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Daily Variations in Oligosaccharides of Human Milk Determined by Microfluidic Chips and Mass Spectrometry

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Departments of Chemistry, Viticulture and Enology, Food Science and Technology, and Biochemistry (School of Medicine) and Microbiology Graduate Group, University of California, Davis, California 95616, Agilent Technologies, Inc., Santa Clara, California 95052, and Department of Biochemistry, University of Nevada, Reno, Nevada 89557
* Corresponding author: Department of Chemistry and Biochemistry (School of Medicine), University of California, One Shields Ave., Davis, CA 95616. Phone: (530) 752-6364 . Fax: (530) 754-5609. E-mail: [email protected]
†Department of Chemistry, University of California.
‡Agilent Technologies, Inc.
§Department of Biochemistry, University of Nevada.
‖Department of Viticulture and Enology, University of California.
⊥Microbiology Graduate Group, University of California.
#Department of Food Science and Technology, University of California.
∇Department of Biochemistry (School of Medicine), University of California.
Cite this: J. Agric. Food Chem. 20082008, 56, 2, 618–626
Publication Date (Web):December 19, 2007
https://doi.org/10.1021/jf071972u
Copyright © 2008 American Chemical Society
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    Abstract

    Human milk is a complex biological fluid that provides not only primary nourishment for infants but also protection against pathogens and influences their metabolic, immunologic, and even cognitive development. The presence of oligosaccharides in remarkable abundance in human milk has been associated to provide diverse biological functions including directing the development of an infant’s intestinal microflora and immune system. Recent advances in analytical tools offer invaluable insights in understanding the specific functions and health benefits these biomolecules impart to infants. Oligosaccharides in human milk samples obtained from five different individual donors over the course of a 3 month lactation period were isolated and analyzed using HPLC-Chip/TOF-MS technology. The levels and compositions of oligosaccharides in human milk were investigated from five individual donors. Comparison of HPLC-Chip/TOF-MS oligosaccharides profiles revealed heterogeneity among multiple individuals with no significant variations at different stages of lactation within individual donors.

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