ACS Publications. Most Trusted. Most Cited. Most Read
The Leaves of Stevia rebaudiana (Bertoni), Their Constituents and the Analyses Thereof: A Review
My Activity

Figure 1Loading Img
    Review

    The Leaves of Stevia rebaudiana (Bertoni), Their Constituents and the Analyses Thereof: A Review
    Click to copy article linkArticle link copied!

    View Author Information
    Department of Nutrition and Food Sciences, Food Chemistry/Bioanalytics, Rheinische Friedrich-Wilhelms-Universität Bonn, Endenicher Allee 11-13, 53115 Bonn, Germany
    *Phone: +49-228-734890. Fax: +49-228-733499. E-mail: [email protected]
    Other Access Options

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2012, 60, 4, 886–895
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf2044907
    Published January 17, 2012
    Copyright © 2012 American Chemical Society

    Abstract

    Click to copy section linkSection link copied!

    The plant Stevia rebaudiana is well-known due to the sweet-tasting ent-kaurene diterpenoid glycosides. Stevioside and rebaudioside A are the most abundant and best analyzed, but more than 30 additional steviol glycosides have been described in the scientific literature to date. Most of them were detected in the last two years. This paper reviews these new compounds and provides an overview about novel trends in their determination, separation, analysis, detection, and quantification. The detection and analysis of further constituents such as nonglycosidic diterpenes, flavonoids, chlorogenic acids, vitamins, nutrients, and miscellaneous minor compounds in the leaves of Stevia rebaudiana are reviewed as well. A critical review of the antioxidant capacity of Stevia leaves and its analysis is also included. These different aspects are discussed in consideration of the scientific literature of the last 10 years.

    Copyright © 2012 American Chemical Society

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Cited By

    Click to copy section linkSection link copied!
    Citation Statements
    Explore this article's citation statements on scite.ai

    This article is cited by 195 publications.

