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Concord Grape Pomace Polyphenols Complexed to Soy Protein Isolate Are Stable and Hypoglycemic in Diabetic Mice

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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2013, 61, 47, 11428-11433
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    Concord Grape Pomace Polyphenols Complexed to Soy Protein Isolate Are Stable and Hypoglycemic in Diabetic Mice
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    † School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, Foran Hall, 59 Dudley Road, New Brunswick, New Jersey 08901, United States
    ‡ Complete Phytochemical Solutions, LLC, 317 South Street, Cambridge, Wisconsin 53523, United States
    § Reed Research Group, Department of Animal Sciences, University of Wisconsin—Madison, 1675 Observatory Drive, Madison, Wisconsin 53706 United States
    ∥ Nutrasorb LLC, 675 US Highway 1, North Brunswick, New Jersey 08902, United States
    ⊥ Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, North Carolina 28081, United States
    *D.E.R.: phone, 848-932-8165; fax, 732-932-6535; e-mail, [email protected]
    *I.R.: phone, 848-932-6267; e-mail, [email protected]
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2013, 61, 47, 11428–11433
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    https://doi.org/10.1021/jf403238e
    Published November 8, 2013
    Copyright © 2013 American Chemical Society
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    Abstract

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    Polyphenols extracted from Concord grape pomace were stabilized by complexation to soy protein isolate (SPI) to produce grape polyphenol–SPI complex (GP–SPI) containing 5% or 10% grape polyphenols. LC–MS and MALDI-TOF analysis showed that a broad range of phytochemicals were present in the grape pomace extract. Anthocyanins and total polyphenols in the GP–SPI complex were stable after a 16-week incubation at 37 °C but were reduced by up 60% in dried grape pomace extract. Compared to vehicle (236 ± 34 mg/dL), a single dose of 300 mg/kg GP–SPI (184 ± 32 mg/dL) or 500 mg/kg GP–SPI (177 ± 28 mg/dL) having 5% grape polyphenols significantly lowered blood glucose in obese and hyperglycemic C57BL/6 mice 6 h after administration. GP–SPI allows the capture of grape pomace polyphenols in a protein-rich food matrix and may be useful as a functional food ingredient for the management of blood glucose levels.

    Copyright © 2013 American Chemical Society

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    This article is cited by 42 publications.

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    Cite this: J. Agric. Food Chem. 2013, 61, 47, 11428–11433
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf403238e
    Published November 8, 2013
    Copyright © 2013 American Chemical Society
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