ACS Publications. Most Trusted. Most Cited. Most Read
Chemical Characterization of Red Wine Grape (Vitis vinifera and Vitis Interspecific Hybrids) and Pomace Phenolic Extracts and Their Biological Activity against Streptococcus mutans

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2007, 55, 25, 10200-10207
    Article

    Chemical Characterization of Red Wine Grape (Vitis vinifera and Vitis Interspecific Hybrids) and Pomace Phenolic Extracts and Their Biological Activity against Streptococcus mutans
    Click to copy article linkArticle link copied!

    View Author Information
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, New York 14620, and Department of Food Science & Technology, New York State Agricultural Experiment Station, Cornell University, Geneva, New York 14456
    * To whom correspondence should be addressed. Tel: 585-273-4216 . Fax: 585-273-1237. E-mail [email protected]
    †University of Rochester Medical Center.
    ‡New York State Agricultural Experiment Station.
    Other Access Options

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2007, 55, 25, 10200–10207
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf0722405
    Published November 14, 2007
    Copyright © 2007 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!

    Grapes are rich sources of potentially bioactive polyphenols. However, the phenolic content is variable depending on grape variety, and may be modified during vinification. In this study, we examined the chemical composition and biological activity of phenolic extracts prepared from several red wine grape varieties and their fermented byproduct of winemaking (pomace) on some of the virulence properties of Streptococcus mutans a well-known dental pathogen. Grape phenolic extracts were obtained from Vitis vinifera varieties Cabernet Franc and Pinot Noir and Vitis interspecific hybrid varieties Baco Noir and Noiret. The anthocyanins and flavan-3-ols content were highly variable depending on grape variety and type of extract (whole fruit vs fermented pomace). Nevertheless, all grape phenolic extracts remarkably inhibited glucosyltransferases B and C (70–85% inhibition) at concentrations as low as 62.5 µg/mL (P < 0.01). Furthermore, the glycolytic pH-drop by S. mutans cells was inhibited by the grape extracts without affecting the bacterial viability; an effect that can be attributed to partial inhibition of F-ATPase activity (30–65% inhibition at 125 µg/mL; P < 0.01). The biological activity of fermented pomace was either as effective as or significantly better than whole fruit grape extracts. The results showed that grape phenolic extracts, especially from pomace, are highly effective against specific virulence traits of S. mutans despite major differences in their phenolic content.

    Copyright © 2007 American Chemical Society

    Subjects

    what are subjects

    Keywords

    what are keywords

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Cited By

    Click to copy section linkSection link copied!
    Citation Statements
    Explore this article's citation statements on scite.ai
    powered by  Scite

    This article is cited by 121 publications.