    1. Soo-Kyung Kim, Brian Guthrie, William A. Goddard, III. Ligand-Dependent and G Protein-Dependent Properties for the Sweet Taste Heterodimer, TAS1R2/1R3. The Journal of Physical Chemistry B 2024, 128 (37) , 8927-8932. https://doi.org/10.1021/acs.jpcb.4c04610
    2. Lifeng Yang, Mengliang Yang, Zhiwei Deng, Zhengshan Luo, Zhenbo Yuan, Yijian Rao, Yan Zhang. Highly Efficient Biosynthesis of Rebaudioside M8 through Structure-Guided Engineering of Glycosyltransferase UGT94E13. Journal of Agricultural and Food Chemistry 2024, 72 (28) , 15823-15831. https://doi.org/10.1021/acs.jafc.4c03565
    3. Jihye Jung, Doreen Schachtschabel, Michael Speitling, Bernd Nidetzky. Controllable Iterative β-Glucosylation from UDP-Glucose by Bacillus cereus Glycosyltransferase GT1: Application for the Synthesis of Disaccharide-Modified Xenobiotics. Journal of Agricultural and Food Chemistry 2021, 69 (48) , 14630-14642. https://doi.org/10.1021/acs.jafc.1c05788
    4. Jaewan Jang, Soo-Kyung Kim, Brian Guthrie, William A. Goddard, III. Synergic Effects in the Activation of the Sweet Receptor GPCR Heterodimer for Various Sweeteners Predicted Using Molecular Metadynamics Simulations. Journal of Agricultural and Food Chemistry 2021, 69 (41) , 12250-12261. https://doi.org/10.1021/acs.jafc.1c03779
    5. Zhiyan Liu, Kangzi Ren, Ye Feng, Tommy Uong, Scott Krepich, Hong You. Rapid and Economic Determination of 13 Steviol Glycosides in Market-Available Food, Dietary Supplements, and Ingredients: Single-Laboratory Validation of an HPLC Method. Journal of Agricultural and Food Chemistry 2020, 68 (37) , 10142-10148. https://doi.org/10.1021/acs.jafc.0c03453
    6. Yu-Qi Gao, Ruoxin Li, Wei-Wei Wang, Shoei-Sheng Lee, Jin-Ming Gao. Microbial Transformations of Two Beyerane-Type Diterpenes by Cunninghamella echinulata. Journal of Agricultural and Food Chemistry 2020, 68 (16) , 4624-4631. https://doi.org/10.1021/acs.jafc.0c00592
    7. Hande Karaköse, Anja Müller, and Nikolai Kuhnert . Profiling and Quantification of Phenolics in Stevia rebaudiana Leaves. Journal of Agricultural and Food Chemistry 2015, 63 (41) , 9188-9198. https://doi.org/10.1021/acs.jafc.5b01944
    8. Silvia Tavarini, Cristina Sgherri, Anna Maria Ranieri, and Luciana G. Angelini . Effect of Nitrogen Fertilization and Harvest Time on Steviol Glycosides, Flavonoid Composition, and Antioxidant Properties in Stevia rebaudiana Bertoni. Journal of Agricultural and Food Chemistry 2015, 63 (31) , 7041-7050. https://doi.org/10.1021/acs.jafc.5b02147
    9. Dina Ripken, Nikkie van der Wielen, Heleen M. Wortelboer, Jocelijn Meijerink, Renger F. Witkamp, and Henk F. J. Hendriks . Steviol Glycoside Rebaudioside A Induces Glucagon-like Peptide-1 and Peptide YY Release in a Porcine ex Vivo Intestinal Model. Journal of Agricultural and Food Chemistry 2014, 62 (33) , 8365-8370. https://doi.org/10.1021/jf501105w
    10. Mohamed A. Ibrahim, Douglas L. Rodenburg, Kamilla Alves, Frank R. Fronczek, James D. McChesney, Chongming Wu, Brian J. Nettles, Sylesh K. Venkataraman, and Frank Jaksch . Minor Diterpene Glycosides from the Leaves of Stevia rebaudiana. Journal of Natural Products 2014, 77 (5) , 1231-1235. https://doi.org/10.1021/np4009656
    11. Stijn Ceunen and Jan M. C. Geuns . Steviol Glycosides: Chemical Diversity, Metabolism, and Function. Journal of Natural Products 2013, 76 (6) , 1201-1228. https://doi.org/10.1021/np400203b
    12. Caroline Hellfritsch, Anne Brockhoff, Frauke Stähler, Wolfgang Meyerhof, and Thomas Hofmann . Human Psychometric and Taste Receptor Responses to Steviol Glycosides. Journal of Agricultural and Food Chemistry 2012, 60 (27) , 6782-6793. https://doi.org/10.1021/jf301297n
    13. Yunxia Xiong, Zhentao He, Qiwen Wu, Hao Xiao, Shuting Cao, Xuefen Yang, Yajing Li, Zongyong Jiang, Cui Zhu, Li Wang. Dietary steviol glycosides mixture supplementation modulates the gene expression of gut chemoreceptors and enhances the antioxidant capacity in weaned piglets. Porcine Health Management 2025, 11 (1) https://doi.org/10.1186/s40813-024-00414-5
    14. S. Zhang, X. Liu, L. Li, H. Lu, W. Li, Z. Sun, L. Liu. Analysis of physicochemical properties and bacterial diversity of stevia waste composting: feasibility of waste mud composting. International Journal of Environmental Science and Technology 2025, 22 (4) , 2697-2708. https://doi.org/10.1007/s13762-024-05764-9
