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T-2 Toxin, a Trichothecene Mycotoxin: Review of Toxicity, Metabolism, and Analytical Methods

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Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, People’s Republic of China
Southern Plains Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, 2881 F&B Road, College Station, Texas 77845-4988, United States
§ Laboratory of Food Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
*Phone: +86-10-6273-1201. Fax: +86-10-6273-1032. E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2011, 59, 8, 3441–3453
Publication Date (Web):March 18, 2011
Copyright © 2011 American Chemical Society

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    This review focuses on the toxicity and metabolism of T-2 toxin and analytical methods used for the determination of T-2 toxin. Among the naturally occurring trichothecenes in food and feed, T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. Following ingestion, T-2 toxin causes acute and chronic toxicity and induces apoptosis in the immune system and fetal tissues. T-2 toxin is usually metabolized and eliminated after ingestion, yielding more than 20 metabolites. Consequently, there is a possibility of human consumption of animal products contaminated with T-2 toxin and its metabolites. Several methods for the determination of T-2 toxin based on traditional chromatographic, immunoassay, or mass spectroscopy techniques are described. This review will contribute to a better understanding of T-2 toxin exposure in animals and humans and T-2 toxin metabolism, toxicity, and analytical methods, which may be useful in risk assessment and control of T-2 toxin exposure.

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    8. Saranyoo Klaiklay, Vatcharin Rukachaisirikul, Saowanit Saithong, Souwalak Phongpaichit, Jariya Sakayaroj. Trichothecenes from a Soil-Derived Trichoderma brevicompactum. Journal of Natural Products 2019, 82 (4) , 687-693.
    9. Dongping Zeng, Zhoumeng Lin, Zhenling Zeng, Binghu Fang, Miao Li, Yi-Hsien Cheng, Yongxue Sun. Assessing Global Human Exposure to T-2 Toxin via Poultry Meat Consumption Using a Lifetime Physiologically Based Pharmacokinetic Model. Journal of Agricultural and Food Chemistry 2019, 67 (5) , 1563-1571.
    10. Victor Limay-Rios, Arthur W. Schaafsma. Effect of Prothioconazole Application Timing on Fusarium Mycotoxin Content in Maize Grain. Journal of Agricultural and Food Chemistry 2018, 66 (19) , 4809-4819.
    11. Xiya Zhang, Xuezhi Yu, Kai Wen, Chenglong Li, Ghulam Mujtaba Mari, Haiyang Jiang, Weimin Shi, Jianzhong Shen, and Zhanhui Wang . Multiplex Lateral Flow Immunoassays Based on Amorphous Carbon Nanoparticles for Detecting Three Fusarium Mycotoxins in Maize. Journal of Agricultural and Food Chemistry 2017, 65 (36) , 8063-8071.
    12. Shupeng Yang, Marthe De Boevre, Huiyan Zhang, Karl De Ruyck, Feifei Sun, Jinzhen Zhang, Yue Jin, Yanshen Li, Zhanhui Wang, Suxia Zhang, Jinhui Zhou, Yi Li, and Sarah De Saeger . Metabolism of T-2 Toxin in Farm Animals and Human In Vitro and in Chickens In Vivo Using Ultra High-Performance Liquid Chromatography- Quadrupole/Time-of-Flight Hybrid Mass Spectrometry Along with Online Hydrogen/Deuterium Exchange Technique. Journal of Agricultural and Food Chemistry 2017, 65 (33) , 7217-7227.
    13. Seung Mok Ryu, Hae Min Lee, Eun Gyeong Song, Young Hye Seo, Jun Lee, Yuanqiang Guo, Beom Seok Kim, Jae-Jin Kim, Jin Sung Hong, Ki Hyun Ryu, and Dongho Lee . Antiviral Activities of Trichothecenes Isolated from Trichoderma albolutescens against Pepper Mottle Virus. Journal of Agricultural and Food Chemistry 2017, 65 (21) , 4273-4279.
    14. Qianfen Wan, Qinghua He, Xianbai Deng, Fuhua Hao, Huiru Tang, and Yulan Wang . Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure. Journal of Agricultural and Food Chemistry 2016, 64 (3) , 714-723.
