Analysis of Hygrine and Cuscohygrine in Coca Leaves Using Gas Chromatography and High-Performance Liquid ChromatographyClick to copy article linkArticle link copied!
Abstract
The alkaloids hygrine and cuscohygrine in Erythroxylum coca var. Coca leaves were analyzed by a gas chromatographic (GC) method using a dimethylsilicone capillary column and a high-performance liquid chromatographic (HPLC) method using a weak cation exchange column. Hygrine content in E. coca leaves was determined as 0.12% by GC and 0.07% by HPLC, whereas cuscohygrine content was 0.25% by GC and 0.21% by HPLC.
Keywords: Hygrine; cuscohygrine; alkaloids; Erythroxylum; coca extracts
Cited By
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by ACS Publications if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
This article is cited by 7 publications.
- Xiao Xia, Yan Lu, Dao-Feng Chen. 2-Acylpyrrole-based alkaloids from the leaves of Sauropus spatulifolius and their α-glucosidase inhibitory activities. Bioorganic Chemistry 2025, 155 , 108134. https://doi.org/10.1016/j.bioorg.2025.108134
- Sophia Laposchan, Ruben F. Kranenburg, Arian C. van Asten. Impurities, adulterants and cutting agents in cocaine as potential candidates for retrospective mining of GC-MS data. Science & Justice 2022, 62
(1)
, 60-75. https://doi.org/10.1016/j.scijus.2021.11.004
- Nelida Cristina Rubio, Denise Thurmann, Franziska Krumbiegel, Fritz Pragst. Behaviour of hygrine and cuscohygrine in illicit cocaine production establishes their use as markers for chewing coca leaves in contrast with cocaine abuse. Drug Testing and Analysis 2017, 9
(2)
, 323-326. https://doi.org/10.1002/dta.1972
- Nelida Cristina Rubio, Martin Hastedt, Jorge Gonzalez, Fritz Pragst. Possibilities for discrimination between chewing of coca leaves and abuse of cocaine by hair analysis including hygrine, cuscohygrine, cinnamoylcocaine and cocaine metabolite/cocaine ratios. International Journal of Legal Medicine 2015, 129
(1)
, 69-84. https://doi.org/10.1007/s00414-014-1061-6
- C. Rubio, S. Strano-Rossi, M.J. Tabernero, L. Anzillotti, M. Chiarotti, A.M. Bermejo. Hygrine and cuscohygrine as possible markers to distinguish coca chewing from cocaine abuse in workplace drug testing. Forensic Science International 2013, 227
(1-3)
, 60-63. https://doi.org/10.1016/j.forsciint.2012.09.005
- Stefan Biastoff, Birgit Dräger. Chapter 2 Calystegines. 2007, 49-102. https://doi.org/10.1016/S1099-4831(07)64002-4
- Birgit Dräger. Analysis of tropane and related alkaloids. Journal of Chromatography A 2002, 978
(1-2)
, 1-35. https://doi.org/10.1016/S0021-9673(02)01387-0
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.