    15. Chengxia Huang, Yang Wang, Cunshan Zhou, Qiaolan Sun, Lei Zhang, Yunwei Niu, Deyang Yao, Linglin Song, Clinton Emeka Okonkwo, Otu Phyllis, Haile Ma. Ultrasonic vacuum synergistic assisted ethanol extraction of steviol glycosides and kinetic studies. Industrial Crops and Products 2024, 221 , 119385. https://doi.org/10.1016/j.indcrop.2024.119385
    16. Minako Anbe-Kitada, Hidetsugu Sotoya, Takashi Asahara, Masahiro Ono. Analysis of rebaudioside A in probiotic-fermented milk via quantitative nuclear magnetic resonance spectroscopy. Journal of Food Composition and Analysis 2024, 136 , 106785. https://doi.org/10.1016/j.jfca.2024.106785
    17. Liliana Celaya, Nicolás Kolb Koslobsky. Effect of Ethyl Acetate on the Defatting of Leaves in the Extraction of Stevia rebaudiana Bertoni. Food Technology and Biotechnology 2024, 62 (3) , 354-360. https://doi.org/10.17113/ftb.62.03.24.8492
    18. Giuseppe Pezzotti, Wenliang Zhu, Takashi Aoki, Akihiro Miyamoto, Isao Fujita, Manabu Nakagawa, Takuya Kobayashi. Raman Spectroscopic Analysis of Steviol Glycosides: Spectral Database and Quality Control Algorithms. Foods 2024, 13 (19) , 3068. https://doi.org/10.3390/foods13193068
    19. Danyal Aghajani, Hasti Seraji, Harpreet Kaur, Jyri Vilko. A sustainable integrated model for multi-objective planning of an agri-food supply chain under uncertain parameters: A case study. Computers & Chemical Engineering 2024, 188 , 108766. https://doi.org/10.1016/j.compchemeng.2024.108766
    20. Huțu Dana, Amariei Sonia. Substituting Sugar in Pastry and Bakery Products with Functional Ingredients. Applied Sciences 2024, 14 (18) , 8563. https://doi.org/10.3390/app14188563
    21. Zhenguang Liu, Zexiang Ding, Yifeng Cao, Baojian Liu, Qiwei Yang, Zhiguo Zhang, Qilong Ren, Zongbi Bao. Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures: Experimental measurements and thermodynamic modeling. Chinese Journal of Chemical Engineering 2024, 72 , 164-176. https://doi.org/10.1016/j.cjche.2024.05.020
    22. Niketa Yadav, Satbeer Singh, Ramesh Chauhan, Ashok Kumar, Probir Kumar Pal, Sanatsujat Singh. Dry Leaf Biomass Stability of Stevia (Stevia rebaudiana) Clones over Different Environments. International Journal of Plant & Soil Science 2024, 36 (8) , 80-89. https://doi.org/10.9734/ijpss/2024/v36i84837
    23. Lifeng Yang, Mengliang Yang, Xiangting Zheng, Qian Ping, Yunfei Song, Yongfu Xie, Yijian Rao, Jinsong Shi, Yan Zhang. Selective biosynthesis and evaluation of rebaudioside M8 with improved organoleptic property and significant inhibition on inflammatory factor TNF-α. Food Bioscience 2024, 59 , 103898. https://doi.org/10.1016/j.fbio.2024.103898
    24. Maria Papaefthimiou, Panagiota I. Kontou, Pantelis G. Bagos, Georgia G. Braliou. Integration of Antioxidant Activity Assays Data of Stevia Leaf Extracts: A Systematic Review and Meta-Analysis. Antioxidants 2024, 13 (6) , 692. https://doi.org/10.3390/antiox13060692
    25. Muhammad Talha Rafiq, Zahoor Ahmad Sajid, Sheza Ayaz Khilji, . Graphene Oxide Nanoparticle-Assisted Promotion of Stevioside, Rebaudioside A, and Selected Biochemical Attributes in Stevia rebaudiana Bertoni. Scientifica 2024, 2024 , 1-10. https://doi.org/10.1155/2024/6693085
    26. Merve Akalan, Kamile Bayrak Akay, Bülent Başyiğit, Mehmet Şükrü Karakuş, Melike Yücetepe, Asliye Karaaslan, Mehmet Karaaslan. Instant stevia powder as a novel potential additive for enhancing nutritional value and quality characteristics of yogurt. Journal of Food Science and Technology 2024, 61 (5) , 958-968. https://doi.org/10.1007/s13197-023-05892-z
    27. Tran Thi Hong Hanh, Pham Thi Mai Huong, Pham Thi Cham, Do Hoang Anh, Tran Hong Quang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh. Ent-kaurane glycosides from Stevia rebaudiana and their α-glucosidase inhibition. Tetrahedron 2024, 158 , 133993. https://doi.org/10.1016/j.tet.2024.133993
    28. Marcos Vinicius Silva de Andrade, Simone Ribeiro Lucho, Renato Delmondez de Castro, Paulo Roberto Ribeiro. Alternative for natural sweeteners: Improving the use of stevia as a source of steviol glycosides. Industrial Crops and Products 2024, 208 , 117801. https://doi.org/10.1016/j.indcrop.2023.117801
    29. Shraddha Patel, Archana Navale. The Natural Sweetener Stevia: An Updated Review on its Phytochemistry, Health Benefits, and Anti-diabetic Study. Current Diabetes Reviews 2024, 20 (2) https://doi.org/10.2174/1573399819666230501210803
