Solubility of (2Z)-N-Cyclohexyl-2-(3-hydroxybenzylidine) Hydrazine Carbothioamide in Different Pure Solvents at (298.15 to 338.15) K
Abstract
The solubility of (2Z)-cyclohexyl-2-(3-hydroxybenzylidine) hydrazine carbothioamide (CHBH) in eight different pure solvents namely water, ethanol, propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), ethylene glycol (EG), isopropyl alcohol (IPA), ethyl acetate (EA), and diethylene glycol monoethyl ether (Transcutol) from (298.15 to 338.15) K was measured using an isothermal method. The experimental solubilities were correlated with Apelblat equation and root mean square deviations (rmsd) were calculated. The rmsd were observed in the range of 0.000 to 0.056 in all pure solvents investigated. The correlation coefficients were observed in the range of 0.997 to 0.999 (n = 5). The mole fraction solubility of CHBH was found to be highest in Transcutol (93.80·10–3 at 298.15 K) followed by PEG-400 (71.01·10–3 at 298.15 K), PG (31.86·10–3 at 298.15 K), IPA (30.25·10–3 at 298.15 K), ethanol (13.85·10–3 at 298.15 K), EA (10.41·10–3 at 298.15 K), EG (1.85·10–3 at 298.15 K) and water (3.90·10–7 at 298.15 K). The mass fraction solubility of CHBH was also observed highest in Transcutol (0.214 kg·kg–1 at 298.15 K) followed by IPA (0.144 kg·kg–1 at 298.15 K), PG (0.120 kg·kg–1 at 298.15 K), ethanol (0.082 kg·kg–1 at 298.15 K), PEG-400 (0.053 kg·kg–1 at 298.15 K), EA (0.033 kg·kg–1 at 298.15 K), EG (8.30·10–3 kg·kg–1 at 298.15 K), and water (6.00·10–6 kg·kg–1 at 298.15 K). On the basis of these results, CHBH has been considered as freely soluble in PG, IPA, and Transcutol, soluble in EG, EA, PEG-400, and ethanol, and practically insoluble in water.
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