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Solid–Liquid Phase Equilibrium and Ternary Phase Diagrams of Ibuprofen–Nicotinamide Cocrystals in Ethanol and Ethanol/Water Mixtures at (298.15 and 313.15) K
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    Solid–Liquid Phase Equilibrium and Ternary Phase Diagrams of Ibuprofen–Nicotinamide Cocrystals in Ethanol and Ethanol/Water Mixtures at (298.15 and 313.15) K
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    School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, People’s Republic of China
    Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300072, People’s Republic of China
    *Phone: 86-22-27405754. Fax: 86-22-27314971. E-mail: [email protected]
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    Journal of Chemical & Engineering Data

    Cite this: J. Chem. Eng. Data 2015, 60, 4, 1166–1172
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    https://doi.org/10.1021/je5011455
    Published March 4, 2015
    Copyright © 2015 American Chemical Society

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    The phase diagrams for ibuprofen (IBU) and nicotinamide (NCT) in both ethanol and ethanol/water mixtures were constructed at (298.15 and 313.15) K under atmospheric pressure using static method. It is revealed that employing solvent mixtures in cocrystallization could significantly affect the symmetry of phase diagrams. In pure ethanol, the two solutes dissolve incongruently and the diagrams are asymmetric, so excessive IBU is needed to isolate cocrystals. However, in ethanol/water mixtures (mass fraction of water was 0.30), the solubility difference between the two components can be leveled out, resulting in more symmetric phase diagrams which can enlarge the processing space for cocrystallization. The solubility of the 1:1 IBU–NCT cocrystal was evaluated as a function of NCT concentration based on the solubility product. These findings are of great importance to develop the cocrystallization process for manufacturing IBU–NCT cocrystal.

    Copyright © 2015 American Chemical Society

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    This article is cited by 21 publications.

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    Journal of Chemical & Engineering Data

    Cite this: J. Chem. Eng. Data 2015, 60, 4, 1166–1172
    Click to copy citationCitation copied!
    https://doi.org/10.1021/je5011455
    Published March 4, 2015
    Copyright © 2015 American Chemical Society

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