    15. Shupeng Yang, Ying Wang, Ross C. Beier, Huiyan Zhang, Karl De Ruyck, Feifei Sun, Xingyuan Cao, Jianzhong Shen, Suxia Zhang, and Zhanhui Wang . Simultaneous Determination of Type A and B Trichothecenes and Their Main Metabolites in Food Animal Tissues by Ultraperformance Liquid Chromatography Coupled with Triple-Quadrupole Mass Spectrometry. Journal of Agricultural and Food Chemistry 2015, 63 (38) , 8592-8600.
    16. Xiujuan Chen, Yukun Huang, Nuo Duan, Shijia Wu, Yu Xia, Xiaoyuan Ma, Changqing Zhu, Yuan Jiang, and Zhouping Wang . Screening and Identification of DNA Aptamers against T-2 Toxin Assisted by Graphene Oxide. Journal of Agricultural and Food Chemistry 2014, 62 (42) , 10368-10374.
    17. Frank Surup, Ajda Medjedović, Michael Szczygielski, Hans-Josef Schroers, and Marc Stadler . Production of Trichothecenes by the Apple Sooty Blotch Fungus Microcyclospora tardicrescens. Journal of Agricultural and Food Chemistry 2014, 62 (16) , 3525-3530.
    18. Yanshen Li, Xiangshu Luo, Shupeng Yang, Xingyuan Cao, Zhanhui Wang, Weimin Shi, and Suxia Zhang . High Specific Monoclonal Antibody Production and Development of an ELISA Method for Monitoring T-2 Toxin in Rice. Journal of Agricultural and Food Chemistry 2014, 62 (7) , 1492-1497.
    19. Shupeng Yang, Yanshen Li, Xingyuan Cao, Dingfei Hu, Zhanhui Wang, Ying Wang, Jianzhong Shen, and Suxia Zhang . Metabolic Pathways of T-2 Toxin in in Vivo and in Vitro Systems of Wistar Rats. Journal of Agricultural and Food Chemistry 2013, 61 (40) , 9734-9743.
    20. Huali Xue, Yang Bi, Jinmei Wei, Yamei Tang, Ying Zhao, and Yi Wang . New Method for the Simultaneous Analysis of Types A and B Trichothecenes by Ultrahigh-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry in Potato Tubers Inoculated with Fusarium sulphureum. Journal of Agricultural and Food Chemistry 2013, 61 (39) , 9333-9338.
    21. Maria Weidner, Marlies Lenczyk, Gerald Schwerdt, Michael Gekle, and Hans-Ulrich Humpf . Neurotoxic Potential and Cellular Uptake of T-2 Toxin in Human Astrocytes in Primary Culture. Chemical Research in Toxicology 2013, 26 (3) , 347-355.
    22. Tanja Welsch and Hans-Ulrich Humpf . HT-2 Toxin 4-Glucuronide as New T-2 Toxin Metabolite: Enzymatic Synthesis, Analysis, and Species Specific Formation of T-2 and HT-2 Toxin Glucuronides by Rat, Mouse, Pig, and Human Liver Microsomes. Journal of Agricultural and Food Chemistry 2012, 60 (40) , 10170-10178.
    23. Zheng Han, Yiping Ren, Junfeng Zhu, Zengxuan Cai, Yong Chen, Lianjun Luan, and Yongjiang Wu . Multianalysis of 35 Mycotoxins in Traditional Chinese Medicines by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry Coupled with Accelerated Solvent Extraction. Journal of Agricultural and Food Chemistry 2012, 60 (33) , 8233-8247.
    24. Maria Weidner, Tanja Welsch, Florian Hübner, Gerald Schwerdt, Michael Gekle, and Hans-Ulrich Humpf . Identification and Apoptotic Potential of T-2 Toxin Metabolites in Human Cells. Journal of Agricultural and Food Chemistry 2012, 60 (22) , 5676-5684.
    25. Meirong Cao, Jing Wang, Mengtian Wang, Xiaoxuan Yuan, Xu Zhang, Junzhan Ma, Yan Zhang, Qiang Li. Simultaneous detection of 22 mycotoxins in grape by QuEChERS and ultra-high-performance liquid chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry. Journal of Future Foods 2024, 4 (4) , 369-375.
