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Solubility of 4-Aminosalicylic Acid in Supercritical Carbon Dioxide and Subcritical 1,1,1,2-Tetrafluoroethane

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† Beijing Key Laboratory of Membrane Science and Technology, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
‡ Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom
*Tel: +86-10-64434788. Fax: +86-10-64436781. E-mail: [email protected]
Cite this: J. Chem. Eng. Data 2014, 59, 6, 2095–2100
Publication Date (Web):May 20, 2014
https://doi.org/10.1021/je5002736
Copyright © 2014 American Chemical Society
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    Abstract

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    The equilibrium solubilities of 4-aminosalicylic acid (PAS) in supercritical carbon dioxide (SCCO2) and subcritical 1,1,1,2-tetrafluoroethane (R134a) are crucial to the process of supercritical and subcritical extraction. After reliability tests of the experimental apparatus were carried out and confirmed, measurements of the solubilities of PAS in SCCO2 and subcritical R134a were implemented from (11.0 to 21.0) MPa at temperatures of (308 to 328) K by the dynamic method in SCCO2 and from (5.0 to 15.0) MPa at temperatures of (308 to 328) K by the static method in subcritical R134a, respectively. It was found that the solubility of PAS is much higher in subcritical R134a than in SCCO2 under the same operational conditions (temperature and pressure). The solubility enhancement factor (δ) was calculated and analyzed. Four density-based models (Chrastil, K-J, M-S-T, and S-S) were used to correlate the PAS solubility data in SCCO2 and subcritical R134a. The calculated results showed that the reasonable agreement was obtained with the experimental solubility data.

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