    30. Samuel Simoni, Alberto Vangelisti, Clarissa Clemente, Gabriele Usai, Marco Santin, Maria Ventimiglia, Flavia Mascagni, Lucia Natali, Luciana G. Angelini, Andrea Cavallini, Silvia Tavarini, Tommaso Giordani. Transcriptomic Analyses Reveal Insights into the Shared Regulatory Network of Phenolic Compounds and Steviol Glycosides in Stevia rebaudiana. International Journal of Molecular Sciences 2024, 25 (4) , 2136. https://doi.org/10.3390/ijms25042136
    31. P. N. Ravindran. Hyssop, Lovage, Sage, Savory, Sweet Honey Leaf (Stevia). 2024, 3315-3368. https://doi.org/10.1007/978-981-19-3728-6_50
    32. Li-Juan Chai, Tianchan Lan, Zhiyuan Cheng, Jing Zhang, Yang Deng, Ying Wang, Yan Li, Fengwu Wang, Meizi Piao. Stevia rebaudiana leaves fermented by Lactobacillus plantarum exhibit resistance to microorganisms and cancer cell lines in vitro: A potential sausage preservative. Food Chemistry 2024, 432 , 137187. https://doi.org/10.1016/j.foodchem.2023.137187
    33. Agata Ptak, Agnieszka Szewczyk, Magdalena Simlat, Alicja Błażejczak, Marzena Warchoł. Meta-Topolin-induced mass shoot multiplication and biosynthesis of valuable secondary metabolites in Stevia rebaudiana Bertoni bioreactor culture. Scientific Reports 2023, 13 (1) https://doi.org/10.1038/s41598-023-42619-8
    34. Sara AlKanderi, Monerah AlFreeh, Radhika G. Bhardwaj, Maribasappa Karched. Sugar Substitute Stevia Inhibits Biofilm Formation, Exopolysaccharide Production, and Downregulates the Expression of Streptococcal Genes Involved in Exopolysaccharide Synthesis. Dentistry Journal 2023, 11 (12) , 267. https://doi.org/10.3390/dj11120267
    35. Ji Li, Pradeep Thaker, Deshou Jiang, Qingrong Huang, Chi-Tang Ho. Herb Stevia rebaudiana ’s functionalities, safety and applications: a review. Nutrition & Food Science 2023, 53 (8) , 1373-1405. https://doi.org/10.1108/NFS-03-2023-0051
    36. Marcos V.S. de Andrade, Simone R. Lucho, Marcelo N. do Amaral, Eugenia J.B. Braga, Paulo R. Ribeiro, Renato D. de Castro. Long-day photoperiodic requirements for steviol glycosides and gibberellins biosynthesis and bio-sweetener levels optimization in Stevia rebaudiana Bertoni. Industrial Crops and Products 2023, 204 , 117363. https://doi.org/10.1016/j.indcrop.2023.117363
    37. Nicholas Romano, Surjya Narayan Datta, Gde Sasmita Julyantoro Pande, Amit Kumar Sinha, Fernando Y. Yamamoto, Benjamin H. Beck, Carl D. Webster. Dietary inclusions of black soldier fly (Hermetia illucens) larvae frass enhanced production of channel catfish (Ictalurus punctatus) juveniles, stevia (Stevia rebaudiana), and lavender (Lavaridula angustifolia) in an aquaponic system. Aquaculture 2023, 575 , 739742. https://doi.org/10.1016/j.aquaculture.2023.739742
    38. Habiba Samreen, Suneela Dhaneshwar. Artificial Sweeteners: Perceptions and Realities. Current Diabetes Reviews 2023, 19 (7) https://doi.org/10.2174/1573399818666220429083052
    39. B.L Ojastha, M Jeevitha. An Evaluation of the Tensile Strength of Polyglactin Sutures After Immersion in Different Herbal Mouthwashes: An In Vitro Study. Cureus 2023, 14 https://doi.org/10.7759/cureus.43407
    40. Maria Papaefthimiou, Panagiota I. Kontou, Pantelis G. Bagos, Georgia G. Braliou. Antioxidant Activity of Leaf Extracts from Stevia rebaudiana Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis. Nutrients 2023, 15 (15) , 3325. https://doi.org/10.3390/nu15153325
    41. Francisca Noya-Leal, Nikkie van der Wielen, Maik Behrens, Sven Rouschop, Jeroen van Arkel, Maarten Jongsma, Renger Witkamp, Jurriaan J. Mes, Shanna Bastiaan-Net, Jocelijn Meijerink. Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. Food & Function 2023, 14 (15) , 6914-6928. https://doi.org/10.1039/D3FO00818E
    42. Mehmet Fuat Gülhan. A New Substrate and Nitrogen Source for Traditional Kombucha Beverage: Stevia rebaudiana Leaves. Applied Biochemistry and Biotechnology 2023, 195 (7) , 4096-4115. https://doi.org/10.1007/s12010-023-04323-1
    43. Puja C. Yavagal, G. K. Divyapriya, D. J. Veeresh, Nousheen Nadaf. Effect of Eating Stevia-coated Fennel Seeds on Salivary pH: A Randomized Controlled Trial. Journal of Indian Association of Public Health Dentistry 2023, 21 (3) , 255-259. https://doi.org/10.4103/jiaphd.jiaphd_69_23
    44. Zhuoyu Zhou, Yongmei Xia, Xueyi Hu. Could one stone hit two or three birds on the Stevia leaves? Harvesting rebaudioside A with enzymatic producing rubusoside directly from the Stevia leaves. Industrial Crops and Products 2023, 192 , 116027. https://doi.org/10.1016/j.indcrop.2022.116027