    1. Gislaine Cristiane Mantovanelli, Márcio Shigueaki Mito, Letycia Lopes Ricardo, Paulo Vinicius Moreira da Costa Menezes, Isabela de Carvalho Contesoto, Caroline Ribeiro Alves do Nascimento, Ana Luiza Wagner Zampieri, Gabriel Felipe Stulp, Rodrigo Polimeni Constantin, Emy Luiza Ishii-Iwamoto. Differential Effects of Exogenous Resveratrol on the Growth and Energy Metabolism of Zea mays and the Weed Ipomoea grandifolia. Journal of Agricultural and Food Chemistry 2020, 68 (10) , 3006-3016. https://doi.org/10.1021/acs.jafc.9b06304
    2. Yousef I. Hassan, Veronika Kosir, Xianhua Yin, Kelly Ross, Moussa S. Diarra. Grape Pomace as a Promising Antimicrobial Alternative in Feed: A Critical Review. Journal of Agricultural and Food Chemistry 2019, 67 (35) , 9705-9718. https://doi.org/10.1021/acs.jafc.9b02861
    3. Brittany J. Allison, Christopher W. Simmons. Obtaining Multiple Coproducts from Red Grape Pomace via Anthocyanin Extraction and Biogas Production. Journal of Agricultural and Food Chemistry 2018, 66 (30) , 8045-8053. https://doi.org/10.1021/acs.jafc.8b02250
    4. Bhavitavya Nijampatnam, Hua Zhang, Xia Cai, Suzanne M. Michalek, Hui Wu, Sadanandan E. Velu. Inhibition of Streptococcus mutans Biofilms by the Natural Stilbene Piceatannol Through the Inhibition of Glucosyltransferases. ACS Omega 2018, 3 (7) , 8378-8385. https://doi.org/10.1021/acsomega.8b00367
    5. Lindsay F. Springer and Gavin L. Sacks . Protein-Precipitable Tannin in Wines from Vitis vinifera and Interspecific Hybrid Grapes (Vitis ssp.): Differences in Concentration, Extractability, and Cell Wall Binding. Journal of Agricultural and Food Chemistry 2014, 62 (30) , 7515-7523. https://doi.org/10.1021/jf5023274
    6. Mendel Friedman . Antibacterial, Antiviral, and Antifungal Properties of Wines and Winery Byproducts in Relation to Their Flavonoid Content. Journal of Agricultural and Food Chemistry 2014, 62 (26) , 6025-6042. https://doi.org/10.1021/jf501266s
    7. Irene Muñoz-González, Thomas Thurnheer, Begoña Bartolomé, and M. Victoria Moreno-Arribas . Red Wine and Oenological Extracts Display Antimicrobial Effects in an Oral Bacteria Biofilm Model. Journal of Agricultural and Food Chemistry 2014, 62 (20) , 4731-4737. https://doi.org/10.1021/jf501768p
    8. Ariel R. Fontana, Andrea Antoniolli, and Rubén Bottini . Grape Pomace as a Sustainable Source of Bioactive Compounds: Extraction, Characterization, and Biotechnological Applications of Phenolics. Journal of Agricultural and Food Chemistry 2013, 61 (38) , 8987-9003. https://doi.org/10.1021/jf402586f
    9. Lorena Diez, Zenaida Guadalupe, Belén Ayestarán and Fernanda Ruiz-Larrea. Effect of Yeast Mannoproteins and Grape Polysaccharides on the Growth of Wine Lactic Acid and Acetic Acid Bacteria. Journal of Agricultural and Food Chemistry 2010, 58 (13) , 7731-7739. https://doi.org/10.1021/jf100199n
    10. Lubna Atta, Ali Raza Siddiqui, Mamona Mushtaq, Sajida Munsif, Mohammad Nur-e-Alam, Aftab Ahmed, Zaheer Ul-Haq. Molecular insights into antibiofilm inhibitors of Streptococcus mutans glucosyltransferases through in silico approaches. Scientific Reports 2025, 15 (1) https://doi.org/10.1038/s41598-025-98927-8
    11. María Jesús Martín-Mateos, Jonathan Delgado-Adámez, María Díaz-Ponce, David Tejerina, María Rosario Ramírez-Bernabé. Frankfurters Manufactured with Valorized Grape Pomace as a Substitute of Nitrifying Salts. Foods 2025, 14 (3) , 391. https://doi.org/10.3390/foods14030391
    12. João Pedro Nunes Sagini, Fernanda Cristina Possamai Rossatto, Felipe Souza, Eduardo Pilau, Caroline Brandão Quines, Daiana Silva Ávila, Rodrigo Ligabue-Braun, Aline Rigon Zimmer, Rebeca Inhoque Pereira, Karine Rigon Zimmer. Inhibition of Staphylococcus epidermidis and Pseudomonas aeruginosa biofilms by grape and rice agroindustrial residues. Microbial Pathogenesis 2024, 197 , 107019. https://doi.org/10.1016/j.micpath.2024.107019
    13. Mattia Di Maro, Luca Gargiulo, Giovanna Gomez d’Ayala, Donatella Duraccio. Exploring Antimicrobial Compounds from Agri-Food Wastes for Sustainable Applications. International Journal of Molecular Sciences 2024, 25 (23) , 13171. https://doi.org/10.3390/ijms252313171
    14. Jingjing Zhang, Hui Wang, Chao Ai, Rui Lu, Lei Chen, Jianbo Xiao, Hui Teng. Food matrix-flavonoid interactions and their effect on bioavailability. Critical Reviews in Food Science and Nutrition 2024, 64 (30) , 11124-11145. https://doi.org/10.1080/10408398.2023.2232880
