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Uniform Biodegradable Fiber-Like Micelles and Block Comicelles via “Living” Crystallization-Driven Self-Assembly of Poly(l-lactide) Block Copolymers: The Importance of Reducing Unimer Self-Nucleation via Hydrogen Bond Disruption

Cite this: J. Am. Chem. Soc. 2019, 141, 48, 19088–19098
Publication Date (Web):October 28, 2019
Copyright © 2019 American Chemical Society

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    Fiber-like micelles based on biodegradable and biocompatible polymers exhibit considerable promise for applications in nanomedicine, but until recently no convenient methods were available to prepare samples with uniform and controllable dimensions and spatial control of functionality. “Living” crystallization-driven self-assembly (CDSA) is a seeded growth method of growing importance for the preparation of uniform 1D and 2D core–shell nanoparticles from a range of crystallizable polymeric amphiphiles. However, in the case of poly(l-lactide) (PLLA), arguably the most widely utilized biodegradable polymer as the crystallizable core-forming block, the controlled formation of uniform fiber-like structures over a substantial range of lengths by “living” CDSA has been a major challenge. Herein, we demonstrate that via simple modulation of the solvent conditions via the addition of trifluoroethanol (TFE), DMSO, DMF and acetone, uniform fiber-like nanoparticles from PLLA diblock copolymers with controlled lengths up to 1 μm can be prepared. The probable mechanism involves improved unimer solvation by a reduction of hydrogen bonding interactions among PLLA chains. We provide evidence that this minimizes undesirable unimer aggregation which otherwise favors self-nucleation that competes with epitaxial crystallization from seed termini. This approach has also allowed the formation of well-defined segmented block comicelles with PLLA cores via the sequential seeded-growth of PLLA block copolymers with different corona-forming blocks.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/jacs.9b09885.

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    57. Jie Xu, Changzhu Lv, Qiangqiang Shi, Jialin Zhang, Ning Wang, Guoying Zhang, Jinming Hu, Shiyong Liu. Controlled Self‐Assembly of Discrete Amphiphilic Oligourethanes with a Cascade Self‐Immolative Motif. Angewandte Chemie 2023, 135 (33)
    58. Jie Xu, Changzhu Lv, Qiangqiang Shi, Jialin Zhang, Ning Wang, Guoying Zhang, Jinming Hu, Shiyong Liu. Controlled Self‐Assembly of Discrete Amphiphilic Oligourethanes with a Cascade Self‐Immolative Motif. Angewandte Chemie International Edition 2023, 62 (33)
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    62. Lingyuan Zhu, Bingbing Xiang, Yawei Su, Zaizai Tong. Chemical shield effect of metal complexation on seeded growth of poly(ε-caprolactone) core-forming blends. Polymer 2023, 272 , 125831.
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    65. Bixin Jin, Yiqi Chen, Yunjun Luo, Xiaoyu Li. Precise and Controllable Assembly of Block Copolymers †. Chinese Journal of Chemistry 2023, 41 (1) , 93-110.
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    68. Hui Sun, Shuai Chen, Xiao Li, Ying Leng, Xiaoyan Zhou, Jianzhong Du. Lateral growth of cylinders. Nature Communications 2022, 13 (1)
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    71. Chao Wang, Lei Xu, Li Zhou, Na Liu, Zong‐Quan Wu. Asymmetric Living Supramolecular Polymerization: Precise Fabrication of One‐Handed Helical Supramolecular Polymers. Angewandte Chemie 2022, 134 (33)
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    74. J. Diego Garcia-Hernandez, Hayley C. Parkin, Yangyang Ren, Yifan Zhang, Ian Manners. Hydrophobic cargo loading at the core–corona interface of uniform, length-tunable aqueous diblock copolymer nanofibers with a crystalline polycarbonate core. Polymer Chemistry 2022, 13 (28) , 4100-4110.
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    78. Shin Asano, Jaeyeong Choi, Thi Hang Tran, Nalinthip Chanthaset, Hiroharu Ajiro. The influence of chain‐end functionalization and stereocomplexation on the degradation stability under alkaline condition. Polymers for Advanced Technologies 2022, 33 (3) , 991-999.
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    81. Junyu Ma, Guolin Lu, Xiaoyu Huang, Chun Feng. π-Conjugated-polymer-based nanofibers through living crystallization-driven self-assembly: preparation, properties and applications. Chemical Communications 2021, 57 (98) , 13259-13274.
    82. Oleksandr Shyshov, Shyamkumar Vadakket Haridas, Luca Pesce, Haoyuan Qi, Andrea Gardin, Davide Bochicchio, Ute Kaiser, Giovanni M. Pavan, Max von Delius. Living supramolecular polymerization of fluorinated cyclohexanes. Nature Communications 2021, 12 (1)
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    92. Mingwei Tian, Chen Ma, Xiaoyu Huang, Guolin Lu, Chun Feng. Supramolecular-micelle-directed preparation of uniform magnetic nanofibers with length tunability, colloidal stability and capacity for surface functionalization. Polymer Chemistry 2021, 12 (13) , 1924-1930.
    93. Yuhan Wei, Fujun Liu, Min Li, Zhibo Li, Jing Sun. Dimension control on self-assembly of a crystalline core-forming polypeptoid block copolymer: 1D nanofibers versus 2D nanosheets. Polymer Chemistry 2021, 12 (8) , 1147-1154.
    94. Tobias Klein, Franka V Gruschwitz, Maren T Kuchenbrod, Ivo Nischang, Stephanie Hoeppener, Johannes C Brendel. Adjusting the length of supramolecular polymer bottlebrushes by top-down approaches. Beilstein Journal of Organic Chemistry 2021, 17 , 2621-2628.
    95. Christopher Y. Li. The rise of semicrystalline polymers and why are they still interesting. Polymer 2020, 211 , 123150.
    96. Tobias Klein, Hans F. Ulrich, Franka V. Gruschwitz, Maren T. Kuchenbrod, Rintaro Takahashi, Shota Fujii, Stephanie Hoeppener, Ivo Nischang, Kazuo Sakurai, Johannes C. Brendel. Impact of amino acids on the aqueous self-assembly of benzenetrispeptides into supramolecular polymer bottlebrushes. Polymer Chemistry 2020, 11 (42) , 6763-6771.
    97. Cheng Miao, Xiaomin Zhu, Jian Zhang, Youliang Zhao. Rational design of nonlinear crystalline-amorphous-responsive terpolymers for pH-guided fabrication of 0D–3D nano-objects. Polymer Chemistry 2020, 11 (39) , 6259-6272.
    98. Hayato Onishi, Yuta Koda, Hideo Horibe. Thermoresponsive Conductivity of Acrylamide-based Polymers and Ni Microparticle Composites. Chemistry Letters 2020, 49 (10) , 1224-1227.
    99. Steven T. G. Street, Yunxiang He, Xu-Hui Jin, Lorna Hodgson, Paul Verkade, Ian Manners. Cellular uptake and targeting of low dispersity, dual emissive, segmented block copolymer nanofibers. Chemical Science 2020, 11 (32) , 8394-8408.
    100. Sanghee Yang, Tae-Lim Choi. Rapid formation and real-time observation of micron-sized conjugated nanofibers with tunable lengths and widths in 20 minutes by living crystallization-driven self-assembly. Chemical Science 2020, 11 (32) , 8416-8424.
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