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Correlation of Solubility of Bioactive Compound Reserpine in Eight Green Solvents at (298.15 to 338.15) K

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† Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
‡ Center of Excellence in Biotechnology Research, College of Science, King Saud University, P. O. Box 2460, Riyadh 11451, Saudi Arabia
§ Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
*Phone: +966-537507318. E-mail: [email protected]
Cite this: J. Chem. Eng. Data 2015, 60, 3, 775–780
Publication Date (Web):January 13, 2015
https://doi.org/10.1021/je500893g
Copyright © 2015 American Chemical Society
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    Abstract

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    The solubility of reserpine in eight different green solvents, namely, water, ethanol, ethylene glycol (EG), ethyl acetate (EA), isopropanol (IPA), propylene glycol (PG), poly(ethylene glycol)-400 (PEG-400), and transcutol, was measured and correlated from (298.15 to 338.15) K using the shake flask method. The experimental solubilities were correlated with temperature-dependent Apelblat and ideal equations. For the Apelblat equation, the root-mean-square deviations (RMSD) and correlation coefficients (R2) were obtained as 0.005 to 0.053 and 0.9978 to 0.9999, respectively. For an ideal Apelblat equation, the RMSD and R2 were obtained as 0.005 to 0.018 and 0.9950 to 0.9990, respectively. The mole fraction solubility of reserpine was observed highest in PEG-400 (1.44·10–3 at 298.15 K) followed by transcutol, EG, PG, IPA, ethanol, and water from (298.15 to 338.15) K. However, the mass fraction solubility of reserpine was observed highest in EA (3.60·10–3 at 298.15 K). The dissolution enthalpy, Gibbs energy, and dissolution entropy were determined by van’t Hoff and Krug analysis, and results showed endothermic and spontaneous dissolution of reserpine in all green solvents investigated.

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    Figures showing fitting of ln xe of crystalline reserpine in different solvents, −ln xe as a function of Tref/T, and van’t Hoff plots of experimental solubilities of crystalline reserpine in different solvents. This material is available free of charge via the Internet at http://pubs.acs.org.

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