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Metal–Organic Framework Nanoparticle-Assisted Cryopreservation of Red Blood Cells

  • Wei Zhu*
    Wei Zhu
    Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, United States
    *[email protected]
    More by Wei Zhu
  • Jimin Guo
    Jimin Guo
    Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, United States
    More by Jimin Guo
  • Jacob Ongudi Agola
    Jacob Ongudi Agola
    Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, United States
  • Jonas G. Croissant
    Jonas G. Croissant
    Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, United States
  • Zihao Wang
    Zihao Wang
    Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, United States
    More by Zihao Wang
  • Jin Shang
    Jin Shang
    School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, P.R. China
    More by Jin Shang
  • Eric Coker
    Eric Coker
    Applied Optical/Plasma Sciences, Sandia National Laboratories, P.O. Box 5800, MS 1411, Albuquerque, New Mexico 87185-1411, United States
    More by Eric Coker
  • Benyamin Motevalli
    Benyamin Motevalli
    Department of Mechanical and Aerospace Engineering, Monash University, Clayton, Victoria 3800, Australia
  • Andreas Zimpel
    Andreas Zimpel
    Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), 81377 Munich, Germany
  • Stefan Wuttke
    Stefan Wuttke
    Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), 81377 Munich, Germany
    School of Chemistry, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7TS, United Kingdom
  • , and 
  • C. Jeffrey Brinker*
    C. Jeffrey Brinker
    Center for Micro-Engineered Materials and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, United States
    *[email protected]
Cite this: J. Am. Chem. Soc. 2019, 141, 19, 7789–7796
Publication Date (Web):April 23, 2019
https://doi.org/10.1021/jacs.9b00992
Copyright © 2019 American Chemical Society

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    Abstract

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    The development of hybrid nanomaterials mimicking antifreeze proteins that can modulate/inhibit the growth of ice crystals for cell/tissue cryopreservation has attracted increasing interests. Herein, we describe the first utilization of zirconium (Zr)-based metal–organic framework (MOF) nanoparticles (NPs) with well-defined surface chemistries for the cryopreservation of red blood cells (RBCs) without the need of any (toxic) organic solvents. Distinguishing features of this cryoprotective approach include the exceptional water stability, low hemolytic activity, and the long periodic arrangement of organic linkers on the surface of MOF NPs, which provide a precise spacing of hydrogen donors to recognize and match the ice crystal planes. Five kinds of Zr-based MOF NPs, with different pore size, surface chemistry, and framework topologies, were used for the cryoprotection of RBCs. A “splat” assay confirmed that MOF NPs not only exhibited ice recrystallization inhibition activities but also acted as a “catalyst” to accelerate the melting of ice crystals. The human RBC cryopreservation tests displayed RBC recoveries of up to ∼40%, which is higher than that obtained via commonly used hydroxyethyl starch polymers. This cryopreservation approach will inspire the design and utilization of MOF-derived nanoarchitectures for the effective cryopreservation of various cell types as well as tissue samples.

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