    45. Luis Alfonso Rodriguez-Paez, Ana Melisa Jimenez-Ramirez, Marcelo F. Pompelli, Yirlis Yadeth Pineda-Rodriguez, Alfredo Jarma-Orozco, Juán de Dios Jaraba-Navas, Hermes Aramendiz-Tatis, Enrique Combatt-Caballero, Maria Ileana Oloriz-Ortega, Novisel Veitía Rodríguez. Physiological and Enzymatic Evaluation of Selected Genotypes of Stevia rebaudiana Bertoni. Agronomy 2023, 13 (2) , 403. https://doi.org/10.3390/agronomy13020403
    46. Magdalena Simlat, Agata Ptak, Tomasz Wójtowicz, Agnieszka Szewczyk. The Content of Phenolic Compounds in Stevia rebaudiana (Bertoni) Plants Derived from Melatonin and NaCl Treated Seeds. Plants 2023, 12 (4) , 780. https://doi.org/10.3390/plants12040780
    47. Patil Shivprasad Suresh, Prithvi Pal Singh, Mohit Sharma, Upendra Sharma. Multicomponent natural deep eutectic solvents: Super solvents for the efficient extraction of steviol glycosides (rebaudioside A) from Stevia rebaudiana. Journal of Cleaner Production 2023, 385 , 135639. https://doi.org/10.1016/j.jclepro.2022.135639
    48. Yang Wang, Xiang Luo, Li Chen, Abdullateef Taiye Mustapha, Xiaojie Yu, Cunshan Zhou, Clinton Emeka Okonkwo. Natural and low‐caloric rebaudioside A as a substitute for dietary sugars: A comprehensive review. Comprehensive Reviews in Food Science and Food Safety 2023, 22 (1) , 615-642. https://doi.org/10.1111/1541-4337.13084
    49. Kamelia Miladinova-Georgieva, Maria Geneva, Ira Stancheva, Maria Petrova, Mariana Sichanova, Elisaveta Kirova. Effects of Different Elicitors on Micropropagation, Biomass and Secondary Metabolite Production of Stevia rebaudiana Bertoni—A Review. Plants 2023, 12 (1) , 153. https://doi.org/10.3390/plants12010153
    50. Sara Kolar, Slaven Jurić, Marijan Marijan, Kristina Vlahoviček-Kahlina, Marko Vinceković. Applicability of alginate-based composite microspheres loaded with aqueous extract of Stevia rebaudiana Bertoni leaves in food and pharmaceutical products. Food Bioscience 2022, 50 , 101970. https://doi.org/10.1016/j.fbio.2022.101970
    51. Sitanshu Khilar, Amrat Pal Singh, Marco Biagi, Alok Sharma. An Insight into attributes of  Bertoni: Recent advances in extraction techniques, phytochemistry, food applications and health benefits. Journal of Agriculture and Food Research 2022, 10 , 100458. https://doi.org/10.1016/j.jafr.2022.100458
    52. Modhi O. Alotaibi, Mashael M. Alotibi, Mamdouh A. Eissa, Adel M. Ghoneim. Compost and plant growth-promoting bacteria enhanced steviol glycoside synthesis in stevia (Stevia rebaudiana Bertoni) plants by improving soil quality and regulating nitrogen uptake. South African Journal of Botany 2022, 151 , 306-314. https://doi.org/10.1016/j.sajb.2022.10.010
    53. Muhammad Arslan Ahmad, Xu Deng, Muhammad Adeel, Muhammad Rizwan, Noman Shakoor, Yuesuo Yang, Rabia Javed. Influence of calcium and magnesium elimination on plant biomass and secondary metabolites of Stevia rebaudiana Bertoni. Biotechnology and Applied Biochemistry 2022, 69 (5) , 2008-2016. https://doi.org/10.1002/bab.2263
    54. Shuai Liu, Yunxia Xiong, Shuting Cao, Xiaolu Wen, Hao Xiao, Yajing Li, Lei Chi, Dongsheng He, Zongyong Jiang, Li Wang. Dietary Stevia Residue Extract Supplementation Improves Antioxidant Capacity and Intestinal Microbial Composition of Weaned Piglets. Antioxidants 2022, 11 (10) , 2016. https://doi.org/10.3390/antiox11102016
    55. Jing Wang, Yang Zhao, Yang Yang, Xin Chen, Yu Jin, Yanxiong Ke. Separation of minor steviol glycosides using hydrophilic interaction liquid chromatography (HILIC) and off-line two-dimensional reversed-phase liquid chromatography/HILIC methods. Journal of Food Composition and Analysis 2022, 112 , 104683. https://doi.org/10.1016/j.jfca.2022.104683
    56. Maocheng Jiang, Osmond Datsomor, Zhiqiang Cheng, Zitong Meng, Kang Zhan, Tianyu Yang, Yinghao Huang, Qi Yan, Guoqi Zhao. Partial Substitution of Alfalfa Hay by Stevia (Stevia rebaudiana) Hay Can Improve Lactation Performance, Rumen Fermentation, and Nitrogen Utilization of Dairy Cows. Frontiers in Veterinary Science 2022, 9 https://doi.org/10.3389/fvets.2022.899148
    57. Djéssica Tatiane Raspe, Camila da Silva, Silvio Cláudio da Costa. Compounds from Stevia rebaudiana Bertoni leaves: An overview of non-conventional extraction methods and challenges. Food Bioscience 2022, 46 , 101593. https://doi.org/10.1016/j.fbio.2022.101593