    26. Júlia Vörösházi, Máté Mackei, Csilla Sebők, Patrik Tráj, Rege Anna Márton, Dávid Géza Horváth, Korinna Huber, Zsuzsanna Neogrády, Gábor Mátis. Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures. Scientific Reports 2024, 14 (1)
    27. Yangyan Ge, Lulu Wang, Dapeng Su, Qingsong Yuan, Chenghong Xiao, Min Hu, Chuanzhi Kang, Lanping Guo, Tao Zhou, Jinqiang Zhang. The sweating process promotes toxigenic fungi expansion and increases the risk of combined contamination of mycotoxins in Radix Dipsaci. Frontiers in Microbiology 2024, 15
    28. Cong Yao, Shuichu Hao, Chun Zhang, Li Liu, Yumeng Jia, Peilin Meng, Cuiyan Wu, Xiong Guo. Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity. Food and Chemical Toxicology 2024, 188 , 114630.
    29. Theodora K. Tsouloufi. An overview of mycotoxicoses in rabbits. Journal of Veterinary Diagnostic Investigation 2024, 2002
    30. Bingqian Hou, Dawei Wang, Fangfang Yan, Xinxin Cheng, Yongchang Xu, Xuepeng Xi, Wenyang Ge, Silong Sun, Peisen Su, Lanfei Zhao, Zhongfan Lyu, Yongchao Hao, Hongwei Wang, Lingrang Kong. Fhb7-GST catalyzed glutathionylation effectively detoxifies the trichothecene family. Food Chemistry 2024, 439 , 138057.
    31. Tong Jiang, Junan Yan, Hongxing Tan, Zhu Pu, Ou Wang, Tao Liu, Zhaoyu Chen, Jiaxiang Gao, Jun Wang, Jianhao Lin, Junsheng Huo, Jian Huang. Prevalence of T-2 Toxin in the Food and Beverages of Residents Living in a Kashin–Beck-Disease Area of Qamdo, Tibet. Nutrients 2024, 16 (10) , 1449.
    32. Xinyu Sun, Yongli Ye, Jiadi Sun, Lili Tang, Xingxing Yang, Xiulan Sun. Advances in the study of liver microsomes in the in vitro metabolism and toxicity evaluation of foodborne contaminants. Critical Reviews in Food Science and Nutrition 2024, 64 (11) , 3264-3278.
    33. Monica C. Paul, Regina S. Dass. Trichothecenes. 2024, 109-131.
    34. Yifan Wu, Yi Gong, Yanli Liu, Feihong Chen, Sijie Chen, Feiyu Zhang, Chaowei Wang, Shujin Li, Minhan Hu, Ruitian Huang, Xiong Guo, Xi Wang, Yujie Ning, Lei Yang. Comparative Analysis of Differentially Expressed Genes in Chondrocytes from Rats Exposed to Low Selenium and T-2 Toxin. Biological Trace Element Research 2024, 202 (3) , 1020-1030.
    35. Júlia Vörösházi, Zsuzsanna Neogrády, Gábor Mátis, Máté Mackei. Pathological consequences, metabolism and toxic effects of trichothecene T-2 toxin in poultry. Poultry Science 2024, 103 (3) , 103471.
    36. Fang-fang Yu, Shui-yuan Yu, Lei Sun, Juan Zuo, Kang-ting Luo, Miao Wang, Xiao-li Fu, Feng Zhang, Hui Huang, Guo-yu Zhou, Yan-jie Wang, Yue Ba. T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway. Journal of Hazardous Materials 2024, 465 , 133090.
    37. Rahim Khan, Farooq Anwar, Farinazleen Mohamad Ghazali. A comprehensive review of mycotoxins: Toxicology, detection, and effective mitigation approaches. Heliyon 2024, 85 , e28361.
    38. Frederick Fung. T-2 Toxin (Trichothecene Mycotoxins) Attack. 2024, 834-836.
    39. Guangfei Wei, Yichuan Liang, Guozhuang Zhang, Zhaoyu Zhang, Yongqing Zhang, Shilin Chen, Linlin Dong. Influence of sampling location and processing on the assembly and network of Polygoni Multiflori Radix surface microbiome. International Journal of Food Microbiology 2024, 410 , 110442.
    40. Haobiao Liu, Xue Lin, Mumba Mulutula Chilufya, Lichun Qiao, Miaoye Bao, Xinyue Wen, Rongqi Xiang, Huifang He, Miaoqian Li, Jing Han. Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ERα/PI3K/Akt signaling pathway. Ecotoxicology and Environmental Safety 2024, 269 , 115748.
