
    48. Hongyu Chen, Thomas Moore, Bin Qi, Daniel C. Colvin, Erika K. Jelen, Dale A. Hitchcock, Jian He, O. Thompson Mefford, John C. Gore, Frank Alexis, and Jeffrey N. Anker . Monitoring pH-Triggered Drug Release from Radioluminescent Nanocapsules with X-ray Excited Optical Luminescence. ACS Nano 2013, 7 (2) , 1178-1187. https://doi.org/10.1021/nn304369m
    49. Xueqin An, Fan Zhan, and Yinyan Zhu . Smart Photothermal-Triggered Bilayer Phase Transition in AuNPs–Liposomes to Release Drug. Langmuir 2013, 29 (4) , 1061-1068. https://doi.org/10.1021/la304692h
    50. Petr Klán, Tomáš Šolomek, Christian G. Bochet, Aurélien Blanc, Richard Givens, Marina Rubina, Vladimir Popik, Alexey Kostikov, and Jakob Wirz . Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy. Chemical Reviews 2013, 113 (1) , 119-191. https://doi.org/10.1021/cr300177k
    51. Liang Gao, Jinbo Fei, Jie Zhao, Hong Li, Yue Cui, and Junbai Li . Hypocrellin-Loaded Gold Nanocages with High Two-Photon Efficiency for Photothermal/Photodynamic Cancer Therapy in Vitro. ACS Nano 2012, 6 (9) , 8030-8040. https://doi.org/10.1021/nn302634m
    52. Mingxian Liu, Lihua Gan, Liuhua Chen, Zijie Xu, Dazhang Zhu, Zhixian Hao, and Longwu Chen . Supramolecular Core–Shell Nanosilica@Liposome Nanocapsules for Drug Delivery. Langmuir 2012, 28 (29) , 10725-10732. https://doi.org/10.1021/la3021645
    53. Yuka Matsushita-Ishiodori and Takashi Ohtsuki . Photoinduced RNA Interference. Accounts of Chemical Research 2012, 45 (7) , 1039-1047. https://doi.org/10.1021/ar200227n
    54. Jingyu Huang, Kaliah S. Jackson, and Catherine J. Murphy . Polyelectrolyte Wrapping Layers Control Rates of Photothermal Molecular Release from Gold Nanorods. Nano Letters 2012, 12 (6) , 2982-2987. https://doi.org/10.1021/nl3007402
    55. Franck Thibaudau . Ultrafast Photothermal Release of DNA from Gold Nanoparticles. The Journal of Physical Chemistry Letters 2012, 3 (7) , 902-907. https://doi.org/10.1021/jz3001213
    56. Marites P. Melancon, Min Zhou, and Chun Li . Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles. Accounts of Chemical Research 2011, 44 (10) , 947-956. https://doi.org/10.1021/ar200022e
    57. Wafa’ T. Al-Jamal and Kostas Kostarelos . Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine. Accounts of Chemical Research 2011, 44 (10) , 1094-1104. https://doi.org/10.1021/ar200105p
    58. Chie Kojima, Yasutaka Watanabe, Hironori Hattori, and Takuya Iida . Design of Photosensitive Gold Nanoparticles for Biomedical Applications Based on Self-Consistent Optical Response Theory. The Journal of Physical Chemistry C 2011, 115 (39) , 19091-19095. https://doi.org/10.1021/jp206501h
    59. Ryan Huschka, Jorge Zuloaga, Mark W. Knight, Lisa V. Brown, Peter Nordlander, and Naomi J. Halas . Light-Induced Release of DNA from Gold Nanoparticles: Nanoshells and Nanorods. Journal of the American Chemical Society 2011, 133 (31) , 12247-12255. https://doi.org/10.1021/ja204578e
    60. Megumi Shintani, Ken Yoshida, Shun Sakuraba, Masaru Nakahara, and Nobuyuki Matubayasi . NMR-NOE and MD Simulation Study on Phospholipid Membranes: Dependence on Membrane Diameter and Multiple Time Scale Dynamics. The Journal of Physical Chemistry B 2011, 115 (29) , 9106-9115. https://doi.org/10.1021/jp204051f
    61. Yanjing Chen and Geoffrey D. Bothun . Cationic Gel-Phase Liposomes with “Decorated” Anionic SPIO Nanoparticles: Morphology, Colloidal, and Bilayer Properties. Langmuir 2011, 27 (14) , 8645-8652. https://doi.org/10.1021/la2011138