    58. Marco Bugliani, Silvia Tavarini, Francesca Grano, Silvia Tondi, Serena Lacerenza, Laura Giusti, Maurizio Ronci, Anna Maidecchi, Piero Marchetti, Marta Tesi, Luciana G. Angelini. Protective effects of Stevia rebaudiana extracts on beta cells in lipotoxic conditions. Acta Diabetologica 2022, 59 (1) , 113-126. https://doi.org/10.1007/s00592-021-01793-9
    59. Xinyu Tian, Fang Zhong, Yixun Xia. Dynamic characteristics of sweetness and bitterness and their correlation with chemical structures for six steviol glycosides. Food Research International 2022, 151 , 110848. https://doi.org/10.1016/j.foodres.2021.110848
    60. Yingying Lu, Shuijiao Liao, Yiran Ding, Ying He, Ziyi Gao, Danna Song, Wei Tian, Xing Zhang. Effect of Stevia rebaudiana Bertoni residue on the arsenic phytoextraction efficiency of Pteris vittata L. Journal of Hazardous Materials 2022, 421 , 126678. https://doi.org/10.1016/j.jhazmat.2021.126678
    61. Kuntal Das, Syed Mohammed Basheeruddin Asdaq, M. Saifulla Khan, Sravani Singirikonda, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Sreeharsha Nagaraja, Katharigatta N. Venugopala. Phytochemical Analysis, Estimation of Quercetin, and in Vitro Anti-Diabetic Potential of Stevia Leaves Samples Procured from Two Geographical Origins. Phyton 2022, 91 (10) , 2349-2365. https://doi.org/10.32604/phyton.2022.022379
    62. Roberto Lemus‐Mondaca, Liliana Zura‐Bravo, Kong Ah‐Hen, Karina Di Scala. Effect of drying methods on drying kinetics, energy features, thermophysical and microstructural properties of Stevia rebaudiana leaves. Journal of the Science of Food and Agriculture 2021, 101 (15) , 6484-6495. https://doi.org/10.1002/jsfa.11320
    63. Denggang Wang, Meiqi Chen, Xin Zeng, Wenjie Li, Shuli Liang, Ying Lin. Improving the catalytic performance of Pichia pastoris whole-cell biocatalysts by fermentation process. RSC Advances 2021, 11 (57) , 36329-36339. https://doi.org/10.1039/D1RA06253K
    64. Cristina Cedeño-Pinos, María Cristina Marcucci, Sancho Bañón. Contribution of Green Propolis to the Antioxidant, Physical, and Sensory Properties of Fruity Jelly Candies Made with Sugars or Fructans. Foods 2021, 10 (11) , 2586. https://doi.org/10.3390/foods10112586
    65. Marcos Vinicius Silva de Andrade, Renato Delmondez de Castro, Diego da Silva Cunha, Valdir Gomes Neto, Maria Gabriela Aparecida Carosio, Antonio Gilberto Ferreira, Lourdes Cardoso de Souza-Neta, Luzimar Gonzaga Fernandez, Paulo Roberto Ribeiro. Stevia rebaudiana (Bert.) Bertoni cultivated under different photoperiod conditions: Improving physiological and biochemical traits for industrial applications. Industrial Crops and Products 2021, 168 , 113595. https://doi.org/10.1016/j.indcrop.2021.113595
    66. Aleksey Aleksandrovich Kochetov, Nadezhda Georgiyevna Sinyavina. STEVIA (STEVIA REBAUDIANA BERTONI): BIOCHEMICAL COMPOSITION, THERAPEUTIC PROPERTIES AND USE IN THE FOOD INDUSTRY (REVIEW). chemistry of plant raw material 2021, (2) , 5-27. https://doi.org/10.14258/jcprm.2021027931
    67. Simone Ribeiro Lucho, Marcelo Nogueira do Amaral, Cristini Milech, Valmor João Bianchi, Lorena Almagro, María Ángeles Ferrer, Antonio Asensio Calderón, Eugenia Jacira Bolacel Braga. Gibberellin reverses the negative effect of paclobutrazol but not of chlorocholine chloride on the expression of SGs/GAs biosynthesis-related genes and increases the levels of relevant metabolites in Stevia rebaudiana. Plant Cell, Tissue and Organ Culture (PCTOC) 2021, 146 (1) , 171-184. https://doi.org/10.1007/s11240-021-02059-6
    68. Naveed Ahmad, Abdur Rab, Muhammad Sajid, Nisar Ahmad, Hina Fazal, Mohammad Ali, Ulrika Egertsdotter. Sucrose-dependent production of biomass and low-caloric steviol glycosides in adventitious root cultures of Stevia rebaudiana (Bert.). Industrial Crops and Products 2021, 164 , 113382. https://doi.org/10.1016/j.indcrop.2021.113382
    69. Marta Libik-Konieczny, Ewa Capecka, Monika Tuleja, Robert Konieczny. Synthesis and production of steviol glycosides: recent research trends and perspectives. Applied Microbiology and Biotechnology 2021, 105 (10) , 3883-3900. https://doi.org/10.1007/s00253-021-11306-x
    70. Wilmer H. Perera, James D. McChesney. Approaches toward the Separation, Modification, Identification and Scale up Purification of Tetracyclic Diterpene Glycosides from Stevia rebaudiana (Bertoni) Bertoni. Molecules 2021, 26 (7) , 1915. https://doi.org/10.3390/molecules26071915
