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Solubilities of Betulinic Acid in Thirteen Organic Solvents at Different Temperatures

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† Department of Chemistry, Zhejiang University, Hangzhou 310027, China
‡ Skyherb Ingredients, Anji 313300, China
Tel: 0086 571 87951430. Fax: 0086 571 8795189. E-mail: [email protected]
Cite this: J. Chem. Eng. Data 2011, 56, 12, 4587–4591
Publication Date (Web):October 20, 2011
https://doi.org/10.1021/je200531k
Copyright © 2011 American Chemical Society
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    Abstract

    The solubilities of betulinic acid in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, 1-pentanol, 1-hexanol, ethyl formate, ethyl acetate, butyl acetate, acetone, and tetrahydrofuran were measured by an analytical method in the temperature range of (278.2 to 318.2) K. The experimental data were correlated with a three-parameter empirical equation and UNIQUAC model, respectively. The calculated solubilities showed good agreement with the experimental data over this temperature range. Furthermore, the relation of the solubilities and the crystal habit were discussed.

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    Theoretical yield of recrystallization for betulinic acid in different solvents (Table S1) and DSC curve of betulinic acid (Figure S1). This material is available free of charge via the Internet at http://pubs.acs.org.

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