    62. Wei Cui, Xuemin Lu, Kun Cui, Jun Wu, Yen Wei, and Qinghua Lu . Fluorescent Nanoparticles of Chitosan Complex for Real-Time Monitoring Drug Release. Langmuir 2011, 27 (13) , 8384-8390. https://doi.org/10.1021/la200552k
    63. Abhiruchi Agarwal, Megan A. Mackey, Mostafa A. El-Sayed, and Ravi V. Bellamkonda . Remote Triggered Release of Doxorubicin in Tumors by Synergistic Application of Thermosensitive Liposomes and Gold Nanorods. ACS Nano 2011, 5 (6) , 4919-4926. https://doi.org/10.1021/nn201010q
    64. Alexander S. Urban, Tom Pfeiffer, Michael Fedoruk, Andrey A. Lutich, and Jochen Feldmann . Single-Step Injection of Gold Nanoparticles through Phospholipid Membranes. ACS Nano 2011, 5 (5) , 3585-3590. https://doi.org/10.1021/nn201132a
    65. Kolin C. Hribar, Myung Han Lee, Daeyeon Lee, and Jason A. Burdick . Enhanced Release of Small Molecules from Near-Infrared Light Responsive Polymer−Nanorod Composites. ACS Nano 2011, 5 (4) , 2948-2956. https://doi.org/10.1021/nn103575a
    66. Mangesh M. Kulkarni, Udo Greiser, Timothy O’Brien, and Abhay Pandit . A Temporal Gene Delivery System Based on Fibrin Microspheres. Molecular Pharmaceutics 2011, 8 (2) , 439-446. https://doi.org/10.1021/mp100295z
    67. Albert T. Poortinga . Long-Lived Antibubbles: Stable Antibubbles through Pickering Stabilization. Langmuir 2011, 27 (6) , 2138-2141. https://doi.org/10.1021/la1048419
    68. Anders Kyrsting, Poul M. Bendix, Dimitrios G. Stamou, and Lene B. Oddershede . Heat Profiling of Three-Dimensionally Optically Trapped Gold Nanoparticles using Vesicle Cargo Release. Nano Letters 2011, 11 (2) , 888-892. https://doi.org/10.1021/nl104280c
    69. Kimberly A. D. Gregersen, Zachary B. Hill, Jennifer C. Gadd, Bryant S. Fujimoto, Dustin J. Maly, and Daniel T. Chiu. Intracellular Delivery of Bioactive Molecules using Light-Addressable Nanocapsules. ACS Nano 2010, 4 (12) , 7603-7611. https://doi.org/10.1021/nn102345f
    70. Chengyi Song, Gongpu Zhao, Peijun Zhang, and Nathaniel L. Rosi. Expeditious Synthesis and Assembly of Sub-100 nm Hollow Spherical Gold Nanoparticle Superstructures. Journal of the American Chemical Society 2010, 132 (40) , 14033-14035. https://doi.org/10.1021/ja106833g
    71. Jai Woong Seo, Lisa M. Mahakian, Azadeh Kheirolomoom, Hua Zhang, Claude F. Meares, Riccardo Ferdani, Carolyn J. Anderson and Katherine W. Ferrara . Liposomal Cu-64 Labeling Method Using Bifunctional Chelators: Poly(ethylene glycol) Spacer and Chelator Effects. Bioconjugate Chemistry 2010, 21 (7) , 1206-1215. https://doi.org/10.1021/bc100018n
    72. Yanjing Chen, Arijit Bose and Geoffrey D. Bothun. Controlled Release from Bilayer-Decorated Magnetoliposomes via Electromagnetic Heating. ACS Nano 2010, 4 (6) , 3215-3221. https://doi.org/10.1021/nn100274v
    73. Yongsheng Han, Dmitry Shchukin, Juan Yang, Christian Rone Simon, Hendrik Fuchs and Helmoth Möhwald . Biocompatible Protein Nanocontainers for Controlled Drugs Release. ACS Nano 2010, 4 (5) , 2838-2844. https://doi.org/10.1021/nn100307j
    74. Jian Zhang, Yi Fu, Feng Jiang and Joseph R. Lakowicz . Metal Nanoshell — Capsule for Light-Driven Release of a Small Molecule. The Journal of Physical Chemistry C 2010, 114 (17) , 7653-7659. https://doi.org/10.1021/jp911537w
    75. Calin Hrelescu, Joachim Stehr, Moritz Ringler, Ralph A. Sperling, Wolfgang J. Parak, Thomas A. Klar and Jochen Feldmann . DNA Melting in Gold Nanostove Clusters. The Journal of Physical Chemistry C 2010, 114 (16) , 7401-7411. https://doi.org/10.1021/jp9097167