    41. Vahid Pourbarkhordar, Mahdi Balali-Mood, Leila Etemad, Mohammad Moshiri. Blister agents. 2024, 209-223.
    42. Xinrui Deng, Tingting Yu, Meichen Gao, Jiaqi Wang, Wenying Sun, Shiwen Xu. Sodium selenite (Na2SeO3) attenuates T-2 toxin-induced iron death in LMH cells through the ROS/PI3K/AKT/Nrf2 pathway. Food and Chemical Toxicology 2023, 182 , 114185.
    43. Suisui Gao, Kaixin Wang, Kuankuan Xiong, Shuai Xiao, Chujian Wu, Mingxia Zhou, Linfeng Li, Guoxiang Yuan, Lihuang Jiang, Qianbo Xiong, Lingchen Yang. Unraveling the Nrf2-ARE Signaling Pathway in the DF-1 Chicken Fibroblast Cell Line: Insights into T-2 Toxin-Induced Oxidative Stress Regulation. Toxins 2023, 15 (11) , 627.
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    45. Xianrui Chen, Zhipeng Gao, Tingting Long, Jianhua Xie, Xiujiang Li, Zhibing Huang. Development of two immunochromatographic test strips based on signal amplification and selenium nanoparticles for the rapid detection of T-2 mycotoxin. Food Chemistry 2023, 424 , 136419.
    46. Y. Jiang, Y. Qian, H. Hong, X. Gao, W. Liu, Q. Jin, M. Chen, Z. Jin, Q. Liu, Z. Wei. Morin protects chicks with T-2 toxin poisoning by decreasing heterophil extracellular traps, oxidative stress and inflammatory response. British Poultry Science 2023, 64 (5) , 614-624.
    47. Ting-Yu Huang, Wen-Xi Song, You-Shuang Wang, Yu Liu, Feng-Juan Chen, Yun-He Chen, Yi-Bao Jiang, Cong Zhang, Xu Yang. A review of anorexia induced by T-2 toxin. Food and Chemical Toxicology 2023, 179 , 113982.
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    51. Shuai Xiao, Yingxin Wu, Suisui Gao, Mingxia Zhou, Zhiwei Liu, Qianbo Xiong, Lihuang Jiang, Guoxiang Yuan, Linfeng Li, Lingchen Yang. Deciphering the Hazardous Effects of AFB1 and T-2 Toxins: Unveiling Toxicity and Oxidative Stress Mechanisms in PK15 Cells and Mouse Kidneys. Toxins 2023, 15 (8) , 503.
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    54. Wenli Ding, Luxi Lin, Ke Yue, Yanfeng He, Bowen Xu, Aftab Shaukat, Shucheng Huang. Ferroptosis as a Potential Therapeutic Target of Traditional Chinese Medicine for Mycotoxicosis: A Review. Toxics 2023, 11 (4) , 395.
    55. Meng Liu, Ling Zhao, Jin-Tao Wei, Yu-Xuan Huang, Mahmoud Mohamed Khalil, Wen-Da Wu, Kamil Kuča, Lv-Hui Sun. T-2 toxin-induced intestinal damage with dysregulation of metabolism, redox homeostasis, inflammation, and apoptosis in chicks. Archives of Toxicology 2023, 97 (3) , 805-817.
    56. Mark Makarov, Eduard Korkotian. Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases. Toxins 2023, 15 (3) , 202.
    57. Lirui Fan, Bin Du, Fubin Pei, Wei Hu, Aijiao Guo, Zihao Xie, Bing Liu, Zhaoyang Tong, Xihui Mu, Wenyuan Tan. Surface Plasmon Resonance Sensor Based on Core-Shell Fe3O4@SiO2@Au Nanoparticles Amplification Effect for Detection of T-2 Toxin. Sensors 2023, 23 (6) , 3078.
    58. Asma Ghasemi, , Mohammad Reza Mehrasbi, , Mir Jamal Hosseini, . Mycotoxins Contamination in Tea and Herbal Infusion: A Mini-Review. Journal of Human Environment and Health Promotion 2023, 9 (1) , 5-11.
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    61. Wang Gu, Qiang Bao, Kaiqi Weng, Jinlu Liu, Shuwen Luo, Jianzhou Chen, Zheng Li, Zhengfeng Cao, Yu Zhang, Yang Zhang, Guohong Chen, Qi Xu. Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings. Poultry Science 2023, 102 (2) , 102382.
