Adaptive Photochemical Amination via Co(II) CatalysisClick to copy article linkArticle link copied!
- Geyang SongGeyang SongKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Geyang Song
- Jiameng SongJiameng SongKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Jiameng Song
- Qi LiQi LiKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Qi Li
- Tengfei KangTengfei KangKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Tengfei Kang
- Jianyang DongJianyang DongKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Jianyang Dong
- Gang LiGang LiKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Gang Li
- Juan FanJuan FanKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Juan Fan
- Chao WangChao WangKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Chao Wang
- Dong Xue*Dong Xue*Email: [email protected]Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, ChinaMore by Dong Xue
Abstract

Transition-metal-catalyzed amination of aryl halides is one of the most employed methods for constructing N-arylation adducts. However, the broad success of these reactions largely relies on the screening of precatalysts, elaborated ligands, and case-by-case optimization of reaction conditions (solvent, base, additive, temperature, etc.) for electronically or structurally diverse nucleophiles. Herein, we report an adaptive photochemical C–N coupling of aryl halides with various nitrogen nucleophiles (aliphatic and aromatic amines, amides, sulfonamides, pyrazoles, and ammonium salts) by Co(II) catalysis under the same reaction conditions (same precatalyst, same ligand, same base, same solvent, same temperature) without the addition of any exogenous photocatalyst. This photochemical amination features a wide substrate scope (>130 examples, up to 95% yield) with excellent functional group tolerance. Mechanistic studies indicate that these C–N coupling reactions may proceed via a Co(I)/Co(III) catalytic cycle.
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This article is cited by 1 publications.
- Jianbin Li, Ding Zhang, Zhennan Hu. Ligand-Enabled “Two-in-One” Metallaphotocatalytic Cross Couplings. ACS Catalysis 2025, 15
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, 1635-1654. https://doi.org/10.1021/acscatal.4c07128
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