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Enhancements of Skin Cell Proliferations and Migrations via 6-Dehydrogingerdione

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† School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan, Republic of China
▽ △Department of Biotechnology and ▽Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China
*Postal address: 100 Shih-Chuan first Road, San-Ming District, Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China. Phone: +(886)-7-312-1101, ext. 2804. Fax: +(886)-7-3136059. E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2013, 61, 6, 1349–1356
Publication Date (Web):December 26, 2012
https://doi.org/10.1021/jf304340q
Copyright © 2012 American Chemical Society
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    Abstract

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    Human skin protects the body from mechanical and chemical damages, and skin wound healing is a costly procedure and worldwide issue. A Zingiber officinale compound, 6-dehydrogingerdione (6-DG), is presented as a novel biofunctional healing agent for human skin wound repair. The effectiveness on cell growth/migration, growth factor, collagen amount, and enzymatic activity was assessed. 6-DG treatment accelerated cellular proliferation and migration dose-dependently. Enzyme-linked immunosorbent assay (ELISA) showed that 6-DG brought about higher growth factor productions on transforming growth factor-β (TGF-β), platelet-derived growth factor-αβ (PDGF-αβ), and vascular endothelial growth factors (VEGF). Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. 6-DG also blocked the mitogen-activated protein kinase (MAPK) pathway by suppressing c-Jun protein levels and extracellular signal-regulated kinases (ERK) phosphorylation in fibroblasts. From all of the above, 6-DG has potential to be a novel agent for human skin repair.

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