    62. Panagiotis Stefanopoulos, Stavros Aloizos, Maria Tsironi. Clinical symptoms of chemical warfare agents toxicity including mustards, halogenated oximes, arsenicals, and toxins poisoning. 2023, 431-487.
    63. Long Wang, Xia Lu, Renyong Zhao, Zhenxi Qu, Baoshan He. FeMOF-based nanostructured platforms for T-2 toxin detection in beer by a “fence-type” aptasensing principle. Analytical and Bioanalytical Chemistry 2022, 414 (28) , 7999-8008.
    64. Jian Zhang, Peiyan Wang, Miao Song, Xuliang Zhang, Siming Huo, Jiayu Du, Bo Li, Zheng Cao, Yanfei Li. T-2 toxin inhibits osteoblastic differentiation and mineralization involving mutual regulation between Wnt signaling pathway and autophagy. Chemico-Biological Interactions 2022, 814 , 110266.
    65. Minh Van Nguyen, Jae Woo Han, Hun Kim, Gyung Ja Choi. Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi. The Journal of Antibiotics 2022, 75 (9) , 514-518.
    66. , Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Jean‐Charles Leblanc, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Sven Daenicke, Carlo Stefano Nebbia, Isabelle P Oswald, Elena Rovesti, Hans Steinkellner, Laurentius (Ron) Hoogenboom. Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants. EFSA Journal 2022, 20 (9)
    67. Chongshan Dai, Subhajit Das Gupta, Zhanhui Wang, Haiyang Jiang, Tony Velkov, Jianzhong Shen. T-2 toxin and its cardiotoxicity: New insights on the molecular mechanisms and therapeutic implications. Food and Chemical Toxicology 2022, 167 , 113262.
    68. Zacharia Waithaka Ng’ang’a, Eric Niyonshuti. Animal Feeds Mycotoxins and Risk Management. 2022
    69. Yumeng Jia, Sirong Shi, Bolun Cheng, Shiqiang Cheng, Li Liu, Peilin Meng, Xuena Yang, Xiaoge Chu, Yan Wen, Feng Zhang, Xiong Guo. Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity. Frontiers in Nutrition 2022, 9
    70. Tun Sun, Qinzhi Zhang, Meng Li, Shusheng Tang, Chongshan Dai. T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells. Journal of Fungi 2022, 8 (8) , 761.
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    73. Cheila Pereira, Sara C. Cunha, José O. Fernandes. Mycotoxins of Concern in Children and Infant Cereal Food at European Level: Incidence and Bioaccessibility. Toxins 2022, 14 (7) , 488.
    74. Jian Zhang, Miao Song, Yilong Cui, Bing Shao, Xuliang Zhang, Zheng Cao, Yanfei Li. T‐2 toxin‐induced femur lesion is accompanied by autophagy and apoptosis associated with Wnt/β‐catenin signaling in mice. Environmental Toxicology 2022, 37 (7) , 1653-1661.
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    77. Rastislav Boško, Marek Pernica, Sylvie Běláková, Marie Bjelková, Helena Pluháčková. Determination of T-2 and HT-2 Toxins in Seed of Milk Thistle [Silybum marianum (L.) Gaertn.] Using Immunoaffinity Column by UPLC-MS/MS. Toxins 2022, 14 (4) , 258.
    78. Lena Marie Juraschek, Arne Kappenberg, Wulf Amelung. Mycotoxins in soil and environment. Science of The Total Environment 2022, 814 , 152425.
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    85. Walter Ondiek, Yaling Wang, Lijun Sun, Langhua Zhou, Stephen LW On, Haotian Zheng, Gooneratne Ravi. Removal of aflatoxin b1 and t-2 toxin by bacteria isolated from commercially available probiotic dairy foods. Food Science and Technology International 2022, 28 (1) , 15-25.
    86. Ying Zhang, Zhengzheng Li, Ying He, Yinan Liu, Ge Mi, Jinghong Chen. T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway. Human & Experimental Toxicology 2022, 41 , 096032712210755.
