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    A Replicable Tetrahedral Nanostructure Self-Assembled from a Single DNA Strand
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    The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA, Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287
    [email protected]; [email protected]
    †Arizona State University.
    ‡Hong Kong University of Science and Technology.
    §Arizona State University.
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2009, 131, 36, 13093–13098
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    https://doi.org/10.1021/ja903768f
    Published August 25, 2009
    Copyright © 2009 American Chemical Society
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    Abstract

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    We report the design and construction of a nanometer-sized tetrahedron from a single strand of DNA that is 286 nucleotides long. The formation of the tetrahedron was verified by restriction enzyme digestion, Ferguson analysis, and atomic force microscopy (AFM) imaging. We further demonstrate that synthesis of the tetrahedron can be easily scaled up through in vivo replication using standard molecular cloning techniques. We found that the in vivo replication efficiency of the tetrahedron is significantly higher in comparison to in vitro replication using rolling-circle amplification (RCA). Our results suggest that it is now possible to design and replicate increasingly complex, single-stranded DNA nanostructures in vivo.

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    DNA sequences, materials, detailed methods for in vivo replication, and rolling-circle amplification results.This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cite this: J. Am. Chem. Soc. 2009, 131, 36, 13093–13098
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja903768f
    Published August 25, 2009
    Copyright © 2009 American Chemical Society
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    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.