    15. Jozef Sabo, Natália Čmiková, Miroslava Kačániová. Antimicrobial Activity of Grape Pomace Extracts Against Different Species of Microorganisms. Acta Horticulturae et Regiotecturae 2024, 27 (2) , 117-123. https://doi.org/10.2478/ahr-2024-0018
    16. Lubna Atta, Mamona Mushtaq, Ali Raza Siddiqui, Assad Khalid, Zaheer Ul-Haq. Targeting glucosyltransferases to combat dental caries: Current perspectives and future prospects. International Journal of Biological Macromolecules 2024, 278 , 134645. https://doi.org/10.1016/j.ijbiomac.2024.134645
    17. Vladimir S. Kurćubić, Slaviša B. Stajić, Vladimir Živković, Pavle Z. Mašković, Vesna Matejić, Marko Dmitrić, Saša Živković, Luka V. Kurćubić, Vladimir Jakovljević. Leftover and weed, joint efforts to preserve health: Joke or reality?. Future Postharvest and Food 2024, 1 (3) , 283-299. https://doi.org/10.1002/fpf2.12031
    18. Zonghuan Ma, Wenfang Li, Yusheng Zhang, Baihong Chen, Juan Mao. Analysis of quality and aroma components of ‘Merlot’ grape from different areas in Hexi Corridor, Gansu Province, China. Acta Horticulturae 2024, 36 (1401) , 195-202. https://doi.org/10.17660/ActaHortic.2024.1401.30
    19. Neshkumar KLS, Kavitha Ramar. Evaluation of the Genotoxic Effects of Grape Seed Extract and Marine Collagen Peptide on the Fibroblast Cell Line: An In Vitro Study. Cureus 2024, 340 https://doi.org/10.7759/cureus.61605
    20. Jaiganesh Ramamurthy. Evaluation of Antimicrobial Activity of Nanoformulated Grape Seed Oil against Oral Microbes: An In Vitro Study. World Journal of Dentistry 2024, 15 (1) , 44-47. https://doi.org/10.5005/jp-journals-10015-2360
    21. Elena Iacono, Carlo Di Marzo, Mauro Di Stasi, Emily Cioni, Francesca Gambineri, Antonella Giuliana Luminare, Marinella De Leo, Alessandra Braca, Paola Quaranta, Michele Lai, Giulia Freer, Mauro Pistello. Broad-spectrum virucidal activity of a hydroalcoholic extract of grape pomace. Bioresource Technology Reports 2024, 25 , 101745. https://doi.org/10.1016/j.biteb.2023.101745
    22. Dorota Grabek-Lejko, Tomasz Hyrchel. The Antibacterial Properties of Polish Honey against Streptococcus mutans—A Causative Agent of Dental Caries. Antibiotics 2023, 12 (11) , 1640. https://doi.org/10.3390/antibiotics12111640
    23. Marta C. Coelho, Soudabeh Ghalamara, Ricardo Pereira, António S. Rodrigues, José A. Teixeira, Manuela E. Pintado. Innovation and Winemaking By-Product Valorization: An Ohmic Heating Approach. Processes 2023, 11 (2) , 495. https://doi.org/10.3390/pr11020495
    24. Fitri Ekawati, Doni Hariandi, Meisilva Erona Sitepu, Irfan Suliansyah. The effect of liquid organic fertilizer towards increased vegetative growth some varieties of grapevines (Vitis vinifera L.). 2023, 020004. https://doi.org/10.1063/5.0128023
    25. Rafaela P. Rodrigues, Licínio M. Gando-Ferreira, Margarida J. Quina. Increasing Value of Winery Residues through Integrated Biorefinery Processes: A Review. Molecules 2022, 27 (15) , 4709. https://doi.org/10.3390/molecules27154709
    26. Leonardo Brunetti, Rosalba Leuci, Maria Antonietta Colonna, Rossana Carrieri, Francesco Emanuele Celentano, Giancarlo Bozzo, Fulvio Loiodice, Maria Selvaggi, Vincenzo Tufarelli, Luca Piemontese. Food Industry Byproducts as Starting Material for Innovative, Green Feed Formulation: A Sustainable Alternative for Poultry Feeding. Molecules 2022, 27 (15) , 4735. https://doi.org/10.3390/molecules27154735
    27. Zeeshan Qamar, Tayyaba Zeeshan, Omar Bandar Al Dossary, Tariq Abdullah Alanazi, Jaber Naif Aldhuwayhi, Abdulrahman Hassan Alqarni, Abdulrahman Mohammed Alshalan. Natural products’ potential to maintain/ameliorate oral health: A review. International Food Research Journal 2022, 29 (3) , 487-495. https://doi.org/10.47836/ifrj.29.3.02
    28. Ricardo Vejarano, Mariano Luján-Corro. Red Wine and Health: Approaches to Improve the Phenolic Content During Winemaking. Frontiers in Nutrition 2022, 9 https://doi.org/10.3389/fnut.2022.890066
    29. Giusy Caponio, Mirella Noviello, Francesco Calabrese, Giuseppe Gambacorta, Gianluigi Giannelli, Maria De Angelis. Effects of Grape Pomace Polyphenols and In Vitro Gastrointestinal Digestion on Antimicrobial Activity: Recovery of Bioactive Compounds. Antioxidants 2022, 11 (3) , 567. https://doi.org/10.3390/antiox11030567
