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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Soc. Mass Spectrom. 2012, 23, 9, 1512-1521
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HDX Workbench: Software for the Analysis of H/D Exchange MS Data

  • Bruce D. Pascal
    Bruce D. Pascal
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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    • , 
  • Scooter Willis
    Scooter Willis
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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    • , 
  • Janelle L. Lauer
    Janelle L. Lauer
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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    • , 
  • Rachelle R. Landgraf
    Rachelle R. Landgraf
    Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA
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  • Graham M. West
    Graham M. West
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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    • , 
  • David Marciano
    David Marciano
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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  • Scott Novick
    Scott Novick
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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  • Devrishi Goswami
    Devrishi Goswami
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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  • Michael J. Chalmers
    Michael J. Chalmers
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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  • Patrick R. Griffin
    Patrick R. Griffin
    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, 33458, Jupiter, FL, USA
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Cite this: J. Am. Soc. Mass Spectrom. 2012, 23, 9, 1512–1521
Publication Date (Web):June 13, 2012
https://doi.org/10.1021/jasms.8b04350
Copyright © 2012 © American Society for Mass Spectrometry 2012
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Abstract

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu.

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