    87. Yumei Liu, Haojie Wang, Mengyu Zhang, Jiajia Wang, Zhixiang Zhang, Yuqin Wang, Yingying Sun, Ziqiang Zhang. Protective effect of selenomethionine on T-2 toxin-induced liver injury in New Zealand rabbits. BMC Veterinary Research 2021, 17 (1)
    88. Xu Yang, Pengli Liu, Xuliang Zhang, Jian Zhang, Yilong Cui, Miao Song, Yanfei Li. T-2 toxin causes dysfunction of Sertoli cells by inducing oxidative stress. Ecotoxicology and Environmental Safety 2021, 225 , 112702.
    89. Xinliu Tan, Weidao Yu, Yuwen Wang, Ping Song, Qing Xu, Dengming Ming, Yaqiong Yang. A switchable and signal-amplified aptasensor based on metal organic frameworks as the quencher for turn-on detection of T-2 mycotoxin. Analytical and Bioanalytical Chemistry 2021, 413 (26) , 6595-6603.
    90. Adam Pierzgalski, Marcin Bryła, Joanna Kanabus, Marta Modrzewska, Grażyna Podolska. Updated Review of the Toxicity of Selected Fusarium Toxins and Their Modified Forms. Toxins 2021, 13 (11) , 768.
    91. Edyta Janik, Marcin Niemcewicz, Marcin Podogrocki, Michal Ceremuga, Maksymilian Stela, Michal Bijak. T-2 Toxin—The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies. Molecules 2021, 26 (22) , 6868.
    92. Xiaowen Li, Xianglin Wang, Sha Liu, Ji Wang, XiangYan Liu, Yuanyuan Zhu, Linyu Zhang, Rongfang Li. Betulinic acid attenuates T-2 toxin-induced cytotoxicity in porcine kidney cells by blocking oxidative stress and endoplasmic reticulum stress. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2021, 249 , 109124.
    93. Chi Zhang, Chengmei Jiang, Lingyi Lan, Jianfeng Ping, Zunzhong Ye, Yibin Ying. Nanomaterial-based biosensors for agro-product safety. TrAC Trends in Analytical Chemistry 2021, 143 , 116369.
    94. Ko-Hua Tso, Chompunut Lumsangkul, Min-Chien Cheng, Jyh-Cherng Ju, Yang-Kwang Fan, Hsin-I Chiang. Differential Effects of Green Tea Powders on the Protection of Brown Tsaiya and Kaiya Ducklings against Trichothecene T-2 Toxin Toxicity. Animals 2021, 11 (9) , 2541.
    95. Li You, Xu Wang, Wenda Wu, Vesna Jaćević, Eugenie Nepovimova, Qinghua Wu, Kamil Kuca. Hypothesis: Long non-coding RNA is a potential target of mycotoxins. Food and Chemical Toxicology 2021, 155 , 112397.
    96. Xiaoxuan Chen, Peiqiang Mu, Lang Zhu, Xiaoxiao Mao, Shuang Chen, Huali Zhong, Yiqun Deng. T-2 Toxin Induces Oxidative Stress at Low Doses via Atf3ΔZip2a/2b-Mediated Ubiquitination and Degradation of Nrf2. International Journal of Molecular Sciences 2021, 22 (15) , 7936.
    97. Rubina Tünde Szabó, Mária Kovács-Weber, Krisztián Milán Balogh, Miklós Mézes, Balázs Kovács. Changes of DNA Damage Effect of T-2 or Deoxynivalenol Toxins during Three Weeks Exposure in Common Carp (Cyprinus carpio L.) Revealed by LORD-Q PCR. Toxins 2021, 13 (8) , 576.
    98. Nan Hao, Yu Qiu, Yaqi Li, Jinwen Lu, Xu Han, Jing Qian, Kun Wang. Closed bipolar electrode based fluorescence visualization biosensor for anti-interference detection of T-2 toxin. Chemical Communications 2021, 57 (53) , 6511-6513.
    99. Sara Shahba, Jalil Mehrzad, Amir Mohammad Malvandi. Neuroimmune disruptions from naturally occurring levels of mycotoxins. Environmental Science and Pollution Research 2021, 28 (25) , 32156-32176.
    100. Prabodh Chander Sharma, Diksha Sharma, Archana Sharma, Madhulika Bhagat, Monika Ola, Vijay Kumar Thakur, Jitender Kumar Bhardwaj, Ramesh K. Goyal. Recent advances in microbial toxin-related strategies to combat cancer. Seminars in Cancer Biology 2021, 7
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