    76. Alina Pashkovskaya, Elena Kotova, Yunus Zorlu, Fabienne Dumoulin, Vefa Ahsen, Igor Agapov and Yuri Antonenko . Light-Triggered Liposomal Release: Membrane Permeabilization by Photodynamic Action. Langmuir 2010, 26 (8) , 5726-5733. https://doi.org/10.1021/la903867a
    77. Youqing Shen, Erlei Jin, Bo Zhang, Caitlin J. Murphy, Meihua Sui, Jian Zhao, Jinqiang Wang, Jianbin Tang, Maohong Fan, Edward Van Kirk and William J. Murdoch. Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery. Journal of the American Chemical Society 2010, 132 (12) , 4259-4265. https://doi.org/10.1021/ja909475m
    78. Anan Yaghmur, Lauri Paasonen, Marjo Yliperttula, Arto Urtti and Michael Rappolt . Structural Elucidation of Light Activated Vesicles. The Journal of Physical Chemistry Letters 2010, 1 (6) , 962-966. https://doi.org/10.1021/jz100226v
    79. B. V. Parakhonskiy, M. F. Bedard, T. V. Bukreeva, G. B. Sukhorukov, H. Möhwald and A. G. Skirtach . Nanoparticles on Polyelectrolytes at Low Concentration: Controlling Concentration and Size. The Journal of Physical Chemistry C 2010, 114 (5) , 1996-2002. https://doi.org/10.1021/jp904564v
    80. Tal Dvir, Matthew R. Banghart, Brian P. Timko, Robert Langer and Daniel S. Kohane . Photo-Targeted Nanoparticles. Nano Letters 2010, 10 (1) , 250-254. https://doi.org/10.1021/nl903411s
    81. Yongdong Jin and Xiaohu Gao. Spectrally Tunable Leakage-Free Gold Nanocontainers. Journal of the American Chemical Society 2009, 131 (49) , 17774-17776. https://doi.org/10.1021/ja9076765
    82. D. V. Volodkin, N. Madaboosi, J. Blacklock, A. G. Skirtach and H. Möhwald . Surface-Supported Multilayers Decorated with Bio-active Material Aimed at Light-Triggered Drug Delivery. Langmuir 2009, 25 (24) , 14037-14043. https://doi.org/10.1021/la9015433
    83. Mangayarkarasi Nagarathinam, Kuppan Saravanan, Wei Lee Leong, Palani Balaya, and Jagadese J. Vittal . Hollow Nanospheres and Flowers of CuS from Self-Assembled Cu(II) Coordination Polymer and Hydrogen-Bonded Complexes of N-(2-Hydroxybenzyl)-l-serine. Crystal Growth & Design 2009, 9 (10) , 4461-4470. https://doi.org/10.1021/cg9004938
    84. D. V. Volodkin, M. Delcea, H. Möhwald and A. G. Skirtach. Remote Near-IR Light Activation of a Hyaluronic Acid/Poly(l-lysine) Multilayered Film and Film-Entrapped Microcapsules. ACS Applied Materials & Interfaces 2009, 1 (8) , 1705-1710. https://doi.org/10.1021/am900269c
    85. Gary B. Braun, Alessia Pallaoro, Guohui Wu, Dimitris Missirlis, Joseph A. Zasadzinski, Matthew Tirrell and Norbert O. Reich . Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates. ACS Nano 2009, 3 (7) , 2007-2015. https://doi.org/10.1021/nn900469q
    86. Jayati Banerjee, Andrea J. Hanson, Bhushan Gadam, Adekunle I. Elegbede, Shakila Tobwala, Bratati Ganguly, Anil V. Wagh, Wallace W. Muhonen, Benedict Law, John B. Shabb, D. K. Srivastava and Sanku Mallik . Release of Liposomal Contents by Cell-Secreted Matrix Metalloproteinase-9. Bioconjugate Chemistry 2009, 20 (7) , 1332-1339. https://doi.org/10.1021/bc9000646
    87. Gregory P. Robbins, Masaya Jimbo, Joe Swift, Michael J. Therien, Daniel A. Hammer and Ivan J. Dmochowski. Photoinitiated Destruction of Composite Porphyrin−Protein Polymersomes. Journal of the American Chemical Society 2009, 131 (11) , 3872-3874. https://doi.org/10.1021/ja808586q
    88. Shang-Hsiu Hu, Chia-Hui Tsai, Chen-Fu Liao, Dean-Mo Liu and San-Yuan Chen. Controlled Rupture of Magnetic Polyelectrolyte Microcapsules for Drug Delivery. Langmuir 2008, 24 (20) , 11811-11818. https://doi.org/10.1021/la801138e
