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Optical Imaging of Mammary and Prostate Tumors in Living Animals using a Synthetic Near Infrared Zinc(II)-Dipicolylamine Probe for Anionic Cell Surfaces

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    Optical Imaging of Mammary and Prostate Tumors in Living Animals using a Synthetic Near Infrared Zinc(II)-Dipicolylamine Probe for Anionic Cell Surfaces
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    Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, Indiana 46556, Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, Missouri 63110, and Freimann Life Science Center, 400 Galvin Life Science, University of Notre Dame, Notre Dame, Indiana 46556
    [email protected]
    †Department of Chemistry and Biochemistry, University of Notre Dame.
    ‡Department of Radiology, Washington University School of Medicine.
    §Freimann Life Science Center, University of Notre Dame.
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2010, 132, 1, 67–69
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    https://doi.org/10.1021/ja908467y
    Published December 16, 2009
    Copyright © 2009 American Chemical Society
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    In vivo optical imaging shows that a fluorescent imaging probe, comprised of a near-infrared fluorophore attached to an affinity group containing two zinc(II)-dipicolylamine (Zn-DPA) units, targets prostate and mammary tumors in two different xenograft animal models. The tumor selectivity is absent with control fluorophores whose structures do not have appended Zn-DPA targeting ligands. Ex vivo biodistribution and histological analyses indicate that the probe is targeting the necrotic regions of the tumors, which is consistent with in vitro microscopy showing selective targeting of the anionic membrane surfaces of dead and dying cells.

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    Cite this: J. Am. Chem. Soc. 2010, 132, 1, 67–69
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    Published December 16, 2009
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