    71. Fatih Mehmet Yılmaz, Ahmet Görgüç, Özge Uygun, Cavit Bircan. Steviol glycosides and polyphenols extraction from Stevia rebaudiana Bertoni leaves using maceration, microwave-, and ultrasound-assisted techniques. Separation Science and Technology 2021, 56 (5) , 936-948. https://doi.org/10.1080/01496395.2020.1743311
    72. Veronica A. Vallejo, Ryan M. Warner. Identifying quantitative trait loci for steviol glycoside production in Stevia rebaudiana using transcriptome-derived SSRs. Industrial Crops and Products 2021, 161 , 113176. https://doi.org/10.1016/j.indcrop.2020.113176
    73. Clarissa Clemente, Luciana G. Angelini, Roberta Ascrizzi, Silvia Tavarini. Stevia rebaudiana (Bertoni) as a Multifunctional and Sustainable Crop for the Mediterranean Climate. Agriculture 2021, 11 (2) , 123. https://doi.org/10.3390/agriculture11020123
    74. Chin Hui Lim, Babak Rasti, Joko Sulistyo, Mansoor Abdul Hamid. Comprehensive study on transglycosylation of CGTase from various sources. Heliyon 2021, 7 (2) , e06305. https://doi.org/10.1016/j.heliyon.2021.e06305
    75. Áron Németh, Réka Czinkóczky. Introduction. 2021, 1-30. https://doi.org/10.1016/B978-0-12-820060-5.00001-7
    76. Shokoofeh Hajihashemi. Agronomic practices. 2021, 31-56. https://doi.org/10.1016/B978-0-12-820060-5.00002-9
    77. Raziye Zare Hoseini, Ebrahim Mohammadi Goltapeh, Seyed Ali Mohammad Modarres-Sanavy, Ali Heidarzadeh. Effect of the bio-fertilizers on the steviol glycosides (SGs) content and biomass in Stevia rebaudiana (Bert.) Bertoni at vegetative and flowering stages. Scientia Horticulturae 2021, 275 , 109658. https://doi.org/10.1016/j.scienta.2020.109658
    78. Soichiro Urai, Hiroshi Takiyama. Investigation of improved rebaudioside D solubility and the characteristics of an erythritol/rebaudioside D/fructose ternary complex. Food Science and Technology Research 2021, 27 (2) , 193-201. https://doi.org/10.3136/fstr.27.193
    79. Gualtiero Milani, Maryline Vian, Maria Maddalena Cavalluzzi, Carlo Franchini, Filomena Corbo, Giovanni Lentini, Farid Chemat. Ultrasound and deep eutectic solvents: An efficient combination to tune the mechanism of steviol glycosides extraction. Ultrasonics Sonochemistry 2020, 69 , 105255. https://doi.org/10.1016/j.ultsonch.2020.105255
    80. Sandra Beserra da SILVA, Maysa Ariane FORMIGONI, Maria Rosa ZORZENON, Paula Gimenez MILANI, Antonio Sérgio DACOME, Flávio Augusto Vicente SEIXAS, Silvio Claúdio da COSTA. Development of diet cereal bar sweetened with stevia leaves pre-treated with ethanol. Food Science and Technology 2020, 40 (4) , 894-901. https://doi.org/10.1590/fst.19319
    81. Cristina Cedeño-Pinos, Magdalena Martínez-Tomé, María Antonia Murcia, María José Jordán, Sancho Bañón. Assessment of Rosemary (Rosmarinus officinalis L.) Extract as Antioxidant in Jelly Candies Made with Fructan Fibres and Stevia. Antioxidants 2020, 9 (12) , 1289. https://doi.org/10.3390/antiox9121289
    82. Silvia Tavarini, Clarissa Clemente, Cecilia Bender, Luciana G. Angelini. Health-Promoting Compounds in Stevia: The Effect of Mycorrhizal Symbiosis, Phosphorus Supply and Harvest Time. Molecules 2020, 25 (22) , 5399. https://doi.org/10.3390/molecules25225399
    83. Mubarak Ali Khan, Amir Ali, Sher Mohammad, Huma Ali, Tariq Khan, Zia-ur-Rehman Mashwani, Asif Jan, Pervaiz Ahmad. Iron nano modulated growth and biosynthesis of steviol glycosides in Stevia rebaudiana. Plant Cell, Tissue and Organ Culture (PCTOC) 2020, 143 (1) , 121-130. https://doi.org/10.1007/s11240-020-01902-6
    84. Gertrud E. Morlock, Julia Heil. HI-HPTLC-UV/Vis/FLD-HESI-HRMS and bioprofiling of steviol glycosides, steviol, and isosteviol in Stevia leaves and foods. Analytical and Bioanalytical Chemistry 2020, 412 (24) , 6431-6448. https://doi.org/10.1007/s00216-020-02618-4
    85. Min Lin, Fei Wang, Yushan Zhu. Modeled structure-based computational redesign of a glycosyltransferase for the synthesis of rebaudioside D from rebaudioside A. Biochemical Engineering Journal 2020, 159 , 107626. https://doi.org/10.1016/j.bej.2020.107626
    86. Liangliang Chen, Ruxin Cai, Jingyuan Weng, Yan Li, Honghua Jia, Kequan Chen, Ming Yan, Pingkai Ouyang. Production of rebaudioside D from stevioside using a UGTSL2 Asn358Phe mutant in a multi‐enzyme system. Microbial Biotechnology 2020, 13 (4) , 974-983. https://doi.org/10.1111/1751-7915.13539