    89. Albert T. Poortinga, Cornelus F. van Nostrum. Microbubble-encapsulation of actives for controlled release and its application to the taste-masking of acetaminophen. International Journal of Pharmaceutics 2025, 672 , 125309. https://doi.org/10.1016/j.ijpharm.2025.125309
    90. Yingying Meng, Ji Gao, Xiaoran Huang, Pengke Liu, Chibin Zhang, Peirong Zhou, Yuanqing Bai, Jingjing Guo, Cheng Zhou, Kai Li, Fei Huang, Yong Cao. Molecular Trojan Based on Membrane‐Mimicking Conjugated Electrolyte for Stimuli‐Responsive Drug Release. Advanced Materials 2025, 11 https://doi.org/10.1002/adma.202415705
    91. Jun Li, Yujian Lai, Chen Yang, Lijie Dong. Monitoring of Cu 2+ release from controllably synthesized nano-copper pesticides. Environmental Pollutants and Bioavailability 2024, 36 (1) https://doi.org/10.1080/26395940.2023.2300477
    92. Jielin Shi, Chao Tan, Xiaoqian Ge, Zhenpeng Qin, Hejian Xiong. Recent advances in stimuli-responsive controlled release systems for neuromodulation. Journal of Materials Chemistry B 2024, 12 (24) , 5769-5786. https://doi.org/10.1039/D4TB00720D
    93. You Li, Jing Wang, Ying Li, Ziqiang Luo, Tao Peng, Tao Zou. Nanomaterials based on hollow gold nanospheres for cancer therapy. Regenerative Biomaterials 2024, 11 https://doi.org/10.1093/rb/rbae126
    94. Manu M. Joseph, Kaustabh Kumar Maiti. Recent advances in cancer nanotheranostics. 2024, 281-311. https://doi.org/10.1016/B978-0-323-90838-2.00008-4
    95. Menghui Zhang, Shengyun Hu, Lin Liu, Pengyuan Dang, Yang Liu, Zhenqiang Sun, Bingbing Qiao, Chengzeng Wang. Engineered exosomes from different sources for cancer-targeted therapy. Signal Transduction and Targeted Therapy 2023, 8 (1) https://doi.org/10.1038/s41392-023-01382-y
    96. Wei-tong Pan, Pan-miao Liu, Daqing Ma, Jian-jun Yang. Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies. Journal of Translational Medicine 2023, 21 (1) https://doi.org/10.1186/s12967-023-03988-w
    97. Antoine Uzel, Leonidas Agiotis, Amélie Baron, Igor V. Zhigaltsev, Pieter R. Cullis, Morteza Hasanzadeh Kafshgari, Michel Meunier. Single Pulse Nanosecond Laser‐Stimulated Targeted Delivery of Anti‐Cancer Drugs from Hybrid Lipid Nanoparticles Containing 5 nm Gold Nanoparticles. Small 2023, 19 (52) https://doi.org/10.1002/smll.202305591
    98. Sourour Idoudi, Roua Ismail, Ousama Rachid, Abdelbary Elhissi, Alaaldin M. Alkilany. The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites. Journal of Nanotheranostics 2023, 4 (3) , 201-227. https://doi.org/10.3390/jnt4030010
    99. Gulmi Chakraborty, Minakshi Meher, Sanjay Dash, Rudra Narayan Rout, Sibananda Pradhan, Dipanjali Sahoo. Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers. ChemistrySelect 2023, 8 (29) https://doi.org/10.1002/slct.202301626
    100. Marzieh Ataei, Hsiu-Ping Yi, Aida Zahra Taravatfard, Ken Young Lin, Abraham Phillip Lee. Enhancing Structural Stability of Oil-Shell Microbubbles via Incorporation of a Gold Nanoparticle Protective Shell for Theranostic Applications. Colloids and Interfaces 2023, 7 (2) , 34. https://doi.org/10.3390/colloids7020034
    Load more citations
    Download PDF
    Go to Journal of the American Chemical Society
    Get e-Alerts
    Get e-Alerts

    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2008, 130, 26, 8175–8177
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja802656d
    Published June 11, 2008
    Copyright © 2008 American Chemical Society
    Request reuse permissions

    Article Views

    8318

    Altmetric

    -

    Citations

    438
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.