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Experimental Measurement and Modeling of the Solubility of Biotin in Six Pure Solvents at Temperatures from 298.15 K to 333.85 K

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Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, P. R. China
China Construction Industrial Equipment Installation Company Limited, Nanjing, 210046, P. R. China
*Tel: +86-571-87951615. Fax: +86-571-87951742. E-mail: [email protected]
Cite this: J. Chem. Eng. Data 2014, 59, 11, 3894–3899
Publication Date (Web):October 27, 2014
https://doi.org/10.1021/je500787x
Copyright © 2014 American Chemical Society

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    Abstract

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    The solubilities of biotin in water, methanol, ethanol, acetic acid, dimethylformamide (DMF), and dimethyl sulfoxide (DMSO) were measured at temperatures ranging from 298.15 K to 333.85 K (p = 0.1 MPa) by the synthetic method with a laser monitoring dynamic technique. The mole fraction solubilities of biotin were observed to be highest in DMSO, and be lowest in water. The experimental data were well-correlated with the modified Apelblat equation, van’t Hoff equation, and λh equation, in which the correlation coefficients (R2) were noted in the range of 0.997 to 1.000 and the root-mean-square deviations (rmsd) were less than 2.82 %. Thermodynamic studies showed that dissolution of biotin was an endothermic and spontaneous process in all selected solvents.

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