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Chemical Analysis of Radix Astragali (Huangqi) in China:  A Comparison with Its Adulterants and Seasonal Variations
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    Chemical Analysis of Radix Astragali (Huangqi) in China:  A Comparison with Its Adulterants and Seasonal Variations
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    Department of Biology and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China, State Key Laboratory for New Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China, Department of Chemistry, Shanghai Second Medical University, 280 South Chongqing Road, Shanghai 200025, China, and Jiangsu Research Institute of Traditional Chinese Medicine, Maigaoqiao, Nanjing 210028, China
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2002, 50, 17, 4861–4866
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    https://doi.org/10.1021/jf0202279
    Published July 16, 2002
    Copyright © 2002 American Chemical Society

    Abstract

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    Radix Astragali (root of Astragalus; Huangqi) is a popular traditional Chinese medicine, and Astragalus membranaceus and A. membranaceus var. mongolicus are two commonly used species; however, there are many Astragalus species that could act as adulterants of Radix Astragali. To find the chemical composition of Radix Astragali, the main constituents including flavonoids, saponins, polysaccharides, amino acids, and trace elements were determined in two Radices Astragali, A. membranaceus and A. membranaceus var. mongolicus, and its eight adulterants, Astragalus propinquus, Astragalus lepsensis, Astragalus aksuensis, Astragalus hoantchy, Astragalus hoantchy subsp. dshimensis, Astragalus lehmannianus, Astragalus sieversianus, and Astragalus austrosibiricus. The results showed that the amounts of main constituents such as isoflavonoids and astragalosides varied in different species. In distinction, A. membranaceus and A. membranaceus var. mongolicus contained a higher amount of astragaloside I and IV. In addition, the main constituents of A. membranaceus var. mongholicus changed according to seasonal variation and age of the plant. The chemical composition of different species of Astragalus would provide useful information for the quality control of Radix Astragali.

    Keywords: Astragalosides; HPLC; isoflavonoids; traditional Chinese medicine

    Copyright © 2002 American Chemical Society

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     The Hong Kong University of Science and Technology.

     Chinese Academy of Sciences.

    §

     Shanghai Second Medical University.

     Jiangsu Research Institute of Traditional Chinese Medicine.

    *

     To whom correspondence should be addressed. Tel:  (852)2358-7332. Fax:  (852)2358-1559. E-mail:  [email protected].

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    Tables of amino acid composition and trace element contents. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Published July 16, 2002
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