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trans-Resveratrol Reduces Precancerous Colonic Lesions in Dimethylhydrazine-Treated Rats

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Departament de Fisiologia (Farmàcia) and Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, Spain
*To whom correspondence should be addressed. Tel: +34934024505. Fax: +34934035901. E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2010, 58, 13, 8104–8110
Publication Date (Web):June 3, 2010
https://doi.org/10.1021/jf100702x
Copyright © 2010 American Chemical Society
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    Abstract

    trans-Resveratrol, a natural occurring polyphenol, has been described as an antiproliferative and proapoptotic agent in vitro. Here, we studied the effect of trans-resveratrol administered orally at a dose of 60 mg/kg for 49 days on early preneoplastic markers induced by the intraperitoneal injection of 1,2-dimethylhydrazine (20 mg/kg). We measured trans-resveratrol and its derivates by liquid−liquid extraction followed by high-performance liquid chromatography diode array detection analysis in colon contents. Dihydroresveratrol was the most abundant compound in the colon, followed by trans-resveratrol glucuronide and small amounts of trans-resveratrol and its sulfate. The administration of trans-resveratrol decreased aberrant crypt foci by 52%, and mucin depleted foci by 45% in colon. In conclusion, the correlation between the reduction of precancerous colonic lesions and the availability of trans-resveratrol in the colon provides a new insight into the therapeutical potential of this polyphenol and its metabolites.

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