    87. Jamil Ahmad, Imran Khan, Renald Blundell, Joseph Azzopardi, Mohamad Fawzi Mahomoodally. Stevia rebaudiana Bertoni.: an updated review of its health benefits, industrial applications and safety. Trends in Food Science & Technology 2020, 100 , 177-189. https://doi.org/10.1016/j.tifs.2020.04.030
    88. Carol Díaz-Gutiérrez, Alejandro Hurtado, Amilvia Ortíz, Charlotte Poschenrieder, Catalina Arroyave, Carlos Peláez. Increase in steviol glycosides production from Stevia rebaudiana Bertoni under organo-mineral fertilization. Industrial Crops and Products 2020, 147 , 112220. https://doi.org/10.1016/j.indcrop.2020.112220
    89. . Stevia Species. 2020, 1067-1084. https://doi.org/10.1002/9783527825578.c02-83
    90. Judy Retti Witono, Andy Chandra. The Study on the Method for Maximizing Steviol Glycoside Extract from Stevia Leaves. IOP Conference Series: Materials Science and Engineering 2020, 742 , 012048. https://doi.org/10.1088/1757-899X/742/1/012048
    91. Khaing zar Myint, Ke Wu, Yongmei Xia, Ye Fan, Jie Shen, Peter Zhang, Jianxin Gu. Polyphenols from Stevia rebaudiana (Bertoni) leaves and their functional properties. Journal of Food Science 2020, 85 (2) , 240-248. https://doi.org/10.1111/1750-3841.15017
    92. Pedisić Sandra, Zoran Zorić, Danijela Bursać Kovačević, Ivona Elez Garofulić, Verica Dragović‐Uzelac. Pressurized hot water extraction of phenolic compounds from leaves of Stevia rebaudiana : An UPLC‐ESI‐MSMS study. Journal of Food Process Engineering 2020, 43 (2) https://doi.org/10.1111/jfpe.13319
    93. Tridip Bhattacharjee, Saikat Sen, Raja Chakraborty, Praveen Kumar Maurya, Arup Chattopadhyay. Cultivation of Medicinal Plants: Special Reference to Important Medicinal Plants of India. 2020, 101-115. https://doi.org/10.1007/978-981-13-7248-3_8
    94. Priscila Guerra Ramírez, Diana Guerra Ramírez, Emma Zavaleta Mejía, Sergio Aranda Ocampo, Cristian Nava Díaz, Reyna Isabel Rojas Martínez. Extracts of Stevia rebaudiana against Fusarium oxysporum associated with tomato cultivation. Scientia Horticulturae 2020, 259 , 108683. https://doi.org/10.1016/j.scienta.2019.108683
    95. Xiaomin Zou, QiWen Tan, Bey-Hing Goh, Learn-Han Lee, Kai-Leng Tan, Hooi-Leng Ser. ‘Sweeter’ than its name: anti-inflammatory activities of Stevia rebaudiana. All Life 2020, 13 (1) , 286-309. https://doi.org/10.1080/26895293.2020.1771434
    96. Djaja D. Soejarto, Ermias Mekuria Addo, A. Douglas Kinghorn. Highly sweet compounds of plant origin: From ethnobotanical observations to wide utilization. Journal of Ethnopharmacology 2019, 243 , 112056. https://doi.org/10.1016/j.jep.2019.112056
    97. Weiwei Jia, Zhenbin Chen, Yingyu Zhao, Ke Li, Brandon Tichnell, Zhenghua Tang, Juan M. Ruso, Zhen Liu. The study of ultrasound-assisted extraction of flavonoids from Polygonum cuspidatum Sieb. et Zucc.. Journal of Materials Research 2019, 34 (19) , 3254-3262. https://doi.org/10.1557/jmr.2019.144
    98. David Paniagua-Vega, Norma Cavazos-Rocha, Ariana A. Huerta-Heredia, Aída Parra-Naranjo, Verónica M. Rivas-Galindo, Noemí Waksman, Alma L. Saucedo. A validated NMR method for the quantitative determination of rebaudioside A in commercial sweeteners. Journal of Food Composition and Analysis 2019, 79 , 134-142. https://doi.org/10.1016/j.jfca.2019.02.009
    99. Nathalia D. Aceval Arriola, Peter Ian Chater, Matthew Wilcox, Luigi Lucini, Gabriele Rocchetti, Milene Dalmina, Jeffrey P. Pearson, Renata Dias de Mello Castanho Amboni. Encapsulation of stevia rebaudiana Bertoni aqueous crude extracts by ionic gelation – Effects of alginate blends and gelling solutions on the polyphenolic profile. Food Chemistry 2019, 275 , 123-134. https://doi.org/10.1016/j.foodchem.2018.09.086
    100. Mariana Wolff de Carvalho, Nathalia Darminia Aceval Arriola, Stephanie Silva Pinto, Silvani Verruck, Carlise Beddin Fritzen‐Freire, Elane Schwinden Prudêncio, Renata Dias de Mello Castanho Amboni. Stevia‐fortified yoghurt: Stability, antioxidant activity and in vitro digestion behaviour. International Journal of Dairy Technology 2019, 72 (1) , 57-64. https://doi.org/10.1111/1471-0307.12559
    Load all citations

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2012, 60, 4, 886–895
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf2044907
    Published January 17, 2012
    Copyright © 2012 American Chemical Society

    Article Views

    6370

    Altmetric

    -

    Citations

    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.