    30. Aliona Ghendov-Mosanu, Daniela Cojocari, Greta Balan, Antoanela Patras, Ildiko Lung, Maria-Loredana Soran, Ocsana Opriş, Elena Cristea, Rodica Sturza. Chemometric Optimization of Biologically Active Compounds Extraction from Grape Marc: Composition and Antimicrobial Activity. Molecules 2022, 27 (5) , 1610. https://doi.org/10.3390/molecules27051610
    31. Sineenart Sanpinit, Kotchakorn Moosigapong, Siriporn Jarukitsakul, Kawinsak Jatutasri, Acharaporn Issuriya, Nantiya Joycharat, Katesarin Maneenoon, Patcharawalai Jaisamut, Sasitorn Chusri, Supayang Piyawan Voravuthikunchai, Korakot Wichitsa-nguan Jetwanna, Surasak Limsuwan. Selected Thai traditional polyherbal medicines suppress the cariogenic properties of Streptococcus mutans by disrupting its acid formation and quorum sensing abilities. South African Journal of Botany 2022, 144 , 355-363. https://doi.org/10.1016/j.sajb.2021.09.014
    32. Konstantin Martynenko, Petr Balanov, Irina Smotraeva, Olga I Vanchenko, , . Exploring the potential of total polyphenols in the leaves of berry plants for a healthy diet. BIO Web of Conferences 2022, 48 , 02001. https://doi.org/10.1051/bioconf/20224802001
    33. Verónica Marcillo-Parra, Diego Santiago Tupuna-Yerovi, Zulay González, Jenny Ruales. Encapsulation of bioactive compounds from fruit and vegetable by-products for food application – A review. Trends in Food Science & Technology 2021, 116 , 11-23. https://doi.org/10.1016/j.tifs.2021.07.009
    34. Carmela Gerardi, Loris Pinto, Federico Baruzzi, Giovanna Giovinazzo. Comparison of Antibacterial and Antioxidant Properties of Red (cv. Negramaro) and White (cv. Fiano) Skin Pomace Extracts. Molecules 2021, 26 (19) , 5918. https://doi.org/10.3390/molecules26195918
    35. Justyna Antoniewicz, Karolina Jakubczyk, Paweł Kwiatkowski, Dominika Maciejewska-Markiewicz, Joanna Kochman, Ewa Rębacz-Maron, Katarzyna Janda-Milczarek. Analysis of Antioxidant Capacity and Antimicrobial Properties of Selected Polish Grape Vinegars Obtained by Spontaneous Fermentation. Molecules 2021, 26 (16) , 4727. https://doi.org/10.3390/molecules26164727
    36. Jasmin Flemming, Clara Theres Meyer-Probst, Karl Speer, Isabelle Kölling-Speer, Christian Hannig, Matthias Hannig. Preventive Applications of Polyphenols in Dentistry—A Review. International Journal of Molecular Sciences 2021, 22 (9) , 4892. https://doi.org/10.3390/ijms22094892
    37. María Carmen Sánchez, Andrea Alonso-Español, Honorato Ribeiro-Vidal, Bettina Alonso, David Herrera, Mariano Sanz. Relevance of Biofilm Models in Periodontal Research: From Static to Dynamic Systems. Microorganisms 2021, 9 (2) , 428. https://doi.org/10.3390/microorganisms9020428
    38. Valdemiro Carlos Sgarbieri, Maria Teresa Bertoldo-Pacheco, Nádia Fátima Gibrim, Denise Aparecida Gonçalves de Oliveira, Maria Elisa Caetano-Silva. A importância metabólica de compostos bioativos não nutrientes. 2021, 71-104. https://doi.org/10.7476/9788526815353.0004
    39. Ryohei Fujita, Takahiro Hayasaka, Shigeki Jin, Shu-Ping Hui, Yoichiro Hoshino. Comparison of anthocyanin distribution in berries of Haskap (Lonicera caerulea subsp. edulis (Turcz. ex. Herder) Hultén), Miyama-uguisukagura (Lonicera gracilipes Miq.), and their interspecific hybrid using imaging mass spectrometry. Plant Science 2020, 300 , 110633. https://doi.org/10.1016/j.plantsci.2020.110633
    40. Kenneth R. Sims, Julian P. Maceren, Yuan Liu, Guilherme R. Rocha, Hyun Koo, Danielle S.W. Benoit. Dual antibacterial drug-loaded nanoparticles synergistically improve treatment of Streptococcus mutans biofilms. Acta Biomaterialia 2020, 115 , 418-431. https://doi.org/10.1016/j.actbio.2020.08.032
    41. Jasmin Kirsch, Amira Jung, Kristin Hille, Belinda König, Christian Hannig, Isabelle Kölling-Speer, Karl Speer, Matthias Hannig. Effect of fragaria vesca, hamamelis and tormentil on the initial bacterial colonization in situ. Archives of Oral Biology 2020, 118 , 104853. https://doi.org/10.1016/j.archoralbio.2020.104853
    42. E. Vaňková, M. Paldrychová, P. Kašparová, K. Lokočová, Z. Kodeš, O. Maťátková, I. Kolouchová, J. Masák. Natural antioxidant pterostilbene as an effective antibiofilm agent, particularly for gram-positive cocci. World Journal of Microbiology and Biotechnology 2020, 36 (7) https://doi.org/10.1007/s11274-020-02876-5
