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Solubility of Podophyllotoxin in Six Organic Solvents from (283.2 to 323.2) K

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Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China
* Corresponding author. Tel./Fax: +86-571-88208457. E-mail: [email protected]
Cite this: J. Chem. Eng. Data 2009, 54, 1, 160–161
Publication Date (Web):December 2, 2008
https://doi.org/10.1021/je8007028
Copyright © 2008 American Chemical Society

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    Abstract

    The solubility of podophyllotoxin (furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl), (5R,5aR,8aR,9R)) in ethanol, methanol, acetone, ethyl acetate, propan-2-ol, and butan-1-ol from (283.2 to 323.2) K was measured under atmospheric pressure. The solubility of podophyllotoxin in these solvents increases with increasing temperature. The solubility values were correlated with the Apelblat equation.

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    Cited By

    This article is cited by 6 publications.

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    2. Lian-Jun Luan, Yun Zhou, Yong-Jiang Wu, Xue-Song Liu, and Long-Hu Wang. Solubility of Scutellarin in Methanol, Water, Ethanol, and Ethanol + Water Binary Mixtures from (293.2 to 333.2) K. Journal of Chemical & Engineering Data 2010, 55 (11) , 5299-5301. https://doi.org/10.1021/je100239d
    3. Xin Li, Zhenxing Du, Xiaoquan Huang, Wei Yuan and Hanjie Ying. Solubility of Sucralose in Different Solvents from (283.15 to 333.15) K. Journal of Chemical & Engineering Data 2010, 55 (7) , 2600-2602. https://doi.org/10.1021/je9008427
    4. K. Bhesaniya, S. Baluja. Solubility of esomeprazole magnesium trihydrate in alcohols at temperatures from 298.15 to 318.15 K. Russian Journal of Physical Chemistry A 2013, 87 (13) , 2187-2190. https://doi.org/10.1134/S0036024413130062
    5. Suha H. Abdullah, Shuna Zhao, Gauri S. Mittal, Oon-Doo Baik. Extraction of podophyllotoxin from Podophyllum peltatum using pulsed electric field treatment. Separation and Purification Technology 2012, 93 , 92-97. https://doi.org/10.1016/j.seppur.2012.04.002
    6. Laura M. Sprunger, Sai S. Achi, Racheal Pointer, William E. Acree, Michael H. Abraham. Development of Abraham model correlations for solvation characteristics of secondary and branched alcohols. Fluid Phase Equilibria 2010, 288 (1-2) , 121-127. https://doi.org/10.1016/j.fluid.2009.10.024

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