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Spatial Anion Control on Palladium for Mild C–H Arylation of Arenes

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    Spatial Anion Control on Palladium for Mild C–H Arylation of Arenes
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2020, 142, 45, 19040–19046
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    https://doi.org/10.1021/jacs.0c09611
    Published October 30, 2020
    Copyright © 2020 American Chemical Society
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    Abstract

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    C–H arylation of arenes without the use of directing groups is a challenge, even for simple molecules, such as benzene. We describe spatial anion control as a concept for the design of catalytic sites for C–H bond activation, thereby enabling nondirected C–H arylation of arenes at ambient temperature. The mild conditions enable late-stage structural diversification of biologically relevant small molecules, and site-selectivity complementary to that obtained with other methods of arene functionalization can be achieved. These results reveal the potential of spatial anion control in transition-metal catalysis for the functionalization of C–H bonds under mild conditions.

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    This article is cited by 30 publications.

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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2020, 142, 45, 19040–19046
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jacs.0c09611
    Published October 30, 2020
    Copyright © 2020 American Chemical Society
    Request reuse permissions

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