    43. Christine Fuchs, Tamara Bakuradze, Regina Steinke, Rekha Grewal, Gunter P. Eckert, Elke Richling. Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. Journal of Functional Foods 2020, 70 , 103988. https://doi.org/10.1016/j.jff.2020.103988
    44. Cătălina Bogdan, Anca Pop, Sonia M. Iurian, Daniela Benedec, Mirela L. Moldovan. Research Advances in the Use of Bioactive Compounds from Vitis vinifera By-Products in Oral Care. Antioxidants 2020, 9 (6) , 502. https://doi.org/10.3390/antiox9060502
    45. Nicole M Delimont, Brandi N Carlson. Prevention of dental caries by grape seed extract supplementation: A systematic review. Nutrition and Health 2020, 26 (1) , 43-52. https://doi.org/10.1177/0260106019887890
    46. Zabdiel Alvarado-Martinez, Arpita Aditya, Debabrata Biswas. Plant antioxidants, extraction strategies, and their application in meat. 2020, 241-264. https://doi.org/10.1016/B978-0-12-819233-7.00014-8
    47. Zaleha Shafiei, Zubaidah Haji Abdul Rahim, Koshy Philip, Nalina Thurairajah, Hashim Yaacob. Potential effects of Psidium sp., Mangifera sp., Mentha sp. and its mixture (PEM) in reducing bacterial populations in biofilms, adherence and acid production of S. sanguinis and S. mutans. Archives of Oral Biology 2020, 109 , 104554. https://doi.org/10.1016/j.archoralbio.2019.104554
    48. María C. Sánchez, Honorato Ribeiro-Vidal, Adelaida Esteban-Fernández, Begoña Bartolomé, Elena Figuero, María V. Moreno-Arribas, Mariano Sanz, David Herrera. Antimicrobial activity of red wine and oenological extracts against periodontal pathogens in a validated oral biofilm model. BMC Complementary and Alternative Medicine 2019, 19 (1) https://doi.org/10.1186/s12906-019-2533-5
    49. Neelima Mahato, Mukty Sinha, Kavita Sharma, Rakoti Koteswararao, Moo Hwan Cho. Modern Extraction and Purification Techniques for Obtaining High Purity Food-Grade Bioactive Compounds and Value-Added Co-Products from Citrus Wastes. Foods 2019, 8 (11) , 523. https://doi.org/10.3390/foods8110523
    50. Mohamed Ben Aziz, François Garcia, Laetitia Mouls, Hélène Fulcrand, Hassan Hajjaj. Proanthocyanidins and anthocyanins contents, chromatic and antioxidant properties of red grape pomaces from morocco. Journal of Food Measurement and Characterization 2019, 13 (3) , 2051-2061. https://doi.org/10.1007/s11694-019-00126-3
    51. Kavita Sharma, Neelima Mahato, Yong Rok Lee. Extraction, characterization and biological activity of citrus flavonoids. Reviews in Chemical Engineering 2019, 35 (2) , 265-284. https://doi.org/10.1515/revce-2017-0027
    52. Youri Joh, William G. McGlynn. Phenolic profile of blackberry wine produced using Korean winemaking techniques in earthenware jars. Journal of the Institute of Brewing 2019, 125 (1) , 118-124. https://doi.org/10.1002/jib.534
    53. Martina Paldrychová, Irena Kolouchová, Eva Vaňková, Olga Maťátková, Jan Šmidrkal, Aleš Krmela, Věra Schulzová, Jana Hajšlová, Jan Masák. Effect of resveratrol and Regrapex-R-forte on Trichosporon cutaneum biofilm. Folia Microbiologica 2019, 64 (1) , 73-81. https://doi.org/10.1007/s12223-018-0633-0
    54. Nevena Kardum, Maria Glibetic. Polyphenols and Their Interactions With Other Dietary Compounds: Implications for Human Health. 2018, 103-144. https://doi.org/10.1016/bs.afnr.2017.12.001
    55. Adelaida Esteban-Fernández, Irene Zorraquín-Peña, Dolores González de Llano, Begoña Bartolomé, M. Victoria Moreno-Arribas. The role of wine and food polyphenols in oral health. Trends in Food Science & Technology 2017, 69 , 118-130. https://doi.org/10.1016/j.tifs.2017.09.008
    56. Alvaro Peña‐Neira. Grapes. 2017, 1041-1054. https://doi.org/10.1002/9781119158042.ch51
    57. Samira L. Abdalla, Sônia S. Costa, Marco Antônio Gioso, Livia M. Casanova, Marcela A.S. Coutinho, Marta Fernanda A. Silva, Maria Clara da S.N. Botelho, Raquel S.G. Dias. Efficacy of a Kalanchoe gastonis-bonnieri extract to control bacterial biofilms and dental calculus in dogs. Pesquisa Veterinária Brasileira 2017, 37 (8) , 859-865. https://doi.org/10.1590/s0100-736x2017000800013
    58. Liudmila Korkina, Wolfgang Mayer, Chiara De Luca. Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation. Biomolecules 2017, 7 (2) , 40. https://doi.org/10.3390/biom7020040
    59. Loreto Sanhueza, Ricardo Melo, Ruth Montero, Kevin Maisey, Leonora Mendoza, Marcela Wilkens, . Synergistic interactions between phenolic compounds identified in grape pomace extract with antibiotics of different classes against Staphylococcus aureus and Escherichia coli. PLOS ONE 2017, 12 (2) , e0172273. https://doi.org/10.1371/journal.pone.0172273
    60. Shenli Wang, Miryam Amigo-Benavent, Raquel Mateos, Laura Bravo, Beatriz Sarriá. Effects of in vitro digestion and storage on the phenolic content and antioxidant capacity of a red grape pomace. International Journal of Food Sciences and Nutrition 2017, 68 (2) , 188-200. https://doi.org/10.1080/09637486.2016.1228099
    61. Iva Fernandes, Rosa Pérez-Gregorio, Susana Soares, Nuno Mateus, Victor De Freitas. Wine Flavonoids in Health and Disease Prevention. Molecules 2017, 22 (2) , 292. https://doi.org/10.3390/molecules22020292
    62. Helmut Dietrich, Martin S. Pour Nikfardjam. Influence of Phenolic Compounds and Tannins on Wine-Related Microorganisms. 2017, 421-454. https://doi.org/10.1007/978-3-319-60021-5_18
    63. Aleksandra Radovanović, Biljana Arsić, Vladimir Radovanović, Branimir Jovančičević, Vesna Nikolić. Broad-spectrum of antimicrobial properties of commercial wines from different Vitis vinifera L. varieties. World Journal of Microbiology and Biotechnology 2017, 33 (1) https://doi.org/10.1007/s11274-016-2183-4
    64. Jelena Cvejic Hogervorst, Uroš Miljić, Vladimir Puškaš. Extraction of Bioactive Compounds from Grape Processing By-Products. 2017, 105-135. https://doi.org/10.1016/B978-0-12-809870-7.00005-3
    65. Ariel Fontana, Andrea Antoniolli, María Agustina D'Amario Fernández, Rubén Bottini. Phenolics profiling of pomace extracts from different grape varieties cultivated in Argentina. RSC Advances 2017, 7 (47) , 29446-29457. https://doi.org/10.1039/C7RA04681B
    66. Javier García‐Lomillo, María Luisa González‐SanJosé. Applications of Wine Pomace in the Food Industry: Approaches and Functions. Comprehensive Reviews in Food Science and Food Safety 2017, 16 (1) , 3-22. https://doi.org/10.1111/1541-4337.12238
    67. Tomas Kacergius, Saleh Abu-Lafi, Agne Kirkliauskiene, Vika Gabe, Azmi Adawi, Mahmoud Rayan, Mutaz Qutob, Rimantas Stukas, Algirdas Utkus, Mouhammad Zeidan, Anwar Rayan. Inhibitory capacity of Rhus coriaria L. extract and its major component methyl gallate on Streptococcus mutans biofilm formation by optical profilometry: Potential applications for oral health. Molecular Medicine Reports 2017, 16 (1) , 949-956. https://doi.org/10.3892/mmr.2017.6674
    68. Priscilla Siqueira Melo, Leandro de Oliveira Rodrigues Arrivetti, Severino Matias de Alencar, Leif H. Skibsted. Antioxidative and prooxidative effects in food lipids and synergism with α-tocopherol of açaí seed extracts and grape rachis extracts. Food Chemistry 2016, 213 , 440-449. https://doi.org/10.1016/j.foodchem.2016.06.101
    69. Lívia Slobodníková, Silvia Fialová, Katarína Rendeková, Ján Kováč, Pavel Mučaji. Antibiofilm Activity of Plant Polyphenols. Molecules 2016, 21 (12) , 1717. https://doi.org/10.3390/molecules21121717
    70. Dorota Wojnicz, Dorota Tichaczek-Goska, Kamila Korzekwa, Marta Kicia, Andrzej B. Hendrich. Study of the impact of cranberry extract on the virulence factors and biofilm formation by Enterococcus faecalis strains isolated from urinary tract infections. International Journal of Food Sciences and Nutrition 2016, 67 (8) , 1005-1016. https://doi.org/10.1080/09637486.2016.1211996
    71. J.L. Guil-Guerrero, L. Ramos, C. Moreno, J.C. Zúñiga-Paredes, M. Carlosama-Yépez, P. Ruales. Plant-food by-products to improve farm-animal health. Animal Feed Science and Technology 2016, 220 , 121-135. https://doi.org/10.1016/j.anifeedsci.2016.07.016
    72. Milan Swadas, Soham M Vyas, Nupur Shah. Evaluation and Comparison of the Antibacterial Activity against Streptococcus mutans of Grape Seed Extract at Different Concentrations with Chlorhexidine Gluconate: An in vitro Study. International Journal of Clinical Pediatric Dentistry 2016, 9 (3) , 181-185. https://doi.org/10.5005/jp-journals-10005-1360
    73. Dimitris P. Makris, Vassiliki Passalidi, Stamatina Kallithraka, Ioannis Mourtzinos. Optimization of polyphenol extraction from red grape pomace using aqueous glycerol/tartaric acid mixtures and response surface methodology. Preparative Biochemistry & Biotechnology 2016, 46 (2) , 176-182. https://doi.org/10.1080/10826068.2015.1015562
    74. Soheila Abachi, Song Lee, H. Rupasinghe. Molecular Mechanisms of Inhibition of Streptococcus Species by Phytochemicals. Molecules 2016, 21 (2) , 215. https://doi.org/10.3390/molecules21020215
    75. Lamprini Karygianni, Ali Al-Ahmad, Aikaterini Argyropoulou, Elmar Hellwig, Annette C. Anderson, Alexios L. Skaltsounis. Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms. Frontiers in Microbiology 2016, 6 https://doi.org/10.3389/fmicb.2015.01529
    76. Zaleha Shafiei, Zubaidah Haji Abdul Rahim, Koshy Philip, Nalina Thurairajah. Antibacterial and anti-adherence effects of a plant extract mixture (PEM) and its individual constituent extracts ( Psidium sp. , Mangifera sp ., and Mentha sp .) on single- and dual-species biofilms. PeerJ 2016, 4 , e2519. https://doi.org/10.7717/peerj.2519
    77. Alaa Bekhit, Vern Cheng, Roland Harrison, Zhijing Ye, Adnan Bekhit, Tzi Ng, Lingming Kong. Technological Aspects of By-Product Utilization. 2015, 117-198. https://doi.org/10.1201/b19423-5
    78. Katerina Tzima, Stamatina Kallithraka, Yorgos Kotseridis, Dimitris P. Makris. A Comparative Evaluation of Aqueous Natural Organic Acid Media for the Efficient Recovery of Flavonoids from Red Grape (Vitis vinifera) Pomace. Waste and Biomass Valorization 2015, 6 (3) , 391-400. https://doi.org/10.1007/s12649-015-9358-3
    79. Doglas Cecchin, Ana Paula Farina, Matheus Albino Souza, Lourenço Luís Albarello, Alicia Pamela Schneider, Cristina Mattos Pimenta Vidal, Ana Karina Bedran-Russo. Evaluation of antimicrobial effectiveness and dentine mechanical properties after use of chemical and natural auxiliary irrigants. Journal of Dentistry 2015, 43 (6) , 695-702. https://doi.org/10.1016/j.jdent.2015.03.013
    80. Bochra Kouidhi, Yasir Mohammed A. Al Qurashi, Kamel Chaieb. Drug resistance of bacterial dental biofilm and the potential use of natural compounds as alternative for prevention and treatment. Microbial Pathogenesis 2015, 80 , 39-49. https://doi.org/10.1016/j.micpath.2015.02.007
    81. Pooja Doshi, Pandurang Adsule, Kaushik Banerjee, Dasharath Oulkar. Phenolic compounds, antioxidant activity and insulinotropic effect of extracts prepared from grape (Vitis vinifera L) byproducts. Journal of Food Science and Technology 2015, 52 (1) , 181-190. https://doi.org/10.1007/s13197-013-0991-1
    82. Sandra R. F. Iora, Giselle M. Maciel, Acácio A. F. Zielinski, Marcos V. da Silva, Paula V. de A. Pontes, Charles W. I. Haminiuk, Daniel Granato. Evaluation of the bioactive compounds and the antioxidant capacity of grape pomace. International Journal of Food Science & Technology 2015, 50 (1) , 62-69. https://doi.org/10.1111/ijfs.12583
    83. Lei Cheng, Jiyao Li, Libang He, Xuedong Zhou. Natural Products and Caries Prevention. Caries Research 2015, 49 (Suppl. 1) , 38-45. https://doi.org/10.1159/000377734
    84. Katerina Tzima, Stamatina Kallithraka, Yorgos Kotseridis, Dimitris Makris. Kinetic Modelling for Flavonoid Recovery from Red Grape (Vitis vinifera) Pomace with Aqueous Lactic Acid. Processes 2014, 2 (4) , 901-911. https://doi.org/10.3390/pr2040901
    85. Mohamed Gamaleldin Elsadig Karar, Daniel Pletzer, Rakesh Jaiswal, Helge Weingart, Nikolai Kuhnert. Identification, characterization, isolation and activity against Escherichia coli of quince (Cydonia oblonga) fruit polyphenols. Food Research International 2014, 65 , 121-129. https://doi.org/10.1016/j.foodres.2013.10.040
    86. Lina M. Ramirez‐Lopez, Christina A. M. DeWitt. Analysis of phenolic compounds in commercial dried grape pomace by high‐performance liquid chromatography electrospray ionization mass spectrometry. Food Science & Nutrition 2014, 2 (5) , 470-477. https://doi.org/10.1002/fsn3.136
    87. Apa Juntavee, Ariya Ratanathongkam, Supaporn Chatchiwiwattana, Jomjai Peerapattana, Nartsajee Nualkaew, Panta Treesuwan. The Antibacterial Effects of Apacaries Gel on Streptococcus mutans: An in vitro Study. International Journal of Clinical Pediatric Dentistry 2014, 7 (2) , 77-81. https://doi.org/10.5005/jp-journals-10005-1241
    88. L.M. Ramirez-Lopez, W. McGlynn, C.L. Goad, C.A. Mireles DeWitt. Simultaneous determination of phenolic compounds in Cynthiana grape (Vitis aestivalis) by high performance liquid chromatography–electrospray ionisation–mass spectrometry. Food Chemistry 2014, 149 , 15-24. https://doi.org/10.1016/j.foodchem.2013.10.078
    89. Nimmy Augustine, A.K. Goel, K.C. Sivakumar, R. Ajay Kumar, Sabu Thomas. Resveratrol – A potential inhibitor of biofilm formation in Vibrio cholerae. Phytomedicine 2014, 21 (3) , 286-289. https://doi.org/10.1016/j.phymed.2013.09.010
    90. Enqin Xia, Xiran He, Huabin Li, Shan Wu, Sha Li, Guifang Deng. Biological Activities of Polyphenols from Grapes. 2014, 47-58. https://doi.org/10.1016/B978-0-12-398456-2.00005-0
    91. Loreto Sanhueza, Mario Tello, Marcela Vivanco, Leonora Mendoza, Marcela Wilkens. Relation between Antibacterial Activity against Food Transmitted Pathogens and Total Phenolic Compounds in Grape Pomace Extracts from Cabernet Sauvignon and Syrah Varieties. Advances in Microbiology 2014, 04 (05) , 225-232. https://doi.org/10.4236/aim.2014.45029
    92. Kuldeep Dhama, Ruchi Tiwari, Sandip Chakrabort, Mani Saminathan, Amit Kumar, K. Karthik, Mohd. Yaqoob Wani, Amarpal ., Shoor Vir Singh, Anu Rahal. Evidence Based Antibacterial Potentials of Medicinal Plants and Herbs Countering Bacterial Pathogens Especially in the Era of Emerging Drug Resistance: An Integrated Update. International Journal of Pharmacology 2013, 10 (1) , 1-43. https://doi.org/10.3923/ijp.2014.1.43
    93. Angela Tseng, Yanyun Zhao. Wine grape pomace as antioxidant dietary fibre for enhancing nutritional value and improving storability of yogurt and salad dressing. Food Chemistry 2013, 138 (1) , 356-365. https://doi.org/10.1016/j.foodchem.2012.09.148
    94. David C. Manns, Céline T. M. Coquard Lenerz, Anna Katharine Mansfield. Impact of Processing Parameters on the Phenolic Profile of Wines Produced from Hybrid Red Grapes Maréchal Foch, Corot noir, and Marquette. Journal of Food Science 2013, 78 (5) https://doi.org/10.1111/1750-3841.12108
    95. Daniela A. Oliveira, Ana Augusta Salvador, Artur Smânia, Elza F.A. Smânia, Marcelo Maraschin, Sandra R.S. Ferreira. Antimicrobial activity and composition profile of grape (Vitis vinifera) pomace extracts obtained by supercritical fluids. Journal of Biotechnology 2013, 164 (3) , 423-432. https://doi.org/10.1016/j.jbiotec.2012.09.014
    96. Lap Ho, Mario G. Ferruzzi, Elsa M. Janle, Jun Wang, Bing Gong, Tzu‐Ying Chen, Jessica Lobo, Bruce Cooper, Qing Li Wu, Stephen T. Talcott, Susan S. Percival, James E. Simon, Giulio Maria Pasinetti. Identification of brain‐targeted bioactive dietary quercetin‐3‐ O ‐glucuronide as a novel intervention for Alzheimer's disease. The FASEB Journal 2013, 27 (2) , 769-781. https://doi.org/10.1096/fj.12-212118
    97. Angela Tseng, Yanyun Zhao. Effect of Different Drying Methods and Storage Time on the Retention of Bioactive Compounds and Antibacterial Activity of Wine Grape Pomace (Pinot Noir and Merlot). Journal of Food Science 2012, 77 (9) https://doi.org/10.1111/j.1750-3841.2012.02840.x
    98. Shiny Benjamin, Roshni LNU, Sabeena Susan Thomas, Mohan Thomas Nainan. Grape Seed Extract as a Potential Remineralizing Agent: A Comparative in vitro Study. The Journal of Contemporary Dental Practice 2012, 13 (4) , 425-430. https://doi.org/10.5005/jp-journals-10024-1162
    99. Akira Yano, Sayaka Kikuchi, Tohru Takahashi, Keiko Kohama, Yasuo Yoshida. Inhibitory effects of the phenolic fraction from the pomace of Vitis coignetiae on biofilm formation by Streptococcus mutans. Archives of Oral Biology 2012, 57 (6) , 711-719. https://doi.org/10.1016/j.archoralbio.2012.01.001
    100. C. Cueva, S. Mingo, I. Muñoz-González, I. Bustos, T. Requena, R. del Campo, P.J. Martín-Álvarez, B. Bartolomé, M.V. Moreno-Arribas. Antibacterial activity of wine phenolic compounds and oenological extracts against potential respiratory pathogens. Letters in Applied Microbiology 2012, 54 (6) , 557-563. https://doi.org/10.1111/j.1472-765X.2012.03248.x
    Load all citations
    Download PDF
    Go to Journal of Agricultural and Food Chemistry
    Get e-Alerts
    Get e-Alerts

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2007, 55, 25, 10200–10207
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf0722405
    Published November 14, 2007
    Copyright © 2007 American Chemical Society
    Request reuse permissions

    Article Views

    2461

    Altmetric

    -

    Citations

    121
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.