ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Figure 1Loading Img

Solubility of Rofecoxib in the Presence of Mannitol, Poly(vinylpyrrolidone) K30, Urea, Polyethylene Glycol 4000, and Polyethylene Glycol 6000 at (298.15, 303.15, and 308.15) K

View Author Information
Life Science College, Ocean University of China, 5 Yushan Road, Qingdao 266003, People's Republic of China
Cite this: J. Chem. Eng. Data 2005, 50, 2, 661–665
Publication Date (Web):January 25, 2005
https://doi.org/10.1021/je049631p
Copyright © 2005 American Chemical Society

    Article Views

    263

    Altmetric

    -

    Citations

    LEARN ABOUT THESE METRICS
    Other access options

    Abstract

    The present study investigated the solubilization of rofecoxib in aqueous solution using mannitol, poly(vinylpyrrolidone) K30, urea, poly(ethylene glycol) 4000, and poly(ethylene glycol) 6000 at (298.15, 303.15, and 308.15) K. The analysis of rofecoxib is carried out by high-performance liquid chromatography (HPLC). The aqueous solubility of rofecoxib could be enhanced by the addition of increasing mass fraction of all of the hydrophilic carriers tested except mannitol as well as by increasing the temperature of the dissolution medium. Among the hydrophilic carriers studied, urea exhibited a higher solubilization potential than the other carriers. Calculated Gibbs free energy values were all negative for all of the hydrophilic carriers + water mixtures at (298.15, 303.15, and 308.15) K, indicating the spontaneous nature of rofecoxib solubilization. In the case of urea + water mixtures, the ΔtrG° values decreased to a greater extent than those for the other carriers (mannitol, poly(vinylpyrrolidone) K30, poly(ethylene glycol) 4000, and poly(ethylene glycol) 6000) + water mixtures, indicating that the reaction conditions were more favorable in urea + water mixtures than in other carriers + water mixtures.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    *

     Corresponding author. E-mail:  [email protected].

    Cited By

    This article is cited by 7 publications.

    1. Yajie Yang, Lu Cheng, Mengdan Wang, Liqiang Yin, Ye Feng, Chengyu Wang, Yanzhong Li. Difunctionalization of Alkynones by Base-Mediated Reaction with α,α-Dithioketones. Organic Letters 2021, 23 (14) , 5339-5343. https://doi.org/10.1021/acs.orglett.1c01640
    2. Shahla Soltanpour, William E. Acree, Jr. and Abolghasem Jouyban. Effects of Different Concentrations of Poly(vinyl pyrrolidone) on the Solubility of Lamotrigine and Diazepam in Ethanol + Water Mixtures at 298.2 K. Journal of Chemical & Engineering Data 2010, 55 (1) , 570-573. https://doi.org/10.1021/je900369w
    3. Chengsheng Liu,, Kashappa Goud H. Desai,, Xiguang Chen, and, Xuexi Tang. Solubility of Valdecoxib in the Presence of Glycerol, Propylene Glycol, and Poly(ethylene glycol) 400 at (298.15, 303.15, and 308.15) K. Journal of Chemical & Engineering Data 2005, 50 (5) , 1736-1739. https://doi.org/10.1021/je050190z
    4. Wanlop Weecharangsan, Robert J. Lee. Enhanced dissolution rates of glibenclamide through solid dispersions on microcrystalline cellulose and mannitol, combined with phosphatidylcholine. Drug Development and Industrial Pharmacy 2024, 50 (4) , 297-305. https://doi.org/10.1080/03639045.2024.2321388
    5. Eun-Sol Ha, Dong-Hyeon Ha, Do-Hoon Kuk, Woo-Yong Sim, In-hwan Baek, Jeong-Soo Kim, Hee Jun Park, Min-Soo Kim. Solubility of cilostazol in the presence of polyethylene glycol 4000, polyethylene glycol 6000, polyvinylpyrrolidone K30, and poly(1-vinylpyrrolidone-co-vinyl acetate) at different temperatures. The Journal of Chemical Thermodynamics 2017, 113 , 6-10. https://doi.org/10.1016/j.jct.2017.05.040
    6. . Solubility Data in Binary Solvent Mixtures. 2009, 203-505. https://doi.org/10.1201/9781439804889-c3
    7. Chengsheng Liu, Kashappa Goud H. Desai. Characteristics of Rofecoxib-Polyethylene Glycol 4000 Solid Dispersions and Tablets Based on Solid Dispersions. Pharmaceutical Development and Technology 2005, 10 (4) , 467-477. https://doi.org/10